Bernard Malissen


Country: France


  1. Terhorst D, Fossum E, Baranska A, Tamoutounour S, Malosse C, Garbani M, et al. Laser-assisted intradermal delivery of adjuvant-free vaccines targeting XCR1+ dendritic cells induces potent antitumoral responses. J Immunol. 2015;194:5895-902 pubmed publisher
  2. Terhorst D, Chelbi R, Wohn C, Malosse C, Tamoutounour S, Jorquera A, et al. Dynamics and Transcriptomics of Skin Dendritic Cells and Macrophages in an Imiquimod-Induced, Biphasic Mouse Model of Psoriasis. J Immunol. 2015;195:4953-61 pubmed publisher
    ..Therefore, our data support an anti-inflammatory role of LCs during the course of psoriasis-like inflammation. ..
  3. Voisinne G, García Blesa A, Chaoui K, Fiore F, Bergot E, Girard L, et al. Co-recruitment analysis of the CBL and CBLB signalosomes in primary T cells identifies CD5 as a key regulator of TCR-induced ubiquitylation. Mol Syst Biol. 2016;12:876 pubmed publisher
    ..Our results offer an integrated view of the CBL and CBLB signaling complexes induced by TCR stimulation and provide a molecular basis for their negative regulatory function in normal T cells. ..
  4. Roncagalli R, Cucchetti M, Jarmuzynski N, Gregoire C, Bergot E, Audebert S, et al. The scaffolding function of the RLTPR protein explains its essential role for CD28 co-stimulation in mouse and human T cells. J Exp Med. 2016;213:2437-2457 pubmed
    ..RLTPR was also expressed in both human and mouse B cells. In the mouse, RLTPR did not play, however, any detectable role in BCR-mediated signaling and T cell-independent B cell responses. ..
  5. Malissen B, Bongrand P. Early T cell activation: integrating biochemical, structural, and biophysical cues. Annu Rev Immunol. 2015;33:539-61 pubmed publisher
  6. Guilliams M, Malissen B. A Death Notice for In-Vitro-Generated GM-CSF Dendritic Cells?. Immunity. 2015;42:988-90 pubmed publisher
    ..2015) show that this classical method produces heterogeneous populations of myeloid cells that are only distantly related to macrophages and DCs found in vivo. ..
  7. Baranska A, Shawket A, Jouve M, Baratin M, Malosse C, Voluzan O, et al. Unveiling skin macrophage dynamics explains both tattoo persistence and strenuous removal. J Exp Med. 2018;215:1115-1133 pubmed publisher
    ..Therefore, congruent with dermal macrophage dynamics, long-term tattoo persistence likely relies on macrophage renewal rather than on macrophage longevity. ..
  8. request reprint
    Malissen B, Malissen M. Functions of TCR and pre-TCR subunits: lessons from gene ablation. Curr Opin Immunol. 1996;8:383-93 pubmed
    ..By activating intracellular effectors, the CD3 subunits probably modulate gene expression profiles and drive the maturing alpha beta T cells through a precise developmental sequence. ..
  9. Reginald K, Chaoui K, Roncagalli R, Beau M, Goncalves Menoita M, Monsarrat B, et al. Revisiting the Timing of Action of the PAG Adaptor Using Quantitative Proteomics Analysis of Primary T Cells. J Immunol. 2015;195:5472-81 pubmed publisher

More Information


  1. Ardouin L, Luche H, Chelbi R, Carpentier S, Shawket A, Montanana Sanchis F, et al. Broad and Largely Concordant Molecular Changes Characterize Tolerogenic and Immunogenic Dendritic Cell Maturation in Thymus and Periphery. Immunity. 2016;45:305-18 pubmed publisher
  2. Guilliams M, Dutertre C, Scott C, McGovern N, Sichien D, Chakarov S, et al. Unsupervised High-Dimensional Analysis Aligns Dendritic Cells across Tissues and Species. Immunity. 2016;45:669-684 pubmed publisher
    ..This framework represents the way forward to a universal, high-throughput, and standardized analysis of DC populations from mutant mice and human patients. ..
  3. Caron E, Roncagalli R, Hase T, Wolski W, Choi M, Menoita M, et al. Precise Temporal Profiling of Signaling Complexes in Primary Cells Using SWATH Mass Spectrometry. Cell Rep. 2017;18:3219-3226 pubmed publisher