Research Topics
Genomes and GenesSpecies | Alfred MahrSummaryCountry: France Publications
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Publications
Prevalences of polyarteritis nodosa, microscopic polyangiitis, Wegener's granulomatosis, and Churg-Strauss syndrome in a French urban multiethnic population in 2000: a capture-recapture estimateAlfred Mahr
INSERM SC11, Paris, and Hôpital Avicenne, Universite Paris Nord, Assistance Publique Hopitaux de Paris, Bobigny, France
Arthritis Rheum 51:92-9. 2004..To estimate the prevalences of polyarteritis nodosa (PAN), microscopic polyangiitis (MPA), Wegener's granulomatosis (WG), and Churg-Strauss syndrome (CSS)...
Treatment of Churg-Strauss syndrome without poor-prognosis factors: a multicenter, prospective, randomized, open-label study of seventy-two patientsCamillo Ribi
Hopital Cochin, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, Paris, France
Arthritis Rheum 58:586-94. 2008....- Churg-Strauss syndrome with poor-prognosis factors: A prospective multicenter trial comparing glucocorticoids and six or twelve cyclophosphamide pulses in forty-eight patientsPascal Cohen
Hopital Cochin, Assistance Publique Hopitaux de Paris, Université René Descartes Paris, Recherche Clinique et Thérapeutique, Paris, France
Arthritis Rheum 57:686-93. 2007..To compare long and short durations of adjunctive cyclophosphamide for the treatment of severe Churg-Strauss syndrome (CSS)... - Clinical features and outcomes in 348 patients with polyarteritis nodosa: a systematic retrospective study of patients diagnosed between 1963 and 2005 and entered into the French Vasculitis Study Group DatabaseChristian Pagnoux
Universite Paris Descartes, Hopital Cochin, Assistance Publique Hopitaux de Paris, Paris, France
Arthritis Rheum 62:616-26. 2010..This study was undertaken to describe the main characteristics of and long-term outcomes in patients with well-characterized PAN diagnoses... - Treatment of polyarteritis nodosa and microscopic polyangiitis without poor-prognosis factors: A prospective randomized study of one hundred twenty-four patientsCamillo Ribi
Hopital Cochin, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, 75679 Paris, France
Arthritis Rheum 62:1186-97. 2010.... - Azathioprine or methotrexate maintenance for ANCA-associated vasculitisChristian Pagnoux
Universite Paris Descartes, Hopital Cochin, Assistance Publique Hopitaux de Paris, Paris, France
N Engl J Med 359:2790-803. 2008..However, azathioprine and methotrexate have not been compared with regard to safety and efficacy... - The Five-Factor Score revisited: assessment of prognoses of systemic necrotizing vasculitides based on the French Vasculitis Study Group (FVSG) cohortLoic Guillevin
Department of Internal Medicine, National Referral Center for Rare Systemic and Autoimmune Diseases Vasculitides and Scleroderma, Hopital Cochin, Assistance Publique Hopitaux de Paris, UPRES 4058, Universite Paris Descartes, INSERM 1016, Paris, France loic guillevin cch aphp fr
Medicine (Baltimore) 90:19-27. 2011..The better WG prognosis for patients with ENT manifestations, even for patients with other visceral involvement, compared with the prognosis for those without ENT manifestations, probably reflects WG phenotype heterogeneity... - Treatment strategies and outcome of induction-refractory Wegener's granulomatosis or microscopic polyangiitis: analysis of 32 patients with first-line induction-refractory disease in the WEGENT trialRaphaele Seror
Department of Internal Medicine, National Referral Center for Necrotizing Vasculitides and Systemic Sclerosis, Hopital Cochin, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, Paris, France
Ann Rheum Dis 69:2125-30. 2010.... - Antineutrophil cytoplasmic antibodies and the Churg-Strauss syndromeRégis Sablé-Fourtassou
Hopital Cochin, Assistance Publique Hopitaux de Paris, Universite Paris 5 Rene Descartes, Paris, France
Ann Intern Med 143:632-8. 2005..Since testing for antineutrophil cytoplasmic antibodies (ANCA) became available for routine evaluation, no large homogeneous cohort of patients with the Churg-Strauss syndrome has been studied... - Population-based prevalence study of Behçet's disease: differences by ethnic origin and low variation by age at immigrationAlfred Mahr
Department of Internal Medicine, Universite Paris 5 Rene Descartes, Hopital Cochin, Assistance Publique Hopitaux de Paris, Paris, France
Arthritis Rheum 58:3951-9. 2008..To estimate the prevalence of Behçet's disease (BD) in a multiethnic population living in France, with particular focus on disease risk among immigrants... - Extraocular manifestations of birdshot chorioretinopathy in 118 French patientsChristian Pagnoux
Department of Internal Medicine, National referral center for Systemic necrotizing vasculitides and systemic scleroderma, Hopital Cochin, Universite Paris Descartes, Assistance Publique Hopitaux de Paris, 75879 Paris cedex 14, France
Presse Med 39:e97-e102. 2010..Published studies on birdshot chorioretinopathy (BCR) did not provide definitive information on possibly associated extraocular manifestations... - Treating polyarteritis nodosa: current state of the artMathilde de Menthon
Department of Internal Medicine, Hospital Saint Louis, University Paris 7 Paris Diderot, Paris, France
Clin Exp Rheumatol 29:S110-6. 2011..Although more data are needed to resolve outstanding questions, it is unclear whether all these matters can be studied in the future in large, sufficiently powered trials... - Intravenous immunoglobulins for relapses of systemic vasculitides associated with antineutrophil cytoplasmic autoantibodies: results of a multicenter, prospective, open-label study of twenty-two patientsValerie Martinez
Hopital Cochin, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, Paris, France
Arthritis Rheum 58:308-17. 2008.... - Incidence and predictors of urotoxic adverse events in cyclophosphamide-treated patients with systemic necrotizing vasculitidesGuillaume Le Guenno
Hopital Cochin, Assistance Publique Hopitaux de Paris, and Université Paris 5, Paris, France
Arthritis Rheum 63:1435-45. 2011..To assess hemorrhagic cystitis and urinary tract cancer incidence and predictors in cyclophosphamide (CYC)-treated patients with systemic necrotizing vasculitis (SNV)... - Serum eosinophil cationic protein: a marker of disease activity in Churg-Strauss syndromePhilippe Guilpain
Paris Descartes University, Faculty of Medicine, Cochin Hospital, Paris, France
Ann N Y Acad Sci 1107:392-9. 2007..6264; P < 0.05) and during periods of remission (R = 0.4798; P < 0.05). Our results support that ECP might be used as a disease activity marker in CSS... - Predicting mortality in systemic Wegener's granulomatosis: a survival analysis based on 93 patientsDominique Bligny
, , , , Bobigny, France
Arthritis Rheum 51:83-91. 2004..These findings could indicate that the prognosis of WG might be governed by the balance between the granulomatosis as opposed to the vasculitic disease process... - IgM and IgG autoantibodies from microscopic polyangiitis patients but not those with other small- and medium-sized vessel vasculitides recognize multiple endothelial cell antigensYouri Chanseaud
UPRES EA 3408, , , Bobigny, France
Clin Immunol 109:165-78. 2003..Our results provide evidence that IgM and to a lesser degree IgG from MPA patients specifically recognize multiple EC antigens... - Central nervous system involvement in Wegener granulomatosisRaphaele Seror
Department of Internal Medicine, Hopital Cochin, Universite Rene Descartes Paris 5, Assistance Publique Hopitaux de Paris, Paris, France
Medicine (Baltimore) 85:54-65. 2006.... - Analysis of Wegener's granulomatosis responses to rituximab: current evidence and therapeutic prospectsAchille Aouba
Department of Internal Medicine and the French Vasculitis Study Group, Assistance Publique Hopitaux de Paris, Universite Paris, 5 René Descartes, Hopital Cochin, 27, rue du Faubourg Saint Jacques, 75679, Paris Cedex 14, France
Clin Rev Allergy Immunol 34:65-73. 2008..This promising biotherapy opens the way for other therapeutic agents targeting B lymphocytes and to improve our understanding of the pathophysiology of ANCA-associated vasculitis... - Patients with systemic inflammatory and autoimmune diseases are at risk of vaccine-preventable illnessesCecile Marchand-Janssen
Universite Paris Descartes, Faculte de Medecine, INSERM, CIC BT505, Assistance Publique Hopitaux de Paris, Groupe Hospitalier Cochin Saint Vincent De Paul, Pôle de médecine, CIC de vaccinologie Cochin Pasteur, Paris, France
Rheumatology (Oxford) 50:1099-105. 2011..To evaluate vaccine coverage and humoral immunity to tetanus, diphtheria and poliomyelitis in adults followed for systemic inflammatory and/or autoimmune diseases (SIADs)... - Limited value of temporal artery ultrasonography examinations for diagnosis of giant cell arteritis: analysis of 77 subjectsCarla Maldini
National Referral Center for Necrotizing Vasculitides and Systemic Sclerosis, Hospital Cochin, Assistance Publique Hopitaux de Paris, University Paris 5 René Descartes, Paris, France
J Rheumatol 37:2326-30. 2010..We retrospectively evaluated operating characteristics of temporal artery ultrasonography (TA-US) in a single teaching hospital... - Lessons from French National Guidelines on the treatment of venous thrombosis and central venous catheter thrombosis in cancer patientsDominique Farge
Service de médecine interne et pathologie vasculaire, Hôpital Saint Louis and INSERM U976, Assistance Publique Hopitaux de Paris, Paris, France
Thromb Res 125:S108-16. 2010.... - Microscopic polyangiitis and polyarteritis nodosa: how and when do they start?Christian Agard
Hopital Avicenne, Assistance Publique Hopitaux de Paris, France
Arthritis Rheum 49:709-15. 2003..To describe initial clinical symptoms attributable to microscopic polyangiitis (MPA) or polyarteritis nodosa (PAN)... - Effect of race/ethnicity on risk, presentation and course of connective tissue diseases and primary systemic vasculitidesMaryam Piram
Department of Internal Medicine, Hospital Saint Louis, Assistance Publique Hopitaux de Paris, University Paris 7 Paris Diderot, Paris, France
Curr Opin Rheumatol 24:193-200. 2012.... - Therapeutic plasma exchange in systemic vasculitis: an update on indications and resultsAlfred Mahr
Department of Internal Medicine, Hospital Saint Louis, University Paris, Paris, France
Curr Opin Rheumatol 24:261-6. 2012..This review summarizes the available evidence for the effectiveness of plasma exchange in systemic vasculitis... - Hepatitis B virus-associated polyarteritis nodosa: clinical characteristics, outcome, and impact of treatment in 115 patientsLoic Guillevin
Department of Internal Medicine, Hopital Cochin, Assistance Publique Hopitaux de Paris, Paris, France
Medicine (Baltimore) 84:313-22. 2005..The major cause of death is gastrointestinal tract involvement. Importantly, the frequency of HBV-PAN has decreased in relation to improved blood safety and vaccination campaigns... - Scleroderma renal crisis, still a life-threatening complicationLuis Teixeira
Department of Internal Medicine and Reference Center for Necrotizing Vasculitis and Systemic Sclerosis, Cochin Hospital, Assistance Publique Hopitaux de Paris AP HP, and UPRES EA 4058, Paris Descartes University, Faculty of Medicine, Paris, France
Ann N Y Acad Sci 1108:249-58. 2007..Quite a large proportion of patients require dialysis, although this therapy may be stopped in approximately one-third of patients. Patients remaining on dialysis after 2 years can be proposed for a renal transplantation... - Seasonal variations in onset of Wegener's granulomatosis: increased in summer?Alfred Mahr
Department of Internal Medicine, Hopital Cochin, Universite Rene Descartes, Paris, France
J Rheumatol 33:1615-22. 2006..Investigators have reported significant seasonal variations of onset of Wegener's granulomatosis (WG), but those data were not confirmed by others. We reexamined the hypothesis of a seasonal pattern of onset of WG... - HLA-B51/B5 and the risk of Behçet's disease: a systematic review and meta-analysis of case-control genetic association studiesMathilde de Menthon
Hôpital Cochin Université Paris René Descartes, Assistance Publique Hopitaux de Paris, Paris, France
Arthritis Rheum 61:1287-96. 2009..To quantify by meta-analysis the genetic effect of the HLA-B5 or HLA-B51 (HLA-B51/B5) allele on the risk of developing Behçet's disease (BD) and to look for potential effect modifiers... - Treatment of polyarteritis nodosa and microscopic polyangiitis with poor prognosis factors: a prospective trial comparing glucocorticoids and six or twelve cyclophosphamide pulses in sixty-five patientsLoic Guillevin
Hopital Avicenne, Assistance Publique Hopitaux de Paris, Universite Paris Nord, Bobigny, France
Arthritis Rheum 49:93-100. 2003.... - Deaths occurring during the first year after treatment onset for polyarteritis nodosa, microscopic polyangiitis, and Churg-Strauss syndrome: a retrospective analysis of causes and factors predictive of mortality based on 595 patientsAnne Bourgarit
Department of Internal Medicine, , , France
Medicine (Baltimore) 84:323-30. 2005..Cyclophosphamide-induced cytopenia and infection were responsible for 2 deaths. Despite these iatrogenic complications, early deaths were more frequently the consequence of insufficient or inappropriate therapy... - Long-term outcome of 37 patients with Wegener's granulomatosis with renal involvementJacques Eric Gottenberg
Department of Internal Medicine, Nationale referral center for Vasculitides and Scleroderma, Hopital Cochin, AP HP, Universite Paris 5, Paris
Presse Med 36:771-8. 2007..This prospective study sought to assess the long-term outcome and identify prognostic factors of patients with kidney disease related to Wegener's granulomatosis (WG)... - Aortic involvement in recent-onset giant cell (temporal) arteritis: a case-control prospective study using helical aortic computed tomodensitometric scanChristian Agard
Internal Medicine, Hotel Dieu, Place Alexis Ricordeau, Nantes Cedex 01, France
Arthritis Rheum 59:670-6. 2008..Computed tomodensitometric (CT) scan allows analysis of both the aortic wall and endoluminal part of the aorta. Therefore, we conducted a study using CT scan to analyze aortic abnormalities in patients with recent-onset GCA... - Presentation and outcome of gastrointestinal involvement in systemic necrotizing vasculitides: analysis of 62 patients with polyarteritis nodosa, microscopic polyangiitis, Wegener granulomatosis, Churg-Strauss syndrome, or rheumatoid arthritis-associated Christian Pagnoux
Hopital Cochin, Service de Medecine Interne, 27, rue du Faubourg Saint Jacques, Paris Cedex 14, France
Medicine (Baltimore) 84:115-28. 2005.... 
Development and validation of a consensus methodology for the classification of the ANCA-associated vasculitides and polyarteritis nodosa for epidemiological studiesRichard Watts
Department of Rheumatology, Ipswich Hospital NHS Trust, Heath Road, Ipswich IP4 5PD, UK
Ann Rheum Dis 66:222-7. 2007..Aim: To develop a consensus method of using these criteria and definitions for epidemiological studies to permit comparison without confounding by classification...