Alfred Mahr

Summary

Country: France

Publications

  1. ncbi request reprint Prevalences of polyarteritis nodosa, microscopic polyangiitis, Wegener's granulomatosis, and Churg-Strauss syndrome in a French urban multiethnic population in 2000: a capture-recapture estimate
    Alfred Mahr
    INSERM SC11, Paris, and Hôpital Avicenne, Universite Paris Nord, Assistance Publique Hopitaux de Paris, Bobigny, France
    Arthritis Rheum 51:92-9. 2004
  2. doi request reprint Treatment of Churg-Strauss syndrome without poor-prognosis factors: a multicenter, prospective, randomized, open-label study of seventy-two patients
    Camillo Ribi
    Hopital Cochin, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, Paris, France
    Arthritis Rheum 58:586-94. 2008
  3. ncbi request reprint Churg-Strauss syndrome with poor-prognosis factors: A prospective multicenter trial comparing glucocorticoids and six or twelve cyclophosphamide pulses in forty-eight patients
    Pascal Cohen
    Hopital Cochin, Assistance Publique Hopitaux de Paris, Université René Descartes Paris, Recherche Clinique et Thérapeutique, Paris, France
    Arthritis Rheum 57:686-93. 2007
  4. doi request reprint Clinical features and outcomes in 348 patients with polyarteritis nodosa: a systematic retrospective study of patients diagnosed between 1963 and 2005 and entered into the French Vasculitis Study Group Database
    Christian Pagnoux
    Universite Paris Descartes, Hopital Cochin, Assistance Publique Hopitaux de Paris, Paris, France
    Arthritis Rheum 62:616-26. 2010
  5. doi request reprint Treatment of polyarteritis nodosa and microscopic polyangiitis without poor-prognosis factors: A prospective randomized study of one hundred twenty-four patients
    Camillo Ribi
    Hopital Cochin, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, 75679 Paris, France
    Arthritis Rheum 62:1186-97. 2010
  6. doi request reprint Azathioprine or methotrexate maintenance for ANCA-associated vasculitis
    Christian Pagnoux
    Universite Paris Descartes, Hopital Cochin, Assistance Publique Hopitaux de Paris, Paris, France
    N Engl J Med 359:2790-803. 2008
  7. doi request reprint The Five-Factor Score revisited: assessment of prognoses of systemic necrotizing vasculitides based on the French Vasculitis Study Group (FVSG) cohort
    Loic Guillevin
    Department of Internal Medicine, National Referral Center for Rare Systemic and Autoimmune Diseases Vasculitides and Scleroderma, Hopital Cochin, Assistance Publique Hopitaux de Paris, UPRES 4058, Universite Paris Descartes, INSERM 1016, Paris, France loic guillevin cch aphp fr
    Medicine (Baltimore) 90:19-27. 2011
  8. doi request reprint Treatment strategies and outcome of induction-refractory Wegener's granulomatosis or microscopic polyangiitis: analysis of 32 patients with first-line induction-refractory disease in the WEGENT trial
    Raphaele Seror
    Department of Internal Medicine, National Referral Center for Necrotizing Vasculitides and Systemic Sclerosis, Hopital Cochin, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, Paris, France
    Ann Rheum Dis 69:2125-30. 2010
  9. ncbi request reprint Antineutrophil cytoplasmic antibodies and the Churg-Strauss syndrome
    Régis Sablé-Fourtassou
    Hopital Cochin, Assistance Publique Hopitaux de Paris, Universite Paris 5 Rene Descartes, Paris, France
    Ann Intern Med 143:632-8. 2005
  10. doi request reprint Extraocular manifestations of birdshot chorioretinopathy in 118 French patients
    Christian Pagnoux
    Department of Internal Medicine, National referral center for Systemic necrotizing vasculitides and systemic scleroderma, Hopital Cochin, Universite Paris Descartes, Assistance Publique Hopitaux de Paris, 75879 Paris cedex 14, France
    Presse Med 39:e97-e102. 2010

Collaborators

Detail Information

Publications39

  1. ncbi request reprint Prevalences of polyarteritis nodosa, microscopic polyangiitis, Wegener's granulomatosis, and Churg-Strauss syndrome in a French urban multiethnic population in 2000: a capture-recapture estimate
    Alfred Mahr
    INSERM SC11, Paris, and Hôpital Avicenne, Universite Paris Nord, Assistance Publique Hopitaux de Paris, Bobigny, France
    Arthritis Rheum 51:92-9. 2004
    ..To estimate the prevalences of polyarteritis nodosa (PAN), microscopic polyangiitis (MPA), Wegener's granulomatosis (WG), and Churg-Strauss syndrome (CSS)...
  2. doi request reprint Treatment of Churg-Strauss syndrome without poor-prognosis factors: a multicenter, prospective, randomized, open-label study of seventy-two patients
    Camillo Ribi
    Hopital Cochin, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, Paris, France
    Arthritis Rheum 58:586-94. 2008
    ....
  3. ncbi request reprint Churg-Strauss syndrome with poor-prognosis factors: A prospective multicenter trial comparing glucocorticoids and six or twelve cyclophosphamide pulses in forty-eight patients
    Pascal Cohen
    Hopital Cochin, Assistance Publique Hopitaux de Paris, Université René Descartes Paris, Recherche Clinique et Thérapeutique, Paris, France
    Arthritis Rheum 57:686-93. 2007
    ..To compare long and short durations of adjunctive cyclophosphamide for the treatment of severe Churg-Strauss syndrome (CSS)...
  4. doi request reprint Clinical features and outcomes in 348 patients with polyarteritis nodosa: a systematic retrospective study of patients diagnosed between 1963 and 2005 and entered into the French Vasculitis Study Group Database
    Christian Pagnoux
    Universite Paris Descartes, Hopital Cochin, Assistance Publique Hopitaux de Paris, Paris, France
    Arthritis Rheum 62:616-26. 2010
    ..This study was undertaken to describe the main characteristics of and long-term outcomes in patients with well-characterized PAN diagnoses...
  5. doi request reprint Treatment of polyarteritis nodosa and microscopic polyangiitis without poor-prognosis factors: A prospective randomized study of one hundred twenty-four patients
    Camillo Ribi
    Hopital Cochin, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, 75679 Paris, France
    Arthritis Rheum 62:1186-97. 2010
    ....
  6. doi request reprint Azathioprine or methotrexate maintenance for ANCA-associated vasculitis
    Christian Pagnoux
    Universite Paris Descartes, Hopital Cochin, Assistance Publique Hopitaux de Paris, Paris, France
    N Engl J Med 359:2790-803. 2008
    ..However, azathioprine and methotrexate have not been compared with regard to safety and efficacy...
  7. doi request reprint The Five-Factor Score revisited: assessment of prognoses of systemic necrotizing vasculitides based on the French Vasculitis Study Group (FVSG) cohort
    Loic Guillevin
    Department of Internal Medicine, National Referral Center for Rare Systemic and Autoimmune Diseases Vasculitides and Scleroderma, Hopital Cochin, Assistance Publique Hopitaux de Paris, UPRES 4058, Universite Paris Descartes, INSERM 1016, Paris, France loic guillevin cch aphp fr
    Medicine (Baltimore) 90:19-27. 2011
    ..The better WG prognosis for patients with ENT manifestations, even for patients with other visceral involvement, compared with the prognosis for those without ENT manifestations, probably reflects WG phenotype heterogeneity...
  8. doi request reprint Treatment strategies and outcome of induction-refractory Wegener's granulomatosis or microscopic polyangiitis: analysis of 32 patients with first-line induction-refractory disease in the WEGENT trial
    Raphaele Seror
    Department of Internal Medicine, National Referral Center for Necrotizing Vasculitides and Systemic Sclerosis, Hopital Cochin, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, Paris, France
    Ann Rheum Dis 69:2125-30. 2010
    ....
  9. ncbi request reprint Antineutrophil cytoplasmic antibodies and the Churg-Strauss syndrome
    Régis Sablé-Fourtassou
    Hopital Cochin, Assistance Publique Hopitaux de Paris, Universite Paris 5 Rene Descartes, Paris, France
    Ann Intern Med 143:632-8. 2005
    ..Since testing for antineutrophil cytoplasmic antibodies (ANCA) became available for routine evaluation, no large homogeneous cohort of patients with the Churg-Strauss syndrome has been studied...
  10. doi request reprint Extraocular manifestations of birdshot chorioretinopathy in 118 French patients
    Christian Pagnoux
    Department of Internal Medicine, National referral center for Systemic necrotizing vasculitides and systemic scleroderma, Hopital Cochin, Universite Paris Descartes, Assistance Publique Hopitaux de Paris, 75879 Paris cedex 14, France
    Presse Med 39:e97-e102. 2010
    ..Published studies on birdshot chorioretinopathy (BCR) did not provide definitive information on possibly associated extraocular manifestations...
  11. doi request reprint Population-based prevalence study of Behçet's disease: differences by ethnic origin and low variation by age at immigration
    Alfred Mahr
    Department of Internal Medicine, Universite Paris 5 Rene Descartes, Hopital Cochin, Assistance Publique Hopitaux de Paris, Paris, France
    Arthritis Rheum 58:3951-9. 2008
    ..To estimate the prevalence of Behçet's disease (BD) in a multiethnic population living in France, with particular focus on disease risk among immigrants...
  12. ncbi request reprint Treating polyarteritis nodosa: current state of the art
    Mathilde de Menthon
    Department of Internal Medicine, Hospital Saint Louis, University Paris 7 Paris Diderot, Paris, France
    Clin Exp Rheumatol 29:S110-6. 2011
    ..Although more data are needed to resolve outstanding questions, it is unclear whether all these matters can be studied in the future in large, sufficiently powered trials...
  13. doi request reprint Intravenous immunoglobulins for relapses of systemic vasculitides associated with antineutrophil cytoplasmic autoantibodies: results of a multicenter, prospective, open-label study of twenty-two patients
    Valerie Martinez
    Hopital Cochin, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, Paris, France
    Arthritis Rheum 58:308-17. 2008
    ....
  14. doi request reprint Incidence and predictors of urotoxic adverse events in cyclophosphamide-treated patients with systemic necrotizing vasculitides
    Guillaume Le Guenno
    Hopital Cochin, Assistance Publique Hopitaux de Paris, and Université Paris 5, Paris, France
    Arthritis Rheum 63:1435-45. 2011
    ..To assess hemorrhagic cystitis and urinary tract cancer incidence and predictors in cyclophosphamide (CYC)-treated patients with systemic necrotizing vasculitis (SNV)...
  15. ncbi request reprint Serum eosinophil cationic protein: a marker of disease activity in Churg-Strauss syndrome
    Philippe Guilpain
    Paris Descartes University, Faculty of Medicine, Cochin Hospital, Paris, France
    Ann N Y Acad Sci 1107:392-9. 2007
    ..6264; P < 0.05) and during periods of remission (R = 0.4798; P < 0.05). Our results support that ECP might be used as a disease activity marker in CSS...
  16. doi request reprint Eosinophilic granulomatosis with polyangiitis (Churg-Strauss): Clinical characteristics and long-term followup of the 383 patients enrolled in the French Vasculitis Study Group cohort
    Cloé Comarmond
    Hopital Cochin, AP HP, and Universite Paris Descartes, Paris 5, Paris, France
    Arthritis Rheum 65:270-81. 2013
    ..This study was undertaken to describe the main characteristics of a larger patient cohort and their long-term outcomes...
  17. ncbi request reprint IgM and IgG autoantibodies from microscopic polyangiitis patients but not those with other small- and medium-sized vessel vasculitides recognize multiple endothelial cell antigens
    Youri Chanseaud
    UPRES EA 3408, Formation Associee Claude Bernard, UFR SMBH Leonard de Vinci, Bobigny, France
    Clin Immunol 109:165-78. 2003
    ..Our results provide evidence that IgM and to a lesser degree IgG from MPA patients specifically recognize multiple EC antigens...
  18. ncbi request reprint Predicting mortality in systemic Wegener's granulomatosis: a survival analysis based on 93 patients
    Dominique Bligny
    UPRES EA 3409 Recherche Clinique et Thérapeutique, Hopital Avicenne, Assistance Publique des Hopitaux de Paris, Universite Paris Nord, Bobigny, France
    Arthritis Rheum 51:83-91. 2004
    ..To determine predictors of survival of patients with systemic Wegener's granulomatosis (WG)...
  19. ncbi request reprint Central nervous system involvement in Wegener granulomatosis
    Raphaele Seror
    Department of Internal Medicine, Hopital Cochin, Universite Rene Descartes Paris 5, Assistance Publique Hopitaux de Paris, Paris, France
    Medicine (Baltimore) 85:54-65. 2006
    ....
  20. doi request reprint Analysis of Wegener's granulomatosis responses to rituximab: current evidence and therapeutic prospects
    Achille Aouba
    Department of Internal Medicine and the French Vasculitis Study Group, Assistance Publique Hopitaux de Paris, Universite Paris, 5 René Descartes, Hopital Cochin, 27, rue du Faubourg Saint Jacques, 75679, Paris Cedex 14, France
    Clin Rev Allergy Immunol 34:65-73. 2008
    ..This promising biotherapy opens the way for other therapeutic agents targeting B lymphocytes and to improve our understanding of the pathophysiology of ANCA-associated vasculitis...
  21. doi request reprint Patients with systemic inflammatory and autoimmune diseases are at risk of vaccine-preventable illnesses
    Cecile Marchand-Janssen
    Universite Paris Descartes, Faculte de Medecine, INSERM, CIC BT505, Assistance Publique Hopitaux de Paris, Groupe Hospitalier Cochin Saint Vincent De Paul, Pôle de médecine, CIC de vaccinologie Cochin Pasteur, Paris, France
    Rheumatology (Oxford) 50:1099-105. 2011
    ..To evaluate vaccine coverage and humoral immunity to tetanus, diphtheria and poliomyelitis in adults followed for systemic inflammatory and/or autoimmune diseases (SIADs)...
  22. doi request reprint Limited value of temporal artery ultrasonography examinations for diagnosis of giant cell arteritis: analysis of 77 subjects
    Carla Maldini
    National Referral Center for Necrotizing Vasculitides and Systemic Sclerosis, Hospital Cochin, Assistance Publique Hopitaux de Paris, University Paris 5 René Descartes, Paris, France
    J Rheumatol 37:2326-30. 2010
    ..We retrospectively evaluated operating characteristics of temporal artery ultrasonography (TA-US) in a single teaching hospital...
  23. doi request reprint Lessons from French National Guidelines on the treatment of venous thrombosis and central venous catheter thrombosis in cancer patients
    Dominique Farge
    Service de médecine interne et pathologie vasculaire, Hôpital Saint Louis and INSERM U976, Assistance Publique Hopitaux de Paris, Paris, France
    Thromb Res 125:S108-16. 2010
    ....
  24. doi request reprint Epidemiology of immunoglobulin A vasculitis (Henoch-Schönlein): current state of knowledge
    Maryam Piram
    Department of Pediatrics, Hospital Bicetre, University Paris Sud, Le Kremlin Bicetre, Paris, France
    Curr Opin Rheumatol 25:171-8. 2013
    ..To review the current knowledge of epidemiological features of immunoglobulin (Ig) A vasculitis (Henoch-Schönlein) and disease etiology...
  25. ncbi request reprint Microscopic polyangiitis and polyarteritis nodosa: how and when do they start?
    Christian Agard
    Hopital Avicenne, Assistance Publique Hopitaux de Paris, France
    Arthritis Rheum 49:709-15. 2003
    ..To describe initial clinical symptoms attributable to microscopic polyangiitis (MPA) or polyarteritis nodosa (PAN)...
  26. doi request reprint Effect of race/ethnicity on risk, presentation and course of connective tissue diseases and primary systemic vasculitides
    Maryam Piram
    Department of Internal Medicine, Hospital Saint Louis, Assistance Publique Hopitaux de Paris, University Paris 7 Paris Diderot, Paris, France
    Curr Opin Rheumatol 24:193-200. 2012
    ....
  27. doi request reprint Therapeutic plasma exchange in systemic vasculitis: an update on indications and results
    Alfred Mahr
    Department of Internal Medicine, Hospital Saint Louis, University Paris, Paris, France
    Curr Opin Rheumatol 24:261-6. 2012
    ..This review summarizes the available evidence for the effectiveness of plasma exchange in systemic vasculitis...
  28. ncbi request reprint Scleroderma renal crisis, still a life-threatening complication
    Luis Teixeira
    Department of Internal Medicine and Reference Center for Necrotizing Vasculitis and Systemic Sclerosis, Cochin Hospital, Assistance Publique Hopitaux de Paris AP HP, and UPRES EA 4058, Paris Descartes University, Faculty of Medicine, Paris, France
    Ann N Y Acad Sci 1108:249-58. 2007
    ..Quite a large proportion of patients require dialysis, although this therapy may be stopped in approximately one-third of patients. Patients remaining on dialysis after 2 years can be proposed for a renal transplantation...
  29. ncbi request reprint Hepatitis B virus-associated polyarteritis nodosa: clinical characteristics, outcome, and impact of treatment in 115 patients
    Loic Guillevin
    Department of Internal Medicine, Hopital Cochin, Assistance Publique Hopitaux de Paris, Paris, France
    Medicine (Baltimore) 84:313-22. 2005
    ..The major cause of death is gastrointestinal tract involvement. Importantly, the frequency of HBV-PAN has decreased in relation to improved blood safety and vaccination campaigns...
  30. doi request reprint Revisiting the classification of clinical phenotypes of anti-neutrophil cytoplasmic antibody-associated vasculitis: a cluster analysis
    Alfred Mahr
    Department of Internal Medicine, Hospital Saint Louis, University Paris 7, Paris, France
    Ann Rheum Dis 72:1003-10. 2013
    ..GPA and MPA are heterogeneous entities with overlapping phenotypes. To identify novel subgroupings, cluster analysis was used to explore the phenotypic spectrum of AAV...
  31. ncbi request reprint Seasonal variations in onset of Wegener's granulomatosis: increased in summer?
    Alfred Mahr
    Department of Internal Medicine, Hopital Cochin, Universite Rene Descartes, Paris, France
    J Rheumatol 33:1615-22. 2006
    ..Investigators have reported significant seasonal variations of onset of Wegener's granulomatosis (WG), but those data were not confirmed by others. We reexamined the hypothesis of a seasonal pattern of onset of WG...
  32. doi request reprint ANCA-associated vasculitis and malignancy: current evidence for cause and consequence relationships
    Alfred Mahr
    Department of Internal Medicine, University Hospital Saint Louis, Paris, France
    Best Pract Res Clin Rheumatol 27:45-56. 2013
    ..Although some studies found that prior or concomitant history of cancer increases the risk of AAV, available data are inconsistent and suggest that the fraction of AAV that might be attributable to cancer is at best small...
  33. doi request reprint HLA-B51/B5 and the risk of Behçet's disease: a systematic review and meta-analysis of case-control genetic association studies
    Mathilde de Menthon
    Hôpital Cochin Université Paris René Descartes, Assistance Publique Hopitaux de Paris, Paris, France
    Arthritis Rheum 61:1287-96. 2009
    ..To quantify by meta-analysis the genetic effect of the HLA-B5 or HLA-B51 (HLA-B51/B5) allele on the risk of developing Behçet's disease (BD) and to look for potential effect modifiers...
  34. ncbi request reprint Treatment of polyarteritis nodosa and microscopic polyangiitis with poor prognosis factors: a prospective trial comparing glucocorticoids and six or twelve cyclophosphamide pulses in sixty-five patients
    Loic Guillevin
    Hopital Avicenne, Assistance Publique Hopitaux de Paris, Universite Paris Nord, Bobigny, France
    Arthritis Rheum 49:93-100. 2003
    ....
  35. ncbi request reprint Deaths occurring during the first year after treatment onset for polyarteritis nodosa, microscopic polyangiitis, and Churg-Strauss syndrome: a retrospective analysis of causes and factors predictive of mortality based on 595 patients
    Anne Bourgarit
    Department of Internal Medicine, Hopital Avicenne, UPRES EA 3409 Université Paris XIII, France
    Medicine (Baltimore) 84:323-30. 2005
    ..Cyclophosphamide-induced cytopenia and infection were responsible for 2 deaths. Despite these iatrogenic complications, early deaths were more frequently the consequence of insufficient or inappropriate therapy...
  36. ncbi request reprint Long-term outcome of 37 patients with Wegener's granulomatosis with renal involvement
    Jacques Eric Gottenberg
    Department of Internal Medicine, Nationale referral center for Vasculitides and Scleroderma, Hopital Cochin, AP HP, Universite Paris 5, Paris
    Presse Med 36:771-8. 2007
    ..This prospective study sought to assess the long-term outcome and identify prognostic factors of patients with kidney disease related to Wegener's granulomatosis (WG)...
  37. pmc Development and validation of a consensus methodology for the classification of the ANCA-associated vasculitides and polyarteritis nodosa for epidemiological studies
    Richard Watts
    Department of Rheumatology, Ipswich Hospital NHS Trust, Heath Road, Ipswich IP4 5PD, UK
    Ann Rheum Dis 66:222-7. 2007
    ..Aim: To develop a consensus method of using these criteria and definitions for epidemiological studies to permit comparison without confounding by classification...
  38. ncbi request reprint Presentation and outcome of gastrointestinal involvement in systemic necrotizing vasculitides: analysis of 62 patients with polyarteritis nodosa, microscopic polyangiitis, Wegener granulomatosis, Churg-Strauss syndrome, or rheumatoid arthritis-associated
    Christian Pagnoux
    Hopital Cochin, Service de Medecine Interne, 27, rue du Faubourg Saint Jacques, Paris Cedex 14, France
    Medicine (Baltimore) 84:115-28. 2005
    ....
  39. doi request reprint Aortic involvement in recent-onset giant cell (temporal) arteritis: a case-control prospective study using helical aortic computed tomodensitometric scan
    Christian Agard
    Internal Medicine, Hotel Dieu, Place Alexis Ricordeau, Nantes Cedex 01, France
    Arthritis Rheum 59:670-6. 2008
    ..Computed tomodensitometric (CT) scan allows analysis of both the aortic wall and endoluminal part of the aorta. Therefore, we conducted a study using CT scan to analyze aortic abnormalities in patients with recent-onset GCA...