Isabelle Mahe

Summary

Country: France

Publications

  1. ncbi request reprint Management of oral anticoagulant in clinical practice: a retrospective study of 187 patients
    Isabelle Mahe
    Department of Internal Medicine, Lariboisiere University Hospital, Paris, France
    J Gerontol A Biol Sci Med Sci 59:1339-42. 2004
  2. ncbi request reprint [Age, an independent risk factor for thrombosis. Epidemiologic data]
    I Mahe
    Service de Medecine A, Hopital Lariboisiere, Paris 75
    Presse Med 34:878-86. 2005
  3. pmc Efficacy and safety of three ophthalmic inserts for topical anaesthesia of the cornea. An exploratory comparative dose-ranging, double-blind, randomized trial in healthy volunteers
    Isabelle Mahe
    Unité de recherches thérapeutiques, Hopital Lariboisiere, 2 Rue A Paré 75010 Paris, France
    Br J Clin Pharmacol 59:220-6. 2005
  4. ncbi request reprint D-dimer can predict survival in patients with chronic atrial fibrillation
    Isabelle Mahe
    Department of Internal Medicine, Lariboisiere University Hospital, Paris, France
    Blood Coagul Fibrinolysis 15:413-7. 2004
  5. ncbi request reprint [What explains the increased rate of thromboses among the elderly? Pathophysiological data]
    I Mahe
    Service de Medecine A, Hopital Lariboisiere, Paris
    Presse Med 34:887-95. 2005
  6. ncbi request reprint Does paracetamol potentiate the effects of oral anticoagulants?: a literature review
    Isabelle Mahe
    Service Médecine A, Hopital Lariboisiere, Paris, France
    Drug Saf 27:325-33. 2004
  7. ncbi request reprint Defining the role of calcium channel antagonists in heart failure due to systolic dysfunction
    Isabelle Mahe
    Service Médecine A, Hopital Lariboisiere, Paris, France
    Am J Cardiovasc Drugs 3:33-41. 2003
  8. ncbi request reprint [What are the criteria for evaluation and prevention of venous thromboembolism?]
    Isabelle Mahe
    Service Médecine A, Hopital Lariboisiere, Paris, France
    Therapie 58:327-31. 2003
  9. ncbi request reprint Lack of effect of a low-molecular-weight heparin (nadroparin) on mortality in bedridden medical in-patients: a prospective randomised double-blind study
    I Mahe
    Service Médecine A, AP HP, Hopital Lariboisiere, 2, rue Ambroise Pare, 75010, Paris, France
    Eur J Clin Pharmacol 61:347-51. 2005
  10. ncbi request reprint Aspirin for the prevention of cardiovascular events in the elderly
    Isabelle Mahe
    Service Médecine A, Hopital Lariboisiere, Paris, France
    Drugs Aging 20:999-1010. 2003

Detail Information

Publications40

  1. ncbi request reprint Management of oral anticoagulant in clinical practice: a retrospective study of 187 patients
    Isabelle Mahe
    Department of Internal Medicine, Lariboisiere University Hospital, Paris, France
    J Gerontol A Biol Sci Med Sci 59:1339-42. 2004
    ....
  2. ncbi request reprint [Age, an independent risk factor for thrombosis. Epidemiologic data]
    I Mahe
    Service de Medecine A, Hopital Lariboisiere, Paris 75
    Presse Med 34:878-86. 2005
    ..Their risk of thrombosis justifies the systematic search for acquired risk factors to assess the level of risk and take appropriate prevention measures...
  3. pmc Efficacy and safety of three ophthalmic inserts for topical anaesthesia of the cornea. An exploratory comparative dose-ranging, double-blind, randomized trial in healthy volunteers
    Isabelle Mahe
    Unité de recherches thérapeutiques, Hopital Lariboisiere, 2 Rue A Paré 75010 Paris, France
    Br J Clin Pharmacol 59:220-6. 2005
    ..Cataract surgery requires prolonged anaesthesia, concomitant with permanent hydration and lubrication of the cornea, in order to provide a clear view of the operation area...
  4. ncbi request reprint D-dimer can predict survival in patients with chronic atrial fibrillation
    Isabelle Mahe
    Department of Internal Medicine, Lariboisiere University Hospital, Paris, France
    Blood Coagul Fibrinolysis 15:413-7. 2004
    ..It may contribute to the risk stratification and perhaps to the choice of the antithrombotic therapy in high-risk patients with elevated DD...
  5. ncbi request reprint [What explains the increased rate of thromboses among the elderly? Pathophysiological data]
    I Mahe
    Service de Medecine A, Hopital Lariboisiere, Paris
    Presse Med 34:887-95. 2005
    ..Arterial and venous thromboses involve varying degrees of coagulation and platelet activation...
  6. ncbi request reprint Does paracetamol potentiate the effects of oral anticoagulants?: a literature review
    Isabelle Mahe
    Service Médecine A, Hopital Lariboisiere, Paris, France
    Drug Saf 27:325-33. 2004
    ..Such a study is currently ongoing...
  7. ncbi request reprint Defining the role of calcium channel antagonists in heart failure due to systolic dysfunction
    Isabelle Mahe
    Service Médecine A, Hopital Lariboisiere, Paris, France
    Am J Cardiovasc Drugs 3:33-41. 2003
    ....
  8. ncbi request reprint [What are the criteria for evaluation and prevention of venous thromboembolism?]
    Isabelle Mahe
    Service Médecine A, Hopital Lariboisiere, Paris, France
    Therapie 58:327-31. 2003
    ..These different approaches--with their respective advantages and limitations--will be developed...
  9. ncbi request reprint Lack of effect of a low-molecular-weight heparin (nadroparin) on mortality in bedridden medical in-patients: a prospective randomised double-blind study
    I Mahe
    Service Médecine A, AP HP, Hopital Lariboisiere, 2, rue Ambroise Pare, 75010, Paris, France
    Eur J Clin Pharmacol 61:347-51. 2005
    ....
  10. ncbi request reprint Aspirin for the prevention of cardiovascular events in the elderly
    Isabelle Mahe
    Service Médecine A, Hopital Lariboisiere, Paris, France
    Drugs Aging 20:999-1010. 2003
    ..In conclusion, aspirin should only be given for primary and secondary prevention in the elderly after a comprehensive evaluation of an individual patient's thrombotic and haemorrhagic risk has been conducted...
  11. ncbi request reprint D-dimer: a characteristic of the coagulation state of each patient with chronic atrial fibrillation
    I Mahe
    Department of Internal Medicine, Lariboisiere University Hospital, 2, rue Ambroise Pare, 75010, Paris, France
    Thromb Res 107:1-6. 2002
    ..In order to answer such a question, it has to be established if the D-dimer level in a given patient is characteristic of such a patient (stable over time) if also fluctuating with time (and useless to characterise the patient)...
  12. ncbi request reprint [Fatal fulminant acute amebic colitis in metropolitan France]
    I Mahe
    Service Médecine A, Hopital Lariboisiere, Paris
    Presse Med 30:1295-7. 2001
    ..Emergency care is required for patients presenting dysentery and fever...
  13. ncbi request reprint [Use and monitoring of vitamin K antagonists in everyday medical practice. French results of the international ISAM study of patients with nonvalvular atrial fibrillation]
    Isabelle Mahe
    Service de Medecine Interne A, Clinique des anticoagulants Ile de France, Hopital Lariboisiere, Paris
    Presse Med 35:1797-803. 2006
    ..Bleeding complications of vitamin K antagonist (VKA) therapy are currently the most frequent iatrogenic event in France...
  14. ncbi request reprint Low molecular weight heparin for the prevention of deep venous thrombosis: a suitable monitoring in elderly patients?
    Isabelle Mahe
    Service Médecine A, Hopital Lariboisiere, Paris, France
    Pathophysiol Haemost Thromb 32:134-6. 2002
    ..Our findings question the opportunity to monitor aXa in elderly patients receiving 4000 IU enoxaparin as antithrombotic prophylaxis...
  15. ncbi request reprint Elderly medical patients treated with prophylactic dosages of enoxaparin: influence of renal function on anti-Xa activity level
    Isabelle Mahe
    Internal Medicine Department A, Lariboisiere Hospital, Paris, France
    Drugs Aging 24:63-71. 2007
    ..The safety and optimal use of prophylactic treatment with low-molecular-weight heparins in elderly patients with impaired renal function remain undefined...
  16. ncbi request reprint Early prediction of the sensitivity of warfarin in elderly patients by the fall in factor VIIc and protein C at the induction of treatment
    Jean Pierre Bertola
    Unité de recherches thérapeutiques, Hopital Lariboisiere, Paris, France
    Thromb Res 109:287-91. 2003
  17. ncbi request reprint Interaction between paracetamol and warfarin in patients: a double-blind, placebo-controlled, randomized study
    Isabelle Mahe
    Unité de recherches thérapeutiques, Hopital Lariboisiere, 2, rue Ambroise Pare, 75010 Paris, France
    Haematologica 91:1621-7. 2006
    ..The primary end-point of this study was to investigate whether paracetamol initiation potentiates the anticoagulant effect of warfarin and the mechanism of the interaction...
  18. ncbi request reprint Tinzaparin and enoxaparin given at prophylactic dose for eight days in medical elderly patients with impaired renal function: a comparative pharmacokinetic study
    Isabelle Mahe
    Service Médecine Interne A, Hopital Lariboisiere, 2, rue Ambroise Pare, Paris, France
    Thromb Haemost 97:581-6. 2007
    ..Trials based on clinical end points should be conducted to evaluate the clinical relevance of these observations...
  19. ncbi request reprint Reduced thrombus cohesion in an ex vivo human model of arterial thrombosis induced by clopidogrel treatment: kinetics of the effect and influence of single and double loading-dose regimens
    Claire Bal dit Sollier
    Laboratoire de Thrombose et d Athérosclérose Expérimentales, Hopital Lariboisiere, Paris, France
    Thromb Res 111:19-27. 2003
    ..To compare the effects of clopidogrel on ex vivo thrombogenesis with those on ADP-dependent platelet aggregation, and to compare single and double loading-dose regimens...
  20. ncbi request reprint Pharmacodynamics of a new ophthalmic mydriatic insert in healthy volunteers: potential alternative as drug delivery system prior to cataract surgery
    Stephane Mouly
    Unit of Thepapeutic Research, Lariboisiere Hospital, Paris, France
    Basic Clin Pharmacol Toxicol 98:547-54. 2006
    ....
  21. ncbi request reprint Effects of aspirin and clopidogrel on plasma brain natriuretic peptide in patients with heart failure receiving ACE inhibitors
    Christophe Meune
    Department of Cardiology, Cochin Hospital, Paris, France
    Eur J Heart Fail 9:197-201. 2007
    ..By inhibiting prostaglandins, aspirin may be deleterious in heart failure (HF) and/or may counteract angiotensin-converting enzyme (ACE) inhibitor efficacy. Conversely, clopidogrel has no effect on prostaglandin metabolism...
  22. doi request reprint Interaction between acetaminophen and warfarin in adults receiving long-term oral anticoagulants: a randomized controlled trial
    Qian Zhang
    Unité de Recherches Thérapeutiques Service de Médecine Interne A, Hopital Lariboisiere, 2 rue Ambroise Pare, 75010, Paris, France
    Eur J Clin Pharmacol 67:309-14. 2011
    ..We investigated whether acetaminophen, given at 2 g/day and 3 g/day might potentiate the anticoagulant effect of warfarin...
  23. pmc Effect of widely used combinations of antiretroviral therapy on liver CYP3A4 activity in HIV-infected patients
    Stephane Mouly
    Unit of Therapeutic Research, Department of Internal Medicine, Lariboisiere Hospital, Paris, France
    Br J Clin Pharmacol 62:200-9. 2006
    ..To evaluate the effects of combined antiretroviral drugs (HAART) on liver CYP3A4 activity using the [(14)C-N-methyl]-erythromycin breath test (ERMBT)...
  24. ncbi request reprint Aspirin alters arterial function in patients with chronic heart failure treated with ACE inhibitors: a dose-mediated deleterious effect
    Christophe Meune
    Internal Medicine, Hospital Lariboisiere, Paris, France
    Eur J Heart Fail 5:271-9. 2003
    ..By inhibiting prostaglandin synthesis, aspirin can interfere with both arterial functional and angiotensin-converting enzyme inhibitor (ACEI) properties and be deleterious in chronic heart failure (CHF)...
  25. ncbi request reprint Antiarrhythmic drugs for maintaining sinus rhythm after cardioversion of atrial fibrillation: a systematic review of randomized controlled trials
    Carmelo Lafuente-Lafuente
    Service de Medecine Interne A, Hopital Lariboisiere, Paris, France
    Arch Intern Med 166:719-28. 2006
    ..We performed a systematic review to determine the effect of long-term treatment with those drugs on death, embolisms, adverse effects, and atrial fibrillation recurrence...
  26. ncbi request reprint [Follow-up brain imaging after strokes in internal medicine: frequently requested but rarely used for diagnosis or treatment]
    Aku Sewonou
    Service de Medecine A, Hopital Lariboisiere, Paris
    Presse Med 36:1364-70. 2007
    ..To assess the interest of a second computed tomography (CT) scan of the brain during hospitalization of stroke patients in an internal medicine department and study the characteristics of these patients...
  27. ncbi request reprint Effect of renal function on the pharmacokinetics of enoxaparin and consequences on dose adjustment
    Jean Sebastien Hulot
    Pharmacology Department, Pitie Salpetriere University Hospital, Assistance Publique Hopitaux de Paris, Paris, France
    Ther Drug Monit 26:305-10. 2004
    ....
  28. ncbi request reprint Comparative effect of aspirin and clopidogrel on arterial function in CHF
    Christophe Meune
    Department of Cardiology, Cochin Hospital, Rene Descartes University, 27 rue du Fg St Jacques, 75014 Paris, France
    Int J Cardiol 106:61-6. 2006
    ..Conversely, clopidogrel has no effect on prostaglandin metabolism. The aim of this study was to prospectively investigate the effect of aspirin and clopidogrel on arterial functional properties in CHF patients treated with ACEI...
  29. ncbi request reprint High frequency of detection of human papillomaviruses associated with epidermodysplasia verruciformis in children with psoriasis
    E Mahe
    Unite des Papillomavirus, Institut Pasteur, Paris, France
    Br J Dermatol 149:819-25. 2003
    ..It has been suggested that the human papillomaviruses (HPVs) associated with epidermodysplasia verruciformis (EV), including the oncogenic HPV5, may contribute to the pathogenesis of psoriasis...
  30. ncbi request reprint Interaction between aspirin and ACE inhibitors in patients with heart failure
    I Mahe
    Unité de recherches thérapeutiques, Service de Medicine Interne A, H pital Lariboisière, Paris, France
    Drug Saf 24:167-82. 2001
    ....
  31. ncbi request reprint [Which antithrombotic treatment should be used in the treatment of an elderly patient with chronic atrial fibrillation?]
    I Mahe
    Service Médecine A, Hôpital Lariboisière 2, rue Ambroise Paré 75010 Paris
    Presse Med 32:1170-4. 2003
    ..ADVANTAGES AND RISKS OF ANTICOAGULANTS: Treatment with anticoagulants is the only treatment that has demonstrated its efficacy in reducing the risks of thromboembolism, however there is a risk of haemorrhage...
  32. ncbi request reprint Risks versus benefits of NSAIDs including aspirin in myocarditis: a review of the evidence from animal studies
    Christophe Meune
    Cardiology Department, Cochin Hospital, Rene Descartes University, Paris, France
    Drug Saf 26:975-81. 2003
    ....
  33. ncbi request reprint Initiation of warfarin therapy in elderly medical inpatients: a safe and accurate regimen
    Virginie Siguret
    Hematology Laboratory, Charles Foix Teaching Hospital AP HP, Paris, France
    Am J Med 118:137-42. 2005
    ..We conducted a prospective multicenter study to evaluate the accuracy and safety of this regimen...
  34. pmc Paracetamol: a haemorrhagic risk factor in patients on warfarin
    I Mahe
    Unité de recherches thérapeutiques, Hopital Lariboisiere, AP HP, 2 rue Ambroise Pare, 75010 Paris, France
    Br J Clin Pharmacol 59:371-4. 2005
    ..To quantify the effect of paracetamol on the anticoagulant effect of warfarin under normal clinical conditions...
  35. ncbi request reprint [Treatment trial methodology in internal medicine]
    Isabelle Mahe
    Service de Medecine A, Hopital Lariboisiere, AP HP, Paris
    Presse Med 36:512-8. 2007
    ..This article considers ways to improve the participation of departments of internal medicine to future clinical trials...
  36. doi request reprint [Monitoring of anticoagulant treatment in patients with cancer]
    I Mahe
    Medecine Interne, Hopital Louis Mourier, AP HP, 178, rue des Renouillers, 92700 Colombes, France
    Pathol Biol (Paris) 56:239-44. 2008
    ..Anticoagulant clinics are developed in order to help practitioners and participate in the monitoring of anticoagulant treatments in those patients...
  37. ncbi request reprint [Troponin and other markers of myocardial ischemia injury, what is the relevance in internal medicine?]
    S Pruvot
    Service de Medecine A, Hopital Lariboisiere, Paris, France
    Rev Med Interne 27:215-26. 2006
    ..Then, the literature available about troponin in cardiovascular diseases but also in extracardiac diseases will be analysed. Finally, the difficulties of assay will be discussed...
  38. ncbi request reprint [Quality in health care. What quality? Judged by which criteria? By whom? How?]
    J F Bergmann
    Service de Medecine Interne A, Hopital Lariboisiere, 2 rue Ambroise Pare, 75475 Paris, France
    Therapie 56:99-102. 2001
    ..These recommendations have to change gradually to be adapted to medical progress and evidence-based medicine...
  39. ncbi request reprint Endoscopic evaluation of the gastrotolerance of short-term antalgic treatment with low dose k-diclofenac: a comparison of ibuprofen and aspirin
    I Mahe
    Unité de recherches thérapeutiques, Hopital Lariboisiere, 2 rue Ambroise Pare, 75010 Paris, France
    Fundam Clin Pharmacol 15:61-3. 2001
    ..5 mg (0.33) or ibuprofen 200 mg (0.42, P=0.66) but significantly higher after aspirin 500 mg (2.67, P=0.002)...
  40. doi request reprint Genetic factors (VKORC1, CYP2C9, EPHX1, and CYP4F2) are predictor variables for warfarin response in very elderly, frail inpatients
    E Pautas
    Universite Paris Descartes, Paris, France
    Clin Pharmacol Ther 87:57-64. 2010
    ..8; 95% confidence interval, 2.73-60.0). In this special population of frail elderly patients with multiple comorbidities and polypharmacy, we demonstrated the main impact of genetic factors on warfarin response...