Marie Noëlle Mévélec
Mévélec M, Ducournau C, Bassuny Ismael A, Olivier M, Seche E, Lebrun M, et al
. Mic1-3 Knockout Toxoplasma gondii is a good candidate for a vaccine against T. gondii-induced abortion in sheep. Vet Res. 2010;41:49 pubmed publisher
..Moreover, preliminary results showed the potential of Mic1-3KO to reduce the development of tissue cysts in lambs born to vaccinated ewes. This study demonstrates that Mic1-3KO is a potent vaccine candidate. ..
Hedhli D, MoirÃ© N, Akbar H, Laurent F, HÃ©raut B, Dimier Poisson I, et al
. The antigen-specific response to Toxoplasma gondii profilin, a TLR11/12 ligand, depends on its intrinsic adjuvant properties. Med Microbiol Immunol. 2016;205:345-52 pubmed publisher
..In conclusion, the intrinsic adjuvant properties of TgPRF had significant consequences on the immune response against TgPRF. ..
Rashid I, Moire N, Héraut B, Dimier Poisson I, Mévélec M. Enhancement of the protective efficacy of a ROP18 vaccine against chronic toxoplasmosis by nasal route. Med Microbiol Immunol. 2017;206:53-62 pubmed publisher
..These results suggest that ROP18 could be a component of a subunit vaccine against toxoplasmosis and that strategies designed to enhance mucosal protective immune responses could lead to more encouraging results. ..
Mévélec M, Bout D, Desolme B, Marchand H, Magné R, Bruneel O, et al
. Evaluation of protective effect of DNA vaccination with genes encoding antigens GRA4 and SAG1 associated with GM-CSF plasmid, against acute, chronical and congenital toxoplasmosis in mice. Vaccine. 2005;23:4489-99 pubmed
..gondii SAG1 and GRA4 antigens. Our data demonstrated that protection was improved by associating antigens (SAG1 and GRA4) and cytokine (GM-CSF) for further development of a multiantigenic vaccine against toxoplasmosis...