Research Topics
| Charles Edouard LuytSummaryCountry: France Publications
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Publications
Does invasive diagnosis of nosocomial pneumonia during off-hours delay treatment?Charles Edouard Luyt
Universite Pierre et Marie Curie, Service de Reanimation Medicale, Groupe Hospitalier Pitie Salpetriere, Assistance Publique Hopitaux de Paris, 47 Boulevard de l Hopital, 75651, Paris Cedex 13, France
Intensive Care Med 33:734-7. 2007..m. to 8:29 a.m. the next day for night shifts, from Saturday 1:00 p.m. to Monday 8:29 a.m. for weekends, and from 8:30 a.m. to 8:29 a.m. the following morning for public holidays)...
Outcomes and long-term quality-of-life of patients supported by extracorporeal membrane oxygenation for refractory cardiogenic shockAlain Combes
Service de Reanimation Medicale, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Universite Pierre et Marie Curie, Paris 6, Paris, France
Crit Care Med 36:1404-11. 2008..To assess the outcomes and long-term quality-of-life of patients supported by extracorporeal membrane oxygenation (ECMO) for refractory cardiogenic shock...- Aerosolized antibiotics to treat ventilator-associated pneumoniaCharles Edouard Luyt
Service de Reanimation Medicale, Institut de Cardiologie, Groupe Hospitalier Pitie Salpetriere, 47 83 boulevard de l Hopital, Paris Cedex 13, France
Curr Opin Infect Dis 22:154-8. 2009..This review summarizes the recent data on antibiotic aerosolization to treat ventilator-associated pneumonia... 
Pharmacokinetics and lung delivery of PDDS-aerosolized amikacin (NKTR-061) in intubated and mechanically ventilated patients with nosocomial pneumoniaCharles Edouard Luyt
Service de Reanimation Medicale, Groupe Hospitalier Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Université Paris Pierre et Marie Curie, 75651 Paris Cedex 13, France
Crit Care 13:R200. 2009....- Virus-induced acute respiratory distress syndrome: epidemiology, management and outcomeCharles Edouard Luyt
Assistance Publique Hopitaux de Paris, Universite Paris 6 Pierre et Marie Curie, Institut de Cardiologie, Groupe Hospitalier Pitie Salpetriere, Service de Reanimation Medicale, 75651 Paris Cedex 13, France
Presse Med 40:e561-8. 2011..Ganciclovir can be considered for patients with ARDS and histology- or cytology-proven CMV pneumonia... - Diffusion tensor imaging to predict long-term outcome after cardiac arrest: a bicentric pilot studyCharles Edouard Luyt
Service de Reanimation, School of Medicine, Groupe Hospitalier Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Université Paris Pierre et Marie Curie, Paris, France
Anesthesiology 117:1311-21. 2012..The authors' objective was to determine whether an assessment with diffusion tensor imaging, a brain magnetic resonance imaging sequence, increases the accuracy of 1 yr functional outcome prediction in cardiac arrest survivors... - Long-term outcomes of pandemic 2009 influenza A(H1N1)-associated severe ARDSCharles Edouard Luyt
Service de Reanimation Medicale, Groupe Hospitalier Pitie Salpetriere, Assistance Publique Hôpitaux de Paris et Université Paris 6 Pierre et Marie Curie, Paris, France
Chest 142:583-92. 2012..The objective of this study was to compare the 1-year outcomes of survivors of A(H1N1)-associated ARDS, according to use or no use of extracorporeal lung assist (ECLA), using its need as an ARDS severity surrogate... - Usefulness of cardiac biomarkers to predict cardiac recovery in patients on extracorporeal membrane oxygenation support for refractory cardiogenic shockCharles Edouard Luyt
Service de Reanimation, Institut de Cardiologie, Groupe Hospitalier Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Paris, France
J Crit Care 27:524.e7-14. 2012.... - Viral infections in the ICUCharles Edouard Luyt
Service de Reanimation Medicale, Institut de Cardiologie, Groupe Hospitalier Pitie Salpetriere, Paris, and Université Paris 6 Pierre et Marie Curie, France
Curr Opin Crit Care 14:605-8. 2008..The present study reviews the precise role of viruses as causes of pneumonia in mechanically ventilated patients... - Usefulness of procalcitonin for the diagnosis of ventilator-associated pneumoniaCharles Edouard Luyt
Service de Reanimation Medicale, Groupe Hospitalier Pitie Salpetriere, Universite Paris 6, 75651, Paris Cedex 13, France
Intensive Care Med 34:1434-40. 2008..To assess the predictive capacity for the diagnosis of ventilator-associated pneumonia (VAP) of serum procalcitonin levels before and on the day it is suspected... - Herpes simplex virus lung infection in patients undergoing prolonged mechanical ventilationCharles Edouard Luyt
Service de Reanimation Medicale, Institut de Cardiologie, Groupe Hospitalier Pitie Salpetriere, Université de Paris Pierre et Marie Curie, Assistance Publique Hopitaux de Paris, Paris Cedex 13, France
Am J Respir Crit Care Med 175:935-42. 2007.... - Value of the serum procalcitonin level to guide antimicrobial therapy for patients with ventilator-associated pneumoniaCharles Edouard Luyt
Service de Reanimation Medicale, Institut de Cardiologie, Groupe Hospitalier Pitie Salpetriere, Paris, France
Semin Respir Crit Care Med 32:181-7. 2011..Accordingly, for VAP patients, procalcitonin may be used to stop antibiotics as early as day 3 after their initiation, if its concentration is <0.5 ng/mL or has decreased by ≥80%, compared with the first peak concentration... - Biomarkers to optimize antibiotic therapy for pneumonia due to multidrug-resistant pathogensCharles Edouard Luyt
Service de Reanimation Medicale, Institut de Cardiologie, Groupe Hospitalier Pitie Salpetriere, Assistance Publique Hopitaux de Paris, France
Clin Chest Med 32:431-8. 2011..5 ng/mL or has decreased by 80% or more compared with the peak concentration, antibiotics can be stopped. With this strategy, extreme vigilance must be maintained after terminating antimicrobial therapy to detect a recurrent infection... - Impact of methicillin resistance on outcome of Staphylococcus aureus ventilator-associated pneumoniaAlain Combes
Service de Reanimation Medicale, Hopital Pitie Salpetriere, 75651 Paris Cedex 13, France
Am J Respir Crit Care Med 170:786-92. 2004.... - Impact of antibiotic-resistant bacteria on the outcome of ventilator-associated pneumoniaAlain Combes
Service de Reanimation Medicale, Pr Gibert, Institut de Cardiologie, Groupe Hospitalier Pitie Salpetriere, Paris, France
Semin Respir Crit Care Med 27:23-8. 2006.... - Early predictors for infection recurrence and death in patients with ventilator-associated pneumoniaAlain Combes
Service de Reanimation Medicale, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Universite Pierre et Marie Curie, Paris 6, France
Crit Care Med 35:146-54. 2007..The objective of this study was to describe resolution of VAP variables and to determine early predictors of VAP recurrence and death... - Outcomes, long-term quality of life, and psychologic assessment of fulminant myocarditis patients rescued by mechanical circulatory supportMariana Mirabel
Service de Reanimation Medicale, Institut de Cardiologie, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Universite Pierre et Marie Curie, Paris, France
Crit Care Med 39:1029-35. 2011.... - Procalcitonin kinetics as a prognostic marker of ventilator-associated pneumoniaCharles Edouard Luyt
Service de Reanimation Medicale, Institut de Cardiologie, Groupe Hospitalier Pitie Salpetriere, 47, Boulevard de l Hopital, 75651 Paris Cedex 13, France
Am J Respir Crit Care Med 171:48-53. 2005..Multivariate analyses retained serum procalcitonin levels on Days 1, 3, and 7 as strong predictors of unfavorable outcome. Based on these data, procalcitonin could be a prognostic marker of outcome during VAP... - Impact of piperacillin resistance on the outcome of Pseudomonas ventilator-associated pneumoniaAlain Combes
Groupe Hospitalier Pitie Salpetriere, Assistance Publique, Hôpitaux de Paris Université Pierre et Marie Curie, Paris 6, Service de Reanimation Medicale, Institut de Cardiologie, Paris, France
Intensive Care Med 32:1970-8. 2006.... - Use of quantitative cultures and reduced duration of antibiotic regimens for patients with ventilator-associated pneumonia to decrease resistance in the intensive care unitJean Chastre
Service de Reanimation Medicale, Institut de Cardiologie, Groupe Hospitalier Pitie Salpetriere, 75651 Paris Cedex 13, France
Clin Infect Dis 43:S75-81. 2006.... - New diagnostic and prognostic markers of ventilator-associated pneumoniaJean Chastre
Medical Intensive Care Unit, Pitie Salpetriere Hospital, Pierre and Marie Curie University, Paris, France
Curr Opin Crit Care 12:446-51. 2006..The purpose of this review is to analyze the potential advantages and drawbacks of using biomarkers of bacterial infection for the diagnosis and prognosis of ventilator-associated pneumonia... - Is tracheostomy associated with better outcomes for patients requiring long-term mechanical ventilation?Alain Combes
Service de Reanimation Medicale, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Universite Pierre et Marie Curie, Paris, France
Crit Care Med 35:802-7. 2007..To evaluate the effect of tracheostomy on intensive care unit (ICU) and in-hospital mortality for patients requiring prolonged (> 3 days) mechanical ventilation (MV)... - Early percutaneous tracheotomy versus prolonged intubation of mechanically ventilated patients after cardiac surgery: a randomized trialJean Louis Trouillet
Institut de Cardiologie, Hopital de la Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Universite Pierre et Marie Curie, Institut National de la Sante et de la Recherche Medicale, Paris, France
Ann Intern Med 154:373-83. 2011..Whether early percutaneous tracheotomy in patients who require prolonged mechanical ventilation can shorten mechanical ventilation duration and lower mortality remains controversial... - Predictors of successful extracorporeal membrane oxygenation (ECMO) weaning after assistance for refractory cardiogenic shockNadia Aissaoui
Service de Reanimation Medicale, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie, Paris 6, Paris, France
Intensive Care Med 37:1738-45. 2011..This study evaluated a weaning strategy following support for refractory cardiogenic shock to identify clinical, hemodynamic, and Doppler echocardiography parameters associated with successful ECMO removal... - Predictive risk factors for primary graft failure requiring temporary extra-corporeal membrane oxygenation support after cardiac transplantation in adultsCosimo D'Alessandro
Universite Pierre et Marie Curie, Paris VI, APHP, Groupe Hospitalier Pitie Salpetriere, Institute of Cardiology, Division of Thoracic and Cardiovascular Surgery, Paris, France
Eur J Cardiothorac Surg 40:962-9. 2011..We investigated the predictive risk factors for severe PGF that require extra-corporeal membrane oxygenation (ECMO) circulatory support after cardiac transplantation... - Controversies in ventilator-associated pneumoniaAlain Combes
Service de Reanimation Medicale, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Universite Pierre et Marie Curie, Paris, France
Semin Respir Crit Care Med 31:47-54. 2010.... - Use of procalcitonin to reduce patients' exposure to antibiotics in intensive care units (PRORATA trial): a multicentre randomised controlled trialLila Bouadma
Service de Reanimation Medicale, Universite Paris 7 Denis Diderot, Hopital Bichat Claude Bernard, Assistance Publique Hopitaux de Paris, Paris, France
Lancet 375:463-74. 2010..We aimed to establish the effectiveness of an algorithm based on the biomarker procalcitonin to reduce antibiotic exposure in this setting... - Nosocomial infections in adult cardiogenic shock patients supported by venoarterial extracorporeal membrane oxygenationMatthieu Schmidt
Service de Reanimation Medicale, Institut de Cardiologie
Clin Infect Dis 55:1633-41. 2012..Cardiogenic shock patients who received the latest generation VA-ECMO still had a high risk of developing NIs, particularly VAP. Strategies aimed at preventing these infections may improve the outcomes of these critically ill patients... - Diagnostic techniques and procedures for establishing the microbial etiology of ventilator-associated pneumonia for clinical trials: the pros for quantitative culturesJean Chastre
Service de Reanimation Medicale, Institut de Cardiologie, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Universite Pierre et Marie Curie, Paris, France
Clin Infect Dis 51:S88-92. 2010.... - Mortality among patients admitted to intensive care units during weekday day shifts compared with "off" hoursCharles Edouard Luyt
Service de Reanimation Medicale, Institut de Cardiologie, Groupe Hospitalier Pitie Salpetriere, Paris, France
Crit Care Med 35:3-11. 2007.... - Prolonged mechanical ventilation after cardiac surgery: outcome and predictorsJean Louis Trouillet
Service de Reanimation Medicale, Institut de Cardiologie, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Universite Paris 6 Pierre et Marie Curie, Paris, France
J Thorac Cardiovasc Surg 138:948-53. 2009..Our objective was to identify patients still requiring mechanical ventilation 3 days after the operation and those successfully weaned by day 10 to avoid needless and potentially hazardous interventions, such as tracheostomy... - Pharmacokinetics and tolerability of amikacin administered as BAY41-6551 aerosol in mechanically ventilated patients with gram-negative pneumonia and acute renal failureCharles Edouard Luyt
Service de Reanimation Medicale, Hopital Pitie Salpetriere, Paris, France
J Aerosol Med Pulm Drug Deliv 24:183-90. 2011..Given the predominantly renal clearance of aminoglycosides, understanding systemic amikacin exposure and safety during administration of BAY41-6551 to patients with acute renal failure (ARF) is clinically important... - Estimation of left ventricular systolic function by single transpulmonary thermodilutionAlain Combes
Service de Reanimation Medicale, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, 47, Boulevard de l Hopital, 75651 Paris Cedex 13, France
Intensive Care Med 30:1377-83. 2004..The global cardiac systolic function may be decreased despite preserved left ventricular function in this situation.).. - The invasive (quantitative) diagnosis of ventilator-associated pneumoniaJean Chastre
Service de Reanimation Medicale, Institut de Cardiologie, Hopital Pitie Salpetriere, 43 87 bd de l Hôpital, 75651 Paris Cedex 13, France
Respir Care 50:797-807; discussion 807-12. 2005..Bronchoalveolar lavage may also provide useful clues for the diagnosis of other forms of respiratory failure, such as pulmonary hemorrhage or other types of infections, especially in immunocompromised patients... - Gender impact on the outcomes of critically ill patients with nosocomial infectionsAlain Combes
Service de Reanimation Medicale, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Universite Pierre et Marie Curie, Paris, France
Crit Care Med 37:2506-11. 2009..Highly controversial data exist regarding gender-related differences in outcomes of severe nosocomial infections, reflecting potential confounders related to case-mixes or heterogeneity of populations evaluated... - Impact of extracorporeal membrane oxygenation and continuous venovenous hemodiafiltration on the pharmacokinetics of oseltamivir carboxylate in critically ill patients with pandemic (H1N1) influenzaFlorian Lemaître
Pharmacy Department, Pitie Salpetriere Hospital, Assistance Publique des Hopitaux de Paris, AP HP, Paris, France
Ther Drug Monit 34:171-5. 2012..This study was designed to evaluate the impact of ECMO and CVVHDF on the pharmacokinetics of oseltamivir carboxylate (OC) in critically ill patients with pandemic (H1N1) influenza treated with oseltamivir... - Extracorporeal membrane oxygenation for 2009 influenza A (H1N1) acute respiratory distress syndrome: single-centre experience with 1-year follow-upSylvain Beurtheret
Division of Cardiac Surgery, Pitie Salpetriere Hospital, University Pierre et Marie Curie, Paris, France
Eur J Cardiothorac Surg 41:691-5. 2012..The use of extracorporeal membrane oxygenation (ECMO) could be advocated as therapeutic solution. We present our experience with ECMO utilized in patients with influenza A (H1N1)-associated respiratory failure... - Extra-corporeal membrane oxygenation temporary support for early graft failure after cardiac transplantationCosimo D'Alessandro
Universite Pierre et Marie Curie, Paris VI, APHP, Groupe Hospitalier Pitie Salpetriere, Institute of Cardiology, Division of Thoracic and Cardiovascular Surgery, F 75013 Paris, France
Eur J Cardiothorac Surg 37:343-9. 2010..Early graft failure (EGF) is a major risk for death after heart transplantation. We studied the impact of an extra-corporeal membrane oxygenation (ECMO) temporary support on the operative mortality and the mean-term survival after EGF... - Blood oxygenation and decarboxylation determinants during venovenous ECMO for respiratory failure in adultsMatthieu Schmidt
Service de Reanimation Medicale, Groupe Hospitalier Pitie Salpetriere, Institute of Cardiometabolism and Nutrition ICAN, Assistance Publique Hôpitaux de Paris Université Pierre et Marie Curie, Paris 6, France
Intensive Care Med 39:838-46. 2013.... - Other therapeutic modalities and practices: implications for clinical trials of hospital-acquired or ventilator-associated pneumoniaJean Chastre
Service de Reanimation Medicale, Institut de Cardiologie, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Universite Pierre et Marie Curie, Paris, France
Clin Infect Dis 51:S54-8. 2010..Until results of these trials are known, antibiotic aerosolization can be recommended only for treating patients with multidrug-resistant VAP, for which no effective intravenous regimen is available... - Delivering antibiotics to the lungs of patients with ventilator-associated pneumonia: an updateCharles Edouard Luyt
Service de Reanimation Medicale, Institut de Cardiologie, Groupe Hospitalier Pitie Salpetriere, Assistance Publique Hopitaux de Paris, 47 83, Boulevard de l Hopital, 75651 Paris Cedex 13, France and Université Paris 6, Pierre et Marie Curie, Paris, France
Expert Rev Anti Infect Ther 11:511-21. 2013.... - Out-of-hospital extra-corporeal life support implantation during refractory cardiac arrest in a half-marathon runnerGuillaume Lebreton
Service de Chirurgie Cardio Thoracique, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie Paris 6, Paris, France
Resuscitation 82:1239-42. 2011..The cardiogenic shock resolved progressively, enabling ECLS weaning within 48h, while renal, hepatic, and respiratory functions recovered simultaneously... - Pharmacokinetics and safety of panobacumab: specific adjunctive immunotherapy in critical patients with nosocomial Pseudomonas aeruginosa O11 pneumoniaQin Lu
Multidisciplinary Intensive Care Unit, Department of Anesthesiology, La Pitie Salpetriere Hospital, Assistance Publique Hopitaux de Paris, UPMC Paris 6, France
J Antimicrob Chemother 66:1110-6. 2011..Nosocomial Pseudomonas aeruginosa pneumonia remains a major concern in critically ill patients. We explored the potential impact of microorganism-targeted adjunctive immunotherapy in such patients... - Early corticosteroids in severe influenza A/H1N1 pneumonia and acute respiratory distress syndromeChristian Brun-Buisson
Université Paris Est Créteil and INSERM U955, Creteil, France
Am J Respir Crit Care Med 183:1200-6. 2011..Despite their controversial role, corticosteroids are often administered to patients with adult respiratory distress syndrome (ARDS) secondary to viral pneumonia... - What is the niche for extracorporeal membrane oxygenation in severe acute respiratory distress syndrome?Alain Combes
Service de Reanimation Medicale, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Universite Pierre et Marie Curie, Paris 6, Paris, France
Curr Opin Crit Care 18:527-32. 2012..This article reviews the results of case series and trials which evaluated venovenous extracorporeal membrane oxygenation (VV-ECMO) for severe respiratory failure. Potential indications of the technique in this setting are discussed... - Circulatory support for fulminant myocarditis: consideration for implantation, weaning and explantationPascal Leprince
Service de Chirurgie Thoracique et Cardiovasculaire, Groupe Pitié Salpêtrière, Institut de Cardiologie, 47 83 boulevard de l Hopital, 75013 Paris, France
Eur J Cardiothorac Surg 24:399-403. 2003..Fulminant myocarditis (FM) is an uncommon but life-threatening condition for which a mechanical circulatory support (MCS) device can be life-saving. However, device selection, weaning and explantation procedures remain poorly defined... - Value of the clinical pulmonary infection score for the identification and management of ventilator-associated pneumoniaCharles-Edouard Luyt
, Institut de Cardiologie, , , 75651 Paris Cedex 13, France
Intensive Care Med 30:844-52. 2004..CONCLUSION: A strategy based on the CPIS to decide which patients with suspected VAP should receive prolonged administration of antibiotics would appear to over-prescribe these agents, as compared to a strategy based on bronchoscopy... - High levels of catalytic antibodies correlate with favorable outcome in sepsisSebastien Lacroix-Desmazes
Institut National de la Sante et de la Recherche Medicale, Unite 681, Universite Paris VI, Institut des Cordeliers, 15 rue de l Ecole de Medecine, 75006 Paris, France
Proc Natl Acad Sci U S A 102:4109-13. 2005..Our observations provide the first evidence that hydrolytic antibodies might play a role in recovery from a disease... - Virus diseases in ICU patients: a long time underestimated; but be aware of overestimationCharles-Edouard Luyt
Intensive Care Med 32:968-70. 2006 - Massive intraventricular thrombus complicating extracorporeal membrane oxygenation supportGhassan Moubarak
, , , , Paris, France
Can J Cardiol 24:e1. 2008 - Impact of tracheotomy on sedative administration, sedation level, and comfort of mechanically ventilated intensive care unit patientsAnia Nieszkowska
, , Paris, France
Crit Care Med 33:2527-33. 2005..CONCLUSION: On the basis of these observations, we conclude that tracheotomized mechanically ventilated ICU patients required less intravenous sedative administration, spent less time heavily sedated, and achieved more autonomy earlier... - Adverse effect on a referral intensive care unit's performance of accepting patients transferred from another intensive care unitAlain Combes
, , Paris, France
Crit Care Med 33:705-10. 2005..Future benchmarking and profiling systems should evaluate and adequately account for the ICU-transfer factor to provide healthcare payers and consumers with more accurate and valid information on the true performance of referral centers... - Brain natriuretic peptide: A marker of myocardial dysfunction and prognosis during severe sepsisJulien Charpentier
Medical Intensive Care Unit, Groupe Hospitalier Cochin-Saint Vincent de Paul-La Roche Guyon, Paris, France
Crit Care Med 32:660-5. 2004..In this setting, brain natriuretic peptide seems useful to detect myocardial dysfunction, and high plasma levels appear to be associated with poor outcome of sepsis, but further studies are needed...