Pierre Hervé Luppi

Summary

Country: France

Publications

  1. pmc Localization of the brainstem GABAergic neurons controlling paradoxical (REM) sleep
    Emilie Sapin
    CNRS, UMR5167, Physiopathologie des réseaux neuronaux du cycle veille sommeil, Lyon, France
    PLoS ONE 4:e4272. 2009
  2. doi request reprint Paradoxical (REM) sleep genesis by the brainstem is under hypothalamic control
    Pierre Hervé Luppi
    INSERM, U1028, CNRS, UMR5292, Lyon Neuroscience Research Center, Team Physiopathologie des réseaux neuronaux responsables du cycle veille sommeil, Lyon, France University Lyon 1, Lyon, France Electronic address
    Curr Opin Neurobiol 23:786-92. 2013
  3. doi request reprint New aspects in the pathophysiology of rapid eye movement sleep behavior disorder: the potential role of glutamate, gamma-aminobutyric acid, and glycine
    Pierre Hervé Luppi
    INSERM, U1028, France CNRS, UMR5292, France
    Sleep Med 14:714-8. 2013
  4. ncbi request reprint Neurochemical aspects of sleep regulation with specific focus on slow-wave sleep
    Pierre Hervé Luppi
    University of Lyon, Centre National de la Recherche Scientifique CNRS, Physiologie et physiopathologie du cycle veille sommeil, Institut Fédératif des Neurosciences IFNL, Lyon, France
    World J Biol Psychiatry 11:4-8. 2010
  5. pmc Evidence that neurons of the sublaterodorsal tegmental nucleus triggering paradoxical (REM) sleep are glutamatergic
    Olivier Clement
    Physiopathology of the Neuronal Network Responsible for the Sleep Waking Cycle Team, CNRS UMR5292, INSERM U1028, Lyon Neuroscience, Research Center, Lyon, F 69372, France
    Sleep 34:419-23. 2011
  6. doi request reprint Brainstem mechanisms of paradoxical (REM) sleep generation
    Pierre Hervé Luppi
    INSERM, U1028, CNRS, UMR 5292, Lyon Neuroscience Research Center, Team Physiopathologie des réseaux neuronaux responsables du cycle veille sommeil, Lyon, France
    Pflugers Arch 463:43-52. 2012
  7. doi request reprint The neuronal network responsible for paradoxical sleep and its dysfunctions causing narcolepsy and rapid eye movement (REM) behavior disorder
    Pierre Hervé Luppi
    UMR5167 CNRS, Institut Fédératif des Neurosciences de Lyon IFR 19, Univ Lyon 1, Universite de Lyon, Lyon, France
    Sleep Med Rev 15:153-63. 2011
  8. ncbi request reprint Paradoxical (REM) sleep genesis: the switch from an aminergic-cholinergic to a GABAergic-glutamatergic hypothesis
    Pierre Hervé Luppi
    UMR5167 CNRS, Faculte de Medecine Laennec, Institut Fédératif des Neurosciences de Lyon IFR 19, Universite Claude Bernard Lyon I, 7, Rue Guillaume Paradin, 69372 Lyon Cedex 08, France
    J Physiol Paris 100:271-83. 2006
  9. ncbi request reprint Brainstem structures responsible for paradoxical sleep onset and maintenance
    P H Luppi
    UMR5167 CNRS, Institut Fédératif des Neurosciences de Lyon IFR 19, Universite Claude Bernard, Lyon, Cedex 08, France
    Arch Ital Biol 142:397-411. 2004
  10. pmc A role of melanin-concentrating hormone producing neurons in the central regulation of paradoxical sleep
    Laure Verret
    CNRS UMR5167, Institut Fédératif des Neurosciences de Lyon IFR 19, Universite Claude Bernard Lyon I, 7 rue Guillaume Paradin, 69372 Lyon Cedex 08, France
    BMC Neurosci 4:19. 2003

Collaborators

Detail Information

Publications36

  1. pmc Localization of the brainstem GABAergic neurons controlling paradoxical (REM) sleep
    Emilie Sapin
    CNRS, UMR5167, Physiopathologie des réseaux neuronaux du cycle veille sommeil, Lyon, France
    PLoS ONE 4:e4272. 2009
    ..From these results, we propose a revised model for PS control in which GABAergic PS-on and PS-off neurons localized in the vlPAG/dDPMe region play leading roles...
  2. doi request reprint Paradoxical (REM) sleep genesis by the brainstem is under hypothalamic control
    Pierre Hervé Luppi
    INSERM, U1028, CNRS, UMR5292, Lyon Neuroscience Research Center, Team Physiopathologie des réseaux neuronaux responsables du cycle veille sommeil, Lyon, France University Lyon 1, Lyon, France Electronic address
    Curr Opin Neurobiol 23:786-92. 2013
    ....
  3. doi request reprint New aspects in the pathophysiology of rapid eye movement sleep behavior disorder: the potential role of glutamate, gamma-aminobutyric acid, and glycine
    Pierre Hervé Luppi
    INSERM, U1028, France CNRS, UMR5292, France
    Sleep Med 14:714-8. 2013
    ..We then propose that movements of RBD are induced by descending projections of cortical motor neurons before discussing possible modes of action of clonazepam and melatonin. ..
  4. ncbi request reprint Neurochemical aspects of sleep regulation with specific focus on slow-wave sleep
    Pierre Hervé Luppi
    University of Lyon, Centre National de la Recherche Scientifique CNRS, Physiologie et physiopathologie du cycle veille sommeil, Institut Fédératif des Neurosciences IFNL, Lyon, France
    World J Biol Psychiatry 11:4-8. 2010
    ..At the onset of sleep, the sleep neurons are activated by the circadian clock localized in the suprachiasmatic nucleus and a hypnogenic factor, adenosine, which progressively accumulates in the brain during waking...
  5. pmc Evidence that neurons of the sublaterodorsal tegmental nucleus triggering paradoxical (REM) sleep are glutamatergic
    Olivier Clement
    Physiopathology of the Neuronal Network Responsible for the Sleep Waking Cycle Team, CNRS UMR5292, INSERM U1028, Lyon Neuroscience, Research Center, Lyon, F 69372, France
    Sleep 34:419-23. 2011
    ..To determine whether sublaterodorsal tegmental nucleus (SLD) neurons triggering paradoxical (REM) sleep (PS) are glutamatergic...
  6. doi request reprint Brainstem mechanisms of paradoxical (REM) sleep generation
    Pierre Hervé Luppi
    INSERM, U1028, CNRS, UMR 5292, Lyon Neuroscience Research Center, Team Physiopathologie des réseaux neuronaux responsables du cycle veille sommeil, Lyon, France
    Pflugers Arch 463:43-52. 2012
    ..Activation of PS would depend on the reciprocal interactions between the GABAergic PS-on and PS-off neurons, intrinsic cellular and molecular events, and integration of multiple physiological parameters...
  7. doi request reprint The neuronal network responsible for paradoxical sleep and its dysfunctions causing narcolepsy and rapid eye movement (REM) behavior disorder
    Pierre Hervé Luppi
    UMR5167 CNRS, Institut Fédératif des Neurosciences de Lyon IFR 19, Univ Lyon 1, Universite de Lyon, Lyon, France
    Sleep Med Rev 15:153-63. 2011
    ....
  8. ncbi request reprint Paradoxical (REM) sleep genesis: the switch from an aminergic-cholinergic to a GABAergic-glutamatergic hypothesis
    Pierre Hervé Luppi
    UMR5167 CNRS, Faculte de Medecine Laennec, Institut Fédératif des Neurosciences de Lyon IFR 19, Universite Claude Bernard Lyon I, 7, Rue Guillaume Paradin, 69372 Lyon Cedex 08, France
    J Physiol Paris 100:271-83. 2006
    ..We propose that these GABAergic neurons also inhibit the GABAergic neurons of the DPMe at the onset and during PS and are therefore responsible for the onset and maintenance of PS...
  9. ncbi request reprint Brainstem structures responsible for paradoxical sleep onset and maintenance
    P H Luppi
    UMR5167 CNRS, Institut Fédératif des Neurosciences de Lyon IFR 19, Universite Claude Bernard, Lyon, Cedex 08, France
    Arch Ital Biol 142:397-411. 2004
    ....
  10. pmc A role of melanin-concentrating hormone producing neurons in the central regulation of paradoxical sleep
    Laure Verret
    CNRS UMR5167, Institut Fédératif des Neurosciences de Lyon IFR 19, Universite Claude Bernard Lyon I, 7 rue Guillaume Paradin, 69372 Lyon Cedex 08, France
    BMC Neurosci 4:19. 2003
    ..Next, we compared the effect of MCH and NaCl intracerebroventricular (ICV) administrations on sleep stage quantities to further determine whether MCH neurons play an active role in PS regulation...
  11. pmc A very large number of GABAergic neurons are activated in the tuberal hypothalamus during paradoxical (REM) sleep hypersomnia
    Emilie Sapin
    CNRS, UMR5167, Physiopathologie des réseaux neuronaux du cycle veille sommeil, Universite Claude Bernard Lyon 1, Universite de Lyon, Lyon, France
    PLoS ONE 5:e11766. 2010
    ..Further investigations will be needed to corroborate this original hypothesis...
  12. doi request reprint Dopaminergic neurons expressing Fos during waking and paradoxical sleep in the rat
    Lucienne Leger
    Universite de Lyon, Lyon, Universite Lyon 1, CNRS, UMR5167, Physiologie et physiopathologie du cycle veille sommeil, F 69008, France
    J Chem Neuroanat 39:262-71. 2010
    ..These results suggest that some DA neurons (A11) could participate in waking and/or the inhibition of PS during PS deprivation whereas others (A13) would be involved in the control of PS...
  13. ncbi request reprint GABAergic control of hypothalamic melanin-concentrating hormone-containing neurons across the sleep-waking cycle
    Romain Goutagny
    CNRS, UMR 5167, Faculte de Medecine, RTH Laennec, 7 rue G Paradin, 69372 Lyon Cedex 08, France
    Neuroreport 16:1069-73. 2005
    ..These results suggest that neurons containing melanin-concentrating hormone are not active during waking and that the lack of a potent GABAergic influence during waking is consistent with their role in sleep regulation...
  14. ncbi request reprint Localization of the GABAergic and non-GABAergic neurons projecting to the sublaterodorsal nucleus and potentially gating paradoxical sleep onset
    Romuald Boissard
    CNRS UMR5167, Institut Fédératif des Neurosciences de Lyon IFR 19, Universite Claude Bernard Lyon I, 7, Rue Guillaume Paradin, 69372 Lyon, Cedex 08, France
    Eur J Neurosci 18:1627-39. 2003
    ..They could also terminate on SLD GABAergic interneurons and be indirectly responsible for the inhibition of the PS-on neurons during waking and slow-wave sleep...
  15. ncbi request reprint The rat ponto-medullary network responsible for paradoxical sleep onset and maintenance: a combined microinjection and functional neuroanatomical study
    Romuald Boissard
    CNRS FRE 2469, Institut Fédératif des Neurosciences de Lyon IFR 19, Universite Claude Bernard Lyon I, 8 avenue Rockefeller, 69373 Lyon Cedex 08, France
    Eur J Neurosci 16:1959-73. 2002
    ..Furthermore, they suggest that GABAergic disinhibition and glutamate excitation of these neurons might also play a crucial role in the onset of PS...
  16. doi request reprint Melanin concentrating hormone in central hypersomnia
    Christelle Peyron
    Centre National de la Recherche Scientifique UMR5167, Universite Claude Bernard Lyon 1, Universite de Lyon, Institut Federatif des Neurosciences de Lyon, 7 rue Guillaume Paradin, 69372 Lyon Cedex 08, France
    Sleep Med 12:768-72. 2011
    ..Melanin concentrating hormone (MCH) neurons involved in the homeostatic regulation of REM sleep are intact. We hypothesized that an increased release of MCH in NC would be partly responsible for the abnormal REM sleep manifestations...
  17. ncbi request reprint Cholinergic and noncholinergic brainstem neurons expressing Fos after paradoxical (REM) sleep deprivation and recovery
    Laure Verret
    CNRS UMR 5167, Institut Fédératif des Neurosciences de Lyon IFR 19, Faculté de médecine RTH Laennec, 7, Rue Guillaume Paradin, 69372 Lyon Cedex 08, France
    Eur J Neurosci 21:2488-504. 2005
    ..Altogether, our results open a new avenue of research to identify the specific role of the populations of neurons revealed, their interrelations and their neurochemical identity...
  18. ncbi request reprint Role of the melanin-concentrating hormone neuropeptide in sleep regulation
    Christelle Peyron
    UMR CNRS, Universite Claude Bernard Lyon1, Universite de Lyon, Institut Federatif des Neurosciences de Lyon, France
    Peptides 30:2052-9. 2009
    ....
  19. doi request reprint The lateral hypothalamic area controls paradoxical (REM) sleep by means of descending projections to brainstem GABAergic neurons
    Olivier Clement
    INSERM, U1028 CNRS, UMR5292 Centre de Recherche en Neuroscience de Lyon, Team Physiopathologie des réseaux neuronaux du cycle veille sommeil, F 69372 Lyon, France
    J Neurosci 32:16763-74. 2012
    ..Furthermore, our results strongly suggest that these neurons trigger PS by means of their inhibitory projection to the PS-off GABAergic neurons located in the VLPAG/dDpMe...
  20. pmc Tuberal hypothalamic neurons secreting the satiety molecule Nesfatin-1 are critically involved in paradoxical (REM) sleep homeostasis
    Sonia Jego
    Sleep Waking Neuronal Networks, CNRS UMR5292, Lyon, France
    PLoS ONE 7:e52525. 2012
    ..This could be done through the inhibition of downstream targets comprised primarily of the local hypothalamic wake-active orexin- and histamine-containing neurons...
  21. ncbi request reprint Noradrenergic neurons expressing Fos during waking and paradoxical sleep deprivation in the rat
    Lucienne Leger
    Universite de Lyon, Lyon, France
    J Chem Neuroanat 37:149-57. 2009
    ..They further suggest that the inhibitory effect of noradrenaline on PS may be due to the A1/C1, A2 and to a lesser degree to A5 neurons but not from those of the LC as previously hypothesized...
  22. doi request reprint Role of the dorsal paragigantocellular reticular nucleus in paradoxical (rapid eye movement) sleep generation: a combined electrophysiological and anatomical study in the rat
    R Goutagny
    CNRS, UMR 5167, Institut Fédératif des Neurosciences de Lyon IFR19, Lyon, F 69372, France
    Neuroscience 152:849-57. 2008
    ....
  23. ncbi request reprint Characterization of the melanin-concentrating hormone neurons activated during paradoxical sleep hypersomnia in rats
    Lucie Hanriot
    Centre National de Recherche Scientifique UMR5167, Universite de Lyon, Université Lyon1, Institut Federatif des Neurosciences de Lyon, Lyon, 69372, France
    J Comp Neurol 505:147-57. 2007
    ..Based on these results and the literature, we propose that MCH could be involved in memory processes and in the inhibition of muscle tone during PS...
  24. ncbi request reprint Paradoxical sleep in mice lacking M3 and M2/M4 muscarinic receptors
    Romain Goutagny
    CNRS UMR 5167, Physiopathologie des réseaux neuronaux du cycle veille sommeil, Institut Fédératif des Neurosciences de Lyon IFR19, Université C Bernard, 7 rue Guillaume Paradin, FR 69372 Lyon Cedex 08, France
    Neuropsychobiology 52:140-6. 2005
    ....
  25. pmc Role of the lateral paragigantocellular nucleus in the network of paradoxical (REM) sleep: an electrophysiological and anatomical study in the rat
    Chrystelle Sirieix
    Sleep Team, Lyon Neuroscience Research Center, Lyon, France
    PLoS ONE 7:e28724. 2012
    ..We propose that, during PS, the LPGi is strongly excited by the SLD and hyperpolarizes the motoneurons of the facial nucleus in addition to local and locus coeruleus PS-Off neurons, and by this means contributes to PS genesis...
  26. doi request reprint Major impairments of glutamatergic transmission and long-term synaptic plasticity in the hippocampus of mice lacking the melanin-concentrating hormone receptor-1
    Bastien Pachoud
    Unité Mixte de Recherche 5167 du Centre National de la Recherche Scientifique, Institut Fédératif des Neurosciences de Lyon IFR19, Université Claude, Lyon, France
    J Neurophysiol 104:1417-25. 2010
    ..Recently, it has been shown that MCH neurons fire exclusively during sleep and mainly during rapid eye movement sleep. Thus these findings provide a mechanism by which sleep might facilitate memory consolidation...
  27. ncbi request reprint The inhibition of the dorsal paragigantocellular reticular nucleus induces waking and the activation of all adrenergic and noradrenergic neurons: a combined pharmacological and functional neuroanatomical study
    Olivier Clement
    INSERM, U1028 CNRS, UMR5292 Lyon Neuroscience Research Center, Team SLEEP, Lyon, France University Claude Bernard Lyon 1, Lyon, France
    PLoS ONE 9:e96851. 2014
    ....
  28. ncbi request reprint Effect of the wake-promoting agent modafinil on sleep-promoting neurons from the ventrolateral preoptic nucleus: an in vitro pharmacologic study
    Thierry Gallopin
    UMR 5167 CNRS, Physio pathologie des reseaux neuronaux du cycle veille sommeil, Institut Fédératif des Neurosciences de Lyon IFNL, IFR19, Universite Claude Bernard Lyon I, Lyon, France
    Sleep 27:19-25. 2004
    ..We further determined whether pretreatment with modafinil modifies the effect of noradrenaline, carbachol, serotonin, histamine, dopamine, or clonidine...
  29. ncbi request reprint [Progress in our understanding of the architecture of paradoxical sleep since William Dement and Michel Jouvet]
    Pierre Hervé Luppi
    UMR 5292, CNRS U1028 INSERM, Université Lyon I Faculté de médecine Laennec, 7, rue Guillaume Paradin 69372 Lyon
    Bull Acad Natl Med 195:1517-24; discussion 1524-5. 2011
    ..Further, they suggest that three populations of GABAergic neurons and population of hypothalamic neurons expressing melanin concentrating hormone, a peptide, play a important role in PS control...
  30. doi request reprint Alternating vigilance states: new insights regarding neuronal networks and mechanisms
    P Fort
    UMR5167 CNRS, Institut Fédératif des Neurosciences de Lyon IFR 19, Universite de Lyon, Lyon, France
    Eur J Neurosci 29:1741-53. 2009
    ..Finally, we review human neurological disorders of the network responsible for sleep and propose hypotheses on the mechanisms responsible for REM behavior disorder and narcolepsy...
  31. ncbi request reprint Electrophysiological evidence that noradrenergic neurons of the rat locus coeruleus are tonically inhibited by GABA during sleep
    D Gervasoni
    Laboratoire de Medecine Experimentale, INSERM U480, CNRS ERS 5645, Faculte de Pharmacie, Universite Claude Bernard Lyon I, France
    Eur J Neurosci 10:964-70. 1998
    ....
  32. doi request reprint The satiety molecule nesfatin-1 is co-expressed with melanin concentrating hormone in tuberal hypothalamic neurons of the rat
    P Fort
    CNRS UMR5167, Institut Fédératif des Neurosciences de Lyon IFR 19, Faculté de médecine RTH Laennec, Universite Claude Bernard Lyon I, Lyon Cedex 08, France
    Neuroscience 155:174-81. 2008
    ....
  33. ncbi request reprint Anatomical demonstration of a medullary enkephalinergic pathway potentially implicated in the oro-facial muscle atonia of paradoxical sleep in the cat
    P Fort
    Neurobiologie des tats de Sommeil et d veil, INSERM U480, Universit Claude Bernard, Lyon 69373, France
    Sleep Res Online 1:102-8. 1998
    ..Based on these and previous anatomical and electrophysiological data, we propose that these enkephalin-containing neurons could participate in the hyperpolarization of brainstem and spinal somatic motoneurons during paradoxical sleep...
  34. ncbi request reprint Unrelated course of subthalamic nucleus and globus pallidus neuronal activities across vigilance states in the rat
    N Urbain
    Laboratoire de Neuropharmacologie et Neurochimie, INSERM U512, Frnace
    Eur J Neurosci 12:3361-74. 2000
    ....
  35. pmc Paradoxical (REM) sleep deprivation causes a large and rapidly reversible decrease in long-term potentiation, synaptic transmission, glutamate receptor protein levels, and ERK/MAPK activation in the dorsal hippocampus
    Pascal Ravassard
    UMR 5167 CNRS, Physio pathologie des reseaux neuronaux du cycle veille sommeil, Institut Feddratifdes Neurosciences de Lyon IFNL, IFR 19, Universite Lyon, Lyon, France
    Sleep 32:227-40. 2009
    ..We examined whether PS modulated the excitatory transmission and expression of glutamate receptor subtypes and phosphorylated extracellular signal-regulated kinases (p-ERK1/2)...
  36. ncbi request reprint Forebrain projections of the rostral nucleus raphe magnus shown by iontophoretic application of choleratoxin b in rats
    D M Hermann
    Department of Experimental Medicine, CNRS ERS 5645, INSERM U52, Lyon, France
    Neurosci Lett 216:151-4. 1996
    ..Thus, non-serotonergic rostral nucleus raphe magnus cells might directly modulate hypothalamic thermointegrative neurones...