- ClC-5 mutations associated with Dent's disease: a major role of the dimer interfaceStephane Lourdel
UPMC Univ Paris 06, UMR_S 872, Laboratoire de Génomique, Physiologie et Physiopathologie Rénales, 75005, Paris, France
Pflugers Arch 463:247-56. 2012..Here, we discuss the functional consequences of the three classes of CLCN5 mutations on ClC-5 structure and function...
- Novel CLCN5 mutations in patients with Dent's disease result in altered ion currents or impaired exchanger processingTeddy Grand
UPMC Universite Paris 06, UMR 7134, Paris, France
Kidney Int 76:999-1005. 2009..Thus these mutations have distinct mechanisms by which they could impair ClC-5 function in Dent's disease...
- Hyperaldosteronemia and activation of the epithelial sodium channel are not required for sodium retention in puromycin-induced nephrosisStephane Lourdel
CNRS UPMC UMR 7134, Institut des Cordeliers, Paris, France
J Am Soc Nephrol 16:3642-50. 2005....
- An inward rectifier K(+) channel at the basolateral membrane of the mouse distal convoluted tubule: similarities with Kir4-Kir5.1 heteromeric channelsStephane Lourdel
INSERM U426, Institut Federatif de Recherche 02, Faculte de Medecine Xavier Bichat, Paris, France
J Physiol 538:391-404. 2002..At the current state of knowledge, the channel is similar to Kir4.1-Kir5.1 and Kir4.2-Kir5.1 heteromeric channels, but not to Kir4.1 or Kir4.2 homomeric channels...
- Heterogeneity in the processing of CLCN5 mutants related to Dent diseaseTeddy Grand
UPMC Univ Paris 06, UMR_S 872, Laboratoire de Génomique, Physiologie et Physiopathologie Rénales, Paris, France
Hum Mutat 32:476-83. 2011..Half of these mutants displayed reduced currents, whereas the other half showed abolished currents. Our study revealed distinct cellular mechanisms accounting for ClC-5 loss of function in Dent disease...
- Exploration of the basolateral chloride channels in the renal tubule usingJacques Teulon
UMR 7134 CNRS UPMC, Centre de Recherches Biomedicales des Cordeliers, Paris, France
Nephron Physiol 99:p64-8. 2005..We also discuss the possibility that chloride channels that do not belong to the ClC family may also be involved in the absorption of chloride across the cortical thick ascending limb...
- How Bartter's and Gitelman's syndromes, and Dent's disease have provided important insights into the function of three renal chloride channels: ClC-Ka/b and ClC-5Marie Briet
, , , IFR 58, and Rene Descartes University and School of Medicine, Paris, France
Nephron Physiol 103:p7-13. 2006....