Research Topics
Species | Stephane LourdelSummaryCountry: France Publications
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Publications
ClC-5 mutations associated with Dent's disease: a major role of the dimer interfaceStephane Lourdel
UPMC Univ Paris 06, UMR_S 872, Laboratoire de Génomique, Physiologie et Physiopathologie Rénales, 75005, Paris, France
Pflugers Arch 463:247-56. 2012..Here, we discuss the functional consequences of the three classes of CLCN5 mutations on ClC-5 structure and function...
Novel CLCN5 mutations in patients with Dent's disease result in altered ion currents or impaired exchanger processingTeddy Grand
UPMC Universite Paris 06, UMR 7134, Paris, France
Kidney Int 76:999-1005. 2009..Thus these mutations have distinct mechanisms by which they could impair ClC-5 function in Dent's disease...
Hyperaldosteronemia and activation of the epithelial sodium channel are not required for sodium retention in puromycin-induced nephrosisStephane Lourdel
CNRS UPMC UMR 7134, Institut des Cordeliers, Paris, France
J Am Soc Nephrol 16:3642-50. 2005....
An inward rectifier K(+) channel at the basolateral membrane of the mouse distal convoluted tubule: similarities with Kir4-Kir5.1 heteromeric channelsStephane Lourdel
INSERM U426, Institut Federatif de Recherche 02, Faculte de Medecine Xavier Bichat, Paris, France
J Physiol 538:391-404. 2002..At the current state of knowledge, the channel is similar to Kir4.1-Kir5.1 and Kir4.2-Kir5.1 heteromeric channels, but not to Kir4.1 or Kir4.2 homomeric channels...
Heterogeneity in the processing of CLCN5 mutants related to Dent diseaseTeddy Grand
UPMC Univ Paris 06, UMR_S 872, Laboratoire de Génomique, Physiologie et Physiopathologie Rénales, Paris, France
Hum Mutat 32:476-83. 2011..Half of these mutants displayed reduced currents, whereas the other half showed abolished currents. Our study revealed distinct cellular mechanisms accounting for ClC-5 loss of function in Dent disease...
Exploration of the basolateral chloride channels in the renal tubule usingJacques Teulon
UMR 7134 CNRS UPMC, Centre de Recherches Biomedicales des Cordeliers, Paris, France
Nephron Physiol 99:p64-8. 2005..We also discuss the possibility that chloride channels that do not belong to the ClC family may also be involved in the absorption of chloride across the cortical thick ascending limb...
How Bartter's and Gitelman's syndromes, and Dent's disease have provided important insights into the function of three renal chloride channels: ClC-Ka/b and ClC-5Marie Briet
, , , IFR 58, and Rene Descartes University and School of Medicine, Paris, France
Nephron Physiol 103:p7-13. 2006....
