Species

Philippe Lory

Summary

Country: France

Publications

  1. Monteil A, Chausson P, Boutourlinsky K, Mezghrani A, Huc Brandt S, Blesneac I, et al. Inhibition of Cav3.2 T-type Calcium Channels by Its Intracellular I-II Loop. J Biol Chem. 2015;290:16168-76 pubmed publisher
    ..2 and Cav3.3 channels, only the fast inactivating T-type current (Cav3.2 component) was significantly inhibited. Altogether, these data describe a new strategy to differentially inhibit Cav3 isoforms of the T-type calcium channels. ..
  2. Blesneac I, Chemin J, Bidaud I, Huc Brandt S, Vandermoere F, Lory P. Phosphorylation of the Cav3.2 T-type calcium channel directly regulates its gating properties. Proc Natl Acad Sci U S A. 2015;112:13705-10 pubmed publisher
    ..Our data show that Cav3.2 channels are highly phosphorylated in the mammalian brain and establish phosphorylation as an important mechanism involved in the dynamic regulation of Cav3.2 channel gating properties. ..
  3. Dorgans K, Salvi J, Bertaso F, Bernard L, Lory P, Doussau F, et al. Characterization of the dominant inheritance mechanism of Episodic Ataxia type 2. Neurobiol Dis. 2017;106:110-123 pubmed publisher
    ..1R1497X mice. Altogether, these results reveal a pathogenic mechanism for EA2 based on a dominant negative activity of mutant channels. ..

Collaborators

Detail Information

Publications3

  1. Monteil A, Chausson P, Boutourlinsky K, Mezghrani A, Huc Brandt S, Blesneac I, et al. Inhibition of Cav3.2 T-type Calcium Channels by Its Intracellular I-II Loop. J Biol Chem. 2015;290:16168-76 pubmed publisher
    ..2 and Cav3.3 channels, only the fast inactivating T-type current (Cav3.2 component) was significantly inhibited. Altogether, these data describe a new strategy to differentially inhibit Cav3 isoforms of the T-type calcium channels. ..
  2. Blesneac I, Chemin J, Bidaud I, Huc Brandt S, Vandermoere F, Lory P. Phosphorylation of the Cav3.2 T-type calcium channel directly regulates its gating properties. Proc Natl Acad Sci U S A. 2015;112:13705-10 pubmed publisher
    ..Our data show that Cav3.2 channels are highly phosphorylated in the mammalian brain and establish phosphorylation as an important mechanism involved in the dynamic regulation of Cav3.2 channel gating properties. ..
  3. Dorgans K, Salvi J, Bertaso F, Bernard L, Lory P, Doussau F, et al. Characterization of the dominant inheritance mechanism of Episodic Ataxia type 2. Neurobiol Dis. 2017;106:110-123 pubmed publisher
    ..1R1497X mice. Altogether, these results reveal a pathogenic mechanism for EA2 based on a dominant negative activity of mutant channels. ..