Olivier Lortholary

Summary

Country: France

Publications

  1. pmc Current ciprofloxacin usage in children hospitalized in a referral hospital in Paris
    Zhi Tao Yang
    Service des Maladies Infectieuses et Tropicales and Centre d Infectiologie Necker Pasteur, Universite Paris Descartes, Hopital Necker Enfants Malades, Paris, France
    BMC Infect Dis 13:245. 2013
  2. doi request reprint Fungal infections in immunocompromised travelers
    Olivier Lortholary
    Universite Paris Descartes, Sorbonne Paris Cité, Hopital Necker Enfants Malades, Centre d lnfectiologie Necker Pasteur, and Institut Imagine, Paris, France
    Clin Infect Dis 56:861-9. 2013
  3. doi request reprint ESCMID* guideline for the diagnosis and management of Candida diseases 2012: patients with HIV infection or AIDS
    O Lortholary
    Universite Paris Descartes, Service des Maladies Infectieuses et Tropicales, Hopital Necker Enfants Malades, APHP, Centre d Infectiologie Necker Pasteur, IHU Imagine, Paris, France
    Clin Microbiol Infect 18:68-77. 2012
  4. ncbi request reprint [Immunologic deficiencies. Optimizing diagnostic and therapeutic approaches]
    Olivier Lortholary
    Faculté de Médecine Paris Descartes, Service des Maladies Infectieuses et Tropicales, Centre d Infectiologie Necker Pasteur
    Rev Prat 57:1637-8. 2007
  5. pmc Comparison of albicans vs. non-albicans candidemia in French intensive care units
    Olivier Leroy
    Service de Réanimation Médicale et des Maladies Infectieuses, Centre Hospitalier Gustave Dron, 135 rue du Président Coty, 59208 Tourcoing, France
    Crit Care 14:R98. 2010
  6. doi request reprint [Chronic granulomatous disease: pathogenesis and therapy of associated fungal infections]
    ANNE DESJARDINS
    Service de Maladies Infectieuses et Tropicales, Hopital Necker Enfants Malades, Paris, France
    Med Sci (Paris) 28:963-9. 2012
  7. pmc Therapeutic drug monitoring of posaconazole: a monocentric study with 54 adults
    David Lebeaux
    Universite Paris Descartes, Service des Maladies Infectieuses et Tropicales, Hopital Necker Enfants Malades, Centre d Infectiologie Necker Pasteur, Paris, France
    Antimicrob Agents Chemother 53:5224-9. 2009
  8. doi request reprint Recurrent Mycobacterium avium infection after seven years of latency in a HIV-infected patient receiving efficient antiretroviral therapy
    Guillaume Bussone
    Universite Paris Descartes, Service de Maladies Infectieuses et Tropicales, Centre d Infectiologie Necker Pasteur, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, Paris, France
    J Infect 64:613-7. 2012
  9. doi request reprint Adherence to preventive measures after splenectomy in the hospital setting and in the community
    Hélène Coignard-Biehler
    Paris Descartes University, Paris, France
    J Infect Public Health 4:187-94. 2011
  10. doi request reprint Invasive mold infections in chronic granulomatous disease: a 25-year retrospective survey
    Sophie Blumental
    Immunology and Haematology Unit, Hopital Necker Enfants Malades, Paris, France
    Clin Infect Dis 53:e159-69. 2011

Collaborators

Detail Information

Publications80

  1. pmc Current ciprofloxacin usage in children hospitalized in a referral hospital in Paris
    Zhi Tao Yang
    Service des Maladies Infectieuses et Tropicales and Centre d Infectiologie Necker Pasteur, Universite Paris Descartes, Hopital Necker Enfants Malades, Paris, France
    BMC Infect Dis 13:245. 2013
    ..Here we assessed the prescriptions of ciprofloxacin in a pediatric cohort and their appropriateness...
  2. doi request reprint Fungal infections in immunocompromised travelers
    Olivier Lortholary
    Universite Paris Descartes, Sorbonne Paris Cité, Hopital Necker Enfants Malades, Centre d lnfectiologie Necker Pasteur, and Institut Imagine, Paris, France
    Clin Infect Dis 56:861-9. 2013
    ..Finally, infectious diseases physicians should be aware of major clinical patterns of travel-acquired fungal infection, as well as the fungi involved, and risk factors according to the geographical area visited...
  3. doi request reprint ESCMID* guideline for the diagnosis and management of Candida diseases 2012: patients with HIV infection or AIDS
    O Lortholary
    Universite Paris Descartes, Service des Maladies Infectieuses et Tropicales, Hopital Necker Enfants Malades, APHP, Centre d Infectiologie Necker Pasteur, IHU Imagine, Paris, France
    Clin Microbiol Infect 18:68-77. 2012
    ..For vaginal candidiasis, topical therapy is preferred...
  4. ncbi request reprint [Immunologic deficiencies. Optimizing diagnostic and therapeutic approaches]
    Olivier Lortholary
    Faculté de Médecine Paris Descartes, Service des Maladies Infectieuses et Tropicales, Centre d Infectiologie Necker Pasteur
    Rev Prat 57:1637-8. 2007
  5. pmc Comparison of albicans vs. non-albicans candidemia in French intensive care units
    Olivier Leroy
    Service de Réanimation Médicale et des Maladies Infectieuses, Centre Hospitalier Gustave Dron, 135 rue du Président Coty, 59208 Tourcoing, France
    Crit Care 14:R98. 2010
    ..This analysis sought to compare the characteristics of intensive care unit (ICU) patients with candidemia due to non-albicans Candida species with those of ICU patients with candidemia due to Candida albicans...
  6. doi request reprint [Chronic granulomatous disease: pathogenesis and therapy of associated fungal infections]
    ANNE DESJARDINS
    Service de Maladies Infectieuses et Tropicales, Hopital Necker Enfants Malades, Paris, France
    Med Sci (Paris) 28:963-9. 2012
    ..Here we review the genetic basis, pathogenesis and clinical presentation associated with fungal infections in chronic granulomatous disease as well as the current prophylaxis and newly available therapies...
  7. pmc Therapeutic drug monitoring of posaconazole: a monocentric study with 54 adults
    David Lebeaux
    Universite Paris Descartes, Service des Maladies Infectieuses et Tropicales, Hopital Necker Enfants Malades, Centre d Infectiologie Necker Pasteur, Paris, France
    Antimicrob Agents Chemother 53:5224-9. 2009
    ..Therapeutic drug monitoring of posaconazole is therefore mandatory for immunosuppressed adults, at least for those with gastrointestinal disorders...
  8. doi request reprint Recurrent Mycobacterium avium infection after seven years of latency in a HIV-infected patient receiving efficient antiretroviral therapy
    Guillaume Bussone
    Universite Paris Descartes, Service de Maladies Infectieuses et Tropicales, Centre d Infectiologie Necker Pasteur, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, Paris, France
    J Infect 64:613-7. 2012
    ..avium bacteriaemia. Articular puncture grew M. avium. The isolates of the first and second infection were identical using repetitive-sequence-based Polymerase Chain Reaction analyses...
  9. doi request reprint Adherence to preventive measures after splenectomy in the hospital setting and in the community
    Hélène Coignard-Biehler
    Paris Descartes University, Paris, France
    J Infect Public Health 4:187-94. 2011
    ..Overwhelming post-splenectomy infection (OPSI) remains a long-term risk in asplenic patients, which may be reduced by appropriate preventive measures. Specific guidelines have been developed to lower its incidence...
  10. doi request reprint Invasive mold infections in chronic granulomatous disease: a 25-year retrospective survey
    Sophie Blumental
    Immunology and Haematology Unit, Hopital Necker Enfants Malades, Paris, France
    Clin Infect Dis 53:e159-69. 2011
    ..This study offers a descriptive review of invasive mold infection (mIFI) in children with CGD over an extended period of time...
  11. pmc Recent exposure to caspofungin or fluconazole influences the epidemiology of candidemia: a prospective multicenter study involving 2,441 patients
    Olivier Lortholary
    Institut Pasteur, Unité de Mycologie Moléculaire, Centre National de Référence Mycologie et Antifongiques, Paris, France
    Antimicrob Agents Chemother 55:532-8. 2011
    ..53; 95% CI = 1.43 to 4.48; P = 0.001) and with recent exposure to caspofungin (OR = 4.79; 95% CI = 2.47 to 9.28; P < 0.001). These findings could influence future recommendations for the management of candidemia...
  12. doi request reprint Therapeutic drug monitoring of voriconazole after intravenous administration in infants and children with primary immunodeficiency
    Magdalena Gerin
    Universite Paris Descartes, Assistance Publique Hopitaux de Paris, Paris, France
    Ther Drug Monit 33:464-6. 2011
    ..The aim of this work was to describe the probability of not achieving this target concentration in infants and children receiving intravenous voriconazole...
  13. doi request reprint Mucormycosis in organ and stem cell transplant recipients
    Fanny Lanternier
    Centre d lnfectiologie Necker Pasteur, Universite Paris Descartes, Hopital Necker Enfants Malades, Paris, France
    Clin Infect Dis 54:1629-36. 2012
    ....
  14. pmc Cost-effectiveness of primary prophylaxis of AIDS associated cryptococcosis in Cambodia
    Romain Micol
    Unité d Epidémiologie des Maladies Emergentes, Institut Pasteur, Paris, France
    PLoS ONE 5:e13856. 2010
    ..This study assessed the cost-effectiveness of three strategies for cryptococcosis prevention in HIV-infected patients...
  15. doi request reprint Pediatric mastocytosis is a clonal disease associated with D816V and other activating c-KIT mutations
    Christine Bodemer
    Service de Dermatologie, Hopital Necker, CEREMAST, centre de référence des mastocytoses, Faculte Necker, Universite Rene Descartes Paris V, Paris, France
    J Invest Dermatol 130:804-15. 2010
    ..These findings strongly support the idea that, although pediatric mastocytosis can spontaneously regress, it is a clonal disease most commonly associated with activating mutations in c-KIT...
  16. doi request reprint Healthcare-associated mucormycosis
    Blandine Rammaert
    Sorbonne Paris Cité, Service des Maladies Infectieuses et Tropicales, Hopital Necker Enfants Malades, APHP, Universite Paris Descartes, Centre d Infectiologie Necker Pasteur, 149 rue de Sevres, Paris Cedex 15, France
    Clin Infect Dis 54:S44-54. 2012
    ..Thorough investigations are mandatory to identify healthcare-associated mucormycosis, notably in neonatology, hematological, and transplantation units...
  17. pmc Serum Aspergillus galactomannan for the management of disseminated histoplasmosis in AIDS
    Sébastien Rivière
    Service des Maladies Infectieuses et Tropicales, Centre d Infectiologie Necker Pasteur, Paris, France
    Am J Trop Med Hyg 87:303-5. 2012
    ..Here, we report the contribution of galactomannan serum detection for the management of an HIV-infected patient with disseminated histoplasmosis...
  18. pmc Literature review and case histories of Histoplasma capsulatum var. duboisii infections in HIV-infected patients
    Pierre Loulergue
    University Paris V, Paris, France
    Emerg Infect Dis 13:1647-52. 2007
    ..We report 3 cases of imported African histoplasmosis diagnosed in France in HIV-infected patients and a literature review on similar cases...
  19. ncbi request reprint Risks factors of liver fibrosis in a cohort of intravenous drug users coinfected with HIV and HCV in the HAART era: the role of mixed steatosis
    Fanny Lanternier
    Service des Maladies Infectieuses et Tropicales, Hopital Cochin, 149 rue de Sevres, Paris
    Gastroenterol Clin Biol 31:822-7. 2007
    ..In this cohort of HIV/HCV coinfected intravenous drug user patients, METAVIR activity score, mixed steatosis and a low CD4 cell count were independent factors associated with severe liver fibrosis...
  20. ncbi request reprint [Infectious complications of immune deficiencies]
    Marie Olivia Chandesris
    Faculté de médecine René Descartes Paris 5, Service des Maladies Infectieuses et Tropicales, Hopital Necker Enfants Malades, Centre d Infectiologie Necker Pasteur, 75743 Paris 15
    Rev Prat 57:1653-64. 2007
    ..Most of the time, immune defects are combined, accounting for the variety and the complexity of clinical presentations and microbial investigations...
  21. doi request reprint Severe cutaneous bacillus Calmette-Guérin infection in immunocompromised children: the relevance of skin biopsy
    Amélie Gantzer
    Department of Dermatology, Hopital Necker Enfants Malades, Universite Rene Descartes, APHP, Paris, France
    J Cutan Pathol 40:30-7. 2013
    ..Skin biopsy is a useful part of the diagnostic workup for disseminated BCGitis, directing the clinician toward severe immunodeficiency. Moreover, skin biopsy may be a useful means of monitoring immune restoration for prognostic purposes...
  22. doi request reprint Epidemiology and outcome of invasive fungal diseases in patients with chronic granulomatous disease: a multicenter study in France
    Julien Beauté
    Centre de Référence Déficits Immunitaires Héréditaires, Hopital Necker Enfants Malades, AP HP, Paris, France
    Pediatr Infect Dis J 30:57-62. 2011
    ..This study is aimed at assessing the incidence, prevalence, and outcome of IFDs among CGD patients followed in France...
  23. doi request reprint Morbidity and mortality from ataxia-telangiectasia are associated with ATM genotype
    Romain Micol
    CEREDIH, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, 75743 Paris Cedex 15, France
    J Allergy Clin Immunol 128:382-9.e1. 2011
    ..The course of the disease is characterized by neurologic manifestations, infections, and cancers...
  24. pmc Prior caspofungin exposure in patients with hematological malignancies is a risk factor for subsequent fungemia due to decreased susceptibility in Candida spp.: a case-control study in Paris, France
    Elodie Blanchard
    INSERM U 657, Paris, France
    Antimicrob Agents Chemother 55:5358-61. 2011
    ..25; 95% confidence interval [95% CI], 1.68-16.35) and with an age of ≤ 65 years (OR = 3.27; 95% CI, 1.26-8.50)...
  25. pmc Nocardia pseudobrasiliensis as an emerging cause of opportunistic infection after allogeneic hematopoietic stem cell transplantation
    David Lebeaux
    Université Paris Descartes Service des Maladies Infectieuses et Tropicales, Hopital Necker Enfants Malades, AP HP, Centre d Infectiologie Necker Pasteur, 149 rue de Sevres, 75743 Paris Cedex 15, France
    J Clin Microbiol 48:656-9. 2010
    ..Culture of the bronchoalveolar lavage fluid revealed Nocardia pseudobrasiliensis. This recently described carbapenem-resistant species should be included in the differential diagnosis of fungal infection in this setting...
  26. pmc Autosomal dominant STAT3 deficiency and hyper-IgE syndrome: molecular, cellular, and clinical features from a French national survey
    Marie Olivia Chandesris
    Hematology Department, Necker Enfants Malades Hospital, Assistance Publique Hopitaux de Paris, Paris, France
    Medicine (Baltimore) 91:e1-19. 2012
    ..Overall, the prognosis of STAT3 deficiency may be considered good, provided that multiple prophylactic measures, including IgG infusions, are implemented...
  27. pmc Cryptococcal neuroradiological lesions correlate with severity during cryptococcal meningoencephalitis in HIV-positive patients in the HAART era
    Caroline Charlier
    Centre National de Référence Mycologie et Antifongiques, Unité de Mycologie Moléculaire, CNRS URA 3012, Institut Pasteur, Paris, France
    PLoS ONE 3:e1950. 2008
    ..Given this, we suggest that investigation for cryptococcosis-related lesions is merited, even in the absence of neurological abnormality, if a high fungal burden is suspected on the basis of high serum and/or CSF antigen titers...
  28. pmc Breakthrough Hormographiella aspergillata infections arising in neutropenic patients treated empirically with caspofungin
    Felipe Suarez
    Universite Paris Descartes, Service d Hématologie Adultes, Hopital Necker Enfants Malades, AP HP, 149 rue de Sevres, 75743 Paris Cedex 15, France
    J Clin Microbiol 49:461-5. 2011
    ..A rapid switch to any other potent antifungal should be rapidly considered in case of failure of caspofungin in this setting...
  29. doi request reprint Nontoxinogenic corynebacterium diphtheriae as a rare cause of native endocarditis in childhood
    David Schnell
    Universite Paris Descartes, Faculté de médecine Assistance Publique Hôpitaux de Paris, Hopital Necker Enfants Malades, Laboratoire de Microbiologie, France
    Pediatr Infect Dis J 29:886-8. 2010
    ..We report a pediatric case of negative blood culture pulmonary valve endocarditis caused by a nontoxinogenic Corynebacterium diphtheriae biotype gravis and review the literature on this disease...
  30. doi request reprint [Extension of beta-lactamases producing bacteria is a worldwide concern]
    Jean Ralph Zahar
    Universite Paris Descartes, CHU Necker Enfants Malades, APHP, microbiologie hygiène hospitalière, 149, rue de Sevres, 75743 Paris, France
    Med Sci (Paris) 25:939-44. 2009
    ..Preventing the spread and appropriately managing these infections caused by community acquired ESBL producing bacteria have become mandatory...
  31. doi request reprint Mycobacterium genavense infections: a retrospective multicenter study in France, 1996-2007
    Pierre Charles
    Universite Paris Descartes, Hopital Necker Enfants Malades, Paris, France
    Medicine (Baltimore) 90:223-30. 2011
    ..The 1-year survival rate was 72%.The prognosis of M. genavense infection in HIV-infected patients has dramatically improved with HAART. Clinical presentations in HIV and non-HIV immunocompromised patients were similar...
  32. pmc Antifungal therapy of Aspergillus invasive otitis externa: efficacy of voriconazole and review
    Perrine Parize
    Universite Paris Descartes, Hopital Necker Enfants Malades, Paris, France
    Antimicrob Agents Chemother 53:1048-53. 2009
    ..These observations demonstrate that voriconazole could be an effective and well-tolerated therapeutic option for the management of Aspergillus IOE...
  33. doi request reprint [Risk of fungal disease during systemic diseases]
    David Lebeaux
    Service des Maladies Infectieuses et Tropicales, Universite Paris Descartes, Hopital Necker Enfants Malades, Centre d Infectiologie Necker Pasteur, F 75743 Paris Cedex 15, France
    Presse Med 38:260-73. 2009
    ..Guidelines for invasive fungal disease curative treatment are available but preventive strategies need to be evaluated in the population of patients with systemic diseases...
  34. doi request reprint Fungal internal carotid artery aneurysms: successful embolization of an Aspergillus-associated case and review
    Arnaud Hot
    Services des Maladies Infectieuses et Tropicales, Centre d Infectiologie Necker Pasteur, France
    Clin Infect Dis 45:e156-61. 2007
    ....
  35. doi request reprint Prevalence, risk factors, and impact on outcome of cytomegalovirus replication in serum of Cambodian HIV-infected patients (2004-2007)
    Romain Micol
    Unité d Epidémiologie des Maladies Emergentes, Institut Pasteur, Paris, France
    J Acquir Immune Defic Syndr 51:486-91. 2009
    ..We estimated the prevalence of replicating CMV in sera of newly diagnosed HIV-infected Cambodian patients and examined its impact on mortality...
  36. doi request reprint Blood CD34-c-Kit+ cell rate correlates with aggressive forms of systemic mastocytosis and behaves like a mast cell precursor
    Sophie Georgin-Lavialle
    Service d Hématologie Adultes et Centre de Référence sur les Mastocytoses, Hopital Necker Enfants Malades, Universite Paris Descartes, Assistance Publique Hopitaux de Paris, France
    Blood 118:5246-9. 2011
    ..Monitoring peripheral CD34(-)c-Kit(+) cells by flow cytometry could be a useful and low-invasive tool to determine the disease severity and the relapses and to assess treatment efficiency...
  37. pmc Mycobacterium genavense as a cause of subacute pneumonia in patients with severe cellular immunodeficiency
    Blandine Rammaert
    Universite Paris Descartes, Hopital Necker Enfants Malades, Service des Maladies Infectieuses et Tropicales, Centre d Infectiologie Necker Pasteur, Paris, France
    BMC Infect Dis 11:311. 2011
    ..M. genavense culture is fastidious, requiring supplemented media. Pulmonary involvement rarely occurs as a primary localization...
  38. pmc Case-control cohort study of patients' perceptions of disability in mastocytosis
    Olivier Hermine
    Service de Dermatologie, Centre de référence sur la mastocytose, Hopital Necker, Paris, France
    PLoS ONE 3:e2266. 2008
    ..We therefore performed a case-control cohort study to examine self-reported disability and impact of symptoms on the quality of life in patients with mastocytosis...
  39. pmc Evidence for cognitive impairment in mastocytosis: prevalence, features and correlations to depression
    Daniela Silva Moura
    centre de référence des mastocytoses, Hopital Necker Enfants Malades, Fondation Imagine Paris, Universite Paris Descartes, Sorbonne, Paris Cité, Paris, France
    PLoS ONE 7:e39468. 2012
    ..These results suggest differential effects of mast-cell activity in the brain, on systems involved in emotionality and in cognition...
  40. ncbi request reprint Immune reconstitution inflammatory syndrome in HIV-infected patients with disseminated histoplasmosis
    Guillaume Breton
    Department of Infectious and Tropical Diseases, Hopital Bichat Claude Bernard, Paris, France
    AIDS 20:119-21. 2006
    ..Partial immune reconstitution induced by HAART during disseminated histoplasmosis either related to the variety capsulatum or duboisii may be associated with immune reconstitution inflammatory syndrome...
  41. doi request reprint Pristinamycin for Rickettsia africae infection
    Frédéric Méchaï
    Centre d Infectiologie Necker Pasteur, Paris, France
    J Travel Med 16:136-7. 2009
    ..The gold standard treatment is doxycycline. Here, we present a case of R africae infection associated with quick complete resolution following the initiation of pristinamycin therapy...
  42. pmc In vitro combination of anidulafungin and voriconazole against intrinsically azole-susceptible and -resistant Aspergillus spp
    Virginie Planche
    Universite Paris Descartes, Faculte de Medecine, APHP, Hopital Europeen Georges Pompidou, Unité de Parasitologie Mycologie, Service de Microbiologie, Paris, France
    Antimicrob Agents Chemother 56:4500-3. 2012
    ..5 to 2) and for 100% of the isolates by the agar diffusion method (variation of -2 to +1 log(2) dilutions)...
  43. ncbi request reprint [Infections in splenectomized patient]
    Hélène Coignard-Biehler
    Universite Paris Descartes, Assistance Publique Hopitaux de Paris, Hopital Necker Enfants Malades, Paris, France
    Rev Prat 58:2209-14. 2008
    ..Furthermore, long-term education is mandatory. Application of preventing measures is effective and patient's education remains the cornerstone of prevention...
  44. pmc Major role for amphotericin B-flucytosine combination in severe cryptococcosis
    Francoise Dromer
    Institut Pasteur, Mycologie Moléculaire, Centre National de Référence Mycologie et Antifongiques, CNRS URA3012, Paris, France
    PLoS ONE 3:e2870. 2008
    ..We assessed here the optimal therapeutic strategies for severe cryptococcosis using the observational prospective CryptoA/D study after analyzing routine clinical care of cryptococcosis in university or tertiary care hospitals...
  45. doi request reprint [Pregnancy: a high risk factor in influenza infection]
    Caroline Charlier
    Universite Paris Descartes, Service de Maladies Infectieuses et Tropicales, Centre d Infectiologie Necker Pasteur, Hopital Necker Enfants Malades, Groupe infections de la mère et de l enfant, Assistance Publique Hopitaux de Paris, 149, rue de Sevres, 75015 Paris, France
    Med Sci (Paris) 26:100-4. 2010
    ..We also provide an update on the epidemiological data available for the A/H1N1v infection in this population, and discuss the benefit/risk ratio of treatment with the antiviral medications...
  46. doi request reprint Plasma exchange for disseminated cryptococcosis
    Guillaume Bollée
    Department of Nephrology, AP HP, Hopital Necker, Universite Paris V, Paris, France
    Am J Kidney Dis 53:673-6. 2009
    ..We report a peculiar case of disseminated cryptococcosis complicated by acute renal failure associated with obstruction of intrarenal capillaries by Cryptococus neoformans dead bodies and successfully treated with plasma exchanges...
  47. doi request reprint Success of posaconazole therapy in a heart transplanted patient with Alternaria infectoria cutaneous infection
    Blandine Rammaert
    Service des Maladies Infectieuses et Tropicales, Hopital Necker Enfants Malades, Universite Paris Descartes, 149, rue de Sevres, 75743 Paris Cedex 15, France
    Med Mycol 50:518-21. 2012
    ..in solid organ transplant recipients...
  48. pmc Altered responses to homeostatic cytokines in patients with idiopathic CD4 lymphocytopenia
    Florence Bugault
    Unité d Immunogénétique Cellulaire, Institut Pasteur, Paris, France
    PLoS ONE 8:e55570. 2013
    ..Increased TSLP responses point to a compensatory homeostatic mechanism that may mitigate defects in γc cytokine responses...
  49. doi request reprint [Mucormycosis: therapeutic news]
    Benoit Pilmis
    Universite Paris Descartes, Hopital Necker Enfants Malades, Service des Maladies Infectieuses et Tropicales, Centre d Infectiologie Necker Pasteur, Paris, France
    Med Sci (Paris) 29:25-30. 2013
    ..Maintenance therapy/secondary prophylaxis by posaconazole has to be considered in persistently immuno compromised patients...
  50. pmc Phylogenetic and genomic diversity of human bacteremic Escherichia coli strains
    Françoise Jaureguy
    INSERM UMR570, Faculte de Medecine, Universite Paris Descartes, Paris, France
    BMC Genomics 9:560. 2008
    ..A subset representative of the clonal diversity was subjected to comparative genomic hybridization (CGH) using 2,324 amplicons from the flexible gene pool of E. coli...
  51. doi request reprint Protective effect of IgM against colonization of the respiratory tract by nontypeable Haemophilus influenzae in patients with hypogammaglobulinemia
    Romain Micol
    CEREDIH network French National Reference Center for Primary Immunodeficiencies, Hopital Necker Enfants Malades, AP HP, Paris, France
    J Allergy Clin Immunol 129:770-7. 2012
    ..It is not known whether patients able to secrete IgM (eg, those with hyper-IgM [HIgM] syndrome) are as susceptible to these infections as patients who lack IgM production (eg, those with panhypogammaglobulinemia [PHG])...
  52. ncbi request reprint Prevalence, determinants of positivity, and clinical utility of cryptococcal antigenemia in Cambodian HIV-infected patients
    Romain Micol
    Unité d Epidémiologie des Maladies Emergentes, Institut Pasteur, Paris, France
    J Acquir Immune Defic Syndr 45:555-9. 2007
    ..To determine the prevalence, determinants ofpositivity, and clinical utility of serum cryptococcal polysaccharide (CPS) antigen testing among HIV-infected patients in 2004 in Cambodia, an area highly endemic for cryptococcosis...
  53. ncbi request reprint Fever of unknown origin in HIV/AIDS patients
    Arnaud Hot
    Universite Paris V, Service des Maladies Infectieuses et Tropicales, Centre d Infectiologie Necker Pasteur, Hopital Necker Enfants Malades, 149 rue de Sevres, 75743 Paris Cedex 15, France
    Infect Dis Clin North Am 21:1013-32, ix. 2007
    ..This article discusses the causes, diagnosis, and treatment of FUO in HIV-infected individuals...
  54. ncbi request reprint Long-term outcome of AIDS-associated cryptococcosis in the era of combination antiretroviral therapy
    Olivier Lortholary
    Centre National de Référence Mycologie et Antifongiques, Unité de Mycologie Moléculaire, Institut Pasteur, Paris, France
    AIDS 20:2183-91. 2006
    ..Immune restoration following combination antiretroviral therapy (cART) questions the maintenance of prophylaxis among HIV-infected patients with cryptococcosis...
  55. doi request reprint Adjuvant corticosteroid therapy for chronic disseminated candidiasis
    Faezeh Legrand
    Universite Paris 7, Service d Hématologie Pédiatrique, Hopital Robert Debre, Paris, France
    Clin Infect Dis 46:696-702. 2008
    ..Chronic disseminated candidiasis (CDC) is typically observed during neutrophil recovery in patients with acute leukemia and requires protracted antifungal therapy...
  56. pmc Determinants of disease presentation and outcome during cryptococcosis: the CryptoA/D study
    Francoise Dromer
    Unité de Mycologie Moléculaire, Centre National de Référence Mycologie et Antifongiques, CNRS URA3042, Institut Pasteur, Paris, France
    PLoS Med 4:e21. 2007
    ....
  57. ncbi request reprint Successful treatment of black-grain mycetoma with voriconazole
    Pierre Loulergue
    Centre d Infectiologie Necker Pasteur, et Service de Radiologie, Hopital Necker Enfants Malades, Universite Paris V, Paris, France
    Am J Trop Med Hyg 75:1106-7. 2006
    ..We report a case of black-grain fungal mycetoma successfully treated with voriconazole without side effects. The duration of the treatment remains unclear, but must be prolonged because of the frequency of relapses...
  58. pmc International retrospective analysis of 73 cases of invasive fusariosis treated with voriconazole
    Olivier Lortholary
    Institut Pasteur, National Reference Center for Mycoses and Antifungals, Molecular Mycology Unit, CNRS URA3012, Paris, France
    Antimicrob Agents Chemother 54:4446-50. 2010
    ..02). Median survival (in days) by species was as follows: F. solani, 213; F. oxysporum, 112; Fusarium spp., 101; F. proliferatum, 84; F. moniliforme, 76. We conclude that voriconazole is a therapeutic option for invasive fusariosis...
  59. doi request reprint Systemic antifungal therapy in critically ill patients without invasive fungal infection*
    Elie Azoulay
    Paris 7 University, EA, Saint Louis Hospital, Paris, France
    Crit Care Med 40:813-22. 2012
    ..To determine the number of adult or pediatric intensive care unit patients without documented invasive fungal infection who receive systemic antifungal therapy...
  60. pmc Unmasking leprosy: an unusual immune reconstitution inflammatory syndrome in a patient infected with human immunodeficiency virus
    Guillaume Bussone
    Service de Maladies Infectieuses et Tropicales, et Service de Microbiologie, Centre d Infectiologie Necker Pasteur, Universite Paris Descartes, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, Paris, France
    Am J Trop Med Hyg 83:13-4. 2010
    ..These lesions were associated with microbiologically proven leprosy. Thus, latent leprosy can appear as IRIS, and leprosy-associated IRIS should be considered in HIV-infected patients from areas endemic for leprosy...
  61. doi request reprint Pneumocystis jirovecii Pneumonia
    Emilie Catherinot
    Universite Paris Descartes, Service de Maladies Infectieuses et Tropicales, 149 rue de Sevres, Centre d Infectiologie Necker Pasteur, Hopital Necker Enfants Malades, Paris 75015, France
    Infect Dis Clin North Am 24:107-38. 2010
    ..Pneumocystis pneumonia still remains a severe opportunistic infection, associated with a high mortality rate...
  62. pmc Imported acquired immunodeficiency syndrome-related histoplasmosis in metropolitan France: a comparison of pre-highly active anti-retroviral therapy and highly active anti-retroviral therapy eras
    Vincent Peigne
    Institut Pasteur, Unité de Mycologie Moléculaire, Centre National de Référence Mycologie et Antifongiques, Paris, France
    Am J Trop Med Hyg 85:934-41. 2011
    ..Histoplasmosis is a rare invasive fungal infection outside disease-endemic areas. Its prognosis improved significantly during the HAART era...
  63. doi request reprint Residual HIV-1 RNA and HIV-1 DNA production in the genital tract reservoir of women treated with HAART: the prospective ANRS EP24 GYNODYN study
    Odile Launay
    Faculté de Médecine Paris Descartes, Universite Paris Descartes, Paris, France
    Antivir Ther 16:843-52. 2011
    ..The objective of this study was to prospectively assess residual HIV-1 RNA and HIV-1 DNA production in the genital tract reservoir of women initiating HAART over an 18-month period...
  64. doi request reprint Cutaneous findings in sporadic and familial autosomal dominant hyper-IgE syndrome: a retrospective, single-center study of 21 patients diagnosed using molecular analysis
    Amani Olaiwan
    Department of Dermatology, Necker Enfants Malades Hospital, Assistance Publique Hopitaux de Paris AP HP, Paris, France
    J Am Acad Dermatol 65:1167-72. 2011
    ..Recent identification of STAT3 mutations in autosomal dominant (AD) hyper-IgE syndrome (HIES) has improved the clinical, genetic, and molecular classification of the HIES...
  65. doi request reprint Impact of norovirus/sapovirus-related diarrhea in renal transplant recipients hospitalized for diarrhea
    Damien Roos-Weil
    Service des Maladies Infectieuses et Tropicales, Hopital Necker Enfants Malades, AP HP, Centre d Infectiologie Necker Pasteur, Paris, France
    Transplantation 92:61-9. 2011
    ..Norovirus (NoV) and sapovirus (SaV) have been sporadically reported to cause chronic diarrhea in immunocompromised patients...
  66. ncbi request reprint Contribution of molecular tools for the diagnosis of endogenous pneumococcal endophthalmitis in a patient with the acquired immunodeficiency syndrome
    Marie Olivia Chandesris
    Departments of Infectious Diseases and Tropical Medicine, Necker Enfants Malades Hospital, Paris, France
    Scand J Infect Dis 39:1080-1. 2007
    ..Here we report the first case of Streptococcus pneumoniae endophthalmitis diagnosed by polymerase chain reaction. Molecular biology should be considered as a new tool for the diagnosis of such sequestered sites as the eye...
  67. doi request reprint Listeria monocytogenes-associated joint and bone infections: a study of 43 consecutive cases
    Caroline Charlier
    Institut Pasteur, French National Reference Center and WHO Collaborating Center for Listeria, Microbes and Host Barriers Group, Universite Paris Descartes, Centre d Infectiologie Necker Pasteur, Hopital Necker Enfants Malades, Paris, France
    Clin Infect Dis 54:240-8. 2012
    ..Little is known about Listeria monocytogenes-associated bone and joint infections. Only case reports of this infection have been published...
  68. doi request reprint Gastrointestinal involvement and manifestations in systemic mastocytosis
    Harry Sokol
    Department of Gastroenterology and Nutrition, Saint Antoine Hospital, Universite Paris VI, Faculte de Medecine, Assistance Publique Hopitaux de Paris, Paris, France
    Inflamm Bowel Dis 16:1247-53. 2010
    ..Diagnosis of mastocytosis GI manifestations should be evoked in the case of unexplained severe GI disorders...
  69. doi request reprint Cervical schistosomiasis as a risk factor of cervical uterine dysplasia in a traveler
    Arnaud Dzeing-Ella
    Faculte de Medecine, Paris Descartes, Centre d Infectiologie Necker Pasteur, Hopital Necker Enfants Malades, Service des Maladies Infectieuses et Tropicales, Paris Cedex, France
    Am J Trop Med Hyg 81:549-50. 2009
    ..FGS should be kept in mind as a possible cause of cervical dysplasia in endemic areas. Medical treatment with praziquantel improves this condition...
  70. pmc Treatment of candidemia and invasive candidiasis in the intensive care unit: post hoc analysis of a randomized, controlled trial comparing micafungin and liposomal amphotericin B
    Bertrand F Dupont
    Universite Paris Descartes, Hopital Necker Enfants Malades, Centre d Infectiologie Necker Pasteur, 149 rue de Sevres, 75015 Paris, France
    Crit Care 13:R159. 2009
    ..Invasive candidiasis and candidemia are life-threatening nosocomial infections in intensive care patients...
  71. doi request reprint Fournier's gangrene due to Candida glabrata
    Pierre Loulergue
    Service des Maladies Infectieuses et Tropicales, Faculte de Medecine, Hopital Necker Enfants Malades, Universite Paris Descartes, Paris, France
    Med Mycol 46:171-3. 2008
    ..albicans Candida sp. Fournier's gangrene who survived with an appropriate antifungal therapy. Yeasts should be considered as emerging pathogens in pelvic infections due to the increase in long-term immunocompromised patients...
  72. doi request reprint Presentation of HIV-associated nephropathy and outcome in HAART-treated patients
    Naïke Bigé
    Department of Nephrology, Necker Enfants Malades Hospital, Assistance Publique Hopitaux de Paris, Paris Descartes University, Paris, France
    Nephrol Dial Transplant 27:1114-21. 2012
    ..The purpose of our study was to describe the presentation and outcome of HIVAN in the era of highly active antiretroviral therapy (HAART)...
  73. pmc Depression in patients with mastocytosis: prevalence, features and effects of masitinib therapy
    Daniela Silva Moura
    Universite Paris Descartes, Sorbonne, Paris Cité, Service d Hematologie, centre de référence des mastocytoses, Hopital Necker Enfants Malades, Paris, France
    PLoS ONE 6:e26375. 2011
    ..We conclude that depression in mastocytosis may originate from processes related to mast cells activation. Masitinib could therefore be a useful treatment for mastocytosis patients with depression and anxiety symptoms...
  74. doi request reprint [Positive interaction between immunosuppressive and antifungal drugs]
    Blandine Rammaert
    Institut Pasteur du Cambodge, unité d épidémiologie et de santé publique, BP 983, Phnom Penh, Royaume du Cambodge, Paris, France
    Med Sci (Paris) 26:747-52. 2010
    ..These results are confirmed by clinical findings and thus offer further therapeutic possibilities in the context of solid organ transplantation. double dagger...
  75. pmc Human listeriosis caused by Listeria ivanovii
    Christelle Guillet
    Universite Paris Descartes, Paris, France
    Emerg Infect Dis 16:136-8. 2010
    ..We report L. ivanovii-associated gastroenteritis and bacteremia in a man. This isolate was indistinguishable from prototypic ruminant strains. L. ivanovii is thus an enteric opportunistic human pathogen...
  76. ncbi request reprint [Listeriosis, a rare but severe foodborne infection]
    Caroline Charlier-Woerther
    Universite Paris Descartes, Service de Maladies Infectieuses et Tropicales, Centre d Infectiologie Necker Pasteur, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, 75015 Paris, France
    Rev Prat 59:905-11. 2009
    ..Diagnosis is based on the isolation of L. monocytogenes from blood and cerebrospinal fluid cultures. Treatment relies on the synergic combination amoxicillin and gentamicin, with a mortality rate up to 30% despite adequate therapy...
  77. ncbi request reprint Addressing the challenge of extended-spectrum beta-lactamases
    Jean Ralph Zahar
    Universite Rene Descartes, Hygiene Hospitaliere, Centre d Infectiologie Necker Pasteur, CHU Necker Enfants Malades, Paris, France
    Curr Opin Investig Drugs 10:172-80. 2009
    ..Carbapenems should be considered as the drug of choice for treating serious systemic infections caused by ESBL-producing bacteria, but preventing the spread of and appropriately managing these infections remains difficult...
  78. doi request reprint Sexually transmitted hepatitis C virus superinfection in HIV/hepatitis C virus co-infected men who have sex with men
    Jade Ghosn
    AP HP, EA MRT 3620, Universite Paris Descartes, Department of Virology, Necker Hospital, Paris, France
    AIDS 22:658-61. 2008
    ..HCV serology and serum HCV RNA should be examined periodically in HIV-infected men who have sex with men engaging in high-risk sexual behaviours...
  79. doi request reprint Immunological efficacy of a three-dose schedule of hepatitis A vaccine in HIV-infected adults: HEPAVAC study
    Odile Launay
    Universite Paris Descartes, Faculte de Medecine, Paris, France
    J Acquir Immune Defic Syndr 49:272-5. 2008
    ..The immunogenicity of vaccines, including vaccine against hepatitis A virus (HAV), is impaired in patients with HIV infection, requiring revised immunization regimens...
  80. ncbi request reprint Emerging invasive fungal diseases in transplantation
    Perrine Parize
    Universite Paris Descartes, Sorbonne Paris Cité, Hopital Necker Enfants Malades, Service des Maladies Infectieuses et Tropicales, APHP, Centre d Infectiologie Necker Pasteur, Institut Hospitalo Universitaire Imagine, 149, rue de Sevres, 75743, Paris Cedex 15, France
    Curr Infect Dis Rep 14:668-75. 2012
    ..The current literature was reviewed to synthesize new trends in epidemiology, recent outbreaks, clinical findings, and advances in diagnostic and therapeutic resources...