Thierry Lorca

Summary

Country: France

Publications

  1. doi request reprint The Greatwall kinase: a new pathway in the control of the cell cycle
    T Lorca
    Centre de Recherche de Biochimie Macromoleculaire, CNRS UMR 5237, Universités Montpellier 2 et 1, Montpellier, France
    Oncogene 32:537-43. 2013
  2. doi request reprint Constant regulation of both the MPF amplification loop and the Greatwall-PP2A pathway is required for metaphase II arrest and correct entry into the first embryonic cell cycle
    Thierry Lorca
    Universités Montpellier 2 et 1, Centre de Recherche de Biochimie Macromoleculaire, CNRS UMR 5237, IFR 122, 1919 Route de Mende, 34293 Montpellier Cedex 5, France
    J Cell Sci 123:2281-91. 2010
  3. doi request reprint The substrate of Greatwall kinase, Arpp19, controls mitosis by inhibiting protein phosphatase 2A
    Aicha Gharbi-Ayachi
    Universités Montpellier 2 et 1, Centre de Recherche de Biochimie Macromoleculaire, CNRS UMR 5237, IFR 122, 1919 Route de Mende, 34293 Montpellier Cedex 5, France
    Science 330:1673-7. 2010
  4. pmc Xkid is degraded in a D-box, KEN-box, and A-box-independent pathway
    Anna Castro
    Centre de Recherche de Biochimie Macromoleculaire, CNRS UPR 1086, 34293 Montpellier Cedex 5, France
    Mol Cell Biol 23:4126-38. 2003
  5. pmc Greatwall maintains mitosis through regulation of PP2A
    Suzanne Vigneron
    Centre de Recherche de Biochimie Macromoleculaire, CNRS UMR 5237, IFR 122, Labellisée Ligue Nationale Contre le Cancer, Universités Montpellier 2 et 1, Montpellier, France
    EMBO J 28:2786-93. 2009
  6. pmc Pin1 stabilizes Emi1 during G2 phase by preventing its association with SCF(betatrcp)
    Cyril Bernis
    Centre de Recherche de Biochimie Macromoleculaire, CNRS FRE 2593, 1919 Route de Mende, 34293 Montpellier Cedex 5, France
    EMBO Rep 8:91-8. 2007
  7. pmc Loss of human Greatwall results in G2 arrest and multiple mitotic defects due to deregulation of the cyclin B-Cdc2/PP2A balance
    Andrew Burgess
    Universités Montpellier 2 et 1, Centre de Recherche de Biochimie Macromoleculaire, Centre National de la Recherche Scientifique UMR 5237, 34293 Montpellier Cedex 5, France
    Proc Natl Acad Sci U S A 107:12564-9. 2010
  8. pmc Kinetochore localization of spindle checkpoint proteins: who controls whom?
    Suzanne Vigneron
    Centre de Recherche de Biochimie Macromoleculaire, Centre National de la Recherche Scientifique Formation de Recherche en Evolution 2593, 34293 Montpellier Cedex 5, France
    Mol Biol Cell 15:4584-96. 2004
  9. pmc Characterization of the mechanisms controlling Greatwall activity
    Suzanne Vigneron
    Universités Montpellier 2 et 1, Centre de Recherche de Biochimie Macromoleculaire, CNRS UMR 5237, IFR 122, 1919 Route de Mende, 34293 Montpellier Cedex 5, France
    Mol Cell Biol 31:2262-75. 2011
  10. pmc The D-Box-activating domain (DAD) is a new proteolysis signal that stimulates the silent D-Box sequence of Aurora-A
    Anna Castro
    Centre de Recherche de Biochimie Macromoleculaire, CNRS UPR 1086, 1919 Route de Mende, 34293 Montpellier Cedex 5, France
    EMBO Rep 3:1209-14. 2002

Collaborators

Detail Information

Publications22

  1. doi request reprint The Greatwall kinase: a new pathway in the control of the cell cycle
    T Lorca
    Centre de Recherche de Biochimie Macromoleculaire, CNRS UMR 5237, Universités Montpellier 2 et 1, Montpellier, France
    Oncogene 32:537-43. 2013
    ..These new findings support the view that Gwl, Arpp19 and ENSA could function as the core of a new signalization pathway that, by targeting different final substrates, could participate in a variety of physiological functions...
  2. doi request reprint Constant regulation of both the MPF amplification loop and the Greatwall-PP2A pathway is required for metaphase II arrest and correct entry into the first embryonic cell cycle
    Thierry Lorca
    Universités Montpellier 2 et 1, Centre de Recherche de Biochimie Macromoleculaire, CNRS UMR 5237, IFR 122, 1919 Route de Mende, 34293 Montpellier Cedex 5, France
    J Cell Sci 123:2281-91. 2010
    ....
  3. doi request reprint The substrate of Greatwall kinase, Arpp19, controls mitosis by inhibiting protein phosphatase 2A
    Aicha Gharbi-Ayachi
    Universités Montpellier 2 et 1, Centre de Recherche de Biochimie Macromoleculaire, CNRS UMR 5237, IFR 122, 1919 Route de Mende, 34293 Montpellier Cedex 5, France
    Science 330:1673-7. 2010
    ..Although both proteins can inhibit PP2A, endogenous Arpp19, but not α-Endosulfine, is responsible for PP2A inhibition at mitotic entry in Xenopus egg extracts...
  4. pmc Xkid is degraded in a D-box, KEN-box, and A-box-independent pathway
    Anna Castro
    Centre de Recherche de Biochimie Macromoleculaire, CNRS UPR 1086, 34293 Montpellier Cedex 5, France
    Mol Cell Biol 23:4126-38. 2003
    ..Finally, we demonstrate that both a D-box and a GXEN-containing peptides completely block APC-dependent degradation of cyclin B and Xkid, indicating that the GXEN domain might mediate the recognition and association of Xkid with the APC...
  5. pmc Greatwall maintains mitosis through regulation of PP2A
    Suzanne Vigneron
    Centre de Recherche de Biochimie Macromoleculaire, CNRS UMR 5237, IFR 122, Labellisée Ligue Nationale Contre le Cancer, Universités Montpellier 2 et 1, Montpellier, France
    EMBO J 28:2786-93. 2009
    ..These results suggest that mitotic entry and maintenance is not only mediated by the activation of cyclin B-Cdc2 but also by the regulation of PP2A by GW...
  6. pmc Pin1 stabilizes Emi1 during G2 phase by preventing its association with SCF(betatrcp)
    Cyril Bernis
    Centre de Recherche de Biochimie Macromoleculaire, CNRS FRE 2593, 1919 Route de Mende, 34293 Montpellier Cedex 5, France
    EMBO Rep 8:91-8. 2007
    ..We propose that S- and M-phase entries are mediated by the accumulation of cyclin A and cyclin B through a Pin1-dependent stabilization of Emi1 during G2...
  7. pmc Loss of human Greatwall results in G2 arrest and multiple mitotic defects due to deregulation of the cyclin B-Cdc2/PP2A balance
    Andrew Burgess
    Universités Montpellier 2 et 1, Centre de Recherche de Biochimie Macromoleculaire, Centre National de la Recherche Scientifique UMR 5237, 34293 Montpellier Cedex 5, France
    Proc Natl Acad Sci U S A 107:12564-9. 2010
    ..These results suggest that the balance between cyclin B-Cdc2 and PP2A must be tightly regulated for correct mitotic entry and exit and that Gwl is crucial for mediating this regulation in somatic human cells...
  8. pmc Kinetochore localization of spindle checkpoint proteins: who controls whom?
    Suzanne Vigneron
    Centre de Recherche de Biochimie Macromoleculaire, Centre National de la Recherche Scientifique Formation de Recherche en Evolution 2593, 34293 Montpellier Cedex 5, France
    Mol Biol Cell 15:4584-96. 2004
    ..Thus, at the last step of the spindle checkpoint cascade, Mad1/Mad2, Cdc20, and APC are recruited at the kinetochores independently from each other...
  9. pmc Characterization of the mechanisms controlling Greatwall activity
    Suzanne Vigneron
    Universités Montpellier 2 et 1, Centre de Recherche de Biochimie Macromoleculaire, CNRS UMR 5237, IFR 122, 1919 Route de Mende, 34293 Montpellier Cedex 5, France
    Mol Cell Biol 31:2262-75. 2011
    ..In summary, our results identify Gwl as a member of the AGC family of kinases that appears to be regulated by unique mechanisms and that differs from the other members of this family...
  10. pmc The D-Box-activating domain (DAD) is a new proteolysis signal that stimulates the silent D-Box sequence of Aurora-A
    Anna Castro
    Centre de Recherche de Biochimie Macromoleculaire, CNRS UPR 1086, 1919 Route de Mende, 34293 Montpellier Cedex 5, France
    EMBO Rep 3:1209-14. 2002
    ..The first one, which we designated D-Box-activating domain, within the N-terminal domain of Aurora-A confers the functionality to the second, a silent D-Box, present within the C-terminus of the kinase...
  11. pmc Budding yeast greatwall and endosulfines control activity and spatial regulation of PP2A(Cdc55) for timely mitotic progression
    María Angeles Juanes
    Centre de Recherche en Biochimie Macromoleculaire, Montpellier, France
    PLoS Genet 9:e1003575. 2013
    ..However, this conserved module is adapted to account for differences in the regulation of mitotic entry in different organisms. ..
  12. ncbi request reprint The anaphase-promoting complex: a key factor in the regulation of cell cycle
    Anna Castro
    Centre de Recherche de Biochimie Macromoleculaire, CNRS FRE 2593 1919 Route de Mende, 34293 Montpellier Cedex 5, France
    Oncogene 24:314-25. 2005
    ..We pay particular attention to the latest results concerning APC structure, APC regulation and substrate recognition, and we discuss the implication of these findings in the understanding the APC function...
  13. ncbi request reprint MyoD undergoes a distinct G2/M-specific regulation in muscle cells
    Sabrina Batonnet-Pichon
    Laboratoire de Génomique Fonctionnelle et Myogenèse, UMR 866 Différenciation, Cellulaire et Croissance, INRA UM II, Campus INRA ENSA, 2 Place Pierre Viala, 34060, Montpellier, Cedex 1, France
    Exp Cell Res 312:3999-4010. 2006
    ....
  14. ncbi request reprint Involvement of Aurora A kinase during meiosis I-II transition in Xenopus oocytes
    Anna Castro
    Centre de Recherches de Biochimie Macromoleculaire, UPR 1086 CNRS, 1919 Route de Mende, 34293 Montpellier Cedex 5, France
    J Biol Chem 278:2236-41. 2003
    ..Moreover, these oocytes are able to undergo parthenogenetic activation. We conclude that Aurora A and Eg5 are involved in meiosis I to meiosis II transition in Xenopus oocytes...
  15. pmc Bovine papillomavirus replicative helicase E1 is a target of the ubiquitin ligase APC
    Francisca Mechali
    Centre de Recherches de Biochimie Macromoleculaire, CNRS FRE 2593, IFR 122, 34 293 Montpellier Cedex 5, France
    J Virol 78:2615-9. 2004
    ..These findings involve APC as the ubiquitin ligase that controls E1 levels to maintain a constant low copy number of the viral genome during latent infection...
  16. ncbi request reprint [Mitosis under control]
    Anna Castro
    Centre de Recherche de Biochimie Macromoleculaire, CNRS UPR 1086, 1919, route de Mende, 34293 Montpellier, France
    Med Sci (Paris) 19:309-17. 2003
    ..Loss of this checkpoint results in chromosome missegregation in higher eukaryotes and may contribute to the genomic instability observed in most of the tumour cells...
  17. pmc APC/Fizzy-Related targets Aurora-A kinase for proteolysis
    Anna Castro
    Centre de Recherche de Biochimie Macromoleculaire, CNRS UPR 1086, 1919 Route de Mende, F 34293 Montpellier cedex 5, France
    EMBO Rep 3:457-62. 2002
    ..Aurora-A is thus the first protein, at least in our assay system, that undergoes a D-Box-dependent degradation mediated by APC/Fizzy-Related but not by APC/Fizzy...
  18. ncbi request reprint Ubiquitin-mediated protein degradation in Xenopus egg extracts
    Anna Castro
    Centre de Recherche de Biochimie Macromoleculaire, Montpellier, France
    Methods Mol Biol 322:223-34. 2006
    ..Finally, the Notes provide a series of practical details that explain the different problems that can occur and the possible solutions used to overcome them...
  19. pmc Exploring meiotic division in Cargèse. Meeting on meiotic divisions and checkpoints
    Anna Castro
    Centre de Recherche de Biochimie Macromoleculaire, CNRS FRE 2593, 1919 Route de Mende, 34293 Montpellier Cedex 5, France
    EMBO Rep 6:821-5. 2005
  20. pmc Multiple phosphorylation events control mitotic degradation of the muscle transcription factor Myf5
    Christine Doucet
    Centre de Recherches de Biochimie Macromoleculaire, CNRS FRE 2593, Montpellier, France
    BMC Biochem 6:27. 2005
    ..To this aim, we undertook the biochemical analysis of the mechanisms governing Myf5 mitotic degradation, using heterologous systems...
  21. pmc Deciphering the New Role of the Greatwall/PP2A Pathway in Cell Cycle Control
    Thierry Lorca
    Universités Montpellier 2 et 1, Centre de Recherche de Biochimie Macromoleculaire, CNRS UMR, Montpellier, France
    Genes Cancer 3:712-20. 2012
    ..Here we describe the new pathway involved in phosphatase regulation and the questions that this discovery raises concerning the classic view of cell cycle regulation...
  22. doi request reprint CDK-dependent potentiation of MPS1 kinase activity is essential to the mitotic checkpoint
    Violeta Morin
    Universite Montpellier, CRBM, 34293 Montpellier, France
    Curr Biol 22:289-95. 2012
    ....