Gérald M London

Summary

Country: France

Publications

  1. pmc The new kidney disease: improving global outcomes (KDIGO) guidelines - expert clinical focus on bone and vascular calcification
    G London
    Service de Nephrologie, Centre Hospitalier Manhes, Fleury Merogis, France
    Clin Nephrol 74:423-32. 2010
  2. ncbi request reprint Brachial arterial pressure to assess cardiovascular structural damage: an overview and lessons from clinical trials
    Gérald M London
    Department of Nephrology and Hemodialysis, Manhes Hospital, Fleury Merogis, France
    J Nephrol 21:23-31. 2008
  3. ncbi request reprint [Arterial hypertension, chronic renal insufficiency and dialysis]
    G London
    Centre Hospitalier F H MANHES, 8 rue Roger Clavier, 91712 Fleury Merogis, France
    Nephrol Ther 3:S156-61. 2007
  4. doi request reprint Soft bone - hard arteries: a link?
    Gerard M London
    Service de Nephrologie, Centre Hospitalier Manhes, Fleury Merogis, and INSERM U970, Hopital Europeen Georges Pompidou, Paris, France
    Kidney Blood Press Res 34:203-8. 2011
  5. ncbi request reprint Arteriosclerosis, vascular calcifications and cardiovascular disease in uremia
    Gerard M London
    Service d Hemodialyse, Hôpital F H Manhès, 8, rue Roger Clavier, 91712 Fleury Merogis, Cedex, France
    Curr Opin Nephrol Hypertens 14:525-31. 2005
  6. doi request reprint Vascular calcifications, arterial aging and arterial remodeling in ESRD
    Gerard M London
    Service d Hemodialyse, Hôpital F H Manhès, Fleury Merogis, France
    Blood Purif 35:16-21. 2013
  7. doi request reprint Bone-vascular cross-talk
    Gerard M London
    Department of Nephrology, Centre Hospitalier Manhes, Fleury Merogis, and INSERM U970, Hopital Europeen Georges Pompidou, Paris, France
    J Nephrol 25:619-25. 2012
  8. ncbi request reprint Arterial stiffness: pathophysiology and clinical impact
    Gerard M London
    Nephrology Department, Manhes Hospital, Ste Genevieve des Bois, France
    Clin Exp Hypertens 26:689-99. 2004
  9. ncbi request reprint Indapamide SR versus candesartan and amlodipine in hypertension: the X-CELLENT Study
    Gerard London
    Service de Néphrologie et d Hémodialyse, Centre Hospitalier F H MANHES, 8 rue Roger Clavier, Fleury Merogis, Ste Geneviève des Bois 91712, France
    Am J Hypertens 19:113-21. 2006
  10. ncbi request reprint Mineral metabolism and arterial functions in end-stage renal disease: potential role of 25-hydroxyvitamin D deficiency
    Gerard M London
    Hôpital F H Manhès, 8 rue Roger Clavier, 91712 Fleury Mérogis CEDEX, France
    J Am Soc Nephrol 18:613-20. 2007

Detail Information

Publications33

  1. pmc The new kidney disease: improving global outcomes (KDIGO) guidelines - expert clinical focus on bone and vascular calcification
    G London
    Service de Nephrologie, Centre Hospitalier Manhes, Fleury Merogis, France
    Clin Nephrol 74:423-32. 2010
    ..The risks, benefits, and strength of evidence for various treatment options for the abnormalities of CKD-MBD are considered...
  2. ncbi request reprint Brachial arterial pressure to assess cardiovascular structural damage: an overview and lessons from clinical trials
    Gérald M London
    Department of Nephrology and Hemodialysis, Manhes Hospital, Fleury Merogis, France
    J Nephrol 21:23-31. 2008
    ..These studies have focused the attention on the physical properties of large arteries and on the way they influence the level of systolic and pulse pressures along the arterial tree...
  3. ncbi request reprint [Arterial hypertension, chronic renal insufficiency and dialysis]
    G London
    Centre Hospitalier F H MANHES, 8 rue Roger Clavier, 91712 Fleury Merogis, France
    Nephrol Ther 3:S156-61. 2007
    ..Small blood volume increase producing abnormally high pressure while small decrease in blood volume could be associated with deep hypotension...
  4. doi request reprint Soft bone - hard arteries: a link?
    Gerard M London
    Service de Nephrologie, Centre Hospitalier Manhes, Fleury Merogis, and INSERM U970, Hopital Europeen Georges Pompidou, Paris, France
    Kidney Blood Press Res 34:203-8. 2011
    ..This short review aims to illustrate these possible mechanisms...
  5. ncbi request reprint Arteriosclerosis, vascular calcifications and cardiovascular disease in uremia
    Gerard M London
    Service d Hemodialyse, Hôpital F H Manhès, 8, rue Roger Clavier, 91712 Fleury Merogis, Cedex, France
    Curr Opin Nephrol Hypertens 14:525-31. 2005
    ..The mechanisms responsible for arterial calcification include alterations of mineral metabolism and expression of mineral-regulating proteins...
  6. doi request reprint Vascular calcifications, arterial aging and arterial remodeling in ESRD
    Gerard M London
    Service d Hemodialyse, Hôpital F H Manhès, Fleury Merogis, France
    Blood Purif 35:16-21. 2013
    ..Accelerated arterial aging and inadequate outward arterial remodeling are observed in end-stage renal disease (ESRD) patients. Whether these changes could be closely associated with arterial calcifications has never been investigated...
  7. doi request reprint Bone-vascular cross-talk
    Gerard M London
    Department of Nephrology, Centre Hospitalier Manhes, Fleury Merogis, and INSERM U970, Hopital Europeen Georges Pompidou, Paris, France
    J Nephrol 25:619-25. 2012
    ..Inflammation and accumulation of reactive oxygen species are the principal common pathways linking bone and arterial pathologies...
  8. ncbi request reprint Arterial stiffness: pathophysiology and clinical impact
    Gerard M London
    Nephrology Department, Manhes Hospital, Ste Genevieve des Bois, France
    Clin Exp Hypertens 26:689-99. 2004
    ..ACE inhibitors increased AC and reduced WR, and it has been shown that reversibility of aortic stiffening and use of ACE inhbitors had favorable independent effect on survival in hypertensive patients with advanced renal disease...
  9. ncbi request reprint Indapamide SR versus candesartan and amlodipine in hypertension: the X-CELLENT Study
    Gerard London
    Service de Néphrologie et d Hémodialyse, Centre Hospitalier F H MANHES, 8 rue Roger Clavier, Fleury Merogis, Ste Geneviève des Bois 91712, France
    Am J Hypertens 19:113-21. 2006
    ..Effects of different drugs on systolic BP, diastolic BP, and pulse pressure are therefore of interest...
  10. ncbi request reprint Mineral metabolism and arterial functions in end-stage renal disease: potential role of 25-hydroxyvitamin D deficiency
    Gerard M London
    Hôpital F H Manhès, 8 rue Roger Clavier, 91712 Fleury Mérogis CEDEX, France
    J Am Soc Nephrol 18:613-20. 2007
    ..These results suggest that nutritional vitamin D deficiency and low 1,25(OH)(2)D(3) could be associated with arteriosclerosis and endothelial dysfunction in patients who have ESRD and are on hemodialysis...
  11. ncbi request reprint [Arteriosclerosis and arterial calcifications in chronic kidney insufficiency]
    Gerard M London
    Centre Hospitalier F H MANHES, 8, rue Roger Clavier, 91712 Fleury Merogis, France
    Nephrol Ther 1:S351-4. 2005
    ..AC is responsible for stiffening of the arteries with increased left ventricular afterload and abnormal coronary perfusion as the principal clinical consequences...
  12. pmc Association of bone activity, calcium load, aortic stiffness, and calcifications in ESRD
    Gerard M London
    Service de Nephrologie, Centre Hospitalier Manhes, Fleury Merogis, France
    J Am Soc Nephrol 19:1827-35. 2008
    ..Independent of any other factor, including dosage of calcium-containing phosphate binders, adynamic bone was associated with greater aortic stiffening, suggesting cross-talk between the bone and arterial walls...
  13. doi request reprint Arterial functions: how to interpret the complex physiology
    Gerard M London
    INSERM U970, Hopital Europeen Georges Pompidou, Paris, France
    Nephrol Dial Transplant 25:3815-23. 2010
    ....
  14. doi request reprint Arterial calcification: cardiovascular function and clinical outcome
    G M London
    INSERM U970, Paris and Hopital F H Manhès, Fleury Merogis, France
    Nefrologia 31:644-7. 2011
    ..AC is responsible for stiffening of the arteries with increased left ventricular afterload and abnormal coronary perfusion as the principal clinical consequences...
  15. ncbi request reprint Role of arterial wall properties in the pathogenesis of systolic hypertension
    Gerard M London
    Department of Nephrology, Manhes Hospital, Fleury Merogis, France
    Am J Hypertens 18:19S-22S. 2005
    ..Considering the different mechanisms associated with increased SBP, individualized therapeutic approaches will require knowledge of the patient's unique profile of arterial stiffness and wave reflection characteristics...
  16. ncbi request reprint Arterial calcifications and bone histomorphometry in end-stage renal disease
    Gerard M London
    Service d Hemodialyse, Hôpital F H Manhès, Fleury Merogis, France
    J Am Soc Nephrol 15:1943-51. 2004
    ....
  17. ncbi request reprint Arterial wave reflections and survival in end-stage renal failure
    G M London
    Service d Hemodialyse, Hôpital F H Manhès, Fleury Merogis, Ste Genevieve des Bois, France
    Hypertension 38:434-8. 2001
    ..16 to 1.90; P<0.0001) for CV mortality. These results provide the first direct evidence that in ESRF patients increased effect of arterial wave reflections is an independent predictor of all-cause and CV mortality...
  18. ncbi request reprint Alterations of left ventricular hypertrophy in and survival of patients receiving hemodialysis: follow-up of an interventional study
    G M London
    Service d Hemodialyse, Hôpital F H Manhès, Fleury Merogis, France
    J Am Soc Nephrol 12:2759-67. 2001
    ..72 (95% confidence interval, 0.51 to 0.90) for mortality due to CV disease. These results show that a partial LVH regression in patients with ESRD had a favorable and independent effect on patients' all-cause and CV survival...
  19. ncbi request reprint Left ventricular alterations and end-stage renal disease
    Gerard M London
    Centre Hospitalier FH Manhes, Fleury Merogis, France
    Nephrol Dial Transplant 17:29-36. 2002
    ..To improve the clinical outcomes in ESRD, it is essential to prevent LVH and its complications by correcting the factors that contribute to flow and pressure overload, including anaemia...
  20. ncbi request reprint Cardiovascular disease in end-stage renal failure: role of calcium-phosphate disturbances and hyperparathyroidism
    Gerard London
    Department of Nephrology, F H Manhès Hospital, Fleury Merogis, Paris, France
    J Nephrol 15:209-10. 2002
  21. ncbi request reprint Arterial structure and function in end-stage renal disease
    Gerard M London
    Nephrology Department, Manhes Hospital, Fleury Merogis, France
    Nephrol Dial Transplant 17:1713-24. 2002
  22. ncbi request reprint Impairment of arterial function in chronic renal disease: prognostic impact and therapeutic approach
    Gerard M London
    Hopital Manhes, 8 Grande Rue, F 91712 Fleury Mérogis, France
    Nephrol Dial Transplant 17:13-5. 2002
    ..However, response to such treatment may be limited in patients with microinflammation and raised levels of C-reactive protein...
  23. ncbi request reprint Cardiovascular disease in chronic renal failure: pathophysiologic aspects
    Gerard M London
    Department of Nephrology, F H Manhes Hospital Center, Fleury Merogis, France
    Semin Dial 16:85-94. 2003
    ..The present review summarizes the most recent works dealing with the pathophysiology of CVD and some aspects of the therapeutic approach...
  24. ncbi request reprint Cardiovascular calcifications in uremic patients: clinical impact on cardiovascular function
    Gerard M London
    Nephrology Department, Société de Nephrologie, Centre Hospitalier F H Manhès Service d hémodialyse, Fleury Merogis, France
    J Am Soc Nephrol 14:S305-9. 2003
    ..Calcium-free, metal-free phosphate binders such as sevelamer can reduce calcification scores...
  25. ncbi request reprint [Arterial stiffness, wave reflections and myocardial protection: the REASON project]
    Gerard M London
    Centre Hospitalier F H MANHES, Fleury Merogis, France
    Drugs 63:9-17. 2003
    ..3 +/- 15.4 g/m(2)) than atenolol (-5.3 +/- 15.1 g/m(2); p = 0.031). Relative to atenolol, Per/Ind selectively targets SBP and PP, which could be important in reducing cardiovascular risk...
  26. ncbi request reprint Forearm reactive hyperemia and mortality in end-stage renal disease
    Gerard M London
    Service de néphrologie hémodialyse, Hopital Manhes, Fleury Merogis, France
    Kidney Int 65:700-4. 2004
    ....
  27. ncbi request reprint Arterial media calcification in end-stage renal disease: impact on all-cause and cardiovascular mortality
    Gerard M London
    Service d Hemodialyse, Hôpital F H Manhès, Fleury Merogis, France
    Nephrol Dial Transplant 18:1731-40. 2003
    ..The aim of this study was to investigate the prognostic value of AMC in relationship to all-cause or CV mortality for stable haemodialysis (HD) patients...
  28. ncbi request reprint Left ventricular hypertrophy: why does it happen?
    Gerard M London
    Department of Nephrology and Dialysis, Manhes Hospital, Fleury Merogis, France
    Nephrol Dial Transplant 18:viii2-6. 2003
    ..This article examines some of the pathophysiological aspects of LVH in patients with ESRD...
  29. ncbi request reprint Atherosclerosis versus arterial stiffness in advanced renal failure
    A Guerin
    Service de Nephrologie, Centre Hospitalier Manhes, Fleury Merogis, France
    Adv Cardiol 44:187-98. 2007
    ..Vascular endothelium, recognized as a large and complex endocrine organ strategically located between the wall of the blood vessel and the blood stream, could be the link between these two processes evolving during the same course...
  30. ncbi request reprint Pathophysiology of cardiovascular damage in the early renal population
    G London
    Centre Hospitalier FH Manhes, Fleur-Merogis, France
    Nephrol Dial Transplant 16:3-6. 2001
    ..In conclusion, anaemia is a contributory factor to LVH in renal disease and cardiovascular damage starts at an early stage. Therefore, early intervention to treat anaemia in these patients can prevent or delay this damage...
  31. doi request reprint Amlodipine-valsartan combination decreases central systolic blood pressure more effectively than the amlodipine-atenolol combination: the EXPLOR study
    Pierre Boutouyrie
    Department of Pharmacology, INSERM U970, Hopital Europeen Georges Pompidou, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, Paris, France
    Hypertension 55:1314-22. 2010
    ..The amlodipine-valsartan combination decreased central (systolic and pulse) pressure and AIx more than the amlodipine-atenolol combination...
  32. pmc Flow-mediated vasodilation in end-stage renal disease
    Francis H Verbeke
    Hôpital F H Manhès, 8 rue Roger Clavier, 91712 Fleury Mérogis CEDEX, France
    Clin J Am Soc Nephrol 6:2009-15. 2011
    ..Endothelial dysfunction occurs in hypertension, cardiac insufficiency, diabetes, atherosclerosis, and in end-stage renal disease (ESRD) patients, whose renal failure is associated with many of those cardiovascular diseases (CVD)...
  33. ncbi request reprint [Combination of low-dose perindopril/indapamide versus atenolol in the hypertensive patient. Effects on systolic pressure and arterial hemodynamics. REASON Study]
    B Pannier
    Service de Medecine, Hopital Manhes, 8 Grande Rue, 91712 Fleury Mérogis CEDEX, France
    Arch Mal Coeur Vaiss 95:11-6. 2002
    ..Changes in arterial mechanics, non invasively measured, were the same (pulse wave velocity) or in favour of Per/Ind vs atenolol (higher reduction in aortic wave reflection, with higher reductions in central systolic and pulse pressures)...