Chantal Loirat

Summary

Country: France

Publications

  1. doi request reprint Thrombotic thrombocytopenic purpura in children
    Chantal Loirat
    Assistance Publique Hopitaux de Paris, Hopital Robert Debre, Service de Nephrologie, Universite Paris VII, Paris, France
    Curr Opin Pediatr 25:216-24. 2013
  2. ncbi request reprint [Hemolytic uremic syndrome caused by Shiga-toxin-producing Escherichia coli]
    Chantal Loirat
    Service de Nephrologie, AP HP, Hopital Robert Debre, 75019 Paris, France
    Rev Prat 63:11-6. 2013
  3. doi request reprint Management of hemolytic uremic syndrome
    Chantal Loirat
    Assistance Publique Hopitaux de Paris, Hopital Robert Debre, Nephrology Department, 75019 Paris, France
    Presse Med 41:e115-35. 2012
  4. doi request reprint Hemolytic uremic syndrome recurrence after renal transplantation
    Chantal Loirat
    Assistance Publique, Hopitaux de Paris, Hopital Robert Debre, Universite Paris, Faculté de Médecine Denis Diderot, Service de Nephrologie, Paris, France
    Pediatr Transplant 12:619-29. 2008
  5. doi request reprint Non-atheromatous arterial stenoses in atypical haemolytic uraemic syndrome associated with complement dysregulation
    Chantal Loirat
    Pediatric Nephrology Department, Hopital Robert Debre, Assistance Publique Hopitaux de Paris, Universite Paris 7, Paris, France
    Nephrol Dial Transplant 25:3421-5. 2010
  6. doi request reprint Thrombotic thrombocytopenic purpura related to severe ADAMTS13 deficiency in children
    Chantal Loirat
    Service de Nephrologie, Hopital Robert Debre, Assistance Publique Hopitaux de Paris, Universite Paris VII, 48 Boulevard Serurier, 75019, Paris, France
    Pediatr Nephrol 24:19-29. 2009
  7. doi request reprint Autism in three patients with cystic or hyperechogenic kidneys and chromosome 17q12 deletion
    Chantal Loirat
    Department of Pediatric Nephrology, Assistance Publique Hopitaux de Paris, Hopital Robert Debre, Universite Paris Diderot, Paris, France
    Nephrol Dial Transplant 25:3430-3. 2010
  8. doi request reprint Complement and the atypical hemolytic uremic syndrome in children
    Chantal Loirat
    Hopitaux de Paris, Universite Paris 7, Hopital Robert Debre, Pediatric Nephrology, Paris, France
    Pediatr Nephrol 23:1957-72. 2008
  9. pmc Atypical hemolytic uremic syndrome
    Chantal Loirat
    Assistance Publique Hopitaux de Paris, Hopital Robert Debre, Universite Paris VII, Pediatric Nephrology Department, Paris, France
    Orphanet J Rare Dis 6:60. 2011
  10. ncbi request reprint Thrombotic thrombocytopenic purpura associated with von Willebrand factor-cleaving protease (ADAMTS13) deficiency in children
    Chantal Loirat
    Service de Nephrologie Pediatrique, Hopital Robert Debre, Paris, France
    Semin Thromb Hemost 32:90-7. 2006

Detail Information

Publications73

  1. doi request reprint Thrombotic thrombocytopenic purpura in children
    Chantal Loirat
    Assistance Publique Hopitaux de Paris, Hopital Robert Debre, Service de Nephrologie, Universite Paris VII, Paris, France
    Curr Opin Pediatr 25:216-24. 2013
    ..Rapid techniques for ADAMTS 13 assays, long-term follow-up of patients, phenotype-genotype analysis, improved therapeutic schedules, and new therapies have emerged...
  2. ncbi request reprint [Hemolytic uremic syndrome caused by Shiga-toxin-producing Escherichia coli]
    Chantal Loirat
    Service de Nephrologie, AP HP, Hopital Robert Debre, 75019 Paris, France
    Rev Prat 63:11-6. 2013
    ..This prevents the emergence of new cases by withdrawing the suspected food from the market and diffusing the information to the population (return of suspected food)...
  3. doi request reprint Management of hemolytic uremic syndrome
    Chantal Loirat
    Assistance Publique Hopitaux de Paris, Hopital Robert Debre, Nephrology Department, 75019 Paris, France
    Presse Med 41:e115-35. 2012
    ..Here we review the therapeutic options presently available for the various forms of hemolytic uremic syndrome and show how recent knowledge has changed the therapeutic approach and prognosis of atypical HUS...
  4. doi request reprint Hemolytic uremic syndrome recurrence after renal transplantation
    Chantal Loirat
    Assistance Publique, Hopitaux de Paris, Hopital Robert Debre, Universite Paris, Faculté de Médecine Denis Diderot, Service de Nephrologie, Paris, France
    Pediatr Transplant 12:619-29. 2008
    ..Kidney or kidney + liver transplantation with concomitant plasmatherapy need to be evaluated by prospective trials in patients with hereditary complement abnormalities...
  5. doi request reprint Non-atheromatous arterial stenoses in atypical haemolytic uraemic syndrome associated with complement dysregulation
    Chantal Loirat
    Pediatric Nephrology Department, Hopital Robert Debre, Assistance Publique Hopitaux de Paris, Universite Paris 7, Paris, France
    Nephrol Dial Transplant 25:3421-5. 2010
    ..A child, who presented atypical haemolytic uraemic syndrome (aHUS) at the age of 1 month, developed cerebral ischaemic events at the age of 10 years...
  6. doi request reprint Thrombotic thrombocytopenic purpura related to severe ADAMTS13 deficiency in children
    Chantal Loirat
    Service de Nephrologie, Hopital Robert Debre, Assistance Publique Hopitaux de Paris, Universite Paris VII, 48 Boulevard Serurier, 75019, Paris, France
    Pediatr Nephrol 24:19-29. 2009
    ..Therapeutic perspectives are focused on the development of concentrated plasma-derived ADAMTS13 or recombinant ADAMTS13...
  7. doi request reprint Autism in three patients with cystic or hyperechogenic kidneys and chromosome 17q12 deletion
    Chantal Loirat
    Department of Pediatric Nephrology, Assistance Publique Hopitaux de Paris, Hopital Robert Debre, Universite Paris Diderot, Paris, France
    Nephrol Dial Transplant 25:3430-3. 2010
    ..We report autism in 3 out of 53 children with cystic or hyperechogenic kidneys and heterozygous 17q12 region deletion encompassing hepatocyte nuclear factor-1beta (HNF1B)...
  8. doi request reprint Complement and the atypical hemolytic uremic syndrome in children
    Chantal Loirat
    Hopitaux de Paris, Universite Paris 7, Hopital Robert Debre, Pediatric Nephrology, Paris, France
    Pediatr Nephrol 23:1957-72. 2008
    ..New therapies such as factor H concentrate or complement inhibitors offer hope for the future...
  9. pmc Atypical hemolytic uremic syndrome
    Chantal Loirat
    Assistance Publique Hopitaux de Paris, Hopital Robert Debre, Universite Paris VII, Pediatric Nephrology Department, Paris, France
    Orphanet J Rare Dis 6:60. 2011
    ..Half of factor I-HUS progress to end-stage renal failure. Conversely, most patients with MCP-HUS have preserved renal function. Anti-factor H antibodies-HUS has favourable outcome if treated early...
  10. ncbi request reprint Thrombotic thrombocytopenic purpura associated with von Willebrand factor-cleaving protease (ADAMTS13) deficiency in children
    Chantal Loirat
    Service de Nephrologie Pediatrique, Hopital Robert Debre, Paris, France
    Semin Thromb Hemost 32:90-7. 2006
    ..FFP infusions are best used preventively, given that rescue infusions may not prevent central nervous system and renal involvement. It is hoped that plasmatic or recombinant purified ADAMTS13 will be available in the years to come...
  11. doi request reprint Plasmatherapy in atypical hemolytic uremic syndrome
    Chantal Loirat
    Assistance Publique Hopitaux de Paris, Pediatric Nephrology Department, Universite Paris Diderot, Hopital Robert Debre, Paris, France
    Semin Thromb Hemost 36:673-81. 2010
    ..We hope complement blockers will offer patients a better chance to avoid ESRD and provide a better quality of life...
  12. doi request reprint Successful pre-transplant management of a patient with anti-factor H autoantibodies-associated haemolytic uraemic syndrome
    Theresa Kwon
    Pediatric Nephrology, Hopital Robert Debre, Paris, France
    Nephrol Dial Transplant 23:2088-90. 2008
  13. doi request reprint Mycophenolate mofetil for steroid-dependent nephrotic syndrome: a phase II Bayesian trial
    Veronique Baudouin
    Assistance Publique Hopitaux de Paris, Hopital Robert Debre, Pediatric Nephrology Department, Universite Paris 7, 48 Boulevard Serurier, 75019, Paris, France
    Pediatr Nephrol 27:389-96. 2012
    ..MMF reduces relapse rate and steroid dose in children with SDNS and should be proposed before cyclosporine and cyclophosphamide...
  14. pmc Clinical features of anti-factor H autoantibody-associated hemolytic uremic syndrome
    Marie Agnès Dragon-Durey
    Service d Immunologie Biologique, Hopital Europeen Georges Pompidou, Assistance Publique Hopitaux de Paris, Paris, France
    J Am Soc Nephrol 21:2180-7. 2010
    ..Early specific treatment may lead to favorable outcomes. These data should improve the recognition and diagnosis of this form of aHUS and help identify patients at high risk of a poor outcome...
  15. doi request reprint Membranoproliferative glomerulonephritis with C3NeF and genetic complement dysregulation
    Valerie Leroy
    Pediatric Nephrology Department, Universite Paris 7, Hopital Robert Debre, Paris, France
    Pediatr Nephrol 26:419-24. 2011
    ..These observations highlight the possible combination of genetic and acquired defect in complement control in various subtypes of MPGN, a finding that may influence the treatment strategy in some patients...
  16. pmc Genotype-phenotype correlations in non-Finnish congenital nephrotic syndrome
    Eduardo Machuca
    INSERM, U983, Hopital Necker Enfants Malades, Paris, France
    J Am Soc Nephrol 21:1209-17. 2010
    ..In summary, these data demonstrate that CNS is not a distinct clinical entity in non-Finnish populations but rather a clinically and genetically heterogeneous group of disorders...
  17. ncbi request reprint Differential impact of complement mutations on clinical characteristics in atypical hemolytic uremic syndrome
    Anne Laure Sellier-Leclerc
    Service de Nephrologie, Assistance Publique Hopitaux de Paris, Hopital Robert Debre, 48 Boulevard Serurier, 75 019 Paris, France
    J Am Soc Nephrol 18:2392-400. 2007
    ..New therapies are urgently needed, and further research should elucidate the unexplained HUS group...
  18. doi request reprint Growth in boys with idiopathic nephrotic syndrome on long-term cyclosporin and steroid treatment
    Valerie Leroy
    Assistance Publique Hopitaux de Paris, Hopital Robert Debre, Service de Nephrologie Pediatrique, Paris, France
    Pediatr Nephrol 24:2393-400. 2009
    ..Careful monitoring of growth is recommended, given than up to 25% of patients experienced severe growth retardation during the course of their disease...
  19. doi request reprint Cyclophosphamide in steroid-dependent nephrotic syndrome
    Sonia Azib
    Pediatric Nephrology Department, Assistance Publique Hopitaux de Paris, Universite Paris 7, Hopital Robert Debre, Paris, France
    Pediatr Nephrol 26:927-32. 2011
    ..These findings suggest that despite the wide use of new immunosuppressive agents, a short course of CPO remains an effective second-line therapy in SDNS patients. Optimal efficiency was observed in children over 7.5 years...
  20. doi request reprint Mutational analysis of the PLCE1 gene in steroid resistant nephrotic syndrome
    Olivia Boyer
    INSERM U983, Hopital Necker Enfants Malades, 149 rue de Sevres, Paris, France
    J Med Genet 47:445-52. 2010
    ..In addition, two cases of PLCE1 mutations associated with focal segmental glomerulosclerosis (FSGS) and later NS onset have been reported...
  21. doi request reprint Enteric-coated mycophenolate sodium in de novo pediatric renal transplant patients
    Patrick Niaudet
    Pediatric Nephrology, Necker Hospital, 161 rue de Sevres, 75743, Paris, Cedex, France
    Pediatr Nephrol 24:395-402. 2009
    ..However, a larger, controlled trial is required to confirm these results...
  22. doi request reprint Varicella as a trigger of atypical haemolytic uraemic syndrome associated with complement dysfunction: two cases
    Theresa Kwon
    Pediatric Nephrology Department, Hopital Robert Debre, Universite Paris, France
    Nephrol Dial Transplant 24:2752-4. 2009
    ..These observations show that infectious agents such as varicella-zoster virus may be the trigger of haemolytic uraemic syndrome in patients with complement dysregulation...
  23. doi request reprint Rituximab efficiency in children with steroid-dependent nephrotic syndrome
    Anne Laure Sellier-Leclerc
    Pediatric Nephrology Department, Hopital Robert Debre, APHP, Universite Paris VII, 48 Boulevard Serurier, 75019, Paris, France
    Pediatr Nephrol 25:1109-15. 2010
    ..Toxicity of rituximab was limited to reversible cytokine shock in 2 patients and reversible neutropenia in 1 patient. No severe infection was observed...
  24. ncbi request reprint [Hereditary hemolytic uremic syndromes and thrombotic thrombocytopenic purpura]
    Chantal Loirat
    Service de Nephrologie, Hopital Robert Debre, 48 Boulevard Serrurier, 75019 Paris, Assistance Publique Hopitaux de Paris, Paris, France
    Nephrol Ther 2:S149-61. 2006
    ....
  25. ncbi request reprint Recurrence of nephrotic syndrome after renal transplantation: influence of increased immunosuppression
    Sylvie Nathanson
    Pediatric Nephrology Unit, Hopital Armand Trousseau, Paris, France
    Pediatr Nephrol 20:1801-4. 2005
    ....
  26. pmc Population pharmacokinetics and Bayesian estimator of mycophenolic acid in children with idiopathic nephrotic syndrome
    Wei Zhao
    Department of Paediatric Pharmacology and Pharmacogenetics, Clinical Investigation Centre INSERM, Hopital Robert Debre, Paris, France
    Br J Clin Pharmacol 69:358-66. 2010
    ....
  27. ncbi request reprint Acute renal failure in a 3-year-old child as part of the drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome following hepatitis A
    Arnaud Garnier
    Pediatric Nephrology Unit, Assistance Publique Hopitaux de Paris, Hopital Robert Debre, Paris, France
    Pediatr Nephrol 23:667-9. 2008
    ..The final diagnosis was of the syndrome drug reaction with eosinophilia and systemic symptoms or DRESS, induced by cefixime or cotrimoxazole and possibly triggered by the hepatitis A virus infection...
  28. ncbi request reprint Heterozygous and homozygous factor h deficiencies associated with hemolytic uremic syndrome or membranoproliferative glomerulonephritis: report and genetic analysis of 16 cases
    Marie Agnès Dragon-Durey
    INSERM U430, Institut des Cordeliers, Paris, France
    J Am Soc Nephrol 15:787-95. 2004
    ..This report emphasizes the variability in the clinical progression of kidney diseases associated with FH deficiencies. Genetic analysis reveals the molecular abnormalities associated with FH deficiencies to be polymorphous...
  29. doi request reprint Effect of hydrochlorothiazide on urinary calcium excretion in dent disease: an uncontrolled trial
    Anne Blanchard
    Universite Paris 5, Faculté de Médecine Paris Descartes, Paris, France
    Am J Kidney Dis 52:1084-95. 2008
    ..However, they can cause adverse metabolic effects in the long term. In treating hypertension in children, lower thiazide doses have been shown to be as effective and well tolerated...
  30. doi request reprint Hyperfunctional C3 convertase leads to complement deposition on endothelial cells and contributes to atypical hemolytic uremic syndrome
    Lubka T Roumenina
    Cordeliers Research Center, INSERM, Unite Mixte de Recherche en Santé UMRS 872, Paris, France
    Blood 114:2837-45. 2009
    ..Therefore, risk factors for aHUS are not only mutations leading to loss of regulation, but also mutations, resulting in hyperactive C3 convertase...
  31. doi request reprint Mutations in components of complement influence the outcome of Factor I-associated atypical hemolytic uremic syndrome
    Frank Bienaime
    Cordeliers Research Center, INSERM UMRS 872, Paris, France
    Kidney Int 77:339-49. 2010
    ..Our results emphasize the necessity of genetic screening for all susceptibility factors in patients with aHUS...
  32. ncbi request reprint Severe deficiency of the specific von Willebrand factor-cleaving protease (ADAMTS 13) activity in a subgroup of children with atypical hemolytic uremic syndrome
    Agnes Veyradier
    INSERM Unité 143, Le Kremlin Bicetre, Service de Nephrologie, Hopital Robert Debre, Tours, France
    J Pediatr 142:310-7. 2003
    ..Study design We measured VWF-cp activity in the plasma of 64 children with either (d+) HUS (n = 41) or (d-) HUS (n = 23)...
  33. ncbi request reprint The risk of recurrence of hemolytic uremic syndrome after renal transplantation in children
    Chantal Loirat
    Service de Nephrologie, Hopital Robert Debre, 48 Boulevard Serurier, 75019 Paris, France
    Pediatr Nephrol 18:1095-101. 2003
    ....
  34. ncbi request reprint Relationship between CD8+ T-cell phenotype and function, Epstein-Barr virus load, and clinical outcome in pediatric renal transplant recipients: a prospective study
    Veronique Baudouin
    Department of Nephrology, Hopital Robert Debre, Assistance Publique Hopitaux de Paris, Université Denis Diderot Paris VII, Paris, France
    Transplantation 77:1706-13. 2004
    ..The authors studied the relationship between the dynamics of Epstein-Barr virus (EBV) load, CD8 T-cell activation and differentiation, and EBV-associated symptoms in 25 children after kidney transplantation (Tx)...
  35. pmc Nephrin mutations can cause childhood-onset steroid-resistant nephrotic syndrome
    Aurélie Philippe
    Inserm U574, Hopital Necker Enfants Malades, Paris, France
    J Am Soc Nephrol 19:1871-8. 2008
    ..The presence of at least one "mild" mutation in these patients likely explains the later onset and milder course of disease. These results broaden the spectrum of renal disease related to nephrin mutations...
  36. pmc Mutations in complement C3 predispose to development of atypical hemolytic uremic syndrome
    Veronique Fremeaux-Bacchi
    Service d Immunologie Biologique, Hopital Europeen Georges Pompidou, Paris, France
    Blood 112:4948-52. 2008
    ..We have demonstrated that 5 of these mutations are gain-of-function and 2 are inactivating. This establishes C3 as a susceptibility factor for aHUS...
  37. doi request reprint Kidney and liver transplantation in patients with autosomal recessive polycystic kidney disease: a multicentric study
    Marion Chapal
    Nephrology Department, Institut de Transplantation Urologie et Nephrologie, CHU de Nantes, Nantes, France
    Nephrol Dial Transplant 27:2083-8. 2012
    ..Here, we report the results and outcome of renal and/or liver transplantation in a series of patients with ARPKD...
  38. ncbi request reprint [Hemolytic-uremic syndrome: what is the mechanism?]
    Veronique Fremeaux-Bacchi
    Service d Immunologie Biologique, Hopital Europeen Georges Pompidou, 75908 Paris Cedex 15
    Rev Prat 58:2093-6. 2008
    ..In this context, the introduction of gene study considerably accelerated advances...
  39. doi request reprint New insights into postrenal transplant hemolytic uremic syndrome
    Julien Zuber
    Service de Transplantation Rénale Adulte, Universite Paris Descartes, Hopital Necker, 161 rue de Sevres, Paris F 75015, France
    Nat Rev Nephrol 7:23-35. 2011
    ..This finding suggests that the burden of endothelial injury in a post-transplantation setting may trigger de novo HUS in the presence of mild genetic susceptibility to HUS...
  40. ncbi request reprint Inhibitory ITAM signaling by Fc alpha RI-FcR gamma chain controls multiple activating responses and prevents renal inflammation
    Yutaka Kanamaru
    INSERM Unité 699, Universite Paris 7 Denis Diderot, Faculte de Medecine, Site Xavier Bichat, 16 rue Henri Huchard, Paris, France
    J Immunol 180:2669-78. 2008
    ..They also identify anti-FcalphaRI Fab as a new potential therapeutic tool for preventing progression of renal inflammatory diseases...
  41. ncbi request reprint A humanized mouse model of idiopathic nephrotic syndrome suggests a pathogenic role for immature cells
    Anne Laure Sellier-Leclerc
    INSERM U699, Faculté de Médecine Denis Diderot, Universite Paris 7, France
    J Am Soc Nephrol 18:2732-9. 2007
    ..Therefore, our data suggest that the cells responsible for the pathogenesis of idiopathic nephrotic syndrome are more likely to be immature differentiating cells rather than mature peripheral T cells...
  42. doi request reprint In vivo confocal microscopy and anterior segment optical coherence tomography analysis of the cornea in nephropathic cystinosis
    Antoine Labbe
    Department of Ophthalmology III, Quinze Vingts National Ophthalmology Hospital, 28 rue de Charenton, Paris, France
    Ophthalmology 116:870-6. 2009
    ..To analyze the corneas of patients with nephropathic cystinosis using in vivo confocal microscopy (IVCM) and anterior segment optical coherence tomography (AS-OCT)...
  43. ncbi request reprint Escherichia coli strains causing urinary tract infection in uncircumcised infants resemble urosepsis-like adult strains
    Stephane Bonacorsi
    Laboratoire d études de génétique bactérienne dans les infections de l enfant EA3105, Universite Denis Diderot Paris 7, Paris, France
    J Urol 173:195-7; discussion 197. 2005
    ..In an attempt to unravel further the pathophysiology of UTI in this age group we used molecular methods to characterize Escherichia coli strains responsible for community acquired UTI in male and female infants and in adults...
  44. pmc Predictive features of severe acquired ADAMTS13 deficiency in idiopathic thrombotic microangiopathies: the French TMA reference center experience
    Paul Coppo
    Service d Hématologie et de Thérapie Cellulaire, AP HP, Hopital Saint Antoine, Paris, France
    PLoS ONE 5:e10208. 2010
    ..3%, sensitivity of 98.8%, and specificity of 48.1%. Our criteria should be useful to identify rapidly newly diagnosed patients with an acquired ADAMTS13 deficiency to better tailor treatment for different pathophysiological groups...
  45. ncbi request reprint Sudden blindness caused by anterior ischemic optic neuropathy in 5 children on continuous peritoneal dialysis
    Anne Laure Lapeyraque
    Service de Néphrologie and the Service d Ophtalmologie, Hopital Robert Debre, Assistance Publique Hopitaux de Paris, Paris, France
    Am J Kidney Dis 42:E3-9. 2003
    ..Because the prognosis of ischemic optic neuropathy is very poor, diagnosis and treatment of chronic hypovolemia in children on continuous peritoneal dialysis is essential to prevent such a devastating complication...
  46. ncbi request reprint A pediatric cluster of Shigella dysenteriae serotype 1 diarrhea with hemolytic uremic syndrome in 2 families from France
    Véronique Houdouin
    Services de Microbiologie, Hopital Robert Debre, Paris, France
    Clin Infect Dis 38:e96-9. 2004
    ..On the basis of our findings, the choice of antimicrobial treatment for infections with S. dysenteriae serotype 1 should take into account widespread drug resistance and the risk of HUS...
  47. doi request reprint Adult social and professional outcomes of pediatric renal transplant recipients
    Hélène Mellerio
    1 INSERM, CIE 5, Paris, France 2 Unité d Epidémiologie Clinique, Assistance Publique Hopitaux de Paris, Hopital Robert Debre, Paris, France 3 Université Paris Diderot, Sorbonne Paris Cité, Paris, France 4 Agence de la Biomédecine, Direction médicale et scientifique, Saint Denis La Plaine, France 5 Service de Néphrologie, Assistance Publique Hopitaux de Paris, Hopital Robert Debre, Paris, France 6 Address correspondence to Chantal Loirat, M D, Pediatric Nephrology Department, Hopital Robert Debre, 48 Boulevard Serurier, 75019 Paris, France
    Transplantation 97:196-205. 2014
    ..This nationwide French cohort study documented the socioprofessional outcomes of adults who underwent kidney transplantation before age 16 years between 1985 and 2002...
  48. doi request reprint Targeted strategies in the prevention and management of atypical HUS recurrence after kidney transplantation
    Julien Zuber
    Universite Paris Descartes, Sorbonne Paris Cité, Paris, France Service de Transplantation Rénale adulte, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, France Electronic address
    Transplant Rev (Orlando) 27:117-25. 2013
    ..A global therapeutic approach should thus attempt to reduce exposure to these triggers. ..
  49. ncbi request reprint Anaphylactic shock caused by immunoglobulin E sensitization after retreatment with the chimeric anti-interleukin-2 receptor monoclonal antibody basiliximab
    Veronique Baudouin
    Department of Nephrology, Hopital Robert Debre, Paris, France
    Transplantation 76:459-63. 2003
    ..We therefore searched for the presence of anti-basiliximab immunoglobulin (Ig) E in this patient...
  50. ncbi request reprint Pharmacokinetics of ganciclovir in pediatric renal transplant recipients
    Daolun Zhang
    Department of Pediatric Pharmacology and Pharmacogenetics, Hopital Robert Debre, 48 Boulevard Serurier, 75019 Paris, France
    Pediatr Nephrol 18:943-8. 2003
    ..o. GCV (50 mg/kg per 12 h) were administered and were associated with trough levels over 0.5 microg/ml. In 1 patient who received an erroneously low dosage p.o., CMV resistance to GCV appeared, requiring foscarnet...
  51. doi request reprint Genotype-phenotype correlations in fetuses and neonates with autosomal recessive polycystic kidney disease
    Erick Denamur
    Assistance Publique Hopitaux de Paris, Universite Paris Diderot, Hopital Robert Debre, Laboratoire de Biochimie Genetique, INSERM U722, Paris, France
    Kidney Int 77:350-8. 2010
    ..Their absence, however, does not guarantee survival to the neonatal period...
  52. pmc In vivo expression of putative LMX1B targets in nail-patella syndrome kidneys
    Laurence Heidet
    Inserm U574, Universite Rene Descartes, Hopital Necker Enfants Malades, Paris, France
    Am J Pathol 163:145-55. 2003
    ..These findings indicate that heterozygous mutations of LMX1B do not appear to dramatically affect the expression of type IV collagen chains, podocin, or CD2AP in NPS patients...
  53. doi request reprint Spectrum of mutations in the renin-angiotensin system genes in autosomal recessive renal tubular dysgenesis
    Olivier Gribouval
    INSERM U983, Faculté de Médecine Paris Descartes, Universite Paris Descartes, Paris, France
    Hum Mutat 33:316-26. 2012
    ..The identification of the disease on the basis of precise clinical and histological analyses and the characterization of the genetic defects allow genetic counseling and early prenatal diagnosis...
  54. ncbi request reprint Clinical quiz. Loin pain haematuria syndrome
    Elie Haddad
    Service de Nephrologie, Hopital Robert Debre, Paris, France
    Pediatr Nephrol 17:217-9. 2002
  55. ncbi request reprint Enhanced expression of the CD71 mesangial IgA1 receptor in Berger disease and Henoch-Schönlein nephritis: association between CD71 expression and IgA deposits
    Elie Haddad
    Service de Nephrologie, Service de Sante Publique, EA 3102, Université Paris 7 and Service de Pathologie, Hopital Robert Debre, Assistance Publique Hopitaux de Paris, Paris, France
    J Am Soc Nephrol 14:327-37. 2003
    ..However, the association between IgA deposits and CD71 expression and their co-localization in the mesangium provide strong evidence that CD71 is a major IgA receptor on mesangial cells...
  56. ncbi request reprint WT1 splice site mutation in a 46,XX female with minimal-change nephrotic syndrome and Wilms' tumour
    Chantal Loirat
    Service de Nephrologie, Hopital Robert Debre, Paris, France
    Nephrol Dial Transplant 18:823-5. 2003
  57. ncbi request reprint Anti-Factor H autoantibodies associated with atypical hemolytic uremic syndrome
    Marie Agnès Dragon-Durey
    Service d Immunologie Biologique, Hopital Europeen Georges Pompidou, 20 rue Leblanc, 75015 Paris, France
    J Am Soc Nephrol 16:555-63. 2005
    ..This new mechanism of functional FH deficiency may lead to the design of new approaches of diagnosis and treatment with a particular interest in plasma exchanges or immunosuppressive therapies...
  58. ncbi request reprint Epidemiology, clinical presentation, and pathophysiology of atypical and recurrent hemolytic uremic syndrome
    L Bernd Zimmerhackl
    Department of Pediatrics, Medical University Innsbruck, Innsbruck, Austria
    Semin Thromb Hemost 32:113-20. 2006
    ..Despite continued efforts, transplantation is not recommended at present for these patients. Living-related transplantation should be abandoned. New therapeutic strategies are urgently needed...
  59. ncbi request reprint Renal transplantation in HUS patients with disorders of complement regulation
    Lothar Bernd Zimmerhackl
    Univ Klinik für Kinder und Jugendheikunde, Innsbruck, Austria
    Pediatr Nephrol 22:10-6. 2007
    ..espn.ucwm.ac.uk . On no account should live related donation take place unless the risks of graft loss are understood. International collaboration to identify safer ways of transplanting these challenging patients is urgently needed...
  60. ncbi request reprint A rational dosing algorithm for basiliximab (Simulect) in pediatric renal transplantation based on pharmacokinetic-dynamic evaluations
    John M Kovarik
    Novartis Pharmaceuticals, Basel, Switzerland
    Transplantation 74:966-71. 2002
    ..The pharmacokinetics and immunodynamics of basiliximab were assessed in 39 pediatric de novo kidney allograft recipients to rationally chose a dose regimen for this age group...
  61. doi request reprint Prospective, randomized trial comparing short and long intravenous antibiotic treatment of acute pyelonephritis in children: dimercaptosuccinic acid scintigraphic evaluation at 9 months
    François Bouissou
    Nephrologie Pediatrique, Hopital des Enfants, Université Paul Sabathier, Centre Hospitalier Universitaire Purpan, Toulouse, France
    Pediatrics 121:e553-60. 2008
    ....
  62. ncbi request reprint A multicenter, open-label, pharmacokinetic/pharmacodynamic safety, and tolerability study of basiliximab (Simulect) in pediatric de novo renal transplant recipients
    Gisela Offner
    Kinderklinik der Medizinische Hochschule, Hannover, Germany
    Transplantation 74:961-6. 2002
    ..We report on the safety and preliminary efficacy of basiliximab in pediatric de novo renal transplant recipients...
  63. doi request reprint Multicenter trial of everolimus in pediatric renal transplant recipients: results at three year
    Robert Ettenger
    Department of Pediatrics, Mattel Children s Hospital, University of California Los Angeles, Los Angeles, CA 90095 1752, USA
    Pediatr Transplant 12:456-63. 2008
    ..4 mg/dL). This is the first long-term prospective study to demonstrate that a regimen of everolimus, cyclosporine, and corticosteroids provides good efficacy, tolerability, and safety in de novo pediatric renal transplant patients...
  64. ncbi request reprint Everolimus in pediatric de nova renal transplant patients
    Peter F Hoyer
    Department of Pediatric Nephrology, Universitätsklinik Essen, Hufelandstr 55, D 45122 Essen, Germany
    Transplantation 75:2082-5. 2003
    ..The steady-state pharmacokinetics of everolimus were longitudinally assessed in pediatric de novo kidney allograft recipients during a 6-month period...
  65. ncbi request reprint Glucocorticoid pharmacokinetics and growth retardation in children with renal transplants
    Claire Chavatte
    Service Pharmacie, Hopital Necker Enfants Malades, 149 rue de Sevres, 75015 Paris, France
    Pediatr Nephrol 19:898-904. 2004
    ..We, therefore, do not recommend using glucocorticoid pharmacokinetics to predict growth retardation in children with renal transplantation...
  66. ncbi request reprint Mutant chromatin remodeling protein SMARCAL1 causes Schimke immuno-osseous dysplasia
    Cornelius F Boerkoel
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Nat Genet 30:215-20. 2002
    ..These observations indicate that some missense mutations allow retention of partial SMARCAL1 function and thus cause milder disease...
  67. ncbi request reprint Genetic investigation of autosomal recessive distal renal tubular acidosis: evidence for early sensorineural hearing loss associated with mutations in the ATP6V0A4 gene
    Rosa Vargas-Poussou
    Centre Hospitalier Universitaire de Rouen, Département de Pédiatrie Médicale, and Faculté de Médecine et de Pharmacie, Rouen, France
    J Am Soc Nephrol 17:1437-43. 2006
    ..The data also demonstrate that mutations in either of these genes may cause early deafness, and they highlight the importance of genetic screening for recessive forms of dRTA independent of hearing status...
  68. ncbi request reprint Genetic and functional analyses of membrane cofactor protein (CD46) mutations in atypical hemolytic uremic syndrome
    Veronique Fremeaux-Bacchi
    Assitance Publique Hôpitaux de Paris, Hopital Europeen Georges Pompidou, Service d Immunologie Biologique, Paris Cedex 15, France
    J Am Soc Nephrol 17:2017-25. 2006
    ....
  69. ncbi request reprint [Corticosensitive nephrotic syndrome (or nephrosis) in children. Therapeutic guideline proposed by the Pediatric Society of Nephrology]
    Etienne Berard
    Service de Pediatrie, hôpital de l Archet II, 151 avenue Saint Antoine de Ginestière, BP 3079, 06202 Nice cedex, France
    Nephrol Ther 1:150-6. 2005
  70. ncbi request reprint Schimke immunoosseous dysplasia: suggestions of genetic diversity
    J Marietta Clewing
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA
    Hum Mutat 28:273-83. 2007
    ..This is the first evidence for nonallelic heterogeneity in SIOD. From analysis of the postmortem histopathology from two patients and the clinical data from most patients, we propose the existence of endophenotypes of SIOD...
  71. ncbi request reprint Mutations in PLCE1 are a major cause of isolated diffuse mesangial sclerosis (IDMS)
    Rasheed Gbadegesin
    Departments of Pediatrics and of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA
    Nephrol Dial Transplant 23:1291-7. 2008
    ..Mutations in two other genes WT1 and LAMB2 may also cause IDMS. We therefore determine in this study the relative frequency of mutations in PLCE1, WT1 or LAMB2 as the cause of IDMS in a worldwide cohort...
  72. doi request reprint Surveillance of hemolytic uremic syndrome in children less than 15 years of age, a system to monitor O157 and non-O157 Shiga toxin-producing Escherichia coli infections in France, 1996-2006
    Emmanuelle Espié
    Institut de Veille Sanitaire, Saint Maurice, France
    Pediatr Infect Dis J 27:595-601. 2008
    ....
  73. ncbi request reprint Darbepoetin, effective treatment of anaemia in paediatric patients with chronic renal failure
    Jean Luc André
    Pediatric Nephrology Unit, Hôpital d Enfants, CHU de Nancy, rue du Morvan, 54511, Vandoeuvre les Nancy, France
    Pediatr Nephrol 22:708-14. 2007
    ..92) and 0.34 (95% CI: 0.16, 0.52) microg/kg per week. Our results indicate the doses of DA necessary to treat CRF patients aged 11 years to 18 years. DA was an effective treatment to stabilise CRF patients at extended dosing intervals...