C Loirat

Summary

Country: France

Publications

  1. ncbi Schimke immunoosseous dysplasia: suggestions of genetic diversity
    J Marietta Clewing
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA
    Hum Mutat 28:273-83. 2007
  2. ncbi [Post-diarrhea hemolytic-uremic syndrome: clinical aspects]
    C Loirat
    Service de Nephrologie, Hopital Robert Debre, 48, bd Serurier, 75019 Paris, France
    Arch Pediatr 8:776s-784s. 2001
  3. ncbi [Hereditary hemolytic uremic syndromes and thrombotic thrombocytopenic purpura]
    Chantal Loirat
    Service de Nephrologie, Hopital Robert Debre, 48 Boulevard Serrurier, 75019 Paris, Assistance Publique Hopitaux de Paris, Paris, France
    Nephrol Ther 2:S149-61. 2006
  4. ncbi The risk of recurrence of hemolytic uremic syndrome after renal transplantation in children
    Chantal Loirat
    Service de Nephrologie, Hopital Robert Debre, 48 Boulevard Serurier, 75019 Paris, France
    Pediatr Nephrol 18:1095-101. 2003
  5. ncbi Organ allocation in pediatric transplantation in France
    C Loirat
    Hopital Robert Debre, 48 Bd Serurier, 75019 Paris, France
    Pediatr Nephrol 16:964-70. 2001
  6. ncbi [Chronic renal insufficiency in children]
    C Loirat
    Service de néphrologie Hôpital Robert Debré 75019 Paris
    Rev Prat 51:410-6. 2001
  7. ncbi The high frequency of complement factor H related CFHR1 gene deletion is restricted to specific subgroups of patients with atypical haemolytic uraemic syndrome
    M A Dragon-Durey
    Assistance Publique Hopitaux de Paris, Hopital Europeen Georges Pompidou, Service d Immunologie Biologique, Paris, France
    J Med Genet 46:447-50. 2009
  8. ncbi Post graft development of short children treated with growth hormone before kidney graft
    D Simon
    Pediatric Endocrinology and Diabetology Unit, Robert Debre Hospital, 48 Boulevard Serurier, F 15019 Paris, France
    Pediatr Nephrol 13:723-9. 1999
  9. ncbi Multicenter trial of one HLA-DR-matched or mismatched blood transfusion prior to cadaveric renal transplantation
    C Hiesse
    Service de Nephrologie, Hopital Bicetre, Le Kremlin Bicetre, France
    Kidney Int 60:341-9. 2001
  10. ncbi The development of atypical haemolytic-uraemic syndrome is influenced by susceptibility factors in factor H and membrane cofactor protein: evidence from two independent cohorts
    V Fremeaux-Bacchi
    Service d Immunologie Biologique, Hopital Europeen Georges Pompidou, Paris, France
    J Med Genet 42:852-6. 2005

Detail Information

Publications55

  1. ncbi Schimke immunoosseous dysplasia: suggestions of genetic diversity
    J Marietta Clewing
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA
    Hum Mutat 28:273-83. 2007
    ..This is the first evidence for nonallelic heterogeneity in SIOD. From analysis of the postmortem histopathology from two patients and the clinical data from most patients, we propose the existence of endophenotypes of SIOD...
  2. ncbi [Post-diarrhea hemolytic-uremic syndrome: clinical aspects]
    C Loirat
    Service de Nephrologie, Hopital Robert Debre, 48, bd Serurier, 75019 Paris, France
    Arch Pediatr 8:776s-784s. 2001
    ..The role of VTEC in D + HUS makes the disease a public health problem. Preventive measures are essential...
  3. ncbi [Hereditary hemolytic uremic syndromes and thrombotic thrombocytopenic purpura]
    Chantal Loirat
    Service de Nephrologie, Hopital Robert Debre, 48 Boulevard Serrurier, 75019 Paris, Assistance Publique Hopitaux de Paris, Paris, France
    Nephrol Ther 2:S149-61. 2006
    ....
  4. ncbi The risk of recurrence of hemolytic uremic syndrome after renal transplantation in children
    Chantal Loirat
    Service de Nephrologie, Hopital Robert Debre, 48 Boulevard Serurier, 75019 Paris, France
    Pediatr Nephrol 18:1095-101. 2003
    ....
  5. ncbi Organ allocation in pediatric transplantation in France
    C Loirat
    Hopital Robert Debre, 48 Bd Serurier, 75019 Paris, France
    Pediatr Nephrol 16:964-70. 2001
    ..Many children still die on the waiting list for thoracic organ transplantation...
  6. ncbi [Chronic renal insufficiency in children]
    C Loirat
    Service de néphrologie Hôpital Robert Debré 75019 Paris
    Rev Prat 51:410-6. 2001
    ..Renal transplantation is the best treatment of end-stage renal failure in children, as it offers them a practically normal life, with the only obligation of absorbing medications every day...
  7. ncbi The high frequency of complement factor H related CFHR1 gene deletion is restricted to specific subgroups of patients with atypical haemolytic uraemic syndrome
    M A Dragon-Durey
    Assistance Publique Hopitaux de Paris, Hopital Europeen Georges Pompidou, Service d Immunologie Biologique, Paris, France
    J Med Genet 46:447-50. 2009
    ..We tested the CFHR1 deletion for association with aHUS in a population of French aHUS cases and controls. Furthermore, we examined the effect of the deletion in the context of known aHUS risk factors...
  8. ncbi Post graft development of short children treated with growth hormone before kidney graft
    D Simon
    Pediatric Endocrinology and Diabetology Unit, Robert Debre Hospital, 48 Boulevard Serurier, F 15019 Paris, France
    Pediatr Nephrol 13:723-9. 1999
    ..Reinitiation of rhGH therapy after transplantation should be considered in order to complete catch-up growth to target height in prepubertal children...
  9. ncbi Multicenter trial of one HLA-DR-matched or mismatched blood transfusion prior to cadaveric renal transplantation
    C Hiesse
    Service de Nephrologie, Hopital Bicetre, Le Kremlin Bicetre, France
    Kidney Int 60:341-9. 2001
    ..Recently, it has been suggested that their clinical benefits are due to HLA-DR sharing between the blood donor and recipient...
  10. ncbi The development of atypical haemolytic-uraemic syndrome is influenced by susceptibility factors in factor H and membrane cofactor protein: evidence from two independent cohorts
    V Fremeaux-Bacchi
    Service d Immunologie Biologique, Hopital Europeen Georges Pompidou, Paris, France
    J Med Genet 42:852-6. 2005
    ..A characteristic feature of both MCP and CFH associated HUS is reduced penetrance and variable inheritance; one possible explanation for this is that functional changes in complement proteins act as modifiers...
  11. ncbi Gastrointestinal complications of post-diarrheal hemolytic uremic syndrome
    A S de Buys Roessingh
    Department of Pediatric Surgery, University Hospital of Robert Debré, AP HP, Paris, France
    Eur J Pediatr Surg 17:328-34. 2007
    ..We tried to define factors predictive of the severity of gastrointestinal complications post D+ HUS...
  12. ncbi Scintigraphic screening for renal damage in siblings of children with symptomatic primary vesico-ureteric reflux
    F Bonnin
    Service de Medecine Nucleaire, Hopital Beaujon, Clichy, France
    BJU Int 87:463-6. 2001
    ..To define prospectively the incidence of renal parenchymal lesions in the siblings of patients treated at one institution for primary vesico-ureteric reflux (VUR)...
  13. ncbi [Disseminated lupus erythematosus in children: guidelines about investigations during the initial evaluation and follow-up]
    B Bader-Meunier
    Service de Pediatrie Generale, Hopital de Bicetre, AP HP, 78, rue du General Leclerc, 94276 Le Kremlin Bicetre, France
    Arch Pediatr 11:941-4. 2004
    ....
  14. ncbi Initial presentation of childhood-onset systemic lupus erythematosus: a French multicenter study
    B Bader-Meunier
    Department of Pediatrics, Hopital de Bicetre, 78 rue du General Leclerc, 94276 Le Kremlin Bicetre, France
    J Pediatr 146:648-53. 2005
    ..To describe the clinical and laboratory manifestations of childhood-onset systemic lupus erythematosus (SLE) at presentation...
  15. ncbi Population pharmacokinetics and pharmacogenetics of tacrolimus in de novo pediatric kidney transplant recipients
    W Zhao
    Department of Pediatric Pharmacology and Pharmacogenetics, Hopital Robert Debre, Paris, France
    Clin Pharmacol Ther 86:609-18. 2009
    ..Individualization of therapy will enable the optimization of tacrolimus exposure, with resultant beneficial effects on kidney function in the initial post-transplantation period...
  16. ncbi [Atypical hemolytic-uremic syndrome related to abnormalities within the complement system]
    V Fremeaux-Bacchi
    Service d Immunologie Biologique, Hopital Europeen Georges Pompidou, Assistance Publique Hopitaux de Paris, 20 40, rue Leblanc, 75908 Paris Cedex 15, France
    Rev Med Interne 32:232-40. 2011
    ....
  17. ncbi Complement factor I: a susceptibility gene for atypical haemolytic uraemic syndrome
    V Fremeaux-Bacchi
    Service d'Immunologie Biologique, , , Paris, France
    J Med Genet 41:e84. 2004
  18. ncbi Mother-to-child transmitted WT1 splice-site mutation is responsible for distinct glomerular diseases
    E Denamur
    Laboratoire de Biochimie Génétique and Institut National de la Santé et de la Recherche Médicale U458, Hopital Robert Debre, Paris, France
    J Am Soc Nephrol 10:2219-23. 1999
    ..It is suggested that WT1 splice site mutations should be sought in phenotypically normal females who present with FSGS or with related glomerulopathies of early onset...
  19. ncbi Ten candidate ADAMTS13 mutations in six French families with congenital thrombotic thrombocytopenic purpura (Upshaw-Schulman syndrome)
    A Veyradier
    INSERM U143, Le Kremlin Bicêtre and Service de Néphrologie, Hopital Robert Debre, Paris, France
    J Thromb Haemost 2:424-9. 2004
    ..This study emphasizes the role of ADAMTS13 mutations in the pathogenesis of congenital TTP and suggests that several structural domains of this metalloprotease are involved in both its biogenesis and its substrate recognition process...
  20. ncbi Pharmacokinetics and tolerance of mycophenolate mofetil in renal transplant children
    E Jacqz-Aigrain
    Unité de Pharmacologie Clinique Pédiatrique, Hopital Robert Debre, 48 Boulevard Serurier, F 75019 Paris, France
    Pediatr Nephrol 14:95-9. 2000
    ....
  21. ncbi Clinical quiz. Loin pain haematuria syndrome
    Elie Haddad
    , , Paris, France
    Pediatr Nephrol 17:217-9. 2002
  22. ncbi Recurrence of nephrotic syndrome after renal transplantation: influence of increased immunosuppression
    Sylvie Nathanson
    Pediatric Nephrology Unit, , Paris, France
    Pediatr Nephrol 20:1801-4. 2005
    ....
  23. ncbi Successful pre-transplant management of a patient with anti-factor H autoantibodies-associated haemolytic uraemic syndrome
    Theresa Kwon
    Pediatric Nephrology, , Paris, France
    Nephrol Dial Transplant 23:2088-90. 2008
  24. ncbi Genetic investigation of autosomal recessive distal renal tubular acidosis: evidence for early sensorineural hearing loss associated with mutations in the ATP6V0A4 gene
    Rosa Vargas-Poussou
    Centre Hospitalier Universitaire de Rouen, Département de Pédiatrie Médicale, and Faculté de Médecine et de Pharmacie, Rouen, France
    J Am Soc Nephrol 17:1437-43. 2006
    ..The data also demonstrate that mutations in either of these genes may cause early deafness, and they highlight the importance of genetic screening for recessive forms of dRTA independent of hearing status...
  25. ncbi Genetic and functional analyses of membrane cofactor protein (CD46) mutations in atypical hemolytic uremic syndrome
    Veronique Fremeaux-Bacchi
    Assitance Publique Hôpitaux de Paris, Hopital Europeen Georges Pompidou, Service d Immunologie Biologique, Paris Cedex 15, France
    J Am Soc Nephrol 17:2017-25. 2006
    ....
  26. ncbi Renal transplantation in HUS patients with disorders of complement regulation
    Lothar Bernd Zimmerhackl
    Univ Klinik für Kinder und Jugendheikunde, Innsbruck, Austria
    Pediatr Nephrol 22:10-6. 2007
    ..espn.ucwm.ac.uk . On no account should live related donation take place unless the risks of graft loss are understood. International collaboration to identify safer ways of transplanting these challenging patients is urgently needed...
  27. ncbi Mutations in PLCE1 are a major cause of isolated diffuse mesangial sclerosis (IDMS)
    Rasheed Gbadegesin
    Departments of Pediatrics and of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA
    Nephrol Dial Transplant 23:1291-7. 2008
    ..Mutations in two other genes WT1 and LAMB2 may also cause IDMS. We therefore determine in this study the relative frequency of mutations in PLCE1, WT1 or LAMB2 as the cause of IDMS in a worldwide cohort...
  28. ncbi A multicenter, open-label, pharmacokinetic/pharmacodynamic safety, and tolerability study of basiliximab (Simulect) in pediatric de novo renal transplant recipients
    Gisela Offner
    Kinderklinik der Medizinische Hochschule, Hannover, Germany
    Transplantation 74:961-6. 2002
    ..These preliminary data suggest that basiliximab, given in combination with cyclosporine and corticosteroids, is an effective immunosuppressive regimen for the prevention of acute rejection in pediatric renal transplantation...
  29. ncbi Differential impact of complement mutations on clinical characteristics in atypical hemolytic uremic syndrome
    Anne Laure Sellier-Leclerc
    Service de Nephrologie, Assistance Publique Hopitaux de Paris, Hopital Robert Debre, 48 Boulevard Serurier, 75 019 Paris, France
    J Am Soc Nephrol 18:2392-400. 2007
    ..New therapies are urgently needed, and further research should elucidate the unexplained HUS group...
  30. ncbi Epidemiology, clinical presentation, and pathophysiology of atypical and recurrent hemolytic uremic syndrome
    L Bernd Zimmerhackl
    Department of Pediatrics, Medical University Innsbruck, Innsbruck, Austria
    Semin Thromb Hemost 32:113-20. 2006
    ..Despite continued efforts, transplantation is not recommended at present for these patients. Living-related transplantation should be abandoned. New therapeutic strategies are urgently needed...
  31. ncbi Enhanced expression of the CD71 mesangial IgA1 receptor in Berger disease and Henoch-Schönlein nephritis: association between CD71 expression and IgA deposits
    Elie Haddad
    Service de Nephrologie, Service de Sante Publique, EA 3102, Université Paris 7 and Service de Pathologie, Hopital Robert Debre, Assistance Publique Hopitaux de Paris, Paris, France
    J Am Soc Nephrol 14:327-37. 2003
    ..However, the association between IgA deposits and CD71 expression and their co-localization in the mesangium provide strong evidence that CD71 is a major IgA receptor on mesangial cells...
  32. ncbi Anti-Factor H autoantibodies associated with atypical hemolytic uremic syndrome
    Marie Agnès Dragon-Durey
    Service d Immunologie Biologique, Hopital Europeen Georges Pompidou, 20 rue Leblanc, 75015 Paris, France
    J Am Soc Nephrol 16:555-63. 2005
    ..This new mechanism of functional FH deficiency may lead to the design of new approaches of diagnosis and treatment with a particular interest in plasma exchanges or immunosuppressive therapies...
  33. ncbi Hemolytic uremic syndrome recurrence after renal transplantation
    Chantal Loirat
    Assistance Publique, Hopitaux de Paris, Hopital Robert Debre, Universite Paris, Faculté de Médecine Denis Diderot, Service de Nephrologie, Paris, France
    Pediatr Transplant 12:619-29. 2008
    ..Kidney or kidney + liver transplantation with concomitant plasmatherapy need to be evaluated by prospective trials in patients with hereditary complement abnormalities...
  34. ncbi Surveillance of hemolytic uremic syndrome in children less than 15 years of age, a system to monitor O157 and non-O157 Shiga toxin-producing Escherichia coli infections in France, 1996-2006
    Emmanuelle Espié
    Institut de Veille Sanitaire, Saint Maurice, France
    Pediatr Infect Dis J 27:595-601. 2008
    ....
  35. ncbi Medication errors in hospitals: computerized unit dose drug dispensing system versus ward stock distribution system
    Jean Eudes Fontan
    Pharmacie et Laboratoire de Toxico pharmacologie, Hôpital Robert Debré AP HP, 48 Bd Serurier 75019 Paris, France
    Pharm World Sci 25:112-7. 2003
    ....
  36. ncbi Severe deficiency of the specific von Willebrand factor-cleaving protease (ADAMTS 13) activity in a subgroup of children with atypical hemolytic uremic syndrome
    Agnes Veyradier
    INSERM Unité 143, Le Kremlin Bicetre, Service de Nephrologie, Hopital Robert Debre, Tours, France
    J Pediatr 142:310-7. 2003
    ..Study design We measured VWF-cp activity in the plasma of 64 children with either (d+) HUS (n = 41) or (d-) HUS (n = 23)...
  37. ncbi Heterozygous and homozygous factor h deficiencies associated with hemolytic uremic syndrome or membranoproliferative glomerulonephritis: report and genetic analysis of 16 cases
    Marie Agnès Dragon-Durey
    INSERM U430, Institut des Cordeliers, Paris, France
    J Am Soc Nephrol 15:787-95. 2004
    ..This report emphasizes the variability in the clinical progression of kidney diseases associated with FH deficiencies. Genetic analysis reveals the molecular abnormalities associated with FH deficiencies to be polymorphous...
  38. ncbi A pediatric cluster of Shigella dysenteriae serotype 1 diarrhea with hemolytic uremic syndrome in 2 families from France
    Véronique Houdouin
    Services de Microbiologie, Hopital Robert Debre, Paris, France
    Clin Infect Dis 38:e96-9. 2004
    ..On the basis of our findings, the choice of antimicrobial treatment for infections with S. dysenteriae serotype 1 should take into account widespread drug resistance and the risk of HUS...
  39. ncbi Acute renal failure in a 3-year-old child as part of the drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome following hepatitis A
    Arnaud Garnier
    Pediatric Nephrology Unit, Assistance Publique Hopitaux de Paris, Hopital Robert Debre, Paris, France
    Pediatr Nephrol 23:667-9. 2008
    ..The final diagnosis was of the syndrome drug reaction with eosinophilia and systemic symptoms or DRESS, induced by cefixime or cotrimoxazole and possibly triggered by the hepatitis A virus infection...
  40. ncbi Mutant chromatin remodeling protein SMARCAL1 causes Schimke immuno-osseous dysplasia
    Cornelius F Boerkoel
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Nat Genet 30:215-20. 2002
    ..These observations indicate that some missense mutations allow retention of partial SMARCAL1 function and thus cause milder disease...
  41. ncbi Inhibitory ITAM signaling by Fc alpha RI-FcR gamma chain controls multiple activating responses and prevents renal inflammation
    Yutaka Kanamaru
    INSERM Unité 699, Universite Paris 7 Denis Diderot, Faculte de Medecine, Site Xavier Bichat, 16 rue Henri Huchard, Paris, France
    J Immunol 180:2669-78. 2008
    ..They also identify anti-FcalphaRI Fab as a new potential therapeutic tool for preventing progression of renal inflammatory diseases...
  42. ncbi Nephrin mutations can cause childhood-onset steroid-resistant nephrotic syndrome
    Aurélie Philippe
    Inserm U574, Hopital Necker Enfants Malades, Paris, France
    J Am Soc Nephrol 19:1871-8. 2008
    ..The presence of at least one "mild" mutation in these patients likely explains the later onset and milder course of disease. These results broaden the spectrum of renal disease related to nephrin mutations...
  43. ncbi Prospective, randomized trial comparing short and long intravenous antibiotic treatment of acute pyelonephritis in children: dimercaptosuccinic acid scintigraphic evaluation at 9 months
    François Bouissou
    Nephrologie Pediatrique, Hopital des Enfants, Université Paul Sabathier, Centre Hospitalier Universitaire Purpan, Toulouse, France
    Pediatrics 121:e553-60. 2008
    ....
  44. ncbi Pharmacokinetics of ganciclovir in pediatric renal transplant recipients
    Daolun Zhang
    Department of Pediatric Pharmacology and Pharmacogenetics, , , 75019 Paris, France
    Pediatr Nephrol 18:943-8. 2003
    ..o. GCV (50 mg/kg per 12 h) were administered and were associated with trough levels over 0.5 microg/ml. In 1 patient who received an erroneously low dosage p.o., CMV resistance to GCV appeared, requiring foscarnet...
  45. ncbi Fc alpha receptor I activation induces leukocyte recruitment and promotes aggravation of glomerulonephritis through the FcR gamma adaptor
    Yutaka Kanamaru
    INSERM U699, Paris, France
    Eur J Immunol 37:1116-28. 2007
    ..Thus, FcalphaRI activation mediates GN progression by initiating a cytokine/chemokine cascade that promotes leukocyte recruitment and kidney damage...
  46. ncbi Everolimus in pediatric de nova renal transplant patients
    Peter F Hoyer
    Department of Pediatric Nephrology, Universitätsklinik Essen, Hufelandstr 55, D 45122 Essen, Germany
    Transplantation 75:2082-5. 2003
    ..The steady-state pharmacokinetics of everolimus were longitudinally assessed in pediatric de novo kidney allograft recipients during a 6-month period...
  47. ncbi In vivo expression of putative LMX1B targets in nail-patella syndrome kidneys
    Laurence Heidet
    Inserm U574, Universite Rene Descartes, Hopital Necker Enfants Malades, Paris, France
    Am J Pathol 163:145-55. 2003
    ..These findings indicate that heterozygous mutations of LMX1B do not appear to dramatically affect the expression of type IV collagen chains, podocin, or CD2AP in NPS patients...
  48. ncbi Glucocorticoid pharmacokinetics and growth retardation in children with renal transplants
    Claire Chavatte
    Service Pharmacie, , , 75015 Paris, France
    Pediatr Nephrol 19:898-904. 2004
    ..We, therefore, do not recommend using glucocorticoid pharmacokinetics to predict growth retardation in children with renal transplantation...
  49. ncbi Relationship between CD8+ T-cell phenotype and function, Epstein-Barr virus load, and clinical outcome in pediatric renal transplant recipients: a prospective study
    Veronique Baudouin
    Department of Nephrology, Hopital Robert Debre, Assistance Publique Hopitaux de Paris, Université Denis Diderot Paris VII, Paris, France
    Transplantation 77:1706-13. 2004
    ..The authors studied the relationship between the dynamics of Epstein-Barr virus (EBV) load, CD8 T-cell activation and differentiation, and EBV-associated symptoms in 25 children after kidney transplantation (Tx)...
  50. ncbi WT1 splice site mutation in a 46,XX female with minimal-change nephrotic syndrome and Wilms' tumour
    Chantal Loirat
    , , Paris, France
    Nephrol Dial Transplant 18:823-5. 2003
  51. ncbi A rational dosing algorithm for basiliximab (Simulect) in pediatric renal transplantation based on pharmacokinetic-dynamic evaluations
    John M Kovarik
    Novartis Pharmaceuticals, Basel, Switzerland
    Transplantation 74:966-71. 2002
    ..The first dose is given before surgery and the second on day 4 after transplantation...
  52. ncbi Thrombotic thrombocytopenic purpura associated with von Willebrand factor-cleaving protease (ADAMTS13) deficiency in children
    Chantal Loirat
    Service de Nephrologie Pediatrique, Hopital Robert Debre, Paris, France
    Semin Thromb Hemost 32:90-7. 2006
    ..FFP infusions are best used preventively, given that rescue infusions may not prevent central nervous system and renal involvement. It is hoped that plasmatic or recombinant purified ADAMTS13 will be available in the years to come...
  53. ncbi [Renovascular hypertension in childhood]
    Albert Bensman
    , , avenue du Docteur Arnold Netter-75012 Paris
    Bull Acad Natl Med 187:1067-77; discussion 1078-9. 2003
    ....
  54. ncbi [Corticosensitive nephrotic syndrome (or nephrosis) in children. Therapeutic guideline proposed by the Pediatric Society of Nephrology]
    Etienne Berard
    Service de Pediatrie, hôpital de l Archet II, 151 avenue Saint Antoine de Ginestière, BP 3079, 06202 Nice cedex, France
    Nephrol Ther 1:150-6. 2005
  55. ncbi Multicenter trial of everolimus in pediatric renal transplant recipients: results at three year
    Robert Ettenger
    Department of Pediatrics, Mattel Children s Hospital, University of California Los Angeles, Los Angeles, CA 90095 1752, USA
    Pediatr Transplant 12:456-63. 2008
    ..4 mg/dL). This is the first long-term prospective study to demonstrate that a regimen of everolimus, cyclosporine, and corticosteroids provides good efficacy, tolerability, and safety in de novo pediatric renal transplant patients...