Emmanuelle Liaudet Coopman

Summary

Country: France

Publications

  1. pmc Catalytically inactive human cathepsin D triggers fibroblast invasive growth
    Valérie Laurent-Matha
    INSERM U540 Endocrinologie Moléculaire et Cellulaire des Cancers, Universite de Montpellier 1, 34090 Montpellier, France
    J Cell Biol 168:489-99. 2005
  2. ncbi request reprint Cathepsin D: newly discovered functions of a long-standing aspartic protease in cancer and apoptosis
    Emmanuelle Liaudet-Coopman
    INSERM U540 Endocrinologie Moléculaire et Cellulaire des Cancers, Universite de Montpellier 1, 60 rue de Navacelles, 34090 Montpellier, France
    Cancer Lett 237:167-79. 2006
  3. ncbi request reprint Down-regulation of cathepsin-D expression by antisense gene transfer inhibits tumor growth and experimental lung metastasis of human breast cancer cells
    Murielle Glondu
    INSERM U540 Endocrinologie Moléculaire et Cellulaire des Cancers, Universite de Montpellier 1, 60 rue de Navacelles, 34090 Montpellier, France
    Oncogene 21:5127-34. 2002
  4. ncbi request reprint Cathepsin-D affects multiple tumor progression steps in vivo: proliferation, angiogenesis and apoptosis
    Guy Berchem
    Laboratoire d Hémato Cancérologie, Centre Hospitalier de Luxembourg 4, Rue Barble
    Oncogene 21:5951-5. 2002
  5. pmc Processing of human cathepsin D is independent of its catalytic function and auto-activation: involvement of cathepsins L and B
    Valérie Laurent-Matha
    INSERM, U540, Montpellier, F 34000 France
    J Biochem 139:363-71. 2006
  6. pmc Cathepsin D overexpressed by cancer cells can enhance apoptosis-dependent chemo-sensitivity independently of its catalytic activity
    Melanie Beaujouin
    Inserm Unit 540, Montpellier, France
    Adv Exp Med Biol 617:453-61. 2008

Collaborators

  • Christine Gilles
  • Gilles Freiss
  • Henri Rochefort
  • Agnes Noel
  • Nobuhiko Katunuma
  • Emmanuelle Liaudet-Coopman
  • Valérie Laurent-Matha
  • Melanie Beaujouin
  • Murielle Glondu
  • Christine Prébois
  • Danielle Derocq
  • Françoise Vignon
  • Marcel Garcia
  • Guy Berchem
  • Murielle Glondu-Lassis
  • Peter Coopman
  • Sylvia Blacher
  • Stephen Baghdiguian
  • Sharon Maruani-Herrmann
  • Marie Luz Alvarez-Gonzalez
  • Jadranka Loncarek
  • Michel Gleizes
  • Jean Paul Brouillet
  • Nadine Platet

Detail Information

Publications6

  1. pmc Catalytically inactive human cathepsin D triggers fibroblast invasive growth
    Valérie Laurent-Matha
    INSERM U540 Endocrinologie Moléculaire et Cellulaire des Cancers, Universite de Montpellier 1, 34090 Montpellier, France
    J Cell Biol 168:489-99. 2005
    ..We conclude that cath-D is crucial for fibroblast invasive outgrowth and could act as a key paracrine communicator between cancer and stromal cells, independently of its catalytic activity...
  2. ncbi request reprint Cathepsin D: newly discovered functions of a long-standing aspartic protease in cancer and apoptosis
    Emmanuelle Liaudet-Coopman
    INSERM U540 Endocrinologie Moléculaire et Cellulaire des Cancers, Universite de Montpellier 1, 60 rue de Navacelles, 34090 Montpellier, France
    Cancer Lett 237:167-79. 2006
    ..This review summarises our current knowledge on cath-D action in cancer progression and metastasis, as well as its dual function in apoptosis...
  3. ncbi request reprint Down-regulation of cathepsin-D expression by antisense gene transfer inhibits tumor growth and experimental lung metastasis of human breast cancer cells
    Murielle Glondu
    INSERM U540 Endocrinologie Moléculaire et Cellulaire des Cancers, Universite de Montpellier 1, 60 rue de Navacelles, 34090 Montpellier, France
    Oncogene 21:5127-34. 2002
    ..Our overall results provide the first evidence on the essential role of cathepsin-D in breast cancer, and support the development of a new cathepsin-D-targeted therapy...
  4. ncbi request reprint Cathepsin-D affects multiple tumor progression steps in vivo: proliferation, angiogenesis and apoptosis
    Guy Berchem
    Laboratoire d Hémato Cancérologie, Centre Hospitalier de Luxembourg 4, Rue Barble
    Oncogene 21:5951-5. 2002
    ..Our overall results provide the first mechanistic evidences on the essential role of cathepsin-D at multiple tumor progression steps, affecting cell proliferation, angiogenesis and apoptosis...
  5. pmc Processing of human cathepsin D is independent of its catalytic function and auto-activation: involvement of cathepsins L and B
    Valérie Laurent-Matha
    INSERM, U540, Montpellier, F 34000 France
    J Biochem 139:363-71. 2006
    ..We therefore conclude that the mechanism of cath-D maturation involves a fully-assisted processing similar to that of pro-renin...
  6. pmc Cathepsin D overexpressed by cancer cells can enhance apoptosis-dependent chemo-sensitivity independently of its catalytic activity
    Melanie Beaujouin
    Inserm Unit 540, Montpellier, France
    Adv Exp Med Biol 617:453-61. 2008
    ..Overall, our results imply that cytosolic CD stimulates apoptotic pathways by interacting with a member of the apoptotic machinery rather than by cleaving specific substrate(s)...