Research Topics
Genomes and Genes | Yves LevySummaryCountry: France Publications
| Collaborators
|
Detail Information
Publications
Effects of recombinant human interleukin 7 on T-cell recovery and thymic output in HIV-infected patients receiving antiretroviral therapy: results of a phase I/IIa randomized, placebo-controlled, multicenter studyY Levy
INSERM, U955, France
Clin Infect Dis 55:291-300. 2012..The immune deficiency of human immunodeficiency virus (HIV) infection is not fully corrected with ARV therapy. Interleukin-7 (IL-7) can boost CD4 T-cell counts, but optimal dosing and mechanisms of cellular increases need to be defined...
Effect of intermittent interleukin-2 therapy on CD4+ T-cell counts following antiretroviral cessation in patients with HIVYves Levy
INSERM, Unité U, Groupe Henri Mondor Albert Chenevier, Service d immunologie clinique, Creteil, France
AIDS 26:711-20. 2012..Interleukin (IL)-2 therapy impacts T-cell homeostasis. Whether IL-2 expanded CD4(+) T cells may persist following viral rebound has not been fully investigated...- Suppression of HIV-1 replication by microRNA effectorsChristine Chable-Bessia
Institut de Génétique Humaine CNRS UPR1142, Laboratoire de Virologie Moleculaire, Montpellier, France
Retrovirology 6:26. 2009..Interestingly, knockdown of RCK/p54 or DGCR8 resulted in virus reactivation in PBMCs isolated from HIV infected patients treated with suppressive HAART... - Enhanced T cell recovery in HIV-1-infected adults through IL-7 treatmentYves Levy
1INSERM U955, Universite Paris 12, and Assistance Publique Hôpitaux de Paris AP HP, Groupe Henri Mondor Albert Chenevier, Immunologie Clinique, Creteil, France
J Clin Invest 119:997-1007. 2009..Therefore, patients may benefit from intermittent therapy with IL-7 in combination with c-ART... - Regulatory T cells differentially modulate the maturation and apoptosis of human CD8+ T-cell subsetsMaria Nikolova
INSERM U955, Creteil, France
Blood 113:4556-65. 2009..Thus, in the setting of a healthy immune system, Treg cells fine-tune the memory/effector cell balance and promote the accumulation of long-living memory cells in case of strong stimulation... 
[Cytokine therapies in HIV infection]Yves Levy
Service d immunologie clinique, Hopital Henri Mondor, 51, Avenue du Marechal de Lattre de Tassigny, 94010 Creteil Cedex, France
Med Sci (Paris) 22:751-4. 2006..Although no data in human are still available, recent studies provide arguments to assess this cytokine in HIV infection. Phase I studies are ongoing or planned...- Therapeutic HIV vaccines: an updateYves Levy
Service d immunologie clinique, Hopital Henri Mondor, 51 Avenue du Marechal de Lattre de Tassigny, 94010 Creteil, France
Curr HIV/AIDS Rep 2:5-9. 2005..In clinical terms, this might allow patients to delay or to stop antiviral therapy and to minimize the duration of the exposition to antiviral drugs... - Sustained control of viremia following therapeutic immunization in chronically HIV-1-infected individualsYves Levy
Hopital Henri Mondor, 51 av Mal de Lattre de Tassigny, 94010 Creteil, France
AIDS 20:405-13. 2006..The randomized ANRS 093 aimed at investigating whether a therapeutic immunization was effective in containing the long-term viral replication following discontinuation of antiretroviral drugs in patients... - Notch increases T/NK potential of human hematopoietic progenitors and inhibits B cell differentiation at a pro-B stageClarisse Benne
INSERM, Unite U955, Creteil, France
Stem Cells 27:1676-85. 2009..These results may have implications both in physiology and for cell manipulation because they demonstrate a tight regulation of the fate of human progenitors by Notch signaling... - Immunological and virological efficacy of a therapeutic immunization combined with interleukin-2 in chronically HIV-1 infected patientsYves Levy
Unité d Immunologie Clinique, Hopital Henri Mondor, 51 Avenue du Marechal de Lattre de Tassigny, 94010 Creteil Cedex, Paris, France
AIDS 19:279-86. 2005..Several lines of evidence suggest that the immune system may control HIV-1 replication, but that it could fail in the long term. Strategies aimed to elicit specific immune responses may enable patients to contain virus replication... - HIV-specific regulatory T cells are associated with higher CD4 cell counts in primary infectionHassen Kared
INSERM, Unite U841, France
AIDS 22:2451-60. 2008..Expansion of regulatory T (Treg) cells has been described in chronically HIV-infected individuals. We investigated whether HIV-suppressive Treg could be detected during primary HIV infection (PHI)... - Erythrocyte and plasma ribavirin concentrations in the assessment of early and sustained virological responses to pegylated interferon-alpha 2a and ribavirin in patients coinfected with hepatitis C virus and HIVStephanie Dominguez
Service Immunologie Clinique, Hopital Henri Mondor, Creteil, France
J Antimicrob Chemother 67:1449-52. 2012.... - A new endpoint definition improved clinical relevance and statistical power in a vaccine trialGaëlle Pédrono
INSERM, U897 and CIC EC7, Bordeaux 33076, France
J Clin Epidemiol 62:1054-61. 2009..When a vaccine includes several types of the same species, we illustrate how an endpoint combining all responses may improve clinical relevance and statistical power... - Immunological efficacy of a prime-boost pneumococcal vaccination in HIV-infected adultsPhilippe Lesprit
Henri Mondor Hospital, Creteil, France bINSERM U593, Bordeaux, France
AIDS 21:2425-34. 2007.... - Primary vasculitis of the central nervous system in patients infected with HIV-1 in the HAART eraGiovanna Melica
Service d immunologie clinique, CHU Henri Mondor, Creteil, France
J Med Virol 81:578-81. 2009..The prognosis of these patients remain poor despite HAART. These observations suggest that the vascular inflammatory process persists despite the control of viral load under HAART in patients with persistent immunosuppression... - HIV-1 Nef protein expression in human CD34+ progenitors impairs the differentiation of an early T/NK cell precursorCéline Dorival
INSERM U 841, Faculte de Medecine, Creteil, France
Virology 377:207-15. 2008..Altogether, these data demonstrate that Nef interferes with the differentiation of a primitive lymphoid human precursor with a T/NK potential... - Notch activation on effector T cells increases their sensitivity to Treg cell-mediated suppression through upregulation of TGF-βRII expressionSophie Hue
INSERM, Unite U955, Creteil, France
Eur J Immunol 42:1796-803. 2012..Thus, the crosstalk between Notch and the TGF-β pathway leads to potentiation of the suppressive effect of Treg cells... - Initiation of c-ART in HIV-1 infected patients is associated with a decrease of the metabolic activity of the thymus evaluated using FDG-PET/computed tomographyJean Daniel Lelievre
INSERM, Unite U955, Creteil, France
J Acquir Immune Defic Syndr 61:56-63. 2012..The role of the thymus in the depletion or restoration of T-cell pool in HIV infection is still debatable. Studies are hampered by the lack of valuable tools to investigate thymic activity... - FcγRIIIa (CD16) induction on human T lymphocytes and CD16pos T-lymphocyte amplificationBéatrice Clémenceau
Institut de Recherche Thérapeutique de l Université de Nantes, INSERM, U892, France
J Immunother 34:542-9. 2011.... - CD39/adenosine pathway is involved in AIDS progressionMaria Nikolova
INSERM, Unite U955, Creteil, France
PLoS Pathog 7:e1002110. 2011..Finally, in a genetic association study performed in three different cohorts, we identified a CD39 gene polymorphism that was associated with down-modulated CD39 expression and a slower progression to AIDS... - AIDS progression is associated with the emergence of IL-17-producing cells early after simian immunodeficiency virus infectionLaure Campillo-Gimenez
Institut National de la Santé et de la Recherche Médicale U 955, Faculté de Médecine de Créteil, Hopital Henri Mondor, Creteil, France
J Immunol 184:984-92. 2010..Altogether, these results demonstrate that IL-17-producing NKT are associated with the pathogenesis of SIV in RMs and suggest that TGF-beta and IL-18 play a role in their development... - NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic functionAhmad Yatim
INSERM U955, Creteil, France
Mol Cell 48:445-58. 2012.... - Maraviroc-containing regimen suppresses HIV replication in the cerebrospinal fluid of patients with neurological symptomsGiovanna Melica
Department of Clinical Immunology, Henri Mondor Hospital, Université Paris XII Creteil, Creteil, France
AIDS 24:2130-3. 2010..The median (range) maraviroc concentration in plasma was 347 ng/ml (123-2678). Four patients had CSF concentrations above the protein-adjusted inhibitory concentration (IC90) of 0.57 ng/ml (0.06-10.7) with a median of 102 ng/ml (35-173)... - Long-term (96-week) follow-up of antiretroviral-naïve HIV-infected patients treated with first-line lopinavir/ritonavir monotherapy in the MONARK trialJade Ghosn
Department of Internal Medicine and Infectious Diseases, AP HP, Bicetre University Hospital, Le Kremlin Bicetre Cedex, France
HIV Med 11:137-42. 2010..MONotherapy AntiRetroviral Kaletra (MONARK) is the first randomized trial comparing lopinavir/ritonavir monotherapy to triple combination therapy with zidovudine/lamivudine and lopinavir/ritonavir in antiretroviral-naïve patients... - Interruption of antiretroviral therapy initiated during primary HIV-1 infection: impact of a therapeutic vaccination strategy combined with interleukin (IL)-2 compared with IL-2 alone in the ANRS 095 Randomized StudyCecile Goujard
Service de Medecine Interne, Bicetre Hospital, AP HP, Le Kremlin Bicetre, Paris, France
AIDS Res Hum Retroviruses 23:1105-13. 2007..Treatment interruption is safe in patients treated early after primary HIV infection. On the basis of this pilot study, HIV immunizations and interleukin-2 appear to have no supplementary benefit... - Protease inhibitor resistance analysis in the MONARK trial comparing first-line lopinavir-ritonavir monotherapy to lopinavir-ritonavir plus zidovudine and lamivudine triple therapyConstance Delaugerre
University Paris Descartes, EA 3620, Virology Department, Necker Hospital AP HP, Paris, France
Antimicrob Agents Chemother 53:2934-9. 2009..The mutation L76V may be considered in further studies of lopinavir resistance... - Immunological success is predicted by enfuvirtide but not interleukin-2 therapy in immunodepressed patientsJean Paul Viard
Assistance Publique Hopitaux de Paris, Hôpital Necker Necker Enfants Malades, Universite Paris Descartes, France
AIDS 23:1383-8. 2009..To evaluate the efficacy of adding interleukin-2 (IL-2) to an optimized background treatment in HIV-1 patients with advanced failure... - Interleukin-2 before antiretroviral therapy in patients with HIV infection: a randomized trial (ANRS 119)Jean Michel Molina
Assistance Publique Hopitaux de Paris, Hopital Saint Louis, France
J Infect Dis 200:206-15. 2009..Interleukin (IL)-2 increases CD4 T cell counts when combined with antiretroviral therapy (ART). Whether IL-2 alone can increase CD4 cell counts is unknown... - Safety and immunogenicity of 4 intramuscular double doses and 4 intradermal low doses vs standard hepatitis B vaccine regimen in adults with HIV-1: a randomized controlled trialOdile Launay
Paris Descartes University, France
JAMA 305:1432-40. 2011..Alternative schedules more immunogenic than the standard hepatitis B vaccine regimen are needed in patients with human immunodeficiency virus 1 (HIV-1) infection... - Relationship between regulatory T cells and immune activation in human immunodeficiency virus-infected patients interrupting antiretroviral therapyLaurence Weiss
Faculte de Medecine, Universite Paris Descartes, Assistance Publique Hopitaux de Paris AP HP, Hopital Europeen Georges Pompidou, Paris, France
PLoS ONE 5:e11659. 2010..However, the insufficient increase in the proportion and/or the decrease in the absolute number of Tregs result in a failure to control immune activation following TI. TRIAL REGISTRATION: ClinicalTrials.gov NCT00118677... - Immunogenicity and safety of an HIV-1 lipopeptide vaccine in healthy adults: a phase 2 placebo-controlled ANRS trialDominique Salmon-Ceron
Universite Paris Descartes, Assistance Publique Hopitaux de Paris, Hopital Cochin, France
AIDS 24:2211-23. 2010..Whether HIV-LIPO-5 immunogenicity varies with the dose is unknown... - Acute kidney injury in sickle patients with painful crisis or acute chest syndrome and its relation to pulmonary hypertensionVincent Audard
Nephrology and Renal Transplantation Department and Institut Francilien de Recherche en Nephrologie et Transplantation IFRNT, Henri Mondor Hospital, 51 Avenue du Marechal de Lattre de Tassigny Creteil, France
Nephrol Dial Transplant 25:2524-9. 2010..The association between chronic kidney involvement and sickle cell disease (SCD) has been well characterized, but our knowledge on acute kidney injury (AKI) in relation to SCD remains limited... - Successful treatment of aciclovir and foscarnet resistant Herpes simplex virus lesions with topical imiquimod in patients infected with human immunodeficiency virus type 1Anne Sophie Lascaux
Department of Clinical Immunology, Hopital Henri Mondor, Creteil, France
J Med Virol 84:194-7. 2012..These patients were treated successfully with topical 5% imiquimod. Imiquimod treatment also appeared to delay the time to recurrence of HSV lesions... - Short exposure to Notch ligand Delta-4 is sufficient to induce T-cell differentiation program and to increase the T cell potential of primary human CD34+ cellsNathalie Lefort
INSERM U 421, Faculte de Medecine, Creteil, France
Exp Hematol 34:1720-9. 2006..The Notch pathway plays a key role in cell fate choices and in T-cell development. The goal of our study was to evaluate whether a short in vitro stimulation of the Notch pathway may alter human progenitor cell behavior... - Acute interstitial nephritis with predominant plasmacytic infiltration in patients with HIV-1 infectionGiovanna Melica
Clinical Immunology Department, AP HP, Groupe Henri Mondor Albert Chenevier and Université Paris Est Créteil, Creteil, France
Am J Kidney Dis 59:711-4. 2012..The acute interstitial nephritis probably was induced by HIV-1-driven nonspecific B-cell activation. Further investigations are needed to confirm the direct pathogenic role of HIV-1... - IL-2 immunotherapy in chronically SIV-infected Rhesus macaquesJulie Garibal
INSERM U955 Equipe 16, Institut Mondor de Recherche Biomedicale, Creteil, F 94010, France
Virol J 9:220. 2012..Several hypotheses were evoked to explain these discrepancies. Here, we investigated the impact of low and high doses of IL-2 in Rhesus macaques of Chinese origin infected with SIVmac251 in the absence of antiretroviral therapy (ART)... - Long-term immunogenicity of two doses of 2009 A/H1N1v vaccine with and without AS03(A) adjuvant in HIV-1-infected adultsChristine Durier
INSERM, SC10, Villejuif, Assistance Publique Hopitaux de Paris AP HP, Hopital Cochin, CIC de vaccinologie Cochin Pasteur, INSERM, CIC BT505, Paris, France
AIDS 27:87-93. 2013..We previously reported that the AS03A-adjuvanted 2009 A/H1N1v vaccine yielded a higher short-term immune response than the nonadjuvanted one in HIV-1-infected adults. This study reports the long-term persistence of the immune response... - Nonpathogenesis of simian immunodeficiency virus infection is associated with reduced inflammation and recruitment of plasmacytoid dendritic cells to lymph nodes, not to lack of an interferon type I response, during the acute phaseLaure Campillo-Gimenez
INSERM U841, Faculté Créteil Henri Mondor, 8 rue du General Sarrail, 94010 Creteil, France
J Virol 84:1838-46. 2010.... - Perspectives on interleukin-7 therapy in HIV infectionJean Daniel Lelievre
Service d immunologie clinique, Hopital Henri Mondor, Universite Paris, Creteil, France
Curr Opin HIV AIDS 2:228-33. 2007..Because of its pleiotropic effects on developing and mature T cells, interleukin-7 may help to restore immune function during HIV infection...