Yves Levy

Summary

Country: France

Publications

  1. pmc CD39/adenosine pathway is involved in AIDS progression
    Maria Nikolova
    INSERM, Unite U955, Creteil, France
    PLoS Pathog 7:e1002110. 2011
  2. pmc Regulatory T cells negatively affect IL-2 production of effector T cells through CD39/adenosine pathway in HIV infection
    Mohammad Ali Jenabian
    Université Paris Est Créteil, Creteil, France
    PLoS Pathog 9:e1003319. 2013
  3. pmc Effects of recombinant human interleukin 7 on T-cell recovery and thymic output in HIV-infected patients receiving antiretroviral therapy: results of a phase I/IIa randomized, placebo-controlled, multicenter study
    Y Levy
    INSERM, U955, France
    Clin Infect Dis 55:291-300. 2012
  4. doi request reprint Effect of intermittent interleukin-2 therapy on CD4+ T-cell counts following antiretroviral cessation in patients with HIV
    Yves Levy
    INSERM, Unité U, Groupe Henri Mondor Albert Chenevier, Service d immunologie clinique, Creteil, France
    AIDS 26:711-20. 2012
  5. pmc Suppression of HIV-1 replication by microRNA effectors
    Christine Chable-Bessia
    Institut de Génétique Humaine CNRS UPR1142, Laboratoire de Virologie Moleculaire, Montpellier, France
    Retrovirology 6:26. 2009
  6. pmc Enhanced T cell recovery in HIV-1-infected adults through IL-7 treatment
    Yves Levy
    1INSERM U955, Universite Paris 12, and Assistance Publique Hôpitaux de Paris AP HP, Groupe Henri Mondor Albert Chenevier, Immunologie Clinique, Creteil, France
    J Clin Invest 119:997-1007. 2009
  7. pmc Regulatory T cells differentially modulate the maturation and apoptosis of human CD8+ T-cell subsets
    Maria Nikolova
    INSERM U955, Creteil, France
    Blood 113:4556-65. 2009
  8. ncbi request reprint [Cytokine therapies in HIV infection]
    Yves Levy
    Service d immunologie clinique, Hopital Henri Mondor, 51, Avenue du Marechal de Lattre de Tassigny, 94010 Creteil Cedex, France
    Med Sci (Paris) 22:751-4. 2006
  9. ncbi request reprint Therapeutic HIV vaccines: an update
    Yves Levy
    Service d immunologie clinique, Hopital Henri Mondor, 51 Avenue du Marechal de Lattre de Tassigny, 94010 Creteil, France
    Curr HIV/AIDS Rep 2:5-9. 2005
  10. ncbi request reprint Immunological and virological efficacy of a therapeutic immunization combined with interleukin-2 in chronically HIV-1 infected patients
    Yves Levy
    Unité d Immunologie Clinique, Hopital Henri Mondor, 51 Avenue du Marechal de Lattre de Tassigny, 94010 Creteil Cedex, Paris, France
    AIDS 19:279-86. 2005

Detail Information

Publications51

  1. pmc CD39/adenosine pathway is involved in AIDS progression
    Maria Nikolova
    INSERM, Unite U955, Creteil, France
    PLoS Pathog 7:e1002110. 2011
    ..Finally, in a genetic association study performed in three different cohorts, we identified a CD39 gene polymorphism that was associated with down-modulated CD39 expression and a slower progression to AIDS...
  2. pmc Regulatory T cells negatively affect IL-2 production of effector T cells through CD39/adenosine pathway in HIV infection
    Mohammad Ali Jenabian
    Université Paris Est Créteil, Creteil, France
    PLoS Pathog 9:e1003319. 2013
    ..These results extend previous data on the role of Treg in HIV infection by filling the gap between expansion of Treg/CD39+ in HIV infection and the suppression of CD4+ T-cell function through inhibition of IL-2 production...
  3. pmc Effects of recombinant human interleukin 7 on T-cell recovery and thymic output in HIV-infected patients receiving antiretroviral therapy: results of a phase I/IIa randomized, placebo-controlled, multicenter study
    Y Levy
    INSERM, U955, France
    Clin Infect Dis 55:291-300. 2012
    ..The immune deficiency of human immunodeficiency virus (HIV) infection is not fully corrected with ARV therapy. Interleukin-7 (IL-7) can boost CD4 T-cell counts, but optimal dosing and mechanisms of cellular increases need to be defined...
  4. doi request reprint Effect of intermittent interleukin-2 therapy on CD4+ T-cell counts following antiretroviral cessation in patients with HIV
    Yves Levy
    INSERM, Unité U, Groupe Henri Mondor Albert Chenevier, Service d immunologie clinique, Creteil, France
    AIDS 26:711-20. 2012
    ..Interleukin (IL)-2 therapy impacts T-cell homeostasis. Whether IL-2 expanded CD4(+) T cells may persist following viral rebound has not been fully investigated...
  5. pmc Suppression of HIV-1 replication by microRNA effectors
    Christine Chable-Bessia
    Institut de Génétique Humaine CNRS UPR1142, Laboratoire de Virologie Moleculaire, Montpellier, France
    Retrovirology 6:26. 2009
    ..Interestingly, knockdown of RCK/p54 or DGCR8 resulted in virus reactivation in PBMCs isolated from HIV infected patients treated with suppressive HAART...
  6. pmc Enhanced T cell recovery in HIV-1-infected adults through IL-7 treatment
    Yves Levy
    1INSERM U955, Universite Paris 12, and Assistance Publique Hôpitaux de Paris AP HP, Groupe Henri Mondor Albert Chenevier, Immunologie Clinique, Creteil, France
    J Clin Invest 119:997-1007. 2009
    ..Therefore, patients may benefit from intermittent therapy with IL-7 in combination with c-ART...
  7. pmc Regulatory T cells differentially modulate the maturation and apoptosis of human CD8+ T-cell subsets
    Maria Nikolova
    INSERM U955, Creteil, France
    Blood 113:4556-65. 2009
    ..Thus, in the setting of a healthy immune system, Treg cells fine-tune the memory/effector cell balance and promote the accumulation of long-living memory cells in case of strong stimulation...
  8. ncbi request reprint [Cytokine therapies in HIV infection]
    Yves Levy
    Service d immunologie clinique, Hopital Henri Mondor, 51, Avenue du Marechal de Lattre de Tassigny, 94010 Creteil Cedex, France
    Med Sci (Paris) 22:751-4. 2006
    ..Although no data in human are still available, recent studies provide arguments to assess this cytokine in HIV infection. Phase I studies are ongoing or planned...
  9. ncbi request reprint Therapeutic HIV vaccines: an update
    Yves Levy
    Service d immunologie clinique, Hopital Henri Mondor, 51 Avenue du Marechal de Lattre de Tassigny, 94010 Creteil, France
    Curr HIV/AIDS Rep 2:5-9. 2005
    ..In clinical terms, this might allow patients to delay or to stop antiviral therapy and to minimize the duration of the exposition to antiviral drugs...
  10. ncbi request reprint Immunological and virological efficacy of a therapeutic immunization combined with interleukin-2 in chronically HIV-1 infected patients
    Yves Levy
    Unité d Immunologie Clinique, Hopital Henri Mondor, 51 Avenue du Marechal de Lattre de Tassigny, 94010 Creteil Cedex, Paris, France
    AIDS 19:279-86. 2005
    ..Several lines of evidence suggest that the immune system may control HIV-1 replication, but that it could fail in the long term. Strategies aimed to elicit specific immune responses may enable patients to contain virus replication...
  11. ncbi request reprint Sustained control of viremia following therapeutic immunization in chronically HIV-1-infected individuals
    Yves Levy
    Hopital Henri Mondor, 51 av Mal de Lattre de Tassigny, 94010 Creteil, France
    AIDS 20:405-13. 2006
    ..The randomized ANRS 093 aimed at investigating whether a therapeutic immunization was effective in containing the long-term viral replication following discontinuation of antiretroviral drugs in patients...
  12. pmc HIV-specific regulatory T cells are associated with higher CD4 cell counts in primary infection
    Hassen Kared
    INSERM, Unite U841, France
    AIDS 22:2451-60. 2008
    ..Expansion of regulatory T (Treg) cells has been described in chronically HIV-infected individuals. We investigated whether HIV-suppressive Treg could be detected during primary HIV infection (PHI)...
  13. ncbi request reprint Notch increases T/NK potential of human hematopoietic progenitors and inhibits B cell differentiation at a pro-B stage
    Clarisse Benne
    INSERM, Unite U955, Creteil, France
    Stem Cells 27:1676-85. 2009
    ..These results may have implications both in physiology and for cell manipulation because they demonstrate a tight regulation of the fate of human progenitors by Notch signaling...
  14. doi request reprint IL-7 modulates in vitro and in vivo human memory T regulatory cell functions through the CD39/ATP axis
    Mehwish Younas
    INSERM U955, Institut Mondor de Recherche Biomedicale, 94010 Creteil, France
    J Immunol 191:3161-8. 2013
    ..Globally, our data show that IL-7 negatively regulates Tregs and contributes to increase the number of tools that may affect Treg function in pathology. ..
  15. ncbi request reprint HIV "elite controllers" are characterized by a high frequency of memory CD8+ CD73+ T cells involved in the antigen-specific CD8+ T-cell response
    Matthieu Carriere
    INSERM U955, Equipe 16, Creteil
    J Infect Dis 209:1321-30. 2014
    ..These observations reveal a novel mechanism involved in the control of viral replication...
  16. pmc IL-2 immunotherapy in chronically SIV-infected Rhesus macaques
    Julie Garibal
    INSERM U955 Equipe 16, Institut Mondor de Recherche Biomedicale, Creteil, F 94010, France
    Virol J 9:220. 2012
    ..Several hypotheses were evoked to explain these discrepancies. Here, we investigated the impact of low and high doses of IL-2 in Rhesus macaques of Chinese origin infected with SIVmac251 in the absence of antiretroviral therapy (ART)...
  17. doi request reprint Erythrocyte and plasma ribavirin concentrations in the assessment of early and sustained virological responses to pegylated interferon-alpha 2a and ribavirin in patients coinfected with hepatitis C virus and HIV
    Stephanie Dominguez
    Service Immunologie Clinique, Hopital Henri Mondor, Creteil, France
    J Antimicrob Chemother 67:1449-52. 2012
    ....
  18. doi request reprint A new endpoint definition improved clinical relevance and statistical power in a vaccine trial
    Gaëlle Pédrono
    INSERM, U897 and CIC EC7, Bordeaux 33076, France
    J Clin Epidemiol 62:1054-61. 2009
    ..When a vaccine includes several types of the same species, we illustrate how an endpoint combining all responses may improve clinical relevance and statistical power...
  19. ncbi request reprint HIV-1 Nef protein expression in human CD34+ progenitors impairs the differentiation of an early T/NK cell precursor
    Céline Dorival
    INSERM U 841, Faculte de Medecine, Creteil, France
    Virology 377:207-15. 2008
    ..Altogether, these data demonstrate that Nef interferes with the differentiation of a primitive lymphoid human precursor with a T/NK potential...
  20. ncbi request reprint Effects of interleukin-2 therapy combined with highly active antiretroviral therapy on immune restoration in HIV-1 infection: a randomized controlled trial
    Yves Levy
    Unit of Clinical Immunology, Hospital Henri Mondor, 51 Avenue du Marechal de Lattre de Tassigny, 94010 Creteil Cedex, France
    AIDS 17:343-51. 2003
    ..Intermittent interleukin-2 (IL-2) therapy leads to a sustained increase of CD4 T cells in HIV-1-infected patients...
  21. ncbi request reprint Primary vasculitis of the central nervous system in patients infected with HIV-1 in the HAART era
    Giovanna Melica
    Service d immunologie clinique, CHU Henri Mondor, Creteil, France
    J Med Virol 81:578-81. 2009
    ..The prognosis of these patients remain poor despite HAART. These observations suggest that the vascular inflammatory process persists despite the control of viral load under HAART in patients with persistent immunosuppression...
  22. doi request reprint AIDS progression is associated with the emergence of IL-17-producing cells early after simian immunodeficiency virus infection
    Laure Campillo-Gimenez
    Institut National de la Santé et de la Recherche Médicale U 955, Faculté de Médecine de Créteil, Hopital Henri Mondor, Creteil, France
    J Immunol 184:984-92. 2010
    ..Altogether, these results demonstrate that IL-17-producing NKT are associated with the pathogenesis of SIV in RMs and suggest that TGF-beta and IL-18 play a role in their development...
  23. pmc NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function
    Ahmad Yatim
    INSERM U955, Creteil, France
    Mol Cell 48:445-58. 2012
    ....
  24. ncbi request reprint Immunological efficacy of a prime-boost pneumococcal vaccination in HIV-infected adults
    Philippe Lesprit
    Henri Mondor Hospital, Creteil, France bINSERM U593, Bordeaux, France
    AIDS 21:2425-34. 2007
    ....
  25. doi request reprint Long-term immunogenicity of two doses of 2009 A/H1N1v vaccine with and without AS03(A) adjuvant in HIV-1-infected adults
    Christine Durier
    INSERM, SC10, Villejuif, Assistance Publique Hopitaux de Paris AP HP, Hopital Cochin, CIC de vaccinologie Cochin Pasteur, INSERM, CIC BT505, Paris, France
    AIDS 27:87-93. 2013
    ..We previously reported that the AS03A-adjuvanted 2009 A/H1N1v vaccine yielded a higher short-term immune response than the nonadjuvanted one in HIV-1-infected adults. This study reports the long-term persistence of the immune response...
  26. doi request reprint Notch activation on effector T cells increases their sensitivity to Treg cell-mediated suppression through upregulation of TGF-βRII expression
    Sophie Hue
    INSERM, Unite U955, Creteil, France
    Eur J Immunol 42:1796-803. 2012
    ..Thus, the crosstalk between Notch and the TGF-β pathway leads to potentiation of the suppressive effect of Treg cells...
  27. doi request reprint Initiation of c-ART in HIV-1 infected patients is associated with a decrease of the metabolic activity of the thymus evaluated using FDG-PET/computed tomography
    Jean Daniel Lelievre
    INSERM, Unite U955, Creteil, France
    J Acquir Immune Defic Syndr 61:56-63. 2012
    ..The role of the thymus in the depletion or restoration of T-cell pool in HIV infection is still debatable. Studies are hampered by the lack of valuable tools to investigate thymic activity...
  28. doi request reprint FcγRIIIa (CD16) induction on human T lymphocytes and CD16pos T-lymphocyte amplification
    Béatrice Clémenceau
    Institut de Recherche Thérapeutique de l Université de Nantes, INSERM, U892, France
    J Immunother 34:542-9. 2011
    ....
  29. pmc Nonpathogenesis of simian immunodeficiency virus infection is associated with reduced inflammation and recruitment of plasmacytoid dendritic cells to lymph nodes, not to lack of an interferon type I response, during the acute phase
    Laure Campillo-Gimenez
    INSERM U841, Faculté Créteil Henri Mondor, 8 rue du General Sarrail, 94010 Creteil, France
    J Virol 84:1838-46. 2010
    ....
  30. doi request reprint Maraviroc-containing regimen suppresses HIV replication in the cerebrospinal fluid of patients with neurological symptoms
    Giovanna Melica
    Department of Clinical Immunology, Henri Mondor Hospital, Université Paris XII Creteil, Creteil, France
    AIDS 24:2130-3. 2010
    ..The median (range) maraviroc concentration in plasma was 347 ng/ml (123-2678). Four patients had CSF concentrations above the protein-adjusted inhibitory concentration (IC90) of 0.57 ng/ml (0.06-10.7) with a median of 102 ng/ml (35-173)...
  31. doi request reprint Acute kidney injury in sickle patients with painful crisis or acute chest syndrome and its relation to pulmonary hypertension
    Vincent Audard
    Nephrology and Renal Transplantation Department and Institut Francilien de Recherche en Nephrologie et Transplantation IFRNT, Henri Mondor Hospital, 51 Avenue du Marechal de Lattre de Tassigny Creteil, France
    Nephrol Dial Transplant 25:2524-9. 2010
    ..The association between chronic kidney involvement and sickle cell disease (SCD) has been well characterized, but our knowledge on acute kidney injury (AKI) in relation to SCD remains limited...
  32. ncbi request reprint Interruption of antiretroviral therapy initiated during primary HIV-1 infection: impact of a therapeutic vaccination strategy combined with interleukin (IL)-2 compared with IL-2 alone in the ANRS 095 Randomized Study
    Cecile Goujard
    Service de Medecine Interne, Bicetre Hospital, AP HP, Le Kremlin Bicetre, Paris, France
    AIDS Res Hum Retroviruses 23:1105-13. 2007
    ..Treatment interruption is safe in patients treated early after primary HIV infection. On the basis of this pilot study, HIV immunizations and interleukin-2 appear to have no supplementary benefit...
  33. pmc Protease inhibitor resistance analysis in the MONARK trial comparing first-line lopinavir-ritonavir monotherapy to lopinavir-ritonavir plus zidovudine and lamivudine triple therapy
    Constance Delaugerre
    University Paris Descartes, EA 3620, Virology Department, Necker Hospital AP HP, Paris, France
    Antimicrob Agents Chemother 53:2934-9. 2009
    ..The mutation L76V may be considered in further studies of lopinavir resistance...
  34. doi request reprint Interleukin-2 before antiretroviral therapy in patients with HIV infection: a randomized trial (ANRS 119)
    Jean Michel Molina
    Assistance Publique Hopitaux de Paris, Hopital Saint Louis, France
    J Infect Dis 200:206-15. 2009
    ..Interleukin (IL)-2 increases CD4 T cell counts when combined with antiretroviral therapy (ART). Whether IL-2 alone can increase CD4 cell counts is unknown...
  35. doi request reprint Long-term (96-week) follow-up of antiretroviral-naïve HIV-infected patients treated with first-line lopinavir/ritonavir monotherapy in the MONARK trial
    Jade Ghosn
    Department of Internal Medicine and Infectious Diseases, AP HP, Bicetre University Hospital, Le Kremlin Bicetre Cedex, France
    HIV Med 11:137-42. 2010
    ..MONotherapy AntiRetroviral Kaletra (MONARK) is the first randomized trial comparing lopinavir/ritonavir monotherapy to triple combination therapy with zidovudine/lamivudine and lopinavir/ritonavir in antiretroviral-naïve patients...
  36. doi request reprint Immunogenicity and safety of an HIV-1 lipopeptide vaccine in healthy adults: a phase 2 placebo-controlled ANRS trial
    Dominique Salmon-Ceron
    Universite Paris Descartes, Assistance Publique Hopitaux de Paris, Hopital Cochin, France
    AIDS 24:2211-23. 2010
    ..Whether HIV-LIPO-5 immunogenicity varies with the dose is unknown...
  37. ncbi request reprint Immunological success is predicted by enfuvirtide but not interleukin-2 therapy in immunodepressed patients
    Jean Paul Viard
    Assistance Publique Hopitaux de Paris, Hôpital Necker Necker Enfants Malades, Universite Paris Descartes, France
    AIDS 23:1383-8. 2009
    ..To evaluate the efficacy of adding interleukin-2 (IL-2) to an optimized background treatment in HIV-1 patients with advanced failure...
  38. doi request reprint Safety and immunogenicity of 4 intramuscular double doses and 4 intradermal low doses vs standard hepatitis B vaccine regimen in adults with HIV-1: a randomized controlled trial
    Odile Launay
    Paris Descartes University, France
    JAMA 305:1432-40. 2011
    ..Alternative schedules more immunogenic than the standard hepatitis B vaccine regimen are needed in patients with human immunodeficiency virus 1 (HIV-1) infection...
  39. pmc Relationship between regulatory T cells and immune activation in human immunodeficiency virus-infected patients interrupting antiretroviral therapy
    Laurence Weiss
    Faculte de Medecine, Universite Paris Descartes, Assistance Publique Hopitaux de Paris AP HP, Hopital Europeen Georges Pompidou, Paris, France
    PLoS ONE 5:e11659. 2010
    ..However, the insufficient increase in the proportion and/or the decrease in the absolute number of Tregs result in a failure to control immune activation following TI...
  40. pmc Quantifying and predicting the effect of exogenous interleukin-7 on CD4+ T cells in HIV-1 infection
    Rodolphe Thiebaut
    INSERM, ISPED, Centre INSERM U897 Epidemiologie Biostatistique, Bordeaux, France Univ Bordeaux, ISPED, Centre INSERM U897 Epidemiologie Biostatistique, Bordeaux, France INRIA, SISTM team, Bordeaux, France
    PLoS Comput Biol 10:e1003630. 2014
    ..This in-depth analysis of clinical data revealed the potential for IL-7 to achieve sustained CD4+ T cell restoration with limited IL-7 exposure in HIV-1 infected patients with immune failure despite antiretroviral therapy. ..
  41. pmc Targeting concatenated HIV antigens to human CD40 expands a broad repertoire of multifunctional CD4+ and CD8+ T cells
    Anne Laure Flamar
    aBaylor Institute for Immunology Research, Dallas, Texas, USA bANRS HIV Vaccine Network Vaccine Research Institute, Paris cEcole doctorale Sciences de la Vie et de la Santé, Universite Paris Est, Creteil, France dINSERM U899 eNorth Texas Infectious Diseases, Dallas, Texas, USA fUniversité Paris Est, Faculte de Medecine, INSERM U955 gAssistance Publique Hôpitaux de Paris, Groupe Henri Mondor Albert Chenevier, Service d immunologie clinique, Creteil, France
    AIDS 27:2041-51. 2013
    ..HIV5pep), and then to demonstrate the capacity of this candidate therapeutic vaccine to target these HIV peptide antigens to human dendritic cells to expand functional HIV-specific T cells...
  42. pmc First evidence of subclinical renal tubular injury during sickle-cell crisis
    Vincent Audard
    Service de Nephrologie et Transplantation, Institut Francilien de recherche en Néphrologie et Transplantation IFRNT, Hopital Henri Mondor, Assistance Publique Hopitaux de Paris AP HP, Universite Paris Est Créteil UPEC, 51, ave du Marechal de Lattre de Tassigny, Creteil Cedex, 94010, France
    Orphanet J Rare Dis 9:67. 2014
    ..Arguments demonstrating that ischemia-reperfusion injury-related kidney damage might coincide with vaso-occlusive crisis (VOC) are lacking...
  43. doi request reprint Long-term CD4(+) and CD8(+) T-cell responses induced in HIV-uninfected volunteers following intradermal or intramuscular administration of an HIV-lipopeptide vaccine (ANRS VAC16)
    Odile Launay
    Universite Paris Descartes, Faculte de Medecine, INSERM, CIC BT505, Assistance Publique Hopitaux de Paris AP HP, Hopital Cochin, CIC de vaccinologie Cochin Pasteur, 27 rue du Faubourg Saint Jacques, 75014 Paris, France
    Vaccine 31:4406-15. 2013
    ..In this long-term follow-up, we aimed to investigate the sustainability and epitopic breadth of the immune responses induced...
  44. doi request reprint Successful treatment of aciclovir and foscarnet resistant Herpes simplex virus lesions with topical imiquimod in patients infected with human immunodeficiency virus type 1
    Anne Sophie Lascaux
    Department of Clinical Immunology, Hopital Henri Mondor, Creteil, France
    J Med Virol 84:194-7. 2012
    ..These patients were treated successfully with topical 5% imiquimod. Imiquimod treatment also appeared to delay the time to recurrence of HSV lesions...
  45. ncbi request reprint Short exposure to Notch ligand Delta-4 is sufficient to induce T-cell differentiation program and to increase the T cell potential of primary human CD34+ cells
    Nathalie Lefort
    INSERM U 421, Faculte de Medecine, Creteil, France
    Exp Hematol 34:1720-9. 2006
    ..The Notch pathway plays a key role in cell fate choices and in T-cell development. The goal of our study was to evaluate whether a short in vitro stimulation of the Notch pathway may alter human progenitor cell behavior...
  46. pmc Role of miR-155 in the regulation of lymphocyte immune function and disease
    Nabila Seddiki
    INSERM U955 Equipe 16, Institut Mondor de Recherche Biomedicale, Creteil, France The Vaccine Research Institute VRI and Université Paris Est Créteil UPEC, Creteil, France
    Immunology 142:32-8. 2014
    ....
  47. ncbi request reprint [Specific immunotherapy for HIV infection: objectives and limits]
    Yves Levy
    Service d immunologie clinique, Hopital Henri Mondor, Creteil, France
    Therapie 60:267-9. 2005
  48. doi request reprint Acute interstitial nephritis with predominant plasmacytic infiltration in patients with HIV-1 infection
    Giovanna Melica
    Clinical Immunology Department, AP HP, Groupe Henri Mondor Albert Chenevier and Université Paris Est Créteil, Creteil, France
    Am J Kidney Dis 59:711-4. 2012
    ..The acute interstitial nephritis probably was induced by HIV-1-driven nonspecific B-cell activation. Further investigations are needed to confirm the direct pathogenic role of HIV-1...
  49. ncbi request reprint Autoimmune thrombocytopenic purpura and common variable immunodeficiency: analysis of 21 cases and review of the literature
    Marc Michel
    Department of Internal Medicine, Hopital Henri Mondor, Assistance Publique Hopitaux de Paris, Creteil, France
    Medicine (Baltimore) 83:254-63. 2004
    ..Steroids and splenectomy seem to have the same efficacy as in idiopathic AITP, but the increased risk of severe infections must be taken into consideration...
  50. ncbi request reprint Perspectives on interleukin-7 therapy in HIV infection
    Jean Daniel Lelievre
    Service d immunologie clinique, Hopital Henri Mondor, Universite Paris, Creteil, France
    Curr Opin HIV AIDS 2:228-33. 2007
    ..Because of its pleiotropic effects on developing and mature T cells, interleukin-7 may help to restore immune function during HIV infection...