Yves Levy

Summary

Country: France

Publications

  1. ncbi request reprint [Specific immunotherapy for HIV infection: objectives and limits]
    Yves Levy
    Service d immunologie clinique, Hopital Henri Mondor, Creteil, France
    Therapie 60:267-9. 2005
  2. ncbi request reprint Comparison of subcutaneous and intravenous interleukin-2 in asymptomatic HIV-1 infection: a randomised controlled trial. ANRS 048 study group
    Y Levy
    Unité d Immunologie Clinique, Hopital Henri Mondor, Creteil, France
    Lancet 353:1923-9. 1999
  3. ncbi request reprint Sustained control of viremia following therapeutic immunization in chronically HIV-1-infected individuals
    Yves Levy
    Hopital Henri Mondor, 51 av Mal de Lattre de Tassigny, 94010 Creteil, France
    AIDS 20:405-13. 2006
  4. ncbi request reprint Immunological and virological efficacy of a therapeutic immunization combined with interleukin-2 in chronically HIV-1 infected patients
    Yves Levy
    Unité d Immunologie Clinique, Hopital Henri Mondor, 51 Avenue du Marechal de Lattre de Tassigny, 94010 Creteil Cedex, Paris, France
    AIDS 19:279-86. 2005
  5. doi request reprint Genomewide association study of an AIDS-nonprogression cohort emphasizes the role played by HLA genes (ANRS Genomewide Association Study 02)
    Sophie Limou
    Conservatoire National des Arts et Metiers, Universite Paris 7, Paris, France
    J Infect Dis 199:419-26. 2009
  6. doi request reprint AIDS progression is associated with the emergence of IL-17-producing cells early after simian immunodeficiency virus infection
    Laure Campillo-Gimenez
    Institut National de la Santé et de la Recherche Médicale U 955, Faculté de Médecine de Créteil, Hopital Henri Mondor, Creteil, France
    J Immunol 184:984-92. 2010
  7. pmc Enhanced T cell recovery in HIV-1-infected adults through IL-7 treatment
    Yves Levy
    1INSERM U955, Universite Paris 12, and Assistance Publique Hôpitaux de Paris AP HP, Groupe Henri Mondor Albert Chenevier, Immunologie Clinique, Creteil, France
    J Clin Invest 119:997-1007. 2009
  8. ncbi request reprint Interruption of antiretroviral therapy initiated during primary HIV-1 infection: impact of a therapeutic vaccination strategy combined with interleukin (IL)-2 compared with IL-2 alone in the ANRS 095 Randomized Study
    Cecile Goujard
    Service de Medecine Interne, Bicetre Hospital, AP HP, Le Kremlin Bicetre, Paris, France
    AIDS Res Hum Retroviruses 23:1105-13. 2007
  9. doi request reprint Cellular CD4 T cell responses to the diphtheria-derived carrier protein of conjugated pneumococcal vaccine and antibody response to pneumococcal vaccination in HIV-infected adults
    Claire Rabian
    Laboratoire d Immunologie et d Histocompatibilité, St Louis Hospital, Paris, France
    Clin Infect Dis 50:1174-83. 2010
  10. pmc Regulatory T cells negatively affect IL-2 production of effector T cells through CD39/adenosine pathway in HIV infection
    Mohammad Ali Jenabian
    Université Paris Est Créteil, Creteil, France
    PLoS Pathog 9:e1003319. 2013

Detail Information

Publications50

  1. ncbi request reprint [Specific immunotherapy for HIV infection: objectives and limits]
    Yves Levy
    Service d immunologie clinique, Hopital Henri Mondor, Creteil, France
    Therapie 60:267-9. 2005
  2. ncbi request reprint Comparison of subcutaneous and intravenous interleukin-2 in asymptomatic HIV-1 infection: a randomised controlled trial. ANRS 048 study group
    Y Levy
    Unité d Immunologie Clinique, Hopital Henri Mondor, Creteil, France
    Lancet 353:1923-9. 1999
    ..We did a randomised study to compare safety and efficacy of antiviral treatment alone or combined with various interleukin-2 regimens in HIV-1-infected patients...
  3. ncbi request reprint Sustained control of viremia following therapeutic immunization in chronically HIV-1-infected individuals
    Yves Levy
    Hopital Henri Mondor, 51 av Mal de Lattre de Tassigny, 94010 Creteil, France
    AIDS 20:405-13. 2006
    ..The randomized ANRS 093 aimed at investigating whether a therapeutic immunization was effective in containing the long-term viral replication following discontinuation of antiretroviral drugs in patients...
  4. ncbi request reprint Immunological and virological efficacy of a therapeutic immunization combined with interleukin-2 in chronically HIV-1 infected patients
    Yves Levy
    Unité d Immunologie Clinique, Hopital Henri Mondor, 51 Avenue du Marechal de Lattre de Tassigny, 94010 Creteil Cedex, Paris, France
    AIDS 19:279-86. 2005
    ..Several lines of evidence suggest that the immune system may control HIV-1 replication, but that it could fail in the long term. Strategies aimed to elicit specific immune responses may enable patients to contain virus replication...
  5. doi request reprint Genomewide association study of an AIDS-nonprogression cohort emphasizes the role played by HLA genes (ANRS Genomewide Association Study 02)
    Sophie Limou
    Conservatoire National des Arts et Metiers, Universite Paris 7, Paris, France
    J Infect Dis 199:419-26. 2009
    ..The present study, the first GWAS of HIV-1 nonprogressors, underscores the potential for some HLA genes to control disease progression soon after infection...
  6. doi request reprint AIDS progression is associated with the emergence of IL-17-producing cells early after simian immunodeficiency virus infection
    Laure Campillo-Gimenez
    Institut National de la Santé et de la Recherche Médicale U 955, Faculté de Médecine de Créteil, Hopital Henri Mondor, Creteil, France
    J Immunol 184:984-92. 2010
    ..Altogether, these results demonstrate that IL-17-producing NKT are associated with the pathogenesis of SIV in RMs and suggest that TGF-beta and IL-18 play a role in their development...
  7. pmc Enhanced T cell recovery in HIV-1-infected adults through IL-7 treatment
    Yves Levy
    1INSERM U955, Universite Paris 12, and Assistance Publique Hôpitaux de Paris AP HP, Groupe Henri Mondor Albert Chenevier, Immunologie Clinique, Creteil, France
    J Clin Invest 119:997-1007. 2009
    ..Therefore, patients may benefit from intermittent therapy with IL-7 in combination with c-ART...
  8. ncbi request reprint Interruption of antiretroviral therapy initiated during primary HIV-1 infection: impact of a therapeutic vaccination strategy combined with interleukin (IL)-2 compared with IL-2 alone in the ANRS 095 Randomized Study
    Cecile Goujard
    Service de Medecine Interne, Bicetre Hospital, AP HP, Le Kremlin Bicetre, Paris, France
    AIDS Res Hum Retroviruses 23:1105-13. 2007
    ..Treatment interruption is safe in patients treated early after primary HIV infection. On the basis of this pilot study, HIV immunizations and interleukin-2 appear to have no supplementary benefit...
  9. doi request reprint Cellular CD4 T cell responses to the diphtheria-derived carrier protein of conjugated pneumococcal vaccine and antibody response to pneumococcal vaccination in HIV-infected adults
    Claire Rabian
    Laboratoire d Immunologie et d Histocompatibilité, St Louis Hospital, Paris, France
    Clin Infect Dis 50:1174-83. 2010
    ..CD4 T cell responses specific to the diphtheria-derived carrier protein CRM(197) were evaluated...
  10. pmc Regulatory T cells negatively affect IL-2 production of effector T cells through CD39/adenosine pathway in HIV infection
    Mohammad Ali Jenabian
    Université Paris Est Créteil, Creteil, France
    PLoS Pathog 9:e1003319. 2013
    ..These results extend previous data on the role of Treg in HIV infection by filling the gap between expansion of Treg/CD39+ in HIV infection and the suppression of CD4+ T-cell function through inhibition of IL-2 production...
  11. doi request reprint IL-7 modulates in vitro and in vivo human memory T regulatory cell functions through the CD39/ATP axis
    Mehwish Younas
    INSERM U955, Institut Mondor de Recherche Biomedicale, 94010 Creteil, France
    J Immunol 191:3161-8. 2013
    ..Globally, our data show that IL-7 negatively regulates Tregs and contributes to increase the number of tools that may affect Treg function in pathology. ..
  12. doi request reprint Erythrocyte and plasma ribavirin concentrations in the assessment of early and sustained virological responses to pegylated interferon-alpha 2a and ribavirin in patients coinfected with hepatitis C virus and HIV
    Stephanie Dominguez
    Service Immunologie Clinique, Hopital Henri Mondor, Creteil, France
    J Antimicrob Chemother 67:1449-52. 2012
    ....
  13. ncbi request reprint Notch increases T/NK potential of human hematopoietic progenitors and inhibits B cell differentiation at a pro-B stage
    Clarisse Benne
    INSERM, Unite U955, Creteil, France
    Stem Cells 27:1676-85. 2009
    ..These results may have implications both in physiology and for cell manipulation because they demonstrate a tight regulation of the fate of human progenitors by Notch signaling...
  14. pmc Relationship between regulatory T cells and immune activation in human immunodeficiency virus-infected patients interrupting antiretroviral therapy
    Laurence Weiss
    Faculte de Medecine, Universite Paris Descartes, Assistance Publique Hopitaux de Paris AP HP, Hopital Europeen Georges Pompidou, Paris, France
    PLoS ONE 5:e11659. 2010
    ..However, the insufficient increase in the proportion and/or the decrease in the absolute number of Tregs result in a failure to control immune activation following TI...
  15. pmc IL-2 immunotherapy in chronically SIV-infected Rhesus macaques
    Julie Garibal
    INSERM U955 Equipe 16, Institut Mondor de Recherche Biomedicale, Creteil, F 94010, France
    Virol J 9:220. 2012
    ..Several hypotheses were evoked to explain these discrepancies. Here, we investigated the impact of low and high doses of IL-2 in Rhesus macaques of Chinese origin infected with SIVmac251 in the absence of antiretroviral therapy (ART)...
  16. ncbi request reprint Identification of IL7RA risk alleles for rapid progression during HIV-1 infection: a comprehensive study in the GRIV cohort
    Sophie Limou
    Conservatoire National des Arts et Metiers, Chaire de Bioinformatique, Paris, France
    Curr HIV Res 10:143-50. 2012
    ..g., multiple sclerosis) by GWAS and by functional studies. Our results contribute to the growing understanding of the role of IL7/IL7R in HIV disease progression, and more widely, in CD4+ T cell homeostasis...
  17. doi request reprint Initiation of c-ART in HIV-1 infected patients is associated with a decrease of the metabolic activity of the thymus evaluated using FDG-PET/computed tomography
    Jean Daniel Lelievre
    INSERM, Unite U955, Creteil, France
    J Acquir Immune Defic Syndr 61:56-63. 2012
    ..The role of the thymus in the depletion or restoration of T-cell pool in HIV infection is still debatable. Studies are hampered by the lack of valuable tools to investigate thymic activity...
  18. doi request reprint Effect of intermittent interleukin-2 therapy on CD4+ T-cell counts following antiretroviral cessation in patients with HIV
    Yves Levy
    INSERM, Unité U, Groupe Henri Mondor Albert Chenevier, Service d immunologie clinique, Creteil, France
    AIDS 26:711-20. 2012
    ..Interleukin (IL)-2 therapy impacts T-cell homeostasis. Whether IL-2 expanded CD4(+) T cells may persist following viral rebound has not been fully investigated...
  19. ncbi request reprint Effects of interleukin-2 therapy combined with highly active antiretroviral therapy on immune restoration in HIV-1 infection: a randomized controlled trial
    Yves Levy
    Unit of Clinical Immunology, Hospital Henri Mondor, 51 Avenue du Marechal de Lattre de Tassigny, 94010 Creteil Cedex, France
    AIDS 17:343-51. 2003
    ..Intermittent interleukin-2 (IL-2) therapy leads to a sustained increase of CD4 T cells in HIV-1-infected patients...
  20. pmc CD39/adenosine pathway is involved in AIDS progression
    Maria Nikolova
    INSERM, Unite U955, Creteil, France
    PLoS Pathog 7:e1002110. 2011
    ..Finally, in a genetic association study performed in three different cohorts, we identified a CD39 gene polymorphism that was associated with down-modulated CD39 expression and a slower progression to AIDS...
  21. pmc Nonpathogenesis of simian immunodeficiency virus infection is associated with reduced inflammation and recruitment of plasmacytoid dendritic cells to lymph nodes, not to lack of an interferon type I response, during the acute phase
    Laure Campillo-Gimenez
    INSERM U841, Faculté Créteil Henri Mondor, 8 rue du General Sarrail, 94010 Creteil, France
    J Virol 84:1838-46. 2010
    ....
  22. pmc Regulatory T cells differentially modulate the maturation and apoptosis of human CD8+ T-cell subsets
    Maria Nikolova
    INSERM U955, Creteil, France
    Blood 113:4556-65. 2009
    ..Thus, in the setting of a healthy immune system, Treg cells fine-tune the memory/effector cell balance and promote the accumulation of long-living memory cells in case of strong stimulation...
  23. ncbi request reprint High-dose therapy plus autologous hematopoietic stem cell transplantation for human immunodeficiency virus (HIV)-related lymphoma: results and impact on HIV disease
    Jean Gabarre
    Service d Hematologie, Hopital Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Paris, France
    Haematologica 89:1100-8. 2004
    ....
  24. ncbi request reprint HIV-1 Nef protein expression in human CD34+ progenitors impairs the differentiation of an early T/NK cell precursor
    Céline Dorival
    INSERM U 841, Faculte de Medecine, Creteil, France
    Virology 377:207-15. 2008
    ..Altogether, these data demonstrate that Nef interferes with the differentiation of a primitive lymphoid human precursor with a T/NK potential...
  25. doi request reprint Subcapsular sinus macrophages promote NK cell accumulation and activation in response to lymph-borne viral particles
    Zacarias Garcia
    Institut Pasteur, Dynamics of Immune Responses Unit, Paris, France
    Blood 120:4744-50. 2012
    ..Our results identify SCS macrophages as primary mediators of NK cell activation in response to lymph-borne viral particles suggesting that they act as early sensors of local infection or delivery of viral-based vaccines...
  26. ncbi request reprint Primary vasculitis of the central nervous system in patients infected with HIV-1 in the HAART era
    Giovanna Melica
    Service d immunologie clinique, CHU Henri Mondor, Creteil, France
    J Med Virol 81:578-81. 2009
    ..The prognosis of these patients remain poor despite HAART. These observations suggest that the vascular inflammatory process persists despite the control of viral load under HAART in patients with persistent immunosuppression...
  27. doi request reprint Long-term immunogenicity of two doses of 2009 A/H1N1v vaccine with and without AS03(A) adjuvant in HIV-1-infected adults
    Christine Durier
    INSERM, SC10, Villejuif, Assistance Publique Hopitaux de Paris AP HP, Hopital Cochin, CIC de vaccinologie Cochin Pasteur, INSERM, CIC BT505, Paris, France
    AIDS 27:87-93. 2013
    ..We previously reported that the AS03A-adjuvanted 2009 A/H1N1v vaccine yielded a higher short-term immune response than the nonadjuvanted one in HIV-1-infected adults. This study reports the long-term persistence of the immune response...
  28. doi request reprint Maraviroc-containing regimen suppresses HIV replication in the cerebrospinal fluid of patients with neurological symptoms
    Giovanna Melica
    Department of Clinical Immunology, Henri Mondor Hospital, Université Paris XII Creteil, Creteil, France
    AIDS 24:2130-3. 2010
    ..The median (range) maraviroc concentration in plasma was 347 ng/ml (123-2678). Four patients had CSF concentrations above the protein-adjusted inhibitory concentration (IC90) of 0.57 ng/ml (0.06-10.7) with a median of 102 ng/ml (35-173)...
  29. doi request reprint Notch activation on effector T cells increases their sensitivity to Treg cell-mediated suppression through upregulation of TGF-βRII expression
    Sophie Hue
    INSERM, Unite U955, Creteil, France
    Eur J Immunol 42:1796-803. 2012
    ..Thus, the crosstalk between Notch and the TGF-β pathway leads to potentiation of the suppressive effect of Treg cells...
  30. doi request reprint Successful treatment of aciclovir and foscarnet resistant Herpes simplex virus lesions with topical imiquimod in patients infected with human immunodeficiency virus type 1
    Anne Sophie Lascaux
    Department of Clinical Immunology, Hopital Henri Mondor, Creteil, France
    J Med Virol 84:194-7. 2012
    ..These patients were treated successfully with topical 5% imiquimod. Imiquimod treatment also appeared to delay the time to recurrence of HSV lesions...
  31. pmc Targeting concatenated HIV antigens to human CD40 expands a broad repertoire of multifunctional CD4+ and CD8+ T cells
    Anne Laure Flamar
    aBaylor Institute for Immunology Research, Dallas, Texas, USA bANRS HIV Vaccine Network Vaccine Research Institute, Paris cEcole doctorale Sciences de la Vie et de la Santé, Universite Paris Est, Creteil, France dINSERM U899 eNorth Texas Infectious Diseases, Dallas, Texas, USA fUniversité Paris Est, Faculte de Medecine, INSERM U955 gAssistance Publique Hôpitaux de Paris, Groupe Henri Mondor Albert Chenevier, Service d immunologie clinique, Creteil, France
    AIDS 27:2041-51. 2013
    ..HIV5pep), and then to demonstrate the capacity of this candidate therapeutic vaccine to target these HIV peptide antigens to human dendritic cells to expand functional HIV-specific T cells...
  32. pmc NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function
    Ahmad Yatim
    INSERM U955, Creteil, France
    Mol Cell 48:445-58. 2012
    ....
  33. pmc Altered thymic function during interferon therapy in HCV-infected patients
    Stéphanie Beq
    Departement de Virologie, Institut Pasteur, Paris, France
    PLoS ONE 7:e34326. 2012
    ..Altogether, this study suggests the therapeutic potential of IL-7 in the maintenance of peripheral T-cell homeostasis in IFNα-treated patients...
  34. ncbi request reprint Therapeutic HIV vaccines: an update
    Yves Levy
    Service d immunologie clinique, Hopital Henri Mondor, 51 Avenue du Marechal de Lattre de Tassigny, 94010 Creteil, France
    Curr HIV/AIDS Rep 2:5-9. 2005
    ..In clinical terms, this might allow patients to delay or to stop antiviral therapy and to minimize the duration of the exposition to antiviral drugs...
  35. ncbi request reprint Human immunodeficiency virus-driven expansion of CD4+CD25+ regulatory T cells, which suppress HIV-specific CD4 T-cell responses in HIV-infected patients
    Laurence Weiss
    Institut National de la Santé et de la Recherche Médicale U430, University of Paris V, France
    Blood 104:3249-56. 2004
    ..Taken together, our results suggest that persistence of HIV antigens might trigger the expansion of CD4(+)CD25(+) regulatory T cells, which might induce a tolerance to HIV in vivo...
  36. pmc Role of miR-155 in the regulation of lymphocyte immune function and disease
    Nabila Seddiki
    INSERM U955 Equipe 16, Institut Mondor de Recherche Biomedicale, Creteil, France The Vaccine Research Institute VRI and Université Paris Est Créteil UPEC, Creteil, France
    Immunology 142:32-8. 2014
    ....
  37. pmc First evidence of subclinical renal tubular injury during sickle-cell crisis
    Vincent Audard
    Service de Nephrologie et Transplantation, Institut Francilien de recherche en Néphrologie et Transplantation IFRNT, Hopital Henri Mondor, Assistance Publique Hopitaux de Paris AP HP, Universite Paris Est Créteil UPEC, 51, ave du Marechal de Lattre de Tassigny, Creteil Cedex, 94010, France
    Orphanet J Rare Dis 9:67. 2014
    ..Arguments demonstrating that ischemia-reperfusion injury-related kidney damage might coincide with vaso-occlusive crisis (VOC) are lacking...
  38. ncbi request reprint Immunological efficacy of a prime-boost pneumococcal vaccination in HIV-infected adults
    Philippe Lesprit
    Henri Mondor Hospital, Creteil, France bINSERM U593, Bordeaux, France
    AIDS 21:2425-34. 2007
    ....
  39. doi request reprint Acute interstitial nephritis with predominant plasmacytic infiltration in patients with HIV-1 infection
    Giovanna Melica
    Clinical Immunology Department, AP HP, Groupe Henri Mondor Albert Chenevier and Université Paris Est Créteil, Creteil, France
    Am J Kidney Dis 59:711-4. 2012
    ..The acute interstitial nephritis probably was induced by HIV-1-driven nonspecific B-cell activation. Further investigations are needed to confirm the direct pathogenic role of HIV-1...
  40. pmc Early divergence in neutrophil apoptosis between pathogenic and nonpathogenic simian immunodeficiency virus infections of nonhuman primates
    Carole Elbim
    Faculte de Medecine, Service d Immunologie et d Hématologie, Assistance Publique Hopitaux de Paris, Centre Hospitalier Universitaire Xavier Bichat, Universite Paris 7 Denis Diderot, Paris, France
    J Immunol 181:8613-23. 2008
    ..This may account for the decline in PMN numbers that occurs during primary SIV infection in pathogenic SIV infection and may have important implications for subsequent viral replication and disease progression...
  41. ncbi request reprint [Cytokine therapies in HIV infection]
    Yves Levy
    Service d immunologie clinique, Hopital Henri Mondor, 51, Avenue du Marechal de Lattre de Tassigny, 94010 Creteil Cedex, France
    Med Sci (Paris) 22:751-4. 2006
    ..Although no data in human are still available, recent studies provide arguments to assess this cytokine in HIV infection. Phase I studies are ongoing or planned...
  42. pmc Preclinical studies of a modified vaccinia virus Ankara-based HIV candidate vaccine: antigen presentation and antiviral effect
    Samantha Brandler
    Unité Virus et Immunite, Institut Pasteur, URA CNRS 3015, Paris, France
    J Virol 84:5314-28. 2010
    ..Deciphering the immune responses to MVA in culture experiments will help in the design of innovative vaccine strategies...
  43. doi request reprint Major histocompatibility complex class II expression deficiency caused by a RFXANK founder mutation: a survey of 35 patients
    Monia Ouederni
    Pediatric Hematology Immunology Unit, Assistance Publique Hopitaux de Paris, Necker Hospital, France
    Blood 118:5108-18. 2011
    ..RFXANK deficiency is a severe, often fatal CID for which HSCT is the only curative treatment. However, some patients may survive for relatively long periods if multiple prophylactic measures are implemented...
  44. doi request reprint Genomewide association study of a rapid progression cohort identifies new susceptibility alleles for AIDS (ANRS Genomewide Association Study 03)
    Sigrid Le Clerc
    Conservatoire National des Arts et Metiers, Paris, France
    J Infect Dis 200:1194-201. 2009
    ..The discovery of genetic factors that predispose individuals to rapid progression to AIDS should also reveal new insights into the molecular etiology of the pathology...
  45. ncbi request reprint Autoimmune thrombocytopenic purpura and common variable immunodeficiency: analysis of 21 cases and review of the literature
    Marc Michel
    Department of Internal Medicine, Hopital Henri Mondor, Assistance Publique Hopitaux de Paris, Creteil, France
    Medicine (Baltimore) 83:254-63. 2004
    ..Steroids and splenectomy seem to have the same efficacy as in idiopathic AITP, but the increased risk of severe infections must be taken into consideration...
  46. ncbi request reprint Short exposure to Notch ligand Delta-4 is sufficient to induce T-cell differentiation program and to increase the T cell potential of primary human CD34+ cells
    Nathalie Lefort
    INSERM U 421, Faculte de Medecine, Creteil, France
    Exp Hematol 34:1720-9. 2006
    ..The Notch pathway plays a key role in cell fate choices and in T-cell development. The goal of our study was to evaluate whether a short in vitro stimulation of the Notch pathway may alter human progenitor cell behavior...
  47. pmc Protease inhibitor resistance analysis in the MONARK trial comparing first-line lopinavir-ritonavir monotherapy to lopinavir-ritonavir plus zidovudine and lamivudine triple therapy
    Constance Delaugerre
    University Paris Descartes, EA 3620, Virology Department, Necker Hospital AP HP, Paris, France
    Antimicrob Agents Chemother 53:2934-9. 2009
    ..The mutation L76V may be considered in further studies of lopinavir resistance...
  48. ncbi request reprint Perspectives on interleukin-7 therapy in HIV infection
    Jean Daniel Lelievre
    Service d immunologie clinique, Hopital Henri Mondor, Universite Paris, Creteil, France
    Curr Opin HIV AIDS 2:228-33. 2007
    ..Because of its pleiotropic effects on developing and mature T cells, interleukin-7 may help to restore immune function during HIV infection...
  49. doi request reprint Safety, tolerability, pharmacokinetics, and efficacy of an interleukin-2 agonist among HIV-infected patients receiving highly active antiretroviral therapy
    Richard T Davey
    National Institutes of Health, National Institute of Allergy and Infectious Disease, Bethesda, MD 20892, USA
    J Interferon Cytokine Res 28:89-100. 2008
    ..Bay 50-4798 was generally well tolerated across the dose range tested, but a lack of potent, sustained immunologic activity suggests that further optimization of dose and schedule will be necessary...
  50. ncbi request reprint CD4 regulation in human lymphoid non-T-cells: a role for the silencer element
    Enguerran Mouly
    Université Pierre et Marie Curie CNRS UMR 7087, Groupe Hospitalier Pitie Salpetriere, 83 Boulevard de l hopital, 75651 Paris Cedex 13, France
    Mol Immunol 44:267-75. 2007
    ..Collectively, our results suggest that beyond its well-characterized function in T-cells, the CD4 silencer also regulates CD4 gene expression in human lymphoid non-T-cells...