Francis Levi

Summary

Country: France

Publications

  1. doi request reprint The circadian timing system: a coordinator of life processes: chronobiological investigations. Implications for the rhythmic delivery of cancer therapeutics
    Francis A Lévi
    U 776 INSERM, Rythmes Biologiques et Cancers, Hopital Paul Brousse, Villejuif, France
    IEEE Eng Med Biol Mag 27:17-9. 2008
  2. ncbi request reprint Chronotherapeutics: the relevance of timing in cancer therapy
    Francis Levi
    INSERM E0354 Chronothérapeutique des cancers, Hôpital Paul Brousse I C I G, 94807 Villejuif Cedex, France
    Cancer Causes Control 17:611-21. 2006
  3. ncbi request reprint The circadian rest-activity rhythm, a potential safety pharmacology endpoint of cancer chemotherapy
    Elisabet Ortiz-Tudela
    Department of Physiology Chronobiology Laboratory, University of Murcia, Murcia, Spain Inserm, UMRS776, Biological Rhythms and Cancers, Villejuif, France
    Int J Cancer 134:2717-25. 2014
  4. ncbi request reprint Phase III trial comparing 4-day chronomodulated therapy versus 2-day conventional delivery of fluorouracil, leucovorin, and oxaliplatin as first-line chemotherapy of metastatic colorectal cancer: the European Organisation for Research and Treatment of Can
    Sylvie Giacchetti
    Hopital Paul Brousse and INSERM, Villejuif, France
    J Clin Oncol 24:3562-9. 2006
  5. ncbi request reprint Chronomodulated irinotecan, oxaliplatin, and leucovorin-modulated 5-Fluorouracil as ambulatory salvage therapy in patients with irinotecan- and oxaliplatin-resistant metastatic colorectal cancer
    Dany Gholam
    INSERM U776 Rythmes Biologiques et Cancers, Hopital Paul Brousse, Villejuif, France
    Oncologist 11:1072-80. 2006
  6. doi request reprint Cetuximab and circadian chronomodulated chemotherapy as salvage treatment for metastatic colorectal cancer (mCRC): safety, efficacy and improved secondary surgical resectability
    Francis Levi
    INSERM, U776 Rythmes biologiques et cancers, Hopital Paul Brousse, 14 avenue Paul Vaillant Couturier, 94807 Villejuif Cedex, France
    Cancer Chemother Pharmacol 67:339-48. 2011
  7. doi request reprint Sex and dosing-time dependencies in irinotecan-induced circadian disruption
    Constance Ahowesso
    INSERM, UMRS 776 Rythmes biologique et cancers, Hopital Paul Brousse, Villejuif, France
    Chronobiol Int 28:458-70. 2011
  8. pmc Tumor marker evolution: comparison with imaging for assessment of response to chemotherapy in patients with colorectal liver metastases
    Robbert J de Haas
    Centre Hepato Biliaire, AP HP Hopital Paul Brousse, Villejuif, France
    Ann Surg Oncol 17:1010-23. 2010
  9. ncbi request reprint Disruption of circadian coordination accelerates malignant growth in mice
    Elisabeth Filipski
    INSERM E 0654 Chronotherapeutique des cancers Université Paris XI, Hopital Paul Brousse, 94800, Villejuif, France
    Pathol Biol (Paris) 51:216-9. 2003
  10. ncbi request reprint Liver histology and surgical outcomes after preoperative chemotherapy with fluorouracil plus oxaliplatin in colorectal cancer liver metastases
    Thomas Aloia
    Department of Hepatobiliary Surgery and Liver Transplantation, Paul Brousse Hospital, Villejuif, France
    J Clin Oncol 24:4983-90. 2006

Collaborators

Detail Information

Publications44

  1. doi request reprint The circadian timing system: a coordinator of life processes: chronobiological investigations. Implications for the rhythmic delivery of cancer therapeutics
    Francis A Lévi
    U 776 INSERM, Rythmes Biologiques et Cancers, Hopital Paul Brousse, Villejuif, France
    IEEE Eng Med Biol Mag 27:17-9. 2008
  2. ncbi request reprint Chronotherapeutics: the relevance of timing in cancer therapy
    Francis Levi
    INSERM E0354 Chronothérapeutique des cancers, Hôpital Paul Brousse I C I G, 94807 Villejuif Cedex, France
    Cancer Causes Control 17:611-21. 2006
    ..This circadian organization is responsible for predictable changes in the tolerability and efficacy of anticancer agents, and possibly also in tumor promotion or growth...
  3. ncbi request reprint The circadian rest-activity rhythm, a potential safety pharmacology endpoint of cancer chemotherapy
    Elisabet Ortiz-Tudela
    Department of Physiology Chronobiology Laboratory, University of Murcia, Murcia, Spain Inserm, UMRS776, Biological Rhythms and Cancers, Villejuif, France
    Int J Cancer 134:2717-25. 2014
    ..Improved clinical tolerability could result from the minimization of circadian disruption through the personalization of chronotherapy delivery...
  4. ncbi request reprint Phase III trial comparing 4-day chronomodulated therapy versus 2-day conventional delivery of fluorouracil, leucovorin, and oxaliplatin as first-line chemotherapy of metastatic colorectal cancer: the European Organisation for Research and Treatment of Can
    Sylvie Giacchetti
    Hopital Paul Brousse and INSERM, Villejuif, France
    J Clin Oncol 24:3562-9. 2006
    ..In two previous randomized trials, the adjustment of chemotherapy delivery to circadian rhythms improved tolerability and anticancer activity compared with constant-rate infusion during 5 days in patients with metastatic colorectal cancer...
  5. ncbi request reprint Chronomodulated irinotecan, oxaliplatin, and leucovorin-modulated 5-Fluorouracil as ambulatory salvage therapy in patients with irinotecan- and oxaliplatin-resistant metastatic colorectal cancer
    Dany Gholam
    INSERM U776 Rythmes Biologiques et Cancers, Hopital Paul Brousse, Villejuif, France
    Oncologist 11:1072-80. 2006
    ..Patients and..
  6. doi request reprint Cetuximab and circadian chronomodulated chemotherapy as salvage treatment for metastatic colorectal cancer (mCRC): safety, efficacy and improved secondary surgical resectability
    Francis Levi
    INSERM, U776 Rythmes biologiques et cancers, Hopital Paul Brousse, 14 avenue Paul Vaillant Couturier, 94807 Villejuif Cedex, France
    Cancer Chemother Pharmacol 67:339-48. 2011
    ..We hypothesized that EGFR blockade with cetuximab would enhance the activity of chronotherapy as a result of improved circadian coordination...
  7. doi request reprint Sex and dosing-time dependencies in irinotecan-induced circadian disruption
    Constance Ahowesso
    INSERM, UMRS 776 Rythmes biologique et cancers, Hopital Paul Brousse, Villejuif, France
    Chronobiol Int 28:458-70. 2011
    ..Thus, the optimal circadian timing of chemotherapy requires precise determination according to sex, and should involve the noninvasive monitoring of circadian biomarkers...
  8. pmc Tumor marker evolution: comparison with imaging for assessment of response to chemotherapy in patients with colorectal liver metastases
    Robbert J de Haas
    Centre Hepato Biliaire, AP HP Hopital Paul Brousse, Villejuif, France
    Ann Surg Oncol 17:1010-23. 2010
    ....
  9. ncbi request reprint Disruption of circadian coordination accelerates malignant growth in mice
    Elisabeth Filipski
    INSERM E 0654 Chronotherapeutique des cancers Université Paris XI, Hopital Paul Brousse, 94800, Villejuif, France
    Pathol Biol (Paris) 51:216-9. 2003
    ..This shows that disruption of circadian coordination accelerates malignant growth in mice, suggesting that the host circadian clock controls tumor progression...
  10. ncbi request reprint Liver histology and surgical outcomes after preoperative chemotherapy with fluorouracil plus oxaliplatin in colorectal cancer liver metastases
    Thomas Aloia
    Department of Hepatobiliary Surgery and Liver Transplantation, Paul Brousse Hospital, Villejuif, France
    J Clin Oncol 24:4983-90. 2006
    ..Preoperative chemotherapy for colorectal liver metastases (CLM) can produce histologic changes in the nontumor-bearing liver (NTBL) that may impact on surgical outcomes...
  11. doi request reprint Fatigue and weight loss predict survival on circadian chemotherapy for metastatic colorectal cancer
    Pasquale F Innominato
    National Institute for Health and Medical Research INSERM Unit 776, Biological Rhythms and Cancers, Villejuif, France
    Cancer 119:2564-73. 2013
    ..The authors hypothesized that the early occurrence of chemotherapy-induced symptoms correlated with circadian disruption would selectively hinder the efficacy of chronotherapy...
  12. pmc Regenerative nodular hyperplasia of the liver related to chemotherapy: impact on outcome of liver surgery for colorectal metastases
    Dennis A Wicherts
    Centre Hepato Biliaire, AP HP Hopital Paul Brousse, Villejuif, France
    Ann Surg Oncol 18:659-69. 2011
    ..The goal was to evaluate its incidence and impact on the outcome of patients resected for colorectal liver metastases (CLM)...
  13. doi request reprint Prediction of survival by neutropenia according to delivery schedule of oxaliplatin-5-Fluorouracil-leucovorin for metastatic colorectal cancer in a randomized international trial (EORTC 05963)
    Pasquale F Innominato
    INSERM, U776, Biological Rhythms and Cancers, Villejuif, France
    Chronobiol Int 28:586-600. 2011
    ..The opposite trend shown here for chronoFLO4 supports the novel concept of jointly optimized hematologic tolerability and efficacy through personalized circadian-timed therapy...
  14. ncbi request reprint Effects of light and food schedules on liver and tumor molecular clocks in mice
    Elisabeth Filipski
    INSERM E 0354 Chronothérapeutique des Cancers, Hôpital P Brousse and Université Paris XI, 94807 Villejuif Cedex, France
    J Natl Cancer Inst 97:507-17. 2005
    ..Disrupted circadian coordination accelerates malignant growth, but the molecular mechanism is unclear...
  15. pmc Tumor progression while on chemotherapy: a contraindication to liver resection for multiple colorectal metastases?
    Rene Adam
    Centre Hepato Biliaire, Hopital Paul Brousse, 14 Av PV Couturier, 94800 Villejuif, France
    Ann Surg 240:1052-61; discussion 1061-4. 2004
    ..To evaluate the influence of the response to preoperative chemotherapy, especially tumor progression, on the outcome following resection of multiple colorectal liver metastases (CRM)...
  16. ncbi request reprint Circadian rhythm of irinotecan tolerability in mice
    Elisabeth Filipski
    INSERM E0354 Cancer Chronotherapeutics, Universite Paris XI, Paul Brousse Hospital, Villejuif, France
    Chronobiol Int 21:613-30. 2004
    ..The results support the administration of CPT-11 to cancer patients in the second half of the night, during sleep, in order to improve drug tolerability...
  17. ncbi request reprint Circadian regulation of cell cycle and apoptosis proteins in mouse bone marrow and tumor
    Teresa G Granda
    Cancer Chronotherapeutics, INSERM E 0354 and Université Paris XI, Hopital Paul Brousse, Villejuif, France
    FASEB J 19:304-6. 2005
    ..Conversely, a molecular circadian clock likely regulated BCL-2 and BAX expression in the bone marrow, increasing cellular protection against apoptosis during the rest span...
  18. ncbi request reprint Host circadian clock as a control point in tumor progression
    Elisabeth Filipski
    Institut National de la Sante et de la Recherche Medicale, Equipe Propre INSERM 0118 Cancer chronotherapeutics, Universite Paris XI, Paul Brousse Hospital, Villejuif, France
    J Natl Cancer Inst 94:690-7. 2002
    ..An alteration in these rhythms is associated with poor survival of patients with metastatic colorectal or breast cancer. We developed a mouse model to investigate the consequences of severe circadian dysfunction upon tumor growth...
  19. ncbi request reprint [Rhythm of expression of BCL-2 protein of MA13/C mammaryadenocarcinoma bearing-mice]
    Teresa G Granda
    Inserm E 0354, Hopital Paul Brousse, Villejuif, France
    Pathol Biol (Paris) 51:220-1. 2003
    ..BCL-2 acrophase coincided with the time of highest docetaxel tolerability and efficacy in this model. This suggests that BCL-2 protects the bone marrow from the drug toxicity, especially during the light phase...
  20. pmc Rescue surgery for unresectable colorectal liver metastases downstaged by chemotherapy: a model to predict long-term survival
    Rene Adam
    Centre Hépato Biliaire and Inserm E0354 Cancer Chronotherapeutics, Hopital Paul Brousse, Assistance Publique Hopitaux de Paris Université Paris, Sud Villejuif, France
    Ann Surg 240:644-57; discussion 657-8. 2004
    ....
  21. doi request reprint Rescue chemotherapy using multidrug chronomodulated hepatic arterial infusion for patients with heavily pretreated metastatic colorectal cancer
    Mohamed Bouchahda
    Chronotherapy Unit, Medical Oncology Department, Hepatobiliary Center, Public Assistance Hospital of Paris, Paul Brousse Hospital, Villejuif, France
    Cancer 115:4990-9. 2009
    ..In this article, the authors report their experience with chronomodulated HAI chemotherapy as rescue therapy in heavily pretreated patients who had metastatic colorectal cancer...
  22. ncbi request reprint Improved tumor control through circadian clock induction by Seliciclib, a cyclin-dependent kinase inhibitor
    Ida Iurisci
    Institut National de la Sante et de la Recherche Medicale, U776 Rythmes biologiques et cancers, Hopital Paul Brousse, Villejuif Cedex, France
    Cancer Res 66:10720-8. 2006
    ..The coordination of clock gene expression patterns in tumor cells was associated with best antitumor activity of Seliciclib. The circadian clock and its upstream regulators represent relevant targets for CDKIs...
  23. doi request reprint Patients with initially unresectable colorectal liver metastases: is there a possibility of cure?
    Rene Adam
    AP HP Hopital Paul Brousse, Centre Hépato Biliaire and Department of Medical Oncology, Villejuif, France
    J Clin Oncol 27:1829-35. 2009
    ..The aim of this study was to evaluate long-term outcome after combining downsizing chemotherapy and rescue surgery and to define prognostic factors of cure...
  24. doi request reprint Cancer inhibition through circadian reprogramming of tumor transcriptome with meal timing
    Xiao Mei Li
    INSERM U776, Rythmes Biologiques et Cancers, Hopital Paul Brousse, Assistance Publique Hopitaux de Paris, Unité de Chronothérapie, Departement d Oncologie Medicale, Hopital Paul Brousse, Villejuif, France
    Cancer Res 70:3351-60. 2010
    ..Targeting circadian clocks represents a novel potential challenge for cancer therapeutics...
  25. ncbi request reprint Cortisol diurnal variation in blood and saliva of patients with metastatic colorectal cancer: relevance for clinical outcome
    Marie Christine Mormon
    INSERM EPI 0118 Chronothérapeutique des cancers and Chronotherapy Unit, Federation des Maladies Sanguines et Tumorales, Villejuif, France
    Anticancer Res 22:1243-9. 2002
    ..In order to confirm these results in a non-hormone-dependent cancer, cortisol concentrations in serum and saliva were compared at different circadian stages, in patients with metastatic colorectal cancer. Patients and..
  26. pmc Strain- and sex-dependent circadian changes in abcc2 transporter expression: implications for irinotecan chronotolerance in mouse ileum
    Alper Okyar
    INSERM, U776 Rythmes biologiques et cancers, Hopital Paul Brousse, Villejuif, France
    PLoS ONE 6:e20393. 2011
    ..Here, we investigate whether circadian changes in local abcc2 expression participate in the circadian rhythm of irinotecan toxicity for ileum mucosa, and further assess whether genetic background or sex modify this relation...
  27. ncbi request reprint Marker rhythms of circadian system function: a study of patients with metastatic colorectal cancer and good performance status
    Marie Christine Mormont
    INSERM EPI 0118 Cancer Chronotherapeutics, Universite Paris XI, Hĵpital Paul Brousse, Villejuif, France
    Chronobiol Int 19:141-55. 2002
    ..Such 24h rhythm alterations appeared to be independent of conventional clinical factors...
  28. pmc Circadian rhythm in rest and activity: a biological correlate of quality of life and a predictor of survival in patients with metastatic colorectal cancer
    Pasquale F Innominato
    INSERM, U776 Biological Rhythms and Cancers, Villejuif, France
    Cancer Res 69:4700-7. 2009
    ..The circadian timing system constitutes a novel therapeutic target. Interventions that normalize circadian timing system dysfunction may affect quality of life and survival in cancer patients...
  29. ncbi request reprint Acquired KRAS mutations during progression of colorectal cancer metastases: possible implications for therapy and prognosis
    Mohamed Bouchahda
    Chronotherapy Unit and Department of Medical Oncology, Assistance Publique Hopitaux de Paris, Villejuif, France
    Cancer Chemother Pharmacol 66:605-9. 2010
    ..We report the first case of multiple KRAS mutations acquired during the metastatic phase of CRC, and retrospectively reviewed all patients with CRC, in whom KRAS was analyzed in at least two tumor samples from distinct lesions...
  30. doi request reprint [Circadian control of muscle transcriptome]
    Sandrine Dulong
    Rythmes Biologiques et Cancers, Hopital Paul Brousse, 14, avenue Paul Vaillant Couturier, 94807 Villejuif, France
    Med Sci (Paris) 24:372-4. 2008
  31. ncbi request reprint From circadian rhythms to cancer chronotherapeutics
    Francis Levi
    INSERM EPI 0118 Cancer Chronotherapeutics, Université Paris XI and Chronotherapy Group, European Organisation for Research and Treatment of Cancer, Hĵpital Paul Brousse, Villejuif, France
    Chronobiol Int 19:1-19. 2002
    ..It is conducting currently six trials and preparing four new studies. The 19 contributions in this special issue reflect the current status and perspectives of the several components of cancer chronotherapeutics...
  32. doi request reprint Circadian disruption in experimental cancer processes
    Elisabeth Filipski
    Hopital Paul Brousse, Villejuif, France
    Integr Cancer Ther 8:298-302. 2009
    ..These results support the role of the CTS in cancer progression and call for the development of therapeutic strategies aimed at preventing or treating circadian clock dysfunctions...
  33. doi request reprint Circadian timing in cancer treatments
    Francis Levi
    INSERM, U Rythmes Biologiques et Cancers, Hopital Paul Brousse, Villejuif, France
    Annu Rev Pharmacol Toxicol 50:377-421. 2010
    ..Mathematical and systems biology approaches currently develop and integrate theoretical, experimental, and technological tools in order to further optimize and personalize the circadian administration of cancer treatments...
  34. ncbi request reprint Implications of circadian clocks for the rhythmic delivery of cancer therapeutics
    Francis Levi
    INSERM, U776 Rythmes biologiques et cancers, Hopital Paul Brousse, Villejuif, F 94807, France
    Adv Drug Deliv Rev 59:1015-35. 2007
    ....
  35. ncbi request reprint Tumor-based rhythms of anticancer efficacy in experimental models
    Teresa G Granda
    INSERM EPI 0118 Cancer Chronotherapeutics, Universite Paris XI, Hĵpital Paul Brousse, Villejuif, France
    Chronobiol Int 19:21-41. 2002
    ..Results of laboratory animal studies have been extrapolated to the design of clinical cancer therapy trials involving a chronobiological approach...
  36. doi request reprint Circadian disruption accelerates liver carcinogenesis in mice
    Elisabeth Filipski
    INSERM, U776 Rythmes biologiques et cancers, Hopital Paul Brousse, Villejuif F 94807, France
    Mutat Res 680:95-105. 2009
    ..Here, we investigate the role of CJL as a tumor promoter in mice exposed to the hepatic carcinogen, diethylnitrosamine (DEN)...
  37. doi request reprint Implications of circadian clocks for the rhythmic delivery of cancer therapeutics
    Francis Levi
    INSERM, U776 Rythmes biologiques et cancers, Villejuif 94807, France
    Philos Trans A Math Phys Eng Sci 366:3575-98. 2008
    ..The models showed that additional therapeutic strategy further sets the constraints for the identification of the most effective chronomodulated schedules...
  38. ncbi request reprint Circadian rhythms: mechanisms and therapeutic implications
    Francis Levi
    INSERM U776, Unité de Chronothérapie, Service de cancérologie, Hôpital Paul Brousse et Université Paris XI, 94800 Villejuif, France
    Annu Rev Pharmacol Toxicol 47:593-628. 2007
    ..This knowledge can in turn be used in improving or designing chronotherapeutics for the patients who suffer from many of the major human diseases...
  39. doi request reprint Liver circadian clock, a pharmacologic target of cyclin-dependent kinase inhibitor seliciclib
    Ida Iurisci
    INSERM, U 776 Rythmes biologiques et cancers, Hôp P Brousse, Villejuif, F 94807, France
    Chronobiol Int 26:1169-88. 2009
    ..Modifications of cell cycle gene expression in the liver likely involve other mechanisms. Circadian clocks represent relevant targets to consider for optimization of therapeutic schedules of CDK inhibitors...
  40. ncbi request reprint Disruption of circadian coordination and malignant growth
    Elizabeth Filipski
    INSERM E 354 Cancer Chronotherapeutics, Hopital Paul Brousse, Villejuif, France
    Cancer Causes Control 17:509-14. 2006
    ..Conclusions:These results indicate that circadian system could play an important role in malignant growth control. This should be taken into consideration in cancer prevention and therapy...
  41. ncbi request reprint Pharmacological effects of vinorelbine on body temperature and locomotor activity circadian rhythms in mice
    Xiao Mei Li
    INSERM EPI 0118 Cancer Chronotherapeutics, Universite Paris XI, Hĵpital Paul Brousse, Villejuif, France
    Chronobiol Int 19:43-55. 2002
    ..Our findings demonstrate that VRL can transiently, yet profoundly, alter circadian clock function. Vinorelbine-induced circadian dysfunction may contribute to the toxicokinetics of this and possibly other anticancer drugs...
  42. ncbi request reprint Cancer chronotherapy: principles, applications, and perspectives
    Marie Christine Mormont
    EPI 0118 INSERM Chronothérapeutique des cancers and Service de Cancerologie, Hôpital Paul Brousse I C I G, 94800 Villejuif Cedex, France
    Cancer 97:155-69. 2003
    ..This circadian organization is responsible for predictable changes in the tolerability and efficacy of anticancer agents, and possibly also may be involved in tumor promotion or growth...
  43. ncbi request reprint Hepatic resection after down-staging of unresectable hepatic colorectal metastases
    Rene Adam
    Department of Surgery, Centre Hepato Biliaire, Hopital Paul Brousse, 12 avenue Paul Vaillant Couturier, 94804 Villejuif, France
    Surg Oncol Clin N Am 12:211-20, xii. 2003
    ..This article reviews the literature and major areas of progress in treatments for unresectable colorectal cancer...
  44. ncbi request reprint Circadian clocks and drug delivery systems: impact and opportunities in chronotherapeutics
    Francis Levi
    Hopital Paul Brousse, INSERM, U776 Rythmes biologiques et cancers, Villejuif, F 94807, France
    Expert Opin Drug Deliv 8:1535-41. 2011
    ..Intelligent drug delivery systems could then integrate the critical rhythmic information stemming from the individual patient and achieve a critical leap forward in the safe administration of potentially toxic therapeutic agents...