Philippe Lestaevel

Summary

Country: France

Publications

  1. ncbi request reprint Effects of a thermal injury on brain and blood nitric oxide (NO) content in the rat
    Philippe Lestaevel
    Departement de Radiobiologie et de Radiopathologie, Centre de Recherches du Service de Santé des Armées Emile Pardé, BP 87, 38702 La, Tronche, France
    Burns 29:557-62. 2003
  2. ncbi request reprint The brain is a target organ after acute exposure to depleted uranium
    P Lestaevel
    Institut de Radioprotection et de Surete Nucleaire, Département de Radio Protection de l Homme, Laboratoire de Radio Toxicologie Expérimentale, BP 166, 26702 Pierrelatte, France
    Toxicology 212:219-26. 2005
  3. doi request reprint Transcriptomic effects of depleted uranium on acetylcholine and cholesterol metabolisms in Alzheimer's disease model
    Philippe Lestaevel
    Direction de la RadioProtection de l Homme, Service de Radiobiologie et d Epidemiologie, Laboratoire de Radiotoxicologie Experimentale, Institut de Radioprotection et de Surete Nucleaire, Fontenay aux Roses, France
    C R Biol 334:85-90. 2011
  4. doi request reprint Neuro-inflammatory response in rats chronically exposed to (137)Cesium
    Philippe Lestaevel
    Institut de Radioprotection et de Surete Nucleaire, Service de Radiobiologie et d Epidemiologie, BP 17, 92262 Fontenay aux Roses, France
    Neurotoxicology 29:343-8. 2008
  5. doi request reprint Different pattern of brain pro-/anti-oxidant activity between depleted and enriched uranium in chronically exposed rats
    P Lestaevel
    Institut de Radioprotection et de Surete Nucleaire, Direction de la RadioProtection de l Homme, Service de Radiobiologie et d Epidemiologie, Laboratoire de RadioToxicologie Expérimentale IRSN, Cedex, France
    Toxicology 258:1-9. 2009
  6. ncbi request reprint Evaluation of the effect of chronic exposure to 137Cesium on sleep-wake cycle in rats
    Philippe Lestaevel
    Institut de Radioprotection et de Surete Nucleaire, Direction de la RadioProtection de l Homme, Service de Radiobiologie et d Epidemiologie, Laboratoire de Radiotoxicologie Experimentale, BP 17, 92262 Fontenay aux Roses, France
    Toxicology 226:118-25. 2006
  7. doi request reprint Heavy metal uranium affects the brain cholinergic system in rat following sub-chronic and chronic exposure
    Helene Bensoussan
    Institut de Radioprotection et de Surete Nucleaire, Département de la Radioprotection de l Homme, Service de Radiobiologie et d Epidemiologie, Laboratoire de Radiotoxicologie Experimentale, BP 17, F 92262 Fontenay aux Roses Cedex, France
    Toxicology 261:59-67. 2009
  8. doi request reprint Distribution of soluble uranium in the nuclear cell compartment at subtoxic concentrations
    Caroline Rouas
    Institut de Radioprotection et de Surete Nucleaire, Direction de la RadioProtection de l Homme, Service de Radiobiologie et d Epidemiologie, Laboratoire de Radiotoxicologie Experimentale, BP17, F 92262 Fontenay aux Roses, France
    Chem Res Toxicol 23:1883-9. 2010
  9. doi request reprint Chronic contamination of rats with 137 cesium radionuclide: impact on the cardiovascular system
    Yann Gueguen
    Institut de Radioprotection et de Surete Nucleaire, Direction de la RadioProtection de l Homme, Service de Radiobiologie et d Epidemiologie, Laboratoire de Radiotoxicologie Experimentale, IRSN, Fontenay aux Roses Cedex, France
    Cardiovasc Toxicol 8:33-40. 2008
  10. doi request reprint Inhalation of uranium nanoparticles: respiratory tract deposition and translocation to secondary target organs in rats
    Fabrice Petitot
    Institut de Radioprotection et de Surete Nucleaire, IRSN PRP HOM SRBE, Laboratoire de Radiotoxicologie Experimentale, BP 166, 26702 Pierrelatte Cedex, France
    Toxicol Lett 217:217-25. 2013

Collaborators

Detail Information

Publications14

  1. ncbi request reprint Effects of a thermal injury on brain and blood nitric oxide (NO) content in the rat
    Philippe Lestaevel
    Departement de Radiobiologie et de Radiopathologie, Centre de Recherches du Service de Santé des Armées Emile Pardé, BP 87, 38702 La, Tronche, France
    Burns 29:557-62. 2003
    ..A thermal injury was thus accompanied by a rapid impairment of the NO-ergic pathways, which might partly have been responsible for numerous changes occurring after burn injury...
  2. ncbi request reprint The brain is a target organ after acute exposure to depleted uranium
    P Lestaevel
    Institut de Radioprotection et de Surete Nucleaire, Département de Radio Protection de l Homme, Laboratoire de Radio Toxicologie Expérimentale, BP 166, 26702 Pierrelatte, France
    Toxicology 212:219-26. 2005
    ..The mechanisms by which uranium causes these early neurophysiological perturbations shall be discussed...
  3. doi request reprint Transcriptomic effects of depleted uranium on acetylcholine and cholesterol metabolisms in Alzheimer's disease model
    Philippe Lestaevel
    Direction de la RadioProtection de l Homme, Service de Radiobiologie et d Epidemiologie, Laboratoire de Radiotoxicologie Experimentale, Institut de Radioprotection et de Surete Nucleaire, Fontenay aux Roses, France
    C R Biol 334:85-90. 2011
    ..Overall, these modifications of acetylcholine and cholesterol metabolisms did not lead to increased disturbances that are specific of AD, suggesting that chronic DU exposure did not worsen the pathology in this experimental model...
  4. doi request reprint Neuro-inflammatory response in rats chronically exposed to (137)Cesium
    Philippe Lestaevel
    Institut de Radioprotection et de Surete Nucleaire, Service de Radiobiologie et d Epidemiologie, BP 17, 92262 Fontenay aux Roses, France
    Neurotoxicology 29:343-8. 2008
    ..This neuro-inflammatory response could contribute to the electrophysiological and biochemical alterations observed after chronic exposure to (137)Cs...
  5. doi request reprint Different pattern of brain pro-/anti-oxidant activity between depleted and enriched uranium in chronically exposed rats
    P Lestaevel
    Institut de Radioprotection et de Surete Nucleaire, Direction de la RadioProtection de l Homme, Service de Radiobiologie et d Epidemiologie, Laboratoire de RadioToxicologie Expérimentale IRSN, Cedex, France
    Toxicology 258:1-9. 2009
    ..Finally, these results demonstrate the importance of the double toxicity, chemical and radiological, of uranium...
  6. ncbi request reprint Evaluation of the effect of chronic exposure to 137Cesium on sleep-wake cycle in rats
    Philippe Lestaevel
    Institut de Radioprotection et de Surete Nucleaire, Direction de la RadioProtection de l Homme, Service de Radiobiologie et d Epidemiologie, Laboratoire de Radiotoxicologie Experimentale, BP 17, 92262 Fontenay aux Roses, France
    Toxicology 226:118-25. 2006
    ..In conclusion, the neurocognitive effects of (137)Cs need further evaluation and central disorders of population living in contaminated territories must be considered...
  7. doi request reprint Heavy metal uranium affects the brain cholinergic system in rat following sub-chronic and chronic exposure
    Helene Bensoussan
    Institut de Radioprotection et de Surete Nucleaire, Département de la Radioprotection de l Homme, Service de Radiobiologie et d Epidemiologie, Laboratoire de Radiotoxicologie Experimentale, BP 17, F 92262 Fontenay aux Roses Cedex, France
    Toxicology 261:59-67. 2009
    ..Taken together, these data indicate that the cholinergic system is a target of uranium exposure in a structure-dependent and time-dependent manner. These cholinergic alterations could participate in behavioural impairments...
  8. doi request reprint Distribution of soluble uranium in the nuclear cell compartment at subtoxic concentrations
    Caroline Rouas
    Institut de Radioprotection et de Surete Nucleaire, Direction de la RadioProtection de l Homme, Service de Radiobiologie et d Epidemiologie, Laboratoire de Radiotoxicologie Experimentale, BP17, F 92262 Fontenay aux Roses, France
    Chem Res Toxicol 23:1883-9. 2010
    ..Moreover, this technique allows us to localize it mainly in the nucleus. These innovative results raise the question of how uranium penetrates into cells and open new perspectives for studying the mechanisms of uranium chemical toxicity...
  9. doi request reprint Chronic contamination of rats with 137 cesium radionuclide: impact on the cardiovascular system
    Yann Gueguen
    Institut de Radioprotection et de Surete Nucleaire, Direction de la RadioProtection de l Homme, Service de Radiobiologie et d Epidemiologie, Laboratoire de Radiotoxicologie Experimentale, IRSN, Fontenay aux Roses Cedex, France
    Cardiovasc Toxicol 8:33-40. 2008
    ....
  10. doi request reprint Inhalation of uranium nanoparticles: respiratory tract deposition and translocation to secondary target organs in rats
    Fabrice Petitot
    Institut de Radioprotection et de Surete Nucleaire, IRSN PRP HOM SRBE, Laboratoire de Radiotoxicologie Experimentale, BP 166, 26702 Pierrelatte Cedex, France
    Toxicol Lett 217:217-25. 2013
    ..5 d). Future long-term experimental studies concerning uranium nanoparticles should focus on the potential lung toxicity of the large fraction of particles cleared slowly from the respiratory tract after inhalation exposure...
  11. doi request reprint The effects of radionuclides on animal behavior
    Beatrice Gagnaire
    Laboratoire de Radioecologie et d Ecotoxicologie, IRSN, Centre de Cadarache, Bat 186, 13115, Saint Paul lez Durance cedex, France
    Rev Environ Contam Toxicol 210:35-58. 2011
    ..Collectively, data are lacking or are meagre on radionuclide pollutants, and a better knowledge of their actions on the cellular and molecular mechanisms that control animal behavior is needed...
  12. ncbi request reprint Bioaccumulation and behavioural effects of depleted uranium in rats exposed to repeated inhalations
    Marjorie Monleau
    Laboratoire de Radiotoxicologie Experimentale, IRSN DRPH SRBE LRTOX, BP166, 26702 Pierrelatte, France
    Neurosci Lett 390:31-6. 2005
    ..These data suggest that depleted uranium is able to enter the brain after exposure to repeated inhalation, producing behavioural changes...
  13. ncbi request reprint Enriched but not depleted uranium affects central nervous system in long-term exposed rat
    Pascale Houpert
    Institut de Radioprotection et de Surete Nucleaire, Direction de la Radioprotection de l Homme Service de Radiobiologie et d Epidémiologie, Laboratoire de Radiotoxicologie Experimentale, BP 166 26702 Pierrelatte, France
    Neurotoxicology 26:1015-20. 2005
    ..Exposure to depleted uranium for 1.5 months did not induce these effects, suggesting that the radiological activity induces the primary events of these effects of uranium...
  14. ncbi request reprint Brain and cognitive impairments from burn injury in rats
    Marie Pierre Halm
    Laboratoire de Biologie du Comportement, UFR SHS, Université Pierre Mendès France, BP47, 38040 Grenoble Cedex 9, France
    Burns 32:570-6. 2006
    ..A choice of neuro-pharmacological agents involved in NO-metabolism, together with a choice of proper anesthetics, should now be tested as means to alleviate cognitive impairments following third-degree burns...