E M Leroy

Summary

Country: France

Publications

  1. ncbi request reprint Sequence analysis of the GP, NP, VP40 and VP24 genes of Ebola virus isolated from deceased, surviving and asymptomatically infected individuals during the 1996 outbreak in Gabon: comparative studies and phylogenetic characterization
    Eric M Leroy
    Centre International de Recherches Medicales de Franceville, BP 769 Franceville, Gabon
    J Gen Virol 83:67-73. 2002
  2. ncbi request reprint Multiple Ebola virus transmission events and rapid decline of central African wildlife
    Eric M Leroy
    Institut de Recherche pour le Developpement, UR034, Centre International de Recherches Medicales de Franceville, BP 769 Franceville, Gabon
    Science 303:387-90. 2004
  3. ncbi request reprint A serological survey of Ebola virus infection in central African nonhuman primates
    E M Leroy
    Centre International de Recherches Medicales de Franceville, Institut de Recherche pour le Developpement, UR034, Franceville, Gabon
    J Infect Dis 190:1895-9. 2004
  4. pmc Wild animal mortality monitoring and human Ebola outbreaks, Gabon and Republic of Congo, 2001-2003
    Pierre Rouquet
    Centre International de Recherches Medicales de Franceville, CIRMF BP 769, Franceville, Gabon
    Emerg Infect Dis 11:283-90. 2005
  5. ncbi request reprint [Bats, reserves of the Ebola virus: the mystery is dissipated]
    Eric LeRoy
    Institut de recherche pour le developpement IRD, UR178, Centre International de Recherches Medicales de Franceville, BP769, Gabon
    Med Sci (Paris) 22:78-9. 2006
  6. pmc New STLV-3 strains and a divergent SIVmus strain identified in non-human primate bushmeat in Gabon
    Florian Liegeois
    UMI 233, Trans VIH MI, Recherches Translationnelles sur le VIH et les Maladies Infectieuses Institut de Recherche pour le Développement IRD, University of Montpellier 1, Montpellier, France
    Retrovirology 9:28. 2012
  7. pmc Molecular typing of PPRV strains detected during an outbreak in sheep and goats in south-eastern Gabon in 2011
    Gael D Maganga
    Centre International de Recherches Medicales de Franceville, Franceville, Gabon
    Virol J 10:82. 2013
  8. pmc Filovirus research in Gabon and equatorial Africa: the experience of a research center in the heart of Africa
    Eric LeRoy
    Centre International de Recherches Médicales de Franceville Franceville International Center for Medical Research, CIRMF, Libreville BP 2105, Gabon
    Viruses 4:1592-604. 2012
  9. pmc Chikungunya virus adapts to tiger mosquito via evolutionary convergence: a sign of things to come?
    Xavier de Lamballerie
    Institut de Recherche pour le Développement UMR190 Unité des Virus Emergents, Universite de la Mediterranee, Marseille, France
    Virol J 5:33. 2008
  10. pmc First serological evidence of West Nile virus in human rural populations of Gabon
    Xavier Pourrut
    Institut de Recherche pour le Developpement, UMR 190, Marseille, France
    Virol J 7:132. 2010

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Sequence analysis of the GP, NP, VP40 and VP24 genes of Ebola virus isolated from deceased, surviving and asymptomatically infected individuals during the 1996 outbreak in Gabon: comparative studies and phylogenetic characterization
    Eric M Leroy
    Centre International de Recherches Medicales de Franceville, BP 769 Franceville, Gabon
    J Gen Virol 83:67-73. 2002
    ..In contrast, nonsynonymous substitutions predominated over synonymous substitutions in the NP gene of the two Gabon strains, pointing to divergent evolution of these strains and to selective pressures on this gene...
  2. ncbi request reprint Multiple Ebola virus transmission events and rapid decline of central African wildlife
    Eric M Leroy
    Institut de Recherche pour le Developpement, UR034, Centre International de Recherches Medicales de Franceville, BP 769 Franceville, Gabon
    Science 303:387-90. 2004
    ..Surveillance of animal mortality may help to predict and prevent human Ebola outbreaks...
  3. ncbi request reprint A serological survey of Ebola virus infection in central African nonhuman primates
    E M Leroy
    Centre International de Recherches Medicales de Franceville, Institut de Recherche pour le Developpement, UR034, Franceville, Gabon
    J Infect Dis 190:1895-9. 2004
    ..They also suggest that future Ebola outbreaks may occur anywhere in the central African forest region...
  4. pmc Wild animal mortality monitoring and human Ebola outbreaks, Gabon and Republic of Congo, 2001-2003
    Pierre Rouquet
    Centre International de Recherches Medicales de Franceville, CIRMF BP 769, Franceville, Gabon
    Emerg Infect Dis 11:283-90. 2005
    ..Wild animal outbreaks began before each of the 5 human Ebola outbreaks. Twice we alerted the health authorities to an imminent risk for human outbreaks, weeks before they occurred...
  5. ncbi request reprint [Bats, reserves of the Ebola virus: the mystery is dissipated]
    Eric LeRoy
    Institut de recherche pour le developpement IRD, UR178, Centre International de Recherches Medicales de Franceville, BP769, Gabon
    Med Sci (Paris) 22:78-9. 2006
  6. pmc New STLV-3 strains and a divergent SIVmus strain identified in non-human primate bushmeat in Gabon
    Florian Liegeois
    UMI 233, Trans VIH MI, Recherches Translationnelles sur le VIH et les Maladies Infectieuses Institut de Recherche pour le Développement IRD, University of Montpellier 1, Montpellier, France
    Retrovirology 9:28. 2012
    ..We conducted a pilot study on 63 blood and/or tissues samples derived from NHP bushmeat seized by the competent authorities in different locations across the country...
  7. pmc Molecular typing of PPRV strains detected during an outbreak in sheep and goats in south-eastern Gabon in 2011
    Gael D Maganga
    Centre International de Recherches Medicales de Franceville, Franceville, Gabon
    Virol J 10:82. 2013
    ..Four genetically distinct lineages of peste des petits ruminants virus (PPRV) have been identified. In Gabon, the virus has not so far been detected...
  8. pmc Filovirus research in Gabon and equatorial Africa: the experience of a research center in the heart of Africa
    Eric LeRoy
    Centre International de Recherches Médicales de Franceville Franceville International Center for Medical Research, CIRMF, Libreville BP 2105, Gabon
    Viruses 4:1592-604. 2012
    ..In addition, academic training is provided at all levels to regional and international students covering emerging conditions (host factors, molecular biology, genetics) that favor the spread of viral diseases...
  9. pmc Chikungunya virus adapts to tiger mosquito via evolutionary convergence: a sign of things to come?
    Xavier de Lamballerie
    Institut de Recherche pour le Développement UMR190 Unité des Virus Emergents, Universite de la Mediterranee, Marseille, France
    Virol J 5:33. 2008
    ..This disconcerting and current unique example of "evolutionary convergence" occurring in nature illustrates rapid pathogen adaptation to ecological perturbation, driven directly as a consequence of human activities...
  10. pmc First serological evidence of West Nile virus in human rural populations of Gabon
    Xavier Pourrut
    Institut de Recherche pour le Developpement, UMR 190, Marseille, France
    Virol J 7:132. 2010
    ..The linear increase with age suggests continuous exposure of Gabonese populations to WNV. Further investigations are needed to determine the WNV cycle and transmission patterns in Gabon...
  11. pmc Prevalence of Plasmodium falciparum infection in asymptomatic rural Gabonese populations
    Dieudonné Nkoghe
    Centre International de Recherches Medicales de Franceville, Franceville, Gabon
    Malar J 10:33. 2011
    ..The prevalence of asymptomatic Plasmodium falciparum carriage is poorly documented in Gabon. A large survey of P. falciparum infection was conducted in asymptomatic individuals living in rural Gabon...
  12. pmc Acute dengue virus 2 infection in Gabonese patients is associated with an early innate immune response, including strong interferon alpha production
    Pierre Becquart
    Centre International de Recherches Medicales de Franceville, BP 769 Franceville, Gabon
    BMC Infect Dis 10:356. 2010
    ....
  13. pmc Large serological survey showing cocirculation of Ebola and Marburg viruses in Gabonese bat populations, and a high seroprevalence of both viruses in Rousettus aegyptiacus
    Xavier Pourrut
    Institut de Recherche pour le Developpement, UR 178, Marseille, France
    BMC Infect Dis 9:159. 2009
    ..Recently, bats of multiple species have been identified as possible natural hosts of Zaire ebolavirus (ZEBOV) in Gabon and Republic of Congo, and also of marburgvirus (MARV) in Gabon and Democratic Republic of Congo...
  14. doi request reprint Human Ebola outbreak resulting from direct exposure to fruit bats in Luebo, Democratic Republic of Congo, 2007
    Eric M Leroy
    Centre International de Recherches Medicales de Franceville CIRMF, Franceville, Gabon
    Vector Borne Zoonotic Dis 9:723-8. 2009
    ..These findings support the suspected role of bats in the natural cycle of Ebola virus and indicate that the massive seasonal fruit bat migrations should be taken into account in operational Ebola risk maps and seasonal alerts in the DRC...
  15. ncbi request reprint Fruit bats as reservoirs of Ebola virus
    Eric M Leroy
    Centre International de Recherches Medicales de Franceville, BP 769 Franceville, Gabon
    Nature 438:575-6. 2005
    ..We find evidence of asymptomatic infection by Ebola virus in three species of fruit bat, indicating that these animals may be acting as a reservoir for this deadly virus...
  16. ncbi request reprint [Ebola and Marburg hemorrhagic fever viruses: update on filoviruses]
    E Leroy
    Centre International de Recherches Medicales de Franceville, Franceville, Gabon
    Med Trop (Mars) 71:111-21. 2011
    ..The purpose of this review is to present the main developments in these particular fields in the last decade...
  17. doi request reprint Ebola and Marburg haemorrhagic fever viruses: major scientific advances, but a relatively minor public health threat for Africa
    E M Leroy
    Centre International de Recherches Medicales de Franceville, Franceville, Gabon
    Clin Microbiol Infect 17:964-76. 2011
    ..As a result, our understanding of the ecology, host interactions, and control of these viruses has improved considerably...
  18. ncbi request reprint Defective humoral responses and extensive intravascular apoptosis are associated with fatal outcome in Ebola virus-infected patients
    S Baize
    Centre International de Recherches Medicales de Franceville, Gabon
    Nat Med 5:423-6. 1999
    ..Thus, events very early in Ebola virus infection determine the control of viral replication and recovery or catastrophic illness and death...
  19. ncbi request reprint Human asymptomatic Ebola infection and strong inflammatory response
    E M Leroy
    Centre International de Recherches Medicales de Franceville, Gabon
    Lancet 355:2210-5. 2000
    ..We aimed to determine whether these individuals were indeed infected with Ebola virus, and how they maintained asymptomatic status...
  20. ncbi request reprint Diagnosis of Ebola haemorrhagic fever by RT-PCR in an epidemic setting
    E M Leroy
    Centre International de Recherches Medicales de Franceville, BP 769 Franceville, Gabon
    J Med Virol 60:463-7. 2000
    ..RT-PCR detected Ebola RNA in PBMC one to three weeks after disappearance of symptoms when antigen was undetectable. RT-PCR was the most sensitive method and able to detect virus from early acute disease throughout early recovery...
  21. ncbi request reprint Ebola hemorrhagic fever outbreaks in Gabon, 1994-1997: epidemiologic and health control issues
    A J Georges
    Centre International de Recherches Medicales de Franceville, Gabon
    J Infect Dis 179:S65-75. 1999
    ..1% in the base pairs. Sequencing also showed that all isolates were very similar to subtype Zaire EBO virus isolates from the Democratic Republic of the Congo...
  22. ncbi request reprint Spatial and temporal patterns of Zaire ebolavirus antibody prevalence in the possible reservoir bat species
    X Pourrut
    Institut de Recherche pour le Developpement, UR178, Franceville, Gabon
    J Infect Dis 196:S176-83. 2007
    ..monstrosus females suggests virus transmission within bat populations through fighting and sexual contact. Our study, thus, helps to describe Ebola virus circulation in bats and offers some insight into the appearance of outbreaks...
  23. pmc Early immune responses accompanying human asymptomatic Ebola infections
    E M Leroy
    Centre International de Recherches Medicales de Franceville, BP 769, Franceville, Gabon
    Clin Exp Immunol 124:453-60. 2001
    ..Taken together, these findings improve our understanding about immune response during human asymptomatic Ebola infection, and throw new light on protection against Ebola virus...
  24. ncbi request reprint [Ebola virus: what the practitioner needs to know]
    A J Georges
    Unité de Biologie des Rétrovirus et Pathogènes Viraux Spéciaux, Centre International de Recherche Médicale de Franceville CIRMF, Franceville, Gabon
    Med Trop (Mars) 58:177-86. 1998
    ..During outbreaks containment depends on implementation of simple precautions including isolation of suspected cases, appropriate protective clothing, disinfection with hypochlorite solutions, and proper waste disposal...
  25. pmc Isolates of Zaire ebolavirus from wild apes reveal genetic lineage and recombinants
    Tatiana J Wittmann
    Centre International de Recherches Medicales de Franceville, BP 769 Franceville, Gabon
    Proc Natl Acad Sci U S A 104:17123-7. 2007
    ..The potential for recombination adds an additional level of complexity to unraveling and potentially controlling the emergence of ZEBOV in humans and wildlife species...
  26. pmc Inflammatory responses in Ebola virus-infected patients
    S Baize
    Centre International de Recherches Medicales de Franceville CIRMF, Franceville, Gabon, France
    Clin Exp Immunol 128:163-8. 2002
    ..In contrast, defective inflammatory responses and massive monocyte/macrophage activation were associated with fatal outcome...
  27. pmc High prevalence of both humoral and cellular immunity to Zaire ebolavirus among rural populations in Gabon
    Pierre Becquart
    Unité des Maladies Virales Emergentes, Centre International de Recherches Medicales de Franceville, Franceville, Gabon
    PLoS ONE 5:e9126. 2010
    ..These findings provide significant new insights into ZEBOV circulation and human exposure, and raise important questions as to the human pathogenicity of ZEBOV and the existence of natural protective immunization...
  28. pmc Ebola virus antibody prevalence in dogs and human risk
    Loïs Allela
    Centre International de Recherches Medicales de Franceville, Franceville, Gabon
    Emerg Infect Dis 11:385-90. 2005
    ..8%. A significant positive direct association existed between seroprevalence and the distances to the Ebola virus-epidemic area. This study suggests that dogs can be infected by Ebola virus and that the putative infection is asymptomatic...
  29. pmc Rift Valley fever virus seroprevalence in human rural populations of Gabon
    Xavier Pourrut
    Institut de Recherche pour le Developpement, UMR 190, Marseille, France
    PLoS Negl Trop Dis 4:e763. 2010
    ..In contrast, the prevalence of RVFV has rarely been investigated in central African countries...
  30. ncbi request reprint Apoptosis in fatal Ebola infection. Does the virus toll the bell for immune system?
    S Baize
    Centre International de Recherches Medicales de Franceville, Gabon, France
    Apoptosis 5:5-7. 2000
    ....
  31. ncbi request reprint Sequence conservation of repeat 3 region of the gene coding for the 15 kDa polyprotein within human and simian Loa loa
    F S Toure
    Centre International de Recherches Medicales de Franceville, Gabon
    J Med Primatol 28:57-61. 1999
    ..loa infections. The study demonstrates the ability of a nested-PCR assay to identify animals naturally infected with simian L. loa...
  32. pmc Prevalence and molecular diversity of hepatitis B virus and hepatitis delta virus in urban and rural populations in northern Gabon in central Africa
    Maria Makuwa
    Unité de virologie, Centre International de Recherches Medicales de Franceville CIRMF, Franceville, Gabon
    J Clin Microbiol 47:2265-8. 2009
    ..Phylogenetic analysis showed the circulation of HBV-A3 and -E genotypes and the presence of HDV-1, HDV-7, and HDV-8 clades...
  33. pmc Concurrent chikungunya and dengue virus infections during simultaneous outbreaks, Gabon, 2007
    Eric M Leroy
    Centre International de Recherches Medicales de Franceville, Franceville, Gabon
    Emerg Infect Dis 15:591-3. 2009
    ..Chikungunya or dengue-2 virus infections were identified in 321 patients; 8 patients had documented co-infections. Aedes albopictus was identified as the principal vector for the transmission of both viruses...
  34. ncbi request reprint Anthrax in Western and Central African great apes
    Fabian H Leendertz
    Great Ape Health Monitoring Unit, c o Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    Am J Primatol 68:928-33. 2006
    ....
  35. pmc Recent common ancestry of Ebola Zaire virus found in a bat reservoir
    Roman Biek
    Center for Disease Ecology, Department of Biology, Emory University, Atlanta, Georgia, USA
    PLoS Pathog 2:e90. 2006