M Leone

Summary

Country: France

Publications

  1. pmc Hypoxia-inducible factor (HIF1α) gene expression in human shock states
    Julien Textoris
    Service d anesthésie et de réanimation, Hopital Nord, Assistance Publique Hopitaux de Marseille, Chemin des Bourrely, 13915, Marseille, France
    Crit Care 16:R120. 2012
  2. doi request reprint Variable compliance with clinical practice guidelines identified in a 1-day audit at 66 French adult intensive care units
    Marc Leone
    Service d anesthésie et de réanimation, Hopital Nord, Aix Marseille Univ, Marseille, France
    Crit Care Med 40:3189-95. 2012
  3. pmc High central venous oxygen saturation in the latter stages of septic shock is associated with increased mortality
    Julien Textoris
    Service d anesthésie et de réanimation, Hopital Nord, Assistance Publique Hopitaux de Marseille, Universite de la Mediterranee, Chemin des Bourrely, 13915 Marseille Cedex 20, France
    Crit Care 15:R176. 2011
  4. pmc Impact of intensive care on renal function before graft harvest: results of a monocentric study
    Valery Blasco
    Département d anesthésie et de réanimation, Hopital Nord, Assistance Publique Hopitaux de Marseille, Chemin des Bourrely, 13915 Marseille Cedex 20, Universite de la Mediterranee, Faculte de Medecine, 13005 Marseille, France
    Crit Care 11:R103. 2007
  5. doi request reprint Long-term outcome in chest trauma
    Marc Leone
    Hopital Nord, Assistance Publique Hopitaux de Marseille, Marseille, France
    Anesthesiology 109:864-71. 2008
  6. ncbi request reprint Comparison of effectiveness of two urinary drainage systems in intensive care unit: a prospective, randomized clinical trial
    Marc Leone
    Intensive Care Unit and Trauma Center, Nord Hospital, Marseilles University Hospital System, AP HM, Marseilles School of Medicine, 13915 Marseille Cedex 20, France
    Intensive Care Med 29:410-3. 2003
  7. ncbi request reprint Survey of the use of catecholamines by French physicians
    Marc Leone
    Department of Anesthesiology and Intensive Care and Trauma Center, Marseille University Hospital System, Marseille School of Medicine, 13915 Marseille Cedex 20, France
    Intensive Care Med 30:984-8. 2004
  8. ncbi request reprint Empirical antimicrobial therapy of septic shock patients: adequacy and impact on the outcome
    Marc Leone
    Intensive Care Unit, Trauma Center, Marseilles University Hospital System, Marseilles School of Medicine, France
    Crit Care Med 31:462-7. 2003
  9. ncbi request reprint Risk factors of nosocomial catheter-associated urinary tract infection in a polyvalent intensive care unit
    Marc Leone
    Intensive Care Unit and Trauma Center, Nord Hospital AP HM, Bd P Dramard, 13915, Marseille, France
    Intensive Care Med 29:1077-80. 2003
  10. ncbi request reprint A reappraisal of isoproterenol in goal-directed therapy of septic shock
    Marc Leone
    Département d anesthésie et de réanimation, UPRES Equipe d Accueil 3784, Centre Hospitalier Universitaire Nord, 13915 Marseille Cedex 20, France
    Shock 26:353-7. 2006

Detail Information

Publications92

  1. pmc Hypoxia-inducible factor (HIF1α) gene expression in human shock states
    Julien Textoris
    Service d anesthésie et de réanimation, Hopital Nord, Assistance Publique Hopitaux de Marseille, Chemin des Bourrely, 13915, Marseille, France
    Crit Care 16:R120. 2012
    ..No information is available on its expression in critically ill patients. Thus, we designed the first clinical study in order to evaluate the role of HIF1α as a prognosis marker in patients with shock...
  2. doi request reprint Variable compliance with clinical practice guidelines identified in a 1-day audit at 66 French adult intensive care units
    Marc Leone
    Service d anesthésie et de réanimation, Hopital Nord, Aix Marseille Univ, Marseille, France
    Crit Care Med 40:3189-95. 2012
    ..Little is known about guideline compliance in real-life practice. To evaluate compliance rates for a large bundle of intensive care unit practice guidelines and determine factors associated with noncompliance to these guidelines...
  3. pmc High central venous oxygen saturation in the latter stages of septic shock is associated with increased mortality
    Julien Textoris
    Service d anesthésie et de réanimation, Hopital Nord, Assistance Publique Hopitaux de Marseille, Universite de la Mediterranee, Chemin des Bourrely, 13915 Marseille Cedex 20, France
    Crit Care 15:R176. 2011
    ..As high levels of ScvO2 may reflect an inadequate use of oxygen, our aim was to evaluate the relation between maximal ScvO2 levels (ScvO2max) and survival among intensive care unit (ICU) patients with septic shock...
  4. pmc Impact of intensive care on renal function before graft harvest: results of a monocentric study
    Valery Blasco
    Département d anesthésie et de réanimation, Hopital Nord, Assistance Publique Hopitaux de Marseille, Chemin des Bourrely, 13915 Marseille Cedex 20, Universite de la Mediterranee, Faculte de Medecine, 13005 Marseille, France
    Crit Care 11:R103. 2007
    ....
  5. doi request reprint Long-term outcome in chest trauma
    Marc Leone
    Hopital Nord, Assistance Publique Hopitaux de Marseille, Marseille, France
    Anesthesiology 109:864-71. 2008
    ..Here, the authors sought to describe chest trauma survivor outcomes 6 months and 1 yr after discharge from the intensive care unit, paying special attention to pulmonary outcomes...
  6. ncbi request reprint Comparison of effectiveness of two urinary drainage systems in intensive care unit: a prospective, randomized clinical trial
    Marc Leone
    Intensive Care Unit and Trauma Center, Nord Hospital, Marseilles University Hospital System, AP HM, Marseilles School of Medicine, 13915 Marseille Cedex 20, France
    Intensive Care Med 29:410-3. 2003
    ..To confirm this result we performed a statistically powerful study assessing the effectiveness of the CCDS and the TCDS in ICU patients...
  7. ncbi request reprint Survey of the use of catecholamines by French physicians
    Marc Leone
    Department of Anesthesiology and Intensive Care and Trauma Center, Marseille University Hospital System, Marseille School of Medicine, 13915 Marseille Cedex 20, France
    Intensive Care Med 30:984-8. 2004
    ..The objective of the study was to perform a descriptive approach of the current use of catecholamines by French physicians...
  8. ncbi request reprint Empirical antimicrobial therapy of septic shock patients: adequacy and impact on the outcome
    Marc Leone
    Intensive Care Unit, Trauma Center, Marseilles University Hospital System, Marseilles School of Medicine, France
    Crit Care Med 31:462-7. 2003
    ..To assess the adequacy of empirical antimicrobial therapy prescribed in septic shock patients and to evaluate the relationship between inadequate antimicrobial therapy and 30-day mortality...
  9. ncbi request reprint Risk factors of nosocomial catheter-associated urinary tract infection in a polyvalent intensive care unit
    Marc Leone
    Intensive Care Unit and Trauma Center, Nord Hospital AP HM, Bd P Dramard, 13915, Marseille, France
    Intensive Care Med 29:1077-80. 2003
    ..To determine the risk factors for catheter-associated urinary tract infection in a polyvalent intensive care unit (ICU)...
  10. ncbi request reprint A reappraisal of isoproterenol in goal-directed therapy of septic shock
    Marc Leone
    Département d anesthésie et de réanimation, UPRES Equipe d Accueil 3784, Centre Hospitalier Universitaire Nord, 13915 Marseille Cedex 20, France
    Shock 26:353-7. 2006
    ..There is a need for future investigations in larger groups of patients to determine whether isoproterenol can be an alternative to dobutamine...
  11. doi request reprint Emerging drugs in sepsis
    Marc Leone
    Service d anesthésie et de réanimation, Hopital Nord, Assistance Publique Hopitaux de Marseille, Universite de la Mediterranee, Chemin des Bourrely, 13915 Marseille Cedex 20, France
    Expert Opin Emerg Drugs 15:41-52. 2010
    ..Sepsis remains a major cause of death in intensive care units. Despite an intense research, a new drug that is effective in reducing mortality in sepsis is still awaited...
  12. doi request reprint How to break the vicious circle of antibiotic resistances?
    Marc Leone
    Service d anesthésie et de réanimation, Hopital Nord, Assistance Publique Hopitaux de Marseille, Universite de la Mediterranee, Marseille, France
    Curr Opin Crit Care 14:587-92. 2008
    ..To review the new findings on the use of antibiotics in the ICU patients...
  13. doi request reprint Oxygen tissue saturation is lower in nonsurvivors than in survivors after early resuscitation of septic shock
    Marc Leone
    Service d anesthésie et de réanimation, Hopital Nord, Assistance Publique Hopitaux de Marseille and Université de la Méditerranée, Marseille, France
    Anesthesiology 111:366-71. 2009
    ..This study's purpose was to explore whether the outcome of septic shock patients after early resuscitation using early goal-directed therapy is related to their muscle tissue oxygenation...
  14. pmc Terlipressin or europressin?
    Marc Leone
    Service d anesthésie et de réanimation, Hopital Nord, Chemin des Bourrely, 13915 Marseille cedex 20 France
    Crit Care 13:192. 2009
    ..For the first time in humans, Morelli and colleagues compared this mode of administration with other vasopressors...
  15. ncbi request reprint Brain tissue penetration of ciprofloxacin following a single intravenous dose
    Marc Leone
    Intensive Care Unit and Trauma Center and Department of Neurosurgery, Nord Hospital, Marseilles School of Medicine, Marseilles, France
    J Antimicrob Chemother 50:607-9. 2002
    ..88 +/- 0.99. Mean (+/- S.D.) concentrations of ciprofloxacin in brain tissue were 0.87 +/- 0.08 mg/kg, suggesting that a dose >200 mg iv ciprofloxacin is required to ensure therapeutic concentrations in brain tissue...
  16. ncbi request reprint Risk factors for late-onset ventilator-associated pneumonia in trauma patients receiving selective digestive decontamination
    Marc Leone
    Département d anesthésie et de réanimation, CHU Nord, chemin des Bourrelys, 13915 Marseille, France
    Intensive Care Med 31:64-70. 2005
    ..To determine the independent risk factors for late-onset ventilator-associated pneumonia (VAP) in trauma patients receiving selective digestive decontamination (SDD)...
  17. ncbi request reprint Comparison of methylprednisolone and ketoprofen after multiple third molar extraction: a randomized controlled study
    Marc Leone
    Department of Intensive Care Medicine and Trauma Center, Centre Hospitalier et Universitaire Nord, Marseille, France
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 103:e7-9. 2007
    ..04), with no difference in the consumption of morphine. We observed only marginal difference between methylprednisolone and ketoprofen to relieve pain after this surgery...
  18. ncbi request reprint Long-term epidemiological survey of Candida species: comparison of isolates found in an intensive care unit and in conventional wards
    M Leone
    Intensive Care Unit and Anesthesiology, Nord Hospital, Marseilles School of Medicine, Marseilles University Hospital System, Marseilles, France
    J Hosp Infect 55:169-74. 2003
    ..The small number of C. glabrata resistant to fluconazole suggested this antifungal agent as suitable empirical treatment for non-immunocompromized patients in whom a fungal infection was suspected...
  19. ncbi request reprint [How about blood pressure in brain injury?]
    M Leone
    Département d anesthésie et de réanimation, CHU Nord, Boulevard Pierre Dramard, 13915 Marseille Cedex 20, France
    Ann Fr Anesth Reanim 25:845-51. 2006
    ..In conclusion, the quality of data on the effects of catecholamines on cerebral haemodynamics of head injured patients do not make it possible to conclude about their use...
  20. ncbi request reprint Ceftriaxone (1 g intravenously) penetration into abdominal tissues when administered as antibiotic prophylaxis during nephrectomy
    M Leone
    Department of Anesthesia and Intensive Care, Hopital Nord, 13915 Marseille Cedex 20, France
    J Chemother 15:139-42. 2003
    ..According to our kinetic evaluation, ceftriaxone is potentially a good antibiotic for prophylaxis in urological surgery...
  21. ncbi request reprint Coxiella burnetii infection in C57BL/6 mice aged 1 or 14 months
    Marc Leone
    Unite des Rickettsies, Centre National de la Recherche Scientifique, Universite de la Mediterranee, Faculte de Medecine, Marseille, France
    FEMS Immunol Med Microbiol 50:396-400. 2007
    ..In addition, macrophage microbicidal competence was similar in mature and young mice. These results suggest the importance of individual host factors in the pathophysiology of an infectious disease such as Q fever...
  22. ncbi request reprint Role of terlipressin in the treatment of infants and neonates with catecholamine-resistant septic shock
    Marc Leone
    Département d Anesthésie et de Réanimation et Centre de Traumatologie, Hopital Nord, Assistance Publique Hopitaux de Marseille, 13915 Marseille 20, France
    Best Pract Res Clin Anaesthesiol 22:323-33. 2008
    ..Future studies are required before any recommendations on the use of terlipressin in children with septic shock can be made...
  23. ncbi request reprint Risk factors of nosocomial catheter-associated urinary tract infection in a polyvalent intensive care unit
    Marc Leone
    Intensive Care Unit and Trauma Center, Nord Hospital AP HM, Marseilles University Hospital System, Marseilles School of Medicine, 13915, Marseille Cedex 20, France
    Intensive Care Med 29:929-32. 2003
    ..To determine the risk factors for catheter-associated urinary tract infection in a polyvalent intensive care unit (ICU)...
  24. ncbi request reprint Comparison of effectiveness of two urinary drainage systems in intensive care unit: a prospective, randomized clinical trial
    Marc Leone
    Intensive Care Unit and Trauma Center, Nord Hospital, Marseilles University Hospital System, AP HM, Marseilles School of Medicine, 13915, Marseilles, France
    Intensive Care Med 29:551-4. 2003
    ..To confirm this result, we performed a randomized, prospective, and powerful study assessing the effectiveness of the CCDS and the TCDS in ICU patients...
  25. ncbi request reprint Target concentrations of remifentanil with propofol to blunt coughing during intubation, cuff inflation, and tracheal suctioning
    M Leone
    Département d Anesthésie et de Réanimation and Département de Chirurgie Maxillo Faciale, Centre Hospitalo Universitaire Nord, Marseille, France
    Br J Anaesth 93:660-3. 2004
    ....
  26. ncbi request reprint A randomized trial of catheter change and short course of antibiotics for asymptomatic bacteriuria in catheterized ICU patients
    Marc Leone
    Département d anesthésie et de réanimation, Assistance Publique Hopitaux de Marseille, CHU Nord, 13915, Marseille Cedex 20, France
    Intensive Care Med 33:726-9. 2007
    ....
  27. ncbi request reprint [Activation of adhesion molecules in patients with septic shock]
    M Leone
    Département d Anesthésie et de Réanimation et Centre de Traumatologie, Hopital Nord, Boulevard P Dramard, 13915 Marseille Cedex 20, France
    Ann Fr Anesth Reanim 22:721-9. 2003
    ..To analyze the pattern of adhesion molecules in patients with septic shock. Data sources. - References obtained from Pubmed databank...
  28. doi request reprint Vasopressor use in septic shock: an update
    Marc Leone
    Département d Anesthésie et de Réanimation et Centre de Traumatologie, Hopital Nord, Assistance Publique Hopitaux de Marseille, Marseille, Cedex 20, France
    Curr Opin Anaesthesiol 21:141-7. 2008
    ..This article reviews new findings on the use of vasopressor agents in septic shock...
  29. ncbi request reprint Pulmonary contusion in severe head trauma patients: impact on gas exchange and outcome
    Marc Leone
    Intensive Care Unit and Trauma Center, Department of Biostatistics, Nord Hospital, AP HM, Marseilles University Hospital System, School of Medicine, 13915 Marseilles cedex, France
    Chest 124:2261-6. 2003
    ..To evaluate the impact on morbidity and mortality of pulmonary contusion in multiple-trauma patients with severe head trauma...
  30. ncbi request reprint [Airway management for anaesthesia performed at the end of labour: survey of practices]
    L Zieleskiewicz
    Service d anesthésie et de réanimation, Faculte de Medecine de Marseille, Hopital Nord, AP HM, Chemin des Bourrely, Marseille Cedex 20, France
    Ann Fr Anesth Reanim 28:119-23. 2009
    ..To describe the airway management during general anaesthesia performed at the end of labour...
  31. ncbi request reprint [Venous oximetry: physiology and therapeutic implications]
    V Blasco
    Département d anesthésie et de réanimation, Faculte de Medecine de Marseille, Hopital Nord, Chemin des Bourrely, 13915 Marseille Cedex 20, France
    Ann Fr Anesth Reanim 27:74-82. 2008
    ....
  32. ncbi request reprint HLA-DR and B7-2 (CD86) monocyte expressions after major cancer surgery: profile in sepsis
    D Mokart
    Department of Anesthesia and Resuscitation, Paoli Calmettes Institute, Marseille, France
    Minerva Anestesiol 77:522-7. 2011
    ..The aim of the present study was to determine the possible role of monocyte HLA-DR and B7-2 molecules in the occurrence of postoperative sepsis after major cancer surgery...
  33. ncbi request reprint Long-term (6-year) effect of selective digestive decontamination on antimicrobial resistance in intensive care, multiple-trauma patients
    Marc Leone
    Intensive Care Unit and Trsuma Center, Hospital Nord, Marseilles University Hospital System, Marseilles School of Medicine, France
    Crit Care Med 31:2090-5. 2003
    ..To determine whether selective digestive decontamination (SDD) had some negative impact on the bacterial resistance observed in strains isolated from samples from patients receiving nonabsorbable antibiotics and cefazolin...
  34. ncbi request reprint Lung ultrasound-guided management of acute breathlessness during pregnancy
    L Zieleskiewicz
    Department of Anaesthesia and Intensive Care Medicine, University Hospital of Marseille, Marseille, France
    Anaesthesia 68:97-101. 2013
    ..We believe that these cases strongly support the prospective validation of lung ultrasound for management of lung disorders in pregnant women...
  35. doi request reprint Comparison of the novel hydroxyethylstarch 130/0.4 and hydroxyethylstarch 200/0.6 in brain-dead donor resuscitation on renal function after transplantation
    V Blasco
    Département d anesthésie et de réanimation, CHU Nord, Assistance Publique Hopitaux de Marseille, 13915 Marseille Cedex 20, France
    Br J Anaesth 100:504-8. 2008
    ..4 or HES 200/0.6) used for the resuscitation of brain-dead donors on the rate of delayed graft function (DGF) and the serum creatinine levels post-transplantation...
  36. ncbi request reprint [Management of ventilator acquired pneumonia]
    I Boyadjiev
    Département d anesthésie et de réanimation, CHU Nord, Boulevard Pierre Dramard, 13915 Marseille Cedex 20, France
    Ann Fr Anesth Reanim 25:761-72. 2006
    ..This review is based on the ATS guidelines, and reviews epidemiology, diagnosis and treatment of ventilator-acquired pneumonia, in non-immunocompromised adults...
  37. doi request reprint Reduced interleukin-12 release from stimulated monocytes in patients with sepsis after major cancer surgery
    D Mokart
    Département d anesthésie et de réanimation, Institut Paoli Calmettes, 232 Bd Sainte Marguerite, 13273 Marseille Cedex 9, France
    Acta Anaesthesiol Scand 54:643-8. 2010
    ..The aim of this study was to assess the relation between the monocyte production of IL-12 and the development of post-operative sepsis in patients undergoing major cancer surgery...
  38. doi request reprint Erythropoietin measurements in severely traumatized patients
    R Vialet
    Department of Anaesthesia, Traumatology and Intensive Care, North University Hospital, Marseilles, France
    Acta Anaesthesiol Scand 52:601-4. 2008
    ..The aim of this study was to describe EPO secretion and its relationship with haemoglobin (Hb) levels in severely injured patients...
  39. ncbi request reprint Prevention of nosocomial urinary tract infection in ICU patients: comparison of effectiveness of two urinary drainage systems
    M Leone
    Intensive Care Unit and Trauma Center, Nord Hospital, Marseilles University Hospital System, Marseilles School of Medicine, Marseilles, France
    Chest 120:220-4. 2001
    ....
  40. ncbi request reprint [Indications of vasopressin in the management of septic shock]
    A Delmas
    Département d anesthésie réanimation et centre de traumatologie, CHU Nord, Boulevard P Dramard, 13915 Marseille 20, France
    Ann Fr Anesth Reanim 22:600-8. 2003
    ..It also has haemostatic, gastrointestinal, and thermoregulatory effects. This article reviews the physiology of vasopressin and all the relevant clinical literature on its use in the treatment of septic shock...
  41. ncbi request reprint [Selective digestive decontamination: the light as changed from red to green]
    J Textoris
    Departement d Anesthesie Reanimation, Centre Hospitalier Universitaire Nord, 13015 Marseille, France
    Ann Fr Anesth Reanim 24:366-76. 2005
    ..To study the efficacy of selective digestive decontamination (SDD) for the prevention of nosocomial infections, particularly pneumonia, as well as its impact on the emergence of multiresistant bacteria...
  42. doi request reprint [Lung ultrasound: clinical applications and perspectives in intensive care unit]
    L Zieleskiewicz
    Service d anesthésie et de réanimation, Aix Marseille Universite, Hopital Nord, Assistance Publique Hopitaux de Marseille, Chemin des Bourrely, 13015 Marseille Cedex 20, France
    Ann Fr Anesth Reanim 31:793-801. 2012
    ..To describe the use of lung ultrasound in clinical practice and the new opportunities offered by this technology in intensive care unit (ICU) patients...
  43. ncbi request reprint Comparative study of three methods of estimation of creatinine clearance in critically ill patients
    V Blasco
    Service d anesthésie et de réanimation, Hopital Nord, Assistance Publique Hopitaux de Marseille, Aix Marseille Universite, Chemin des Bourrely, 13015 Marseille, France
    Ann Fr Anesth Reanim 33:e85-8. 2014
    ..This observational survey aimed at testing the hypothesis that the proposed equations are unreliable to determine accurate creatinine clearance in patients admitted to intensive care unit (ICU)...
  44. ncbi request reprint [Vascular ischemic lesions of the kidney in multiple trauma patients: incidence and management, a report of 7 cases]
    K Chaumoitre
    Service d Imagerie Medicale, Hopital Nord, 13915 Marseille Cedex 20
    J Radiol 91:1135-42. 2010
    ..Study the incidence, type and outcome of traumatic ischemic arterial lesions of the kidney in multiple trauma patients...
  45. ncbi request reprint [Indications and limits of recombinant human erythropoietin in intensive care unit]
    C Ventré
    Département d anesthésie et de réanimation, centre de traumatologie, AP HM, CHU Nord, chemin des Bourrelys, 13915 Marseille Cedex 20, France
    Ann Fr Anesth Reanim 23:714-21. 2004
    ..To analyze the data from the literature on erythropoietin and the future indications of recombinant human erythropoietin in intensive care unit (ICU) patients...
  46. ncbi request reprint [Which therapeutic prospects in the septic syndrome?]
    M Leone
    Département d anesthésie et de réanimation, CHU Nord, Boulevard Pierre Dramard, 13915 Marseille 20, France
    Ann Fr Anesth Reanim 22:798-808. 2003
    ..To evaluate recent data provided on new treatments of patients with septic shock...
  47. doi request reprint [Lemierre's syndrome from necrotizing pneumonia treated with extracorporeal CO2 removal]
    V Blasco
    Département d anesthésie et de réanimation, CHU de Nord, Chemin des Bourrely, 13915 Marseille Cedex 20, France
    Ann Fr Anesth Reanim 27:244-8. 2008
    ..An extracorporeal CO(2) removal was then carried out for 34-days duration. The patient was weaned from mechanical ventilation on day 68. He was then transferred to the chest surgery unit on day 83...
  48. doi request reprint [Medical-surgical management of traumatic cardiac rupture: Relevance of recombinant activated factor VII]
    V Blasco
    Département d anesthésie et de réanimation, Hopital Nord, Assistance Publique Hopitaux de Marseille, Faculte de Medecine de Marseille, CHU Nord, Chemin des Bourrely, 13915 Marseille Cedex 20, France
    Ann Fr Anesth Reanim 27:719-22. 2008
    ..The use of rFVIIa reduced probably the need of blood transfusion in this case of blunt heart trauma. This treatment should be envisaged in similar cases after the failure of standard therapy to control the bleeding...
  49. ncbi request reprint [Venous gas embolism from pleurovenous fistula]
    V Blasco
    Département d anesthésie et de réanimation, CHU de Nord, Chemin des Bourrely, 13915 Marseille Cedex 20, France
    Ann Fr Anesth Reanim 26:242-4. 2007
    ..A leak between the pleura and the left subclavian vein was diagnosed. The insertion of a chest tube stopped the airflow, by suppressing the pneumothorax...
  50. ncbi request reprint [What sedation for prevention and treatment secondary brain insult?]
    M Leone
    Département d anesthésie réanimation et centre de traumatologie, Hopital Nord, 13915 Marseille Cedex 20, France
    Ann Fr Anesth Reanim 25:852-7. 2006
    ..The presence of brain damage in patients makes difficult to assess the level of sedation. One should avoid over sedation, which increases morbidity by prolongation of the duration of mechanical ventilation...
  51. doi request reprint Neuromuscular blockers in early acute respiratory distress syndrome
    Laurent Papazian
    Assistance Publique Hôpitaux de Marseille Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, Centre National de la Recherche Scientifique Unité Mixte de Recherche 6236, Universite de la Mediterranee Aix Marseille II, Marseille, France
    N Engl J Med 363:1107-16. 2010
    ..We evaluated clinical outcomes after 2 days of therapy with neuromuscular blocking agents in patients with early, severe ARDS...
  52. ncbi request reprint High adenosine plasma concentration as a prognostic index for outcome in patients with septic shock
    C Martin
    Intensive Care Unit and Trauma Center, Nord Hospital, Marseilles University, Hospital System, Marseilles School of Medicine, France
    Crit Care Med 28:3198-202. 2000
    ..Indeed, this nucleoside is a strong endogenous vasodilating agent released by endothelial cells and myocytes under circumstances of metabolic stress, such as during critical illness...
  53. ncbi request reprint Predictive perioperative factors for developing severe sepsis after major surgery
    D Mokart
    Intensive Care Unit and Department of Anesthesiology, Institut Paoli Calmettes, Marseille, France
    Br J Anaesth 95:776-81. 2005
    ..Early identification of high-risk patients undergoing major surgery can result in an aggressive management affecting the outcome...
  54. ncbi request reprint [Therapeutic management of peritonitis]
    A Bourgoin
    Departement d Anesthesie Reanimation, Hopital Nord, Chemin des Bourrelly, 13915 Marseille, France
    Med Mal Infect 34:183-95. 2004
    ..An antifungal treatment (fluconazole) is usually necessary, at least until the results of peritoneal fluid culture are available. The duration of treatment is quite variable, ranging from 48 h in less severe forms to 14 days...
  55. ncbi request reprint [Surviving sepsis: where we are today]
    Marc Leone
    Département d anesthésie réanimation et centre de traumatologie, Hopital Nord, Bd Pierre Dramard, Marseille
    Presse Med 35:541-6. 2006
    ..Encouraging results show that applying these therapeutic principles can reduce mortality by 30% (relative percentage) compared with a treatment without specific objectives...
  56. ncbi request reprint Terlipressin in catecholamine-resistant septic shock patients
    Marc Leone
    Intensive Care Unit, Department of Anesthesia and Intensive Care, and Trauma Center, Nord University Hospital, Marseilles, France
    Shock 22:314-9. 2004
    ..Mesenteric circulation was not evaluated, but hepatic function was altered during the study period. Further studies are required to determine whether terlipressin is safe in terms of outcome in septic shock patients...
  57. ncbi request reprint [The agents used for sedation in neurointensive care unit]
    J Albanese
    Département d anesthésie réanimation et centre de traumatologie, CHU Nord, chemin des Bourely, 13326 Marseille Cedex 15, France
    Ann Fr Anesth Reanim 23:528-34. 2004
    ..Its use may be recommended for short time sedations with or without an opioid drug. The curare use should be restrain to refractory intracranial hypertension to usual treatments and happening during stimulation...
  58. doi request reprint [Brain placement of a double balloon catheter after extensive craniofacial trauma]
    V Blasco
    Departement d Anesthesie Reanimation, Hopital Nord, Assistance Publique Hopitaux de Marseille, Faculte de Medecine de Marseille, Chemin des Bourrely, 13915 Marseille Cedex 20, France
    Ann Fr Anesth Reanim 27:843-5. 2008
    ..However, the use of balloon systems may result in an intracranial position. We report here such a case in an 18-year-old man suffering from a severe nasal bleeding...
  59. ncbi request reprint [Epidural intracranial hematomas: practical issues revealed by management of 100 recent cases]
    J R Alliez
    Service de Neurochirurgie, CHU Nord Université de la Méditerranée, Marseille
    Neurochirurgie 51:464-70. 2005
    ..6%), but great concern remains about the high mortality among patients with associated intracranial lesions (33.3%) or multiple trauma (32%)...
  60. ncbi request reprint Catheter-associated urinary tract infections in intensive care units
    Marc Leone
    Department of Anesthesiology and Intensive Care Medicine, CHU Nord, AP HM, Marseilles Hospital University System, chemin des Bourrelys, 13915 Marseille Cedex 20, France
    Microbes Infect 6:1026-32. 2004
    ..The management of CAUTI in ICU patients has not been evaluated in clinical trials. The level of evidence provided in this field is weak, and underlines the need for randomized studies to improve management of patients...
  61. ncbi request reprint Influence on outcome of ventilator-associated pneumonia in multiple trauma patients with head trauma treated with selected digestive decontamination
    Marc Leone
    Intensive Care Unit and Trauma Center, Nord Hospital, Marseilles University Hospital System, Marseilles School of Medicine, Marseilles, France
    Crit Care Med 30:1741-6. 2002
    ..We performed a study to evaluate the attributable morbidity and mortality of ventilator-associated pneumonia in multiple trauma patients with head trauma treated with selective digestive decontamination...
  62. ncbi request reprint Impact of a goal-directed therapy protocol on postoperative fluid balance in patients undergoing liver transplantation: a retrospective study
    L Reydellet
    Service d anesthésie et de réanimation, Hopital de la Conception, Assistance Publique Hopitaux de Marseille, 147, boulevard Baille, 13385 Marseille Cedex 5, France Aix Marseille Université, 13005 Marseille, France Electronic address
    Ann Fr Anesth Reanim 33:e47-54. 2014
    ..Our first goal was to determine its impact on the fluid balance. Secondarily, we evaluated possible improvements in the patient outcomes...
  63. ncbi request reprint [Strategies diagnosis of polytraumatized adult patients with coma]
    M Leone
    Département d anesthésie réanimation et centre de traumatologie, CHU Nord, Bd P Dramard, 13915 Marseille, France
    Ann Fr Anesth Reanim 21:50-66. 2002
    ..To review the diagnostic strategy of management of multiple trauma patient during the first hours...
  64. doi request reprint [Role of genetics in anaesthesia-related variability]
    J Textoris
    Service d anesthésie et de réanimation, Hopital Nord, Assistance Publique Hopitaux de Marseille, Chemin des Bourrely, 13915 Marseille, France
    Ann Fr Anesth Reanim 28:564-74. 2009
    ..This review discusses variability among patients in anesthesia, due to genetic polymorphisms...
  65. ncbi request reprint [A case of type A botulism]
    I Boyadjiev
    Département d anesthésie et de réanimation, CHU de Nord, Boulevard Pierre Dramard, 13915 Marseille Cedex 20, France
    Ann Fr Anesth Reanim 24:1397-9. 2005
    ..The failure of thoracic muscles is responsible for the severity of botulism. We describe a case of a 74 year old woman who presented a severe form of botulism, requiring a prolonged intensive care unit stay...
  66. doi request reprint [Use of ephedrine prefilled syringes reduces anesthesia costs]
    J P Bellefleur
    Service d anesthésie et de réanimation, Universite de la Mediterranee, Hopital Nord, Assistance Publique Hopitaux de Marseille, Chemin des Bourrely, Marseille Cedex 20, France
    Ann Fr Anesth Reanim 28:211-4. 2009
    ..The aim of the present study was to compare the consumption and cost of ephedrine in parturients with respect to two packagings: ampoules and prefilled syringes...
  67. ncbi request reprint Increasing mean arterial pressure in patients with septic shock: effects on oxygen variables and renal function
    Aurelie Bourgoin
    Department of Intensive Care Medicine and Trauma Center, Hospital Nord, 13915 Marseille Cedex 20, France
    Crit Care Med 33:780-6. 2005
    ..To measure the effects of increasing mean arterial pressure on oxygen variables and renal function in septic shock...
  68. ncbi request reprint Terlipressin or norepinephrine in hyperdynamic septic shock: a prospective, randomized study
    Jacques Albanese
    Department of Intensive Care Medicine and Trauma Center, Hospital Nord, Marseille Cedex 20, France
    Crit Care Med 33:1897-902. 2005
    ..To compare, in patients with hyperdynamic septic shock, the effects of norepinephrine or terlipressin on hemodynamic variables and renal function...
  69. pmc Clinical review: Vasopressin and terlipressin in septic shock patients
    Anne Delmas
    Department of Anesthesiology and Intensive Care Medicine, and Trauma Center, Marseilles University Hospital System, Marseilles School of Medicine, Marseilles, France
    Crit Care 9:212-22. 2005
    ..Large randomized clinical trials should be conducted to establish the utility of these drugs as therapeutic agents in patients with septic shock...
  70. pmc Penetration of ertapenem into muscle measured by in vivo microdialysis in mechanically ventilated patients
    I Boyadjiev
    1Service d anesthésie et de réanimation, Hopital Nord, Assistance Publique Hopitaux de Marseille, Universite de la Mediterranee, 13015 Marseille, France
    Antimicrob Agents Chemother 55:3573-5. 2011
    ..In a few patients, the concentrations were below the MIC values. The clinical efficiency of ertapenem at 1 g once daily should be evaluated in a large population of ICU patients...
  71. ncbi request reprint Renal effects of norepinephrine in septic and nonseptic patients
    Jacques Albanese
    Department of Anesthesiology and Intensive Care Medicine and Trauma Center, Marseilles University Hospital System, Marseilles School of Medicine, France
    Chest 126:534-9. 2004
    ..To assess the effects of a norepinephrine-induced vasoconstriction on renal function in septic and nonseptic patients...
  72. ncbi request reprint Decompressive craniectomy for severe traumatic brain injury: Evaluation of the effects at one year
    Jacques Albanese
    Department of Intensive Care and Trauma Center, Marseilles University Hospital System, Marseilles School of Medicine, France
    Crit Care Med 31:2535-8. 2003
    ..To assess the effect on outcome (1 yr) of decompressive craniectomy performed within or after the first 24 hrs post-trauma in severely head-injured trauma patients with intractable cerebral hypertension...
  73. ncbi request reprint Randomized clinical trial of extended use of a hydrophobic condenser humidifier: 1 vs. 7 days
    Laurent Thomachot
    Intensive Care Unit and Trauma Center, Nord Hospital, Marseilles University Hospital System, Marseilles School of Medicine, France
    Crit Care Med 30:232-7. 2002
    ..To determine whether extended use (7 days) would affect the efficiency on heat and water preservation of a hydrophobic condenser humidifier as well as the rate of ventilation-acquired pneumonia, compared with 1 day of use...
  74. doi request reprint Non-adherence to guidelines: an avoidable cause of failure of empirical antimicrobial therapy in the presence of difficult-to-treat bacteria
    Frédéric Garcin
    Service d anesthésie et de réanimation, Hopital Nord, Assistance Publique Hopitaux de Marseille, Universite de la Mediterranee, Chemin des Bourrely, 13915 Marseille Cedex 20, France
    Intensive Care Med 36:75-82. 2010
    ..e., Pseudomonas aeruginosa, Acinetobacter baumannii and oxacillin-resistant Staphylococcus aureus), and to assess the rate and the causes of inappropriateness of empirical antimicrobial therapy...
  75. pmc Sex-related differences in gene expression following Coxiella burnetii infection in mice: potential role of circadian rhythm
    Julien Textoris
    Unité de Recherche sur les Maladies Infectieuses Tropicales et Emergentes, Centre National de la Recherche Scientifique Unité Mixte de Recherche 6236, Faculte de Medecine, Marseille, France
    PLoS ONE 5:e12190. 2010
    ..Here we explore whether the severity of C. burnetii infection in mice is related to differences in male and female gene expression profiles...
  76. ncbi request reprint Effect of sex on Coxiella burnetii infection: protective role of 17beta-estradiol
    Marc Leone
    Unite des Rickettsies, Universite de la Mediterranee, Centre National de la Recherche Scientifique, Unite Mixte de Recherche 6020, Faculte de Medecine, Marseille, France
    J Infect Dis 189:339-45. 2004
    ..These results show that sex hormones control host response to C. burnetii infection and may account for host-dependent clinical presentation of Q fever...
  77. pmc Moxifloxacin penetration in bronchial secretions of mechanically ventilated patients with pneumonia
    Marc Leone
    Department of Anesthesiology and Intensive Care Unit and Trauma Center, Nord Hospital, Marseilles, France
    Antimicrob Agents Chemother 48:638-40. 2004
    ..Blood samples and bronchial secretions were taken on days 1 and 4. A dose of 400 mg of moxifloxacin allows one to achieve efficient concentrations in bronchial secretions and plasma...
  78. doi request reprint A novel intravascular rewarming method to treat severe hypothermia
    Leang Heng Ban
    Department of Intensive Care Medicine and Trauma Center, Nord University and Hospital Center, Marseille, France
    Eur J Emerg Med 15:56-8. 2008
    ..We report here a patient with severe hypothermia (27 degrees C), who was successfully rewarmed by using a novel intravascular rewarming method (in combination with an airways rewarming method) through endotracheal tube...
  79. pmc Gene expression profiles characterize inflammation stages in the acute lung injury in mice
    Isabelle Lesur
    INSERM U928, TAGC, Parc Scientifique de Luminy, Universite de la Mediterranee, and Service d anesthésie et de réanimation, hôpital LaTimone, Marseille, France
    PLoS ONE 5:e11485. 2010
    ..Based on these data, it becomes possible to isolate the impact of a pathogen at the transcriptional level from the global gene expression modifications resulting from the infection associated with the inflammation...
  80. ncbi request reprint Systemic endothelial activation is greater in septic than in traumatic-hemorrhagic shock but does not correlate with endothelial activation in skin biopsies
    Marc Leone
    Intensive Care Unit and Trauma Center, Unite des Rickettsies, CNRS UMR 6020, France
    Crit Care Med 30:808-14. 2002
    ..In addition, the endothelial expression of these adhesive molecules was examined in skin biopsies...
  81. ncbi request reprint Cell adhesion molecules as a marker reflecting the reduction of endothelial activation induced by glucocorticoids
    Marc Leone
    Department of Anesthesiology and Intensive Care Medicine, Marseilles Nord University Hospital System, Marseilles School of Medicine, 13005 Marseille, France
    Shock 21:311-4. 2004
    ..In patients with septic shock, glucocorticoids differently affected the pattern of evolution of sCAMs, with sE-selectin being decreased and sICAM-1 being increased. Expression of sP-selectin and sVCAM-1 was not affected...
  82. pmc Rescue therapy in septic shock--is terlipressin the last frontier?
    Marc Leone
    Intensive Care Unit and Trauma Center, Nord University Hospital, Marseilles School of Medicine, Marseilles, France
    Crit Care 10:131. 2006
    ..The effects of this agent on organ function are poorly evaluated in humans. The limited number of patients evaluated precludes any analysis of adverse outcomes and prognosis...
  83. doi request reprint Results of non-operative therapy for delayed hemorrhage after pancreaticoduodenectomy
    Laura Beyer
    Department of Digestive Surgery, Assistance Publique Hopitaux de Marseille, Hôpital Nord and Université de la Méditerranée, Chemin des Bourrely, 13915, Marseille Cedex 20, France
    J Gastrointest Surg 13:922-8. 2009
    ..Many diagnostic and therapeutic options exist but no one has yet established management guidelines. This study aimed to determine the role of conservative management in delayed hemorrhage...
  84. ncbi request reprint Impact of terlipressin on renal graft function
    Valery Blasco
    Département d anesthésie et de réanimation, Hopital Nord, Marseille, France
    Shock 29:667-9. 2008
    ..Within the limitations of this study, a single bolus of terlipressin in norepinephrine-resistant vasodilatory shock donors does not affect the renal and liver graft quality in the recipients...
  85. ncbi request reprint The effects of remifentanil on endotracheal suctioning-induced increases in intracranial pressure in head-injured patients
    Marc Leone
    Intensive Care Unit and Department of Anesthesiology, Nord Hospital, Marseilles University Hospital System AP HM, Marseilles School of Medicine, Marseilles, France
    Anesth Analg 99:1193-8, table of contents. 2004
    ..Remifentanil used as a continuous infusion in head-injured patients is not an effective drug to block responses to suctioning...
  86. ncbi request reprint Positive inotropic stimulation
    Marc Leone
    Department of Anesthesia and Intensive Care, Nord Hospital, Marseille University Hospital System, Marseille School of Medicine, Marseille, France
    Curr Opin Crit Care 8:395-403. 2002
    ....
  87. ncbi request reprint Ventilator-associated pneumonia: breaking the vicious circle of antibiotic overuse
    Marc Leone
    Intensive Care Unit, Département d anesthésie et de réanimation, Assistance Publique Hopitaux de Marseille, Public Hospitals of Marseille, Marseille Medicine University, France
    Crit Care Med 35:379-85; quizz 386. 2007
    ....
  88. doi request reprint Vasopressin in septic shock
    Walter A Boyle
    N Engl J Med 358:2736; author reply 2737-8. 2008
  89. ncbi request reprint Endpoint: quality of life
    Marc Leone
    Crit Care Med 33:267-8; author reply 268. 2005
  90. ncbi request reprint Decreased vasopressin responsiveness in vasodilatory septic shock-like conditions
    Marc Leone
    Critical Care Division and Anesthesiology Research Unit, Department of Anesthesiology, Washington University School of Medicine, Saint Louis, MO, USA
    Crit Care Med 34:1126-30. 2006
    ..To determine the effect of vasodilatory septic shock-like conditions on vasoconstricting responses to vasopressin and norepinephrine in isolated resistance arteries...
  91. ncbi request reprint Does the timing of tracheal intubation based on neuromuscular monitoring decrease laryngeal injury? Similar method, similar conditions, conflicting results
    Géraldine Slehofer
    Anesth Analg 104:211; author reply 211. 2007
  92. doi request reprint Craniocerebral penetrating injury caused by a spear gun through the mouth: case report
    Leang Heng Ban
    Department of Intensive Care and Anesthesia, Hopital Nord, Assistance Publique Hopitaux de Marseille, France
    J Neurosurg 108:1021-3. 2008
    ....