P J Lenting

Summary

Country: France

Publications

  1. doi request reprint Regulation of von Willebrand factor-platelet interactions
    Peter J Lenting
    INSERM U 770, 80 rue du General Leclerc, 94276 Le Kremlin Bicetre, France
    Thromb Haemost 104:449-55. 2010
  2. ncbi request reprint Von Willebrand factor and thrombosis: risk factor, actor and pharmacological target
    Peter J Lenting
    INSERM U770 and UMR_S 770, Univ Paris Sud, 94276 Le Kremlin Bicetre, France
    Curr Vasc Pharmacol 11:448-56. 2013
  3. doi request reprint von Willebrand factor: the old, the new and the unknown
    P J Lenting
    INSERM U770, 94276 Le Kremlin Bicetre, France
    J Thromb Haemost 10:2428-37. 2012
  4. pmc Factor VIII and von Willebrand factor are ligands for the carbohydrate-receptor Siglec-5
    Julie N Pegon
    Inserm U770 Université Paris Sud, Le Kremlin Bicetre, France
    Haematologica 97:1855-63. 2012
  5. doi request reprint Identification of galectin-1 and galectin-3 as novel partners for von Willebrand factor
    Nathalie Saint-Lu
    INSERM U, Le Kremlin Bicetre, France
    Arterioscler Thromb Vasc Biol 32:894-901. 2012
  6. doi request reprint Factor VIII and von Willebrand factor--too sweet for their own good
    P J Lenting
    INSERM U 770 and Univ Paris Sud, Le Kremlin Bicetre, France
    Haemophilia 16:194-9. 2010
  7. doi request reprint Clearance of von Willebrand factor
    C Casari
    Unit 770, INSERM, Le Kremlin Bicetre, France UMR_S 770, Univ Paris Sud, Le Kremlin Bicetre, France
    J Thromb Haemost 11:202-11. 2013
  8. ncbi request reprint Characterization of the interaction between von Willebrand factor and osteoprotegerin
    S Shahbazi
    INSERM U770, Le Kremlin Bicetre, F 94276, and Univ Paris Sud, Le Kremlin Bicetre, France
    J Thromb Haemost 5:1956-62. 2007
  9. doi request reprint Clearance of von Willebrand factor
    Cecile V Denis
    INSERM U770, 80 rue du General Leclerc, 94276 Le Kremlin Bicetre Cedex, France
    Thromb Haemost 99:271-8. 2008
  10. ncbi request reprint Functional mapping of anti-factor IX inhibitors developed in patients with severe hemophilia B
    O D Christophe
    INSERM U143, Hopital Bicetre, Le Kremlin Bicetre, France
    Blood 98:1416-23. 2001

Collaborators

Detail Information

Publications16

  1. doi request reprint Regulation of von Willebrand factor-platelet interactions
    Peter J Lenting
    INSERM U 770, 80 rue du General Leclerc, 94276 Le Kremlin Bicetre, France
    Thromb Haemost 104:449-55. 2010
    ..In the present review an overview of these mechanisms will be discussed...
  2. ncbi request reprint Von Willebrand factor and thrombosis: risk factor, actor and pharmacological target
    Peter J Lenting
    INSERM U770 and UMR_S 770, Univ Paris Sud, 94276 Le Kremlin Bicetre, France
    Curr Vasc Pharmacol 11:448-56. 2013
    ..In the present review, an update is provided about our current knowledge on VWF as a risk factor, mediator and pharmacological target in association with thrombosis. ..
  3. doi request reprint von Willebrand factor: the old, the new and the unknown
    P J Lenting
    INSERM U770, 94276 Le Kremlin Bicetre, France
    J Thromb Haemost 10:2428-37. 2012
    ..These include angiogenesis, cell proliferation, inflammation, and tumor cell survival. In the present article, an overview of advances concerning the various structural and functional aspects of VWF will be provided...
  4. pmc Factor VIII and von Willebrand factor are ligands for the carbohydrate-receptor Siglec-5
    Julie N Pegon
    Inserm U770 Université Paris Sud, Le Kremlin Bicetre, France
    Haematologica 97:1855-63. 2012
    ..Although structurally unrelated, both share the presence of sialylated glycan-structures, making them potential ligands for sialic-acid-binding-immunoglobulin-like-lectins (Siglecs)...
  5. doi request reprint Identification of galectin-1 and galectin-3 as novel partners for von Willebrand factor
    Nathalie Saint-Lu
    INSERM U, Le Kremlin Bicetre, France
    Arterioscler Thromb Vasc Biol 32:894-901. 2012
    ..Here, we explored its interaction with the glycan-binding proteins galectin-1 and galectin-3...
  6. doi request reprint Factor VIII and von Willebrand factor--too sweet for their own good
    P J Lenting
    INSERM U 770 and Univ Paris Sud, Le Kremlin Bicetre, France
    Haemophilia 16:194-9. 2010
    ..In addition, the interaction of the FVIII/VWF complex with two families of carbohydrate-binding proteins, i.e. Galectins and Siglecs, and their potential physiological relevance will be discussed...
  7. doi request reprint Clearance of von Willebrand factor
    C Casari
    Unit 770, INSERM, Le Kremlin Bicetre, France UMR_S 770, Univ Paris Sud, Le Kremlin Bicetre, France
    J Thromb Haemost 11:202-11. 2013
    ....
  8. ncbi request reprint Characterization of the interaction between von Willebrand factor and osteoprotegerin
    S Shahbazi
    INSERM U770, Le Kremlin Bicetre, F 94276, and Univ Paris Sud, Le Kremlin Bicetre, France
    J Thromb Haemost 5:1956-62. 2007
    ..The present study aimed to elucidate the molecular mechanisms underlying the interaction between OPG and VWF...
  9. doi request reprint Clearance of von Willebrand factor
    Cecile V Denis
    INSERM U770, 80 rue du General Leclerc, 94276 Le Kremlin Bicetre Cedex, France
    Thromb Haemost 99:271-8. 2008
    ..Finally, we discuss recent data describing chemically modification of VWF as an approach to prolong the half-life of the VWF/FVIII complex...
  10. ncbi request reprint Functional mapping of anti-factor IX inhibitors developed in patients with severe hemophilia B
    O D Christophe
    INSERM U143, Hopital Bicetre, Le Kremlin Bicetre, France
    Blood 98:1416-23. 2001
    ..These data demonstrate that inhibitors appearing in patients with severe hemophilia B display specificity against restricted functional domains of factor IX...
  11. doi request reprint Mutation and ADAMTS13-dependent modulation of disease severity in a mouse model for von Willebrand disease type 2B
    Julie Rayes
    Inserm U770 and Universite Paris Sud, Le Kremlin Bicetre, France
    Blood 115:4870-7. 2010
    ..Thus, we established a mouse model for VWD-type 2B and found that phenotype depends on mutation and ADAMTS13...
  12. pmc Efficient inhibition of collagen-induced platelet activation and adhesion by LAIR-2, a soluble Ig-like receptor family member
    Peter J Lenting
    Institut National de la Santé et de la Recherche Médicale INSERM U770 and Univ Paris Sud, Le Kremlin Bicetre, France
    PLoS ONE 5:e12174. 2010
    ..Thus, LAIR-2/Fc has the capacity to interfere with platelet-collagen interactions mediated by Glycoprotein VI and the VWF/Glycoprotein Ib axis...
  13. ncbi request reprint P-selectin glycoprotein ligand 1 and beta2-integrins cooperate in the adhesion of leukocytes to von Willebrand factor
    Ronan Pendu
    INSERM U 770, 80 rue du General Leclerc, 94276 Le Kremlin Bicetre Cedex, France
    Blood 108:3746-52. 2006
    ..VWF is unique in its intrinsic capacity to combine the rolling and the stable adhesion step in the interaction with leukocytes...
  14. ncbi request reprint Increased metastatic potential of tumor cells in von Willebrand factor-deficient mice
    V Terraube
    INSERM U143, Le Kremlin Bicetre, France
    J Thromb Haemost 4:519-26. 2006
    ..As a potential mediator of platelet-tumor cell interactions, VWF could influence this early step of tumor spread and therefore play a role in cancer metastasis...
  15. doi request reprint Correction of bleeding symptoms in von Willebrand factor-deficient mice by liver-expressed von Willebrand factor mutants
    Isabelle Marx
    INSERM U770, 80 rue du General Leclerc, 94276 Le Kremlin Bicetre Cedex, France
    Arterioscler Thromb Vasc Biol 28:419-24. 2008
    ..To investigate the physiological importance of particular vWF domains, we have introduced mutations into murine vWF (mvWF) cDNA inhibiting vWF binding to glycoprotein (Gp) Ib, GpIIbIIIa, and to fibrillar collagen...
  16. doi request reprint Altered thrombus formation in von Willebrand factor-deficient mice expressing von Willebrand factor variants with defective binding to collagen or GPIIbIIIa
    Isabelle Marx
    Inserm U770 and Universite Paris Sud, Le Kremlin Bicetre, France
    Blood 112:603-9. 2008
    ..Our observations suggest that targeting the VWF-collagen or VWF-GPIIbIIIa interactions could be an interesting alternative for new antithrombotic strategies...