- Growth factor-induced p42/p44 MAPK nuclear translocation and retention requires both MAPK activation and neosynthesis of nuclear anchoring proteinsP Lenormand
Centre de Biochimie Centre National de la Recherche Scientifique CNRS UMR 6543, Universite de Nice, 06108 Nice, France
J Cell Biol 142:625-33. 1998..We therefore conclude that the MAPK nuclear translocation requires both activation of the p42/p44 MAPK module and neosynthesis of short-lived proteins that we postulate to be nuclear anchors...
- The nucleus, a site for signal termination by sequestration and inactivation of p42/p44 MAP kinasesV Volmat
Institute of Signaling, Developmental Biology and Cancer Research, CNRS UMR 6543, Centre Antoine Lacassagne, 06189 Nice, France
J Cell Sci 114:3433-43. 2001..Hence, the nucleus is a critical site for mitogenic signal termination by: (1) nuclear sequestration of p42/p44 MAPKs away from MEK, their cytoplasmic activator; and (2) dephosphorylation by specific nuclear phosphatases...