A Leizorovicz

Summary

Country: France

Publications

  1. ncbi request reprint Epidemiology of venous thromboembolism in Asian patients undergoing major orthopedic surgery without thromboprophylaxis. The SMART study
    A Leizorovicz
    Service de Pharmacologie Clinique, EA 3736, Universite de Lyon 1, Lyon, France
    J Thromb Haemost 3:28-34. 2005
  2. ncbi request reprint Epidemiology of post-operative venous thromboembolism in Asian patients. Results of the SMART venography study
    Alain Leizorovicz
    Service de Pharmacologie Clinique, EA 643, Universite de Lyon 1, Lyon, France
    Haematologica 92:1194-200. 2007
  3. pmc Heterogeneity prevails: the state of clinical trial data management in Europe - results of a survey of ECRIN centres
    Wolfgang Kuchinke
    Coordination Centre for Clinical Trials, Heinrich Heine University Duesseldorf, Duesseldorf, Germany
    Trials 11:79. 2010
  4. doi request reprint Safety profile of tinzaparin versus subcutaneous unfractionated heparin in elderly patients with impaired renal function treated for acute deep vein thrombosis: the Innohep® in Renal Insufficiency Study (IRIS)
    Alain Leizorovicz
    Faculte de Medecine Laennec, Service de Pharmacologie, Clinique, Rue Guillaume Paradin, 69008, Lyon, France
    Thromb Res 128:27-34. 2011
  5. ncbi request reprint Preventing venous thromboembolism in medical patients
    Alain Leizorovicz
    Unite de Pharmacologie Clinique, EA 3736, Universite Claude Bernard Lyon I, Rue Guillaume Paradin, 69376 Lyon Cedex 08, France
    Circulation 110:IV13-9. 2004
  6. ncbi request reprint Randomized, placebo-controlled trial of dalteparin for the prevention of venous thromboembolism in acutely ill medical patients
    Alain Leizorovicz
    Unite de Pharmacologie Clinique, Universite Claude Bernard Lyon I, Lyon, France
    Circulation 110:874-9. 2004
  7. ncbi request reprint Bisoprolol for the treatment of chronic heart failure: a meta-analysis on individual data of two placebo-controlled studies--CIBIS and CIBIS II. Cardiac Insufficiency Bisoprolol Study
    Alain Leizorovicz
    Service de Pharmacologie Clinique, Universite Claude Bernard, Lyon, France
    Am Heart J 143:301-7. 2002
  8. ncbi request reprint Coronary reperfusion rates in acute myocardial infarction patients after thrombolytic treatment with anistreplase: correlation with the delay from onset of symptoms to treatment: a review of 424 case records of patients admitted to coronary reperfusion st
    A Leizorovicz
    Hôpital Neuro Cardiologique, Département Méthodologie et Essais Thérapeutiques, Lyon, France
    J Cardiovasc Pharmacol 19:34-9. 1992
  9. ncbi request reprint A randomised placebo-controlled pilot dose-response study with anisoylated plasminogen streptokinase activator complex in acute coronary artery occlusions
    A Leizorovicz
    Unite de Pharmacologie Clinique, Hôpital Neuro Cardiologique, Lyon
    Drugs 33:133-7. 1987
  10. ncbi request reprint EasyMA: a program for the meta-analysis of clinical trials
    M Cucherat
    Service de Pharmacologie Clinique, Hopital Cardiologique, Lyon, France
    Comput Methods Programs Biomed 53:187-90. 1997

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Epidemiology of venous thromboembolism in Asian patients undergoing major orthopedic surgery without thromboprophylaxis. The SMART study
    A Leizorovicz
    Service de Pharmacologie Clinique, EA 3736, Universite de Lyon 1, Lyon, France
    J Thromb Haemost 3:28-34. 2005
    ..In Asian patients undergoing surgery, the incidence of venous thromboembolism (VTE) is thought to be low relative to Western patients, and the routine use of thromboprophylaxis is controversial...
  2. ncbi request reprint Epidemiology of post-operative venous thromboembolism in Asian patients. Results of the SMART venography study
    Alain Leizorovicz
    Service de Pharmacologie Clinique, EA 643, Universite de Lyon 1, Lyon, France
    Haematologica 92:1194-200. 2007
    ..The aim of this study was to estimate the rate of venous thromboembolism, including asymptomatic deep-vein thrombosis, undergoing hip or knee surgery and not receiving pharmacological thromboprophylaxis...
  3. pmc Heterogeneity prevails: the state of clinical trial data management in Europe - results of a survey of ECRIN centres
    Wolfgang Kuchinke
    Coordination Centre for Clinical Trials, Heinrich Heine University Duesseldorf, Duesseldorf, Germany
    Trials 11:79. 2010
    ....
  4. doi request reprint Safety profile of tinzaparin versus subcutaneous unfractionated heparin in elderly patients with impaired renal function treated for acute deep vein thrombosis: the Innohep® in Renal Insufficiency Study (IRIS)
    Alain Leizorovicz
    Faculte de Medecine Laennec, Service de Pharmacologie, Clinique, Rue Guillaume Paradin, 69008, Lyon, France
    Thromb Res 128:27-34. 2011
    ..IRIS aimed to assess whether LMWH is at least as safe as UFH in this population...
  5. ncbi request reprint Preventing venous thromboembolism in medical patients
    Alain Leizorovicz
    Unite de Pharmacologie Clinique, EA 3736, Universite Claude Bernard Lyon I, Rue Guillaume Paradin, 69376 Lyon Cedex 08, France
    Circulation 110:IV13-9. 2004
    ..Based on duration of use in clinical trials in acutely ill medical patients, prophylactic treatment with UFH and LMWH is recommended for 2 weeks...
  6. ncbi request reprint Randomized, placebo-controlled trial of dalteparin for the prevention of venous thromboembolism in acutely ill medical patients
    Alain Leizorovicz
    Unite de Pharmacologie Clinique, Universite Claude Bernard Lyon I, Lyon, France
    Circulation 110:874-9. 2004
    ....
  7. ncbi request reprint Bisoprolol for the treatment of chronic heart failure: a meta-analysis on individual data of two placebo-controlled studies--CIBIS and CIBIS II. Cardiac Insufficiency Bisoprolol Study
    Alain Leizorovicz
    Service de Pharmacologie Clinique, Universite Claude Bernard, Lyon, France
    Am Heart J 143:301-7. 2002
    ..This may help clinicians in their decisions as to whether to prescribe bisoprolol for their individual patients...
  8. ncbi request reprint Coronary reperfusion rates in acute myocardial infarction patients after thrombolytic treatment with anistreplase: correlation with the delay from onset of symptoms to treatment: a review of 424 case records of patients admitted to coronary reperfusion st
    A Leizorovicz
    Hôpital Neuro Cardiologique, Département Méthodologie et Essais Thérapeutiques, Lyon, France
    J Cardiovasc Pharmacol 19:34-9. 1992
    ..This may contribute to the lower mortality rate observed with early fibrinolytic treatment...
  9. ncbi request reprint A randomised placebo-controlled pilot dose-response study with anisoylated plasminogen streptokinase activator complex in acute coronary artery occlusions
    A Leizorovicz
    Unite de Pharmacologie Clinique, Hôpital Neuro Cardiologique, Lyon
    Drugs 33:133-7. 1987
    ..The reperfusion rates were as follows: placebo, 0/9; APSAC 15U, 5/8; APSAC 20U, 5/9; APSAC 25U, 6/9; APSAC 30U, 5/9. Reperfusion was achieved in 60% of treated patients but no dose relationship was revealed...
  10. ncbi request reprint EasyMA: a program for the meta-analysis of clinical trials
    M Cucherat
    Service de Pharmacologie Clinique, Hopital Cardiologique, Lyon, France
    Comput Methods Programs Biomed 53:187-90. 1997
    ..Data-editing and data-manipulating facilities are also possible. Much care has been taken to make the user interface as user-friendly as possible, so that the program is within the reach of all medical researchers...
  11. doi request reprint New insights on the relation between untreated and treated outcomes for a given therapy effect model is not necessarily linear
    Jean Pierre Boissel
    Institute for Theoretical Medicine and CNRS UMR5558, RTH Laennec School of Medicine, Rue Guillaume Paradin, 69008 Lyon, France
    J Clin Epidemiol 61:301-7. 2008
    ..We have called this relation the effect model. Our objectives were to demonstrate that the relation is general and not necessarily linear...
  12. pmc A systematic review of the accuracy of ultrasound in the diagnosis of deep venous thrombosis in asymptomatic patients
    Behrouz Kassai
    Clinical Pharmacology Unit, Rue Guillaume Paradin BP8071 69376, Lyon Cedex 08, France
    Thromb Haemost 91:655-66. 2004
    ..Our results suggest that, particularly for proximal veins, ultrasound is accurate for the diagnosis of DVT in asymptomatic postoperative orthopedic patients. More research is needed in other clinical settings...
  13. ncbi request reprint Ventricular fibrillation following administration of thrombolytic treatment. The EMIP experience. European Myocardial Infarction Project
    J P Boissel
    Service de Pharmacologie Clinique, Lyon, France
    Eur Heart J 17:213-21. 1996
    ..These results suggest the existence of reperfusion-induced ventricular fibrillation in patients developing myocardial infarction who receive thrombolytic treatment...
  14. ncbi request reprint The assessment of deep vein thromboses for therapeutic trials
    Alain Leizorovicz
    Clinical Pharmacology Department, University Claude Bernard, Faculte Laennec, Rue Guillaume Paradin, Lyon, France
    Angiology 54:19-24. 2003
    ..Compression ultrasonography has already been adopted as the principal method for evaluating DVT in several ongoing large scale prevention trials with the approval of major drug agencies...
  15. ncbi request reprint QT dynamicity and sudden death after myocardial infarction: results of a long-term follow-up study
    Philippe Chevalier
    Hopital Louis Pradel, Lyon, France
    J Cardiovasc Electrophysiol 14:227-33. 2003
    ..The aim of this study was to determine whether impaired adaptation of the QT interval to changes in heart rate predicts sudden death after an acute myocardial infarction...
  16. ncbi request reprint Influence of age on the prescription of vitamin K antagonists in outpatients with permanent atrial fibrillation in France
    A Leizorovicz
    Service de Pharmacologie Clinique, EA 3736, Faculté R T H Laennec, Universite Lyon 1, Rue Guillaume Paradin, BP 8071 69376 LYON cedex 08, France
    Pharmacoepidemiol Drug Saf 16:32-8. 2007
    ....
  17. ncbi request reprint Primary angioplasty versus prehospital fibrinolysis in acute myocardial infarction: a randomised study
    Eric Bonnefoy
    Coronary Care Unit, Hopital Louis Pradel, Hospices Civils de Lyon, Lyon, France
    Lancet 360:825-9. 2002
    ..Our aim was to find out whether primary angioplasty was better than prehospital fibrinolysis...
  18. ncbi request reprint Correlation of plasma coagulation parameters with thromboprophylaxis, patient characteristics, and outcome in the MEDENOX study
    Louis Desjardins
    Service hématologie, CHU Laval, Ste Foy, Quebec, Canada
    Arch Pathol Lab Med 128:519-26. 2004
    ..Plasma anti-Xa and anti-IIa activities correlate with the dose of low-molecular-weight heparin, and D-dimer and thrombin-antithrombin complexes are markers of procoagulant activity...
  19. ncbi request reprint Risk factors for venous thromboembolism in hospitalized patients with acute medical illness: analysis of the MEDENOX Study
    Raza Alikhan
    Academic Department of Surgery, Guy s, King s, and St Thomas School of Medicine, London, England
    Arch Intern Med 164:963-8. 2004
    ..There is limited information about risk factors for venous thromboembolism (VTE) in acutely ill hospitalized general medical patients...
  20. ncbi request reprint Prevention of venous thromboembolism in medical patients with enoxaparin: a subgroup analysis of the MEDENOX study
    Raza Alikhan
    Academic Department of Surgery, Guy s, King s, St Thomas School of Medicine, London, UK
    Blood Coagul Fibrinolysis 14:341-6. 2003
    ..22 (95% CI, 0.09-0.51); immobility, 0.53 (95% CI, 0.14-1.72); previous VTE, 0.49 (95% CI, 0.15-1.68); and cancer, 0.50 (95%o CI, 0.14-1.72). The beneficial effects of enoxaparin extend to a wide range of acutely ill medical patients...
  21. ncbi request reprint Factors predictive of venous thrombotic complications in patients with isolated superficial vein thrombosis
    Sara Quenet
    Clinical Pharmacology Department, University Hospital Bellevue, Saint Etienne, France
    J Vasc Surg 38:944-9. 2003
    ..Superficial vein thrombosis may be complicated with venous thromboembolism. We examined factors predictive of venous thromboembolism in superficial vein thrombosis, which, to our knowledge, had not been prospectively studied before...
  22. ncbi request reprint Thromboprophylaxis with dalteparin in medical patients: which patients benefit?
    Alexander T Cohen
    Department of Surgery, King s College Hospital, Bessemer Road, London SE5 9PJ, UK
    Vasc Med 12:123-7. 2007
    ..Our findings, therefore, support the broad application of thromboprophylaxis in acutely ill hospitalized medical patients...
  23. pmc Prevention of venous thromboembolism in medically ill patients: a clinical update
    Alexander G G Turpie
    Department of Medicine, Hamilton General Hospital, HHS McMaster Clinic, 237 Barton Street East, Hamilton, Ontario L8L 2X2, Canada
    Postgrad Med J 82:806-9. 2006
    ....
  24. ncbi request reprint Mortality rates and risk factors for asymptomatic deep vein thrombosis in medical patients
    Paul T Vaitkus
    Cardiology Division, College of Medicine, University of Illinois at Chicago, 840 S Wood St, Chicago, Illinois 60612, USA
    Thromb Haemost 93:76-9. 2005
    ..In conclusion, the high mortality rate in patients with asymptomatic proximal DVT underscores its clinical relevance and supports targeting of asymptomatic proximal DVT as an appropriate endpoint in clinical trials of thromboprophylaxis...
  25. ncbi request reprint Efficacy and safety of fixed low-dose dalteparin in preventing venous thromboembolism among obese or elderly hospitalized patients: a subgroup analysis of the PREVENT trial
    Nils Kucher
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Arch Intern Med 165:341-5. 2005
    ..We were concerned that a fixed rather than a weight-based dosing regimen of dalteparin sodium to prevent venous thromboembolism (VTE) might result in decreased efficacy in obese patients and decreased safety in elderly patients...
  26. ncbi request reprint Impact of time to treatment on mortality after prehospital fibrinolysis or primary angioplasty: data from the CAPTIM randomized clinical trial
    Philippe Gabriel Steg
    Service de cardiologie, Hopital Bichat, 46 rue Henri Huchard, 75877 Paris Cedex 18, France
    Circulation 108:2851-6. 2003
    ....
  27. ncbi request reprint Predictors of cardiovascular events in patients with end-stage renal disease: an analysis from the Fosinopril in dialysis study
    Michele Kessler
    Department of Nephrology, University Hospital of Nancy, Nancy, France
    Nephrol Dial Transplant 22:3573-9. 2007
    ..A risk prediction model was created from the FOSIDIAL trial to identify factors predictive of CVE and to evaluate the relative strength of known predictors when considered together in a multivariate model...
  28. ncbi request reprint Prognosis of patients with atherothrombotic disease: a prospective survey in a non-hospital setting
    Jean Ferrieres
    INSERM U 558, Department of Epidemiology, Toulouse, France
    Int J Cardiol 112:302-7. 2006
    ..However, atherothrombotic diseases are often associated and little is known of the prognosis of these diseases taken as a whole...
  29. ncbi request reprint Antithrombotic management after an ischemic stroke in French primary care practice: results from three pooled cross-sectional studies
    Emmanuel Touze
    Department of Neurology, Hopital Sainte Anne, René Descartes, Paris, France
    Cerebrovasc Dis 20:78-84. 2005
    ..We aimed at quantifying and explaining the underuse of antithrombotic treatments after an ischemic stroke in patients seen in French primary care...
  30. ncbi request reprint Primary angioplasty is cost-minimizing compared with pre-hospital thrombolysis for patients within 60 min of a percutaneous coronary intervention center: the Comparison of Angioplasty and Pre-hospital Thrombolysis in Acute Myocardial Infarction (CAPTIM) c
    Jacques Machecourt
    Coronary Care Unit, CHU Grenoble, Grenoble, France
    J Am Coll Cardiol 45:515-24. 2005
    ....