Ch Legendre

Summary

Country: France

Publications

  1. ncbi request reprint [Renal transplantation in adult]
    Christophe Legendre
    Universite Paris Descartes, Sorbonne Paris Cité, Hopital Necker, 75015 Paris
    Rev Prat 62:65-71. 2012
  2. doi request reprint New insights into postrenal transplant hemolytic uremic syndrome
    Julien Zuber
    Service de Transplantation Rénale Adulte, Universite Paris Descartes, Hopital Necker, 161 rue de Sevres, Paris F 75015, France
    Nat Rev Nephrol 7:23-35. 2011
  3. doi request reprint Co-stimulation blockade as a new strategy in kidney transplantation: benefits and limits
    Renaud Snanoudj
    Service de Transplantation Rénale Adulte, Hopital Necker, Assistance Publique Hopitaux de Paris, Paris, France
    Drugs 70:2121-31. 2010
  4. doi request reprint [Living donors for kidney transplantation: ethical and legal challenges]
    Marie France Mamzer-Bruneel
    Service de transplantation rénale, Laboratoire d éthique médicale et de médecine légale de l université Paris Descartes, Hopital Necker, rue de Sevres, Paris, France
    Med Sci (Paris) 26:522-5. 2010
  5. doi request reprint Recurrence of nephrotic syndrome after transplantation in a mixed population of children and adults: course of glomerular lesions and value of the Columbia classification of histological variants of focal and segmental glomerulosclerosis (FSGS)
    Guillaume Canaud
    Department of Kidney Transplantation, Necker Hospital, 149 rue de Sevres, 75015, Paris, USA
    Nephrol Dial Transplant 25:1321-8. 2010
  6. doi request reprint Eculizumab in renal transplantation
    Christophe Legendre
    Sorbonne Paris Cité, Faculte de Medecine, Universite Paris Descartes, Paris, France
    Transplant Rev (Orlando) 27:90-2. 2013
  7. doi request reprint Terminal complement inhibitor eculizumab in atypical hemolytic-uremic syndrome
    C M Legendre
    Université Paris Descartes and Assistance Publique Hôpitaux de Paris, Hopital Necker, INSERM Unité 845, Paris, France
    N Engl J Med 368:2169-81. 2013
  8. pmc Acute respiratory failure in kidney transplant recipients: a multicenter study
    Emmanuel Canet
    Medical Intensive Care Unit and Biostatistics Departments, Saint Louis Teaching Hospital, 1 avenue Claude Vellefaux, Paris F 75010, France
    Crit Care 15:R91. 2011
  9. ncbi request reprint [Immunosuppression in kidney transplantation]
    C Legendre
    Service de Transplantation Rénale Adulte, Hopital Necker, 149, rue de Sevres, 75015 Paris, France
    Ann Urol (Paris) 41:276-84. 2007
  10. doi request reprint [New faces of acute rejection in 2008]
    C Legendre
    Université Paris Descartes and Service de Transplantation Rénale Adulte, Hopital Necker, 149 rue de Sevres, 75743 Paris Cedex 15
    Nephrol Ther 5:S297-300. 2009

Detail Information

Publications92

  1. ncbi request reprint [Renal transplantation in adult]
    Christophe Legendre
    Universite Paris Descartes, Sorbonne Paris Cité, Hopital Necker, 75015 Paris
    Rev Prat 62:65-71. 2012
    ....
  2. doi request reprint New insights into postrenal transplant hemolytic uremic syndrome
    Julien Zuber
    Service de Transplantation Rénale Adulte, Universite Paris Descartes, Hopital Necker, 161 rue de Sevres, Paris F 75015, France
    Nat Rev Nephrol 7:23-35. 2011
    ..This finding suggests that the burden of endothelial injury in a post-transplantation setting may trigger de novo HUS in the presence of mild genetic susceptibility to HUS...
  3. doi request reprint Co-stimulation blockade as a new strategy in kidney transplantation: benefits and limits
    Renaud Snanoudj
    Service de Transplantation Rénale Adulte, Hopital Necker, Assistance Publique Hopitaux de Paris, Paris, France
    Drugs 70:2121-31. 2010
    ..g. their long half-life, which can be problematic in cases of serious adverse events, their long-term safety and efficacy, and the lack of monitoring tools to allow modulation of their use over time...
  4. doi request reprint [Living donors for kidney transplantation: ethical and legal challenges]
    Marie France Mamzer-Bruneel
    Service de transplantation rénale, Laboratoire d éthique médicale et de médecine légale de l université Paris Descartes, Hopital Necker, rue de Sevres, Paris, France
    Med Sci (Paris) 26:522-5. 2010
    ....
  5. doi request reprint Recurrence of nephrotic syndrome after transplantation in a mixed population of children and adults: course of glomerular lesions and value of the Columbia classification of histological variants of focal and segmental glomerulosclerosis (FSGS)
    Guillaume Canaud
    Department of Kidney Transplantation, Necker Hospital, 149 rue de Sevres, 75015, Paris, USA
    Nephrol Dial Transplant 25:1321-8. 2010
    ..However, the predictive value of this classification to assess the risk of recurrence after transplantation has not been addressed...
  6. doi request reprint Eculizumab in renal transplantation
    Christophe Legendre
    Sorbonne Paris Cité, Faculte de Medecine, Universite Paris Descartes, Paris, France
    Transplant Rev (Orlando) 27:90-2. 2013
    ....
  7. doi request reprint Terminal complement inhibitor eculizumab in atypical hemolytic-uremic syndrome
    C M Legendre
    Université Paris Descartes and Assistance Publique Hôpitaux de Paris, Hopital Necker, INSERM Unité 845, Paris, France
    N Engl J Med 368:2169-81. 2013
    ..Plasma exchange or infusion may transiently maintain normal levels of hematologic measures but does not treat the underlying systemic disease...
  8. pmc Acute respiratory failure in kidney transplant recipients: a multicenter study
    Emmanuel Canet
    Medical Intensive Care Unit and Biostatistics Departments, Saint Louis Teaching Hospital, 1 avenue Claude Vellefaux, Paris F 75010, France
    Crit Care 15:R91. 2011
    ..Data on pulmonary complications in renal transplant recipients are scarce. The aim of this study was to evaluate acute respiratory failure (ARF) in renal transplant recipients...
  9. ncbi request reprint [Immunosuppression in kidney transplantation]
    C Legendre
    Service de Transplantation Rénale Adulte, Hopital Necker, 149, rue de Sevres, 75015 Paris, France
    Ann Urol (Paris) 41:276-84. 2007
    ..Finally, a brief review of current and future perspectives regarding the improvement of both efficacy and tolerability of immunosuppression in kidney transplantation is presented...
  10. doi request reprint [New faces of acute rejection in 2008]
    C Legendre
    Université Paris Descartes and Service de Transplantation Rénale Adulte, Hopital Necker, 149 rue de Sevres, 75743 Paris Cedex 15
    Nephrol Ther 5:S297-300. 2009
    ..The Banffclassification remains a very useful tool to improve the precision of these definitions. The new technologies such as microarrays should help to identify new aspects of acute rejection...
  11. doi request reprint Improving outcomes for solid-organ transplant recipients at risk from cytomegalovirus infection: late-onset disease and indirect consequences
    Christophe Legendre
    Service de transplantation rénale, Hopital Necker, Paris, France
    Clin Infect Dis 46:732-40. 2008
    ....
  12. doi request reprint A tribute to Jean Hamburger's contribution to organ transplantation
    Ch Legendre
    Universite Paris Descartes, Hopital Necker, Assistance Publique Hôpitaux Paris, Paris, France
    Am J Transplant 10:2392-5. 2010
    ..As early as 1956-1957, he understood the potential importance of Jean Dausset's discovery for transplantation...
  13. ncbi request reprint Long-term renal allograft outcome after simultaneous kidney and pancreas transplantation
    Jean Philippe Rerolle
    Service de Nephrologie, Service d Urologie, Hopital Saint Louis, Paris, France
    Nephrol Dial Transplant 17:905-9. 2002
    ..We conducted a retrospective, case-controlled study to compare the function, survival and pathology of renal allografts after SPK and kidney-alone (KA) transplantations...
  14. doi request reprint Interstitial fibrosis evolution on early sequential screening renal allograft biopsies using quantitative image analysis
    A Servais
    Department of Nephrology, Assistance Publique Hopitaux de Paris, Necker Enfants Malades Hospital, Paris, France
    Am J Transplant 11:1456-63. 2011
    ..IF evolution is more important during the first 3 months and has some predictive ability for change in GFR. Intervention to decrease IF should be applied early, i.e. before 3 months, after transplantation...
  15. ncbi request reprint NPHS2 mutation analysis shows genetic heterogeneity of steroid-resistant nephrotic syndrome and low post-transplant recurrence
    Stefanie Weber
    Inserm U574, Necker Enfants Malades Hospital, Paris 5 University, Paris, France
    Kidney Int 66:571-9. 2004
    ..Mutations of NPHS2 are causative in familial autosomal-recessive (AR) and sporadic steroid-resistant nephrotic syndrome (SRNS). This study aimed to determine the spectrum of NPHS2 mutations and to establish genotype-phenotype correlations...
  16. doi request reprint Combined posttransplant prophylactic IVIg/anti-CD 20/plasmapheresis in kidney recipients with preformed donor-specific antibodies: a pilot study
    Alexandre Loupy
    INSERM, U970, Paris Cardiovascular Research Center PARCC, Paris, France
    Transplantation 89:1403-10. 2010
    ....
  17. doi request reprint Intensive and prolonged treatment of focal and segmental glomerulosclerosis recurrence in adult kidney transplant recipients: a pilot study
    G Canaud
    Universite Paris Descartes, 7 Rue de l Ecole de Médecine, Paris 75007, France
    Am J Transplant 9:1081-6. 2009
    ..This small pilot study provides very encouraging results demonstrating that this treatment rapidly achieves complete and sustained remission in a high proportion of patients...
  18. doi request reprint Quantification of interstitial fibrosis by image analysis on routine renal biopsy in patients receiving cyclosporine
    Aude Servais
    Department of Renal Transplantation, Universite Paris 5 Rene Descartes, Necker Hospital, Paris, France
    Transplantation 84:1595-601. 2007
    ..We performed a retrospective analysis to calculate IF on routine renal biopsies performed at 1 year posttransplant...
  19. doi request reprint [Involvement of endoplasmic reticulum stress in solid organ transplantation]
    Nicolas Pallet
    INSERM U775, Centre Universitaire des Saints Peres, Paris, France
    Med Sci (Paris) 26:397-403. 2010
    ....
  20. doi request reprint Cytochrome P450 3A polymorphisms and immunosuppressive drugs: an update
    Dany Anglicheau
    Universite Rene Descartes, Service de Transplantation Rénale et de Soins Intensifs, Hopital Necker, APHP, 149 rue de Sevres, 75743, Cedex 15, Paris, France
    Pharmacogenomics 8:835-49. 2007
    ..It is now of utmost importance to prospectively test these initial results to improve the individualized use of these drugs...
  21. pmc Early epithelial phenotypic changes predict graft fibrosis
    Alexandre Hertig
    Urgences Néphrologiques and Transplantation Rénale, Hopital Tenon, 4 rue de la Chine, 75020 Paris, France
    J Am Soc Nephrol 19:1584-91. 2008
    ..In conclusion, early phenotypic changes indicative of epithelial-to-mesenchymal transition predict the progression toward interstitial fibrosis in human renal allografts...
  22. ncbi request reprint Factors influencing glomerular filtration rate in renal transplantation after cyclosporine withdrawal using sirolimus-based therapy: a multivariate analysis of results at five years
    Christophe Legendre
    Hopital Necker, Paris, France
    Clin Transplant 21:330-6. 2007
    ..010) were significant predictors of GFR change from baseline. In conclusion, patients with risk factors for reduced renal function benefit from SRL maintenance therapy without CsA vs. those remaining on CsA...
  23. ncbi request reprint [New diagnostic tools in renal transplantation]
    Eric Thervet
    Service de Transplantation Rénale et de Soins Intensifs, Hopital Necker, 149, rue de Sevres, 75015 Paris, France
    Nephrol Ther 2:165-75. 2006
    ..Genotyping, transcriptome analysis, proteomic as well as the specific immune response are analyzed in this article...
  24. doi request reprint mToR inhibitors-induced proteinuria: mechanisms, significance, and management
    Emmanuel Letavernier
    Transplantation Unit, Hopital Necker, 75743 Paris, France
    Transplant Rev (Orlando) 22:125-30. 2008
    ..We discuss herein the possible mechanisms and the significance of mToR blockade-induced proteinuria...
  25. pmc High-dosage intravenous immunoglobulin-associated macrovacuoles are associated with chronic tubulointerstitial lesion worsening in renal transplant recipients
    Guillaume Bollée
    Laboratoire d Anatomie Pathologique, Hopital Necker, APHP, and Université René Descartes, Paris, France
    Clin J Am Soc Nephrol 3:1461-8. 2008
    ..Intravenous immunoglobulins (IVIg) may induce acute renal failure associated with tubular vacuolization. Although the use of IVIg is increasing in kidney transplantation, their impact on graft histology and function remains unknown...
  26. doi request reprint Early conservative intervention for candida contamination of preservative fluid without allograft nephrectomy
    Guillaume Canaud
    Department of Kidney Transplantation, Necker Hospital, 149 rue de Sevres, 75015 Paris, France
    Nephrol Dial Transplant 24:1325-7. 2009
    ..Fungal contamination of kidney allograft preservative fluid can lead to renal arteritis and arterial wall rupture...
  27. doi request reprint Deciphering calcineurin inhibitor nephrotoxicity: a pharmacological approach
    Nicolas Pallet
    Necker Hospital and Paris Descartes University, 149, rue de Sevres, 75015, Paris, France
    Pharmacogenomics 11:1491-501. 2010
    ..The importance of global approaches such as toxicogenomics is emphasized to characterize early cellular responses implicated in calcineurin inhibitor nephrotoxicity...
  28. doi request reprint Glomerular collapse associated with subtotal renal infarction in kidney transplant recipients with multiple renal arteries
    Guillaume Canaud
    Universite Paris Descartes, Paris, France
    Am J Kidney Dis 55:558-65. 2010
    ..Together, these data suggest that acute glomerular ischemia may lead to glomerular collapse in kidney transplants...
  29. doi request reprint [Recent approaches of quantification of interstitial fibrosis in renal transplantation]
    Aude Servais
    Service de Nephrologie, Assistance Publique Hopitaux de Paris, Hopital Necker Enfants Malades, 149, rue de Sevres, 75015 Paris, France
    Med Sci (Paris) 25:945-50. 2009
    ..The prognostic value of quantitative image analysis might be increased by techniques addressing the dynamics of fibrosis matrix generation...
  30. doi request reprint Therapeutic approach to focal and segmental glomerulosclerosis recurrence in kidney transplant recipients
    Guillaume Canaud
    Universite Paris Descartes, Paris, France
    Transplant Rev (Orlando) 24:121-8. 2010
    ..Recent advances in our understanding of primary FSGS and podocyte function open the way to more targeted therapies. This review summarizes the therapeutic approach to FSGS recurrence...
  31. doi request reprint Should routine pyeloureterostomy be advocated in adult kidney transplantation? A prospective study of 283 recipients
    Marc Olivier Timsit
    Universite Paris Descartes, Necker Hospital, Assistance Publique Hopitaux de Paris, Paris, France
    J Urol 184:2043-8. 2010
    ..We assessed urological complications and their management after routine pyeloureterostomy in adult kidney transplantation cases...
  32. doi request reprint FOXP3-enriched infiltrates associated with better outcome in renal allografts with inflamed fibrosis
    Julien Zuber
    Universite Paris Descartes, Paris, France
    Nephrol Dial Transplant 24:3847-54. 2009
    ..We hypothesized that Tregs might accumulate within the graft since enrichment of Tregs has been frequently described in chronically inflamed tissues...
  33. ncbi request reprint Proteinuria following a switch from calcineurin inhibitors to sirolimus
    Emmanuel Letavernier
    Service de Transplantation Adulte, Hopital Necker, and Paris V University Service de Néphrologie et Transplantation, Hopital Saint Louis, Paris, France
    Transplantation 80:1198-203. 2005
    ..However, the incidence of proteinuria following a switch from CNI to sirolimus has caused concern, and was therefore investigated here...
  34. doi request reprint HNF1B-related diabetes triggered by renal transplantation
    Julien Zuber
    Service de Transplantation Rénale Adulte, Universite Paris Descartes, Paris Cedex 15, France
    Nat Rev Nephrol 5:480-4. 2009
    ..He had a history of gout, but his fasting blood glucose and glycated hemoglobin concentrations had been normal before transplantation...
  35. doi request reprint Role of pharmacogenetics of immunosuppressive drugs in organ transplantation
    Eric Thervet
    Service de transplantation rénale, Hopital Necker, Paris, France
    Ther Drug Monit 30:143-50. 2008
    ....
  36. ncbi request reprint To biopsy or not to biopsy? Should we screen the histology of stable renal grafts?
    Olivier Thaunat
    Centre de Recherche des Cordeliers, Universite Pierre et Marie Curie, Paris, France
    Transplantation 84:671-6. 2007
    ..In the present review, we summarize the available data from the literature to determine the pros and cons of protocol renal allograft biopsies. On the basis of this evidence, we discuss the ethical concerns raised by this procedure...
  37. ncbi request reprint CYP3A5 and MDR1 genetic polymorphisms and cyclosporine pharmacokinetics after renal transplantation
    Dany Anglicheau
    Unité INSERM UMR S490, Centre Universitaire des Saints Peres, Paris, France
    Clin Pharmacol Ther 75:422-33. 2004
    ..We postulated that, in renal transplant recipients, these SNPs could be associated with interindividual variations in cyclosporine pharmacokinetics...
  38. ncbi request reprint Unusual post-transplantation recurrence of focal segmental glomerulosclerosis which resolved with cyclosporine but not with sirolimus
    Habib Skhiri
    Department of Renal Transplantation, Necker Hospital, Paris, France
    Transpl Int 18:458-60. 2005
    ..This observation points to the effectiveness of cyclosporine for the recurrence of FSGS and indicates that sirolimus should be given with caution in such cases...
  39. ncbi request reprint Autophagy protects renal tubular cells against cyclosporine toxicity
    Nicolas Pallet
    INSERM U775, Centre Universitaire des Saints Peres, Universite Paris Descartes, Paris, France
    Autophagy 4:783-91. 2008
    ..Taken together, these results demonstrate that CsA, through ER stress induction, activates autophagy as a protection against cell death...
  40. ncbi request reprint Impact of surgical procedures and complications on outcomes of third and subsequent kidney transplants
    Alexandre Loupy
    Service de transplantation rénale, Hopital Necker, Paris, France
    Transplantation 83:385-91. 2007
    ..Surgical procedures and complications have rarely been described in patients receiving a third or subsequent renal transplant...
  41. ncbi request reprint Sirolimus early graft nephrotoxicity: clinical and experimental data
    Nicolas Pallet
    Universite Paris Descartes, Faculté de Médecine Hôpital Necker, Service de transplantation rénale, France
    Curr Drug Saf 1:179-87. 2006
    ..For all these reasons, SRL nephrotoxicty has become an important issue after renal transplantation. The review will discuss the clinical and the experimental data regarding this complication, which has been underestimated...
  42. doi request reprint Determination of lowest possible creatinine in living-donor kidney renal transplant recipients based on donor kidney function
    Rebecca Sberro
    Service de transplantation rénale, Hôpital Necker Paris, France
    Transplantation 86:558-63. 2008
    ..The objective of this study was to use information from a donor to establish the lowest possible serum creatinine (SCr) of the recipient as a means of identifying early graft dysfunction...
  43. ncbi request reprint Efficacy and safety of lowering immunosuppression to treat CMV infection in renal transplant recipients on valaciclovir prophylaxis: a pilot study
    Dany Anglicheau
    Service de Néphrologie et de Transplantation Rénale and Service de Virologie, Hopital Saint Louis, Paris, France
    Nephrol Dial Transplant 18:1654-6. 2003
    ..The aim of this pilot study was to evaluate the safety and efficacy of lowering immunosuppression in kidney transplant recipients who exhibit mildly symptomatic CMV infections while on valaciclovir prophylaxis...
  44. ncbi request reprint Adverse neuropsychiatric effects of cytomegalovirus prophylaxis with valaciclovir in renal transplant recipients
    Vincent Das
    Service de transplantation rénale, Hopital Necker Enfants Malades, 149 rue de Sevres, 75015 Paris, France
    Nephrol Dial Transplant 21:1395-401. 2006
    ..Valaciclovir (VACV) has been reported to induce adverse neuropsychiatric effects (ANE), especially in patients with renal failure, but few data are available for renal transplant recipients (RTR)...
  45. ncbi request reprint Tacrolimus-induced alopecia in female kidney-pancreas transplant recipients
    Leila Tricot
    Service de Transplantation Rénale et de Soins Intensifs, Hopital Necker, 149 rue de Sevres, 75015 Paris, France
    Transplantation 80:1546-9. 2005
    ..Since 1998, we have included tacrolimus within the immunosuppressive regimen following kidney-pancreas transplantation. The aim of this study was to evaluate the incidence of alopecia in this population and possible risk factors...
  46. ncbi request reprint Benefit-risk assessment of ciclosporin withdrawal in renal transplant recipients
    Eric Thervet
    Service de Nephrologie et Transplantation Renale, Hopital Saint Louis, Paris, France
    Drug Saf 27:457-76. 2004
    ....
  47. doi request reprint Proteinuria >0.5 g/d, a prevalent prognostic factor for patient and graft survival in kidney transplantation
    Felix Cantarovich
    Hopital Necker, Service de Transplantation Adultes, Paris, France
    Clin Transplant 24:175-80. 2010
    ..5 g/d) or Scr (< or = or >120 micromol/L) along with the log-rank test for all comparisons were computed. Statistical significance was set with p-value < 0.05...
  48. ncbi request reprint Hydrolysis of coagulation factors by circulating IgG is associated with a reduced risk for chronic allograft nephropathy in renal transplanted patients
    Bharath Wootla
    Centre de Recherche des Cordeliers, Universite Pierre et Marie Curie Paris 6, Unité Mixte de Recherche S 872, Universite Paris Descartes, Unité Mixte de Recherche S 872, Institut National de la Sante et de la Recherche Medicale, Unite 872, Paris, France
    J Immunol 180:8455-60. 2008
    ..These data suggest that PFR-MCA hydrolysis may be used as a prognosis marker for CAN in renal-transplanted patients...
  49. ncbi request reprint Replacement kidney lipomatosis after renal transplantation
    Inass Laouad
    Department of Nephrology and Renal Transplantation, Necker Hospital, 149 rue de Sevres, 75015 Paris, France
    Transplantation 79:496-8. 2005
    ..We describe three cases of replacement kidney lipomatosis that occurred after cadaveric renal transplantation and discuss the possible differential diagnosis of this condition...
  50. doi request reprint [Endoplasmic reticulum stress in kidney diseases: a question of life and death?]
    Nicolas Pallet
    INSERM U775, Centre Universitaire des Saints Peres, Universite Paris Descartes, 45, rue des Saints Pères, 75006 Paris, France
    Nephrol Ther 5:173-80. 2009
    ..The purpose of this review is to summarize the existing data concerning the role of the endoplasmic reticulum stress during kidney injury and to clarify its precise role in chronic kidney disease...
  51. ncbi request reprint Impact of cytochrome p450 3A5 genetic polymorphism on tacrolimus doses and concentration-to-dose ratio in renal transplant recipients
    Eric Thervet
    INSERM UMR S490, Centre Universitaire des Saints Peres, Paris, France
    Transplantation 76:1233-5. 2003
    ..Subjects with the CYP3A5*1/*1 genotype express large amounts of CYP3A5. Heterozygotes (genotype CYP3A5*1/*3) also express the enzyme. We postulated that CYP3A5 polymorphism is associated with tacrolimus pharmacokinetic variations...
  52. ncbi request reprint Rapamycin inhibits human renal epithelial cell proliferation: effect on cyclin D3 mRNA expression and stability
    Nicolas Pallet
    Unité INSERM UMR S490, Molecular Toxicology, Centre Universitaire des Saints Peres, Universite Rene Descartes, Paris, France
    Kidney Int 67:2422-33. 2005
    ..Because of the known effects of rapamycin in other cell types, we speculated that this action may be secondary to human renal epithelial cells (HRECs) inhibition of proliferation...
  53. ncbi request reprint [Nephrotoxicity of sirolimus: experimental and clinical data]
    Nicolas Pallet
    Service de Transplantation Rénale et de Soins Intensifs, Hopital Necker Enfants Malades, APHP et université Paris V, René Descartes, 149, rue de Sevres, 75743 cedex 15 Paris, France
    Nephrol Ther 2:183-90. 2006
    ..The aim of this review is to summarize the various renal adverse events reported in clinical studies and to present the experimental evidence for putative mechanisms of action for this SRL-induced nephrotoxicity...
  54. ncbi request reprint Consequences of genetic polymorphisms for sirolimus requirements after renal transplant in patients on primary sirolimus therapy
    Dany Anglicheau
    Unité INSERM UMR S490, Molecular Toxicology, Centre Universitaire des Saints Peres, Universite Rene Descartes, Paris, France
    Am J Transplant 5:595-603. 2005
    ..In patients with SRL-based therapy, genotyping of the CYP3As genes may help to optimize the SRL management in transplant recipients...
  55. ncbi request reprint Long-term outcome of third kidney transplants
    Alexandre Loupy
    Service de Transplantation Rénale et de Soins Intensifs, Hopital Necker, and Université René Descartes, Paris, France
    Nephrol Dial Transplant 22:2693-700. 2007
    ....
  56. doi request reprint The impact of preexisting or acquired Kaposi sarcoma herpesvirus infection in kidney transplant recipients on morbidity and survival
    C Frances
    Department of Dermatology Allergology, Assistance Publique Hopitaux de Paris, Universite Pierre et Marie Curie, Hopital Tenon, Paris, France
    Am J Transplant 9:2580-6. 2009
    ..In conclusion, although kidney recipients should be aware of the additional risk of KSHV morbidity, KSHV+ recipients should not be systematically excluded from kidney transplantation...
  57. ncbi request reprint Severe evolution of chronic hepatitis C in renal transplantation: a case control study
    Hervé Zylberberg
    Service d Hépatologie et INSERM U 370, Hopital Saint Louis, Paris, France
    Nephrol Dial Transplant 17:129-33. 2002
    ..To evaluate the impact of kidney transplantation on histopathological progression of hepatitis C virus (HCV)-related liver disease...
  58. ncbi request reprint Multivariate analysis of donor risk factors for graft survival in kidney transplantation
    Fabienne Pessione
    Département Medical et Scientifique, Etablissement francais des greffes, Paris, France
    Transplantation 75:361-7. 2003
    ..The results of the transplantation of marginal donor kidneys remain controversial. This study aimed to investigate the impact of donor risk factors as predictors of kidney-graft outcome...
  59. ncbi request reprint Pharmacokinetic interaction between corticosteroids and tacrolimus after renal transplantation
    Dany Anglicheau
    Service de Néphrologie et de transplantation rénale, Hopital Saint Louis, Paris, France
    Nephrol Dial Transplant 18:2409-14. 2003
    ..Corticosteroids induce both CYP3A and P-gp activity. This study was designed to investigate the presence of a clinically significant interaction between steroids and tacrolimus after renal transplantation...
  60. ncbi request reprint Hemophagocytic syndrome in renal transplant recipients: report of 17 cases and review of literature
    Alexandre Karras
    Service de Nephrologie et Transplantation Renale, Hopital Saint Louis, Paris, France
    Transplantation 77:238-43. 2004
    ..HPS is often caused by an infectious or neoplastic disease and has rarely been described in renal transplant recipients...
  61. doi request reprint Endoplasmic reticulum stress: an unrecognized actor in solid organ transplantation
    Nicolas Pallet
    INSERM U775 and Université Paris Descartes, Centre Universitaire des Saints Peres, Paris, France
    Transplantation 88:605-13. 2009
    ....
  62. doi request reprint What is the relevance of systematic aorto-femoral Doppler ultrasound in the preoperative assessment of patients awaiting first kidney transplantation: a monocentric prospective study
    Guillaume Ploussard
    Department of Urology and Paris 7 University, Saint Louis Hospital, Paris, France
    Nephrol Dial Transplant 25:270-4. 2010
    ..The purpose of our study was to study the relevance of a systematic aorto-femoral colour Doppler ultrasound (DUS) in the evaluation of first renal transplant receivers...
  63. doi request reprint Antiapoptotic properties of recombinant human erythropoietin protects against tubular cyclosporine toxicity
    Nicolas Pallet
    INSERM U775 and Université Paris Descartes, Paris, France
    Pharmacol Res 61:71-5. 2010
    ..In conclusion, we describe here a new potential target of recombinant human erythropoietin and our results provide an interesting framework for further nephroprotective therapies based on recombinant human erythropoietin...
  64. doi request reprint Effects of vitamin D supplementation on the calcium-phosphate balance in renal transplant patients
    Marie Courbebaisse
    Service d Explorations Fonctionnelles, Hopital Necker Enfants Malades, AP HP, Paris, France
    Kidney Int 75:646-51. 2009
    ..Hence, cholecalciferol treatment significantly increased serum 25-hydroxy vitamin D and decreased parathyroid hormone levels with no adverse effects in 25-hydroxy vitamin D-deficient renal transplant patients...
  65. doi request reprint Response of human renal tubular cells to cyclosporine and sirolimus: a toxicogenomic study
    Nicolas Pallet
    INSERM U775, Universite Paris V, Centre Universitaire des Saints Peres, Paris, France
    Toxicol Appl Pharmacol 229:184-96. 2008
    ..Further studies are needed to evaluate if ER stress detection in tubular cells in human biopsies can predict CsA nephrotoxicity...
  66. ncbi request reprint Comparison of sequential protocol using basiliximab versus antithymocyte globulin with high-dose mycophenolate mofetil in recipients of a kidney graft from an expanded-criteria donor
    Nicolas Pallet
    Service de transplantation rénale, Hopital Necker, 149 rue de Sevres, 75743 Paris Cedex 15, France
    Transplantation 81:949-52. 2006
    ..In conclusion, high-dose MMF, corticosteroids, delayed low-dose cyclosporine and induction therapy offers an excellent risk-to-benefit ratio in patients receiving an ECD allograft...
  67. ncbi request reprint Prognostic value of quantitative Kaposi sarcoma--associated herpesvirus load in posttransplantation Kaposi sarcoma
    Claire Pellet
    Laboratory of Pharmacology, Hopital Saint Louis, Paris, France
    J Infect Dis 186:110-3. 2002
    ..01). Thus, quantification of KSHV load in peripheral blood mononuclear cells could represent a useful tool for monitoring transplant recipients with KS...
  68. ncbi request reprint Successful renal retransplantation after post-transplant lymphoproliferative disease
    Alexandre Karras
    Nephrology and Renal Transplantation, Hopital Saint Louis, Paris, France
    Am J Transplant 4:1904-9. 2004
    ..In conclusion, renal retransplantation can be considered in patients with monomorphic PTLD history, without major risk of hematological recurrence...
  69. doi request reprint Sirolimus interacts with pathways essential for podocyte integrity
    Emmanuel Letavernier
    INSERM, U702 and Université Pierre et Marie Curie Paris 6, UMRS702, Paris, France
    Nephrol Dial Transplant 24:630-8. 2009
    ..Podocyte injury and focal segmental glomerulosclerosis have been related to sirolimus therapy in some patients but the pathways underlying these lesions remain hypothetical...
  70. ncbi request reprint Pharmacogenetics in solid organ transplantation: present knowledge and future perspectives
    Dany Anglicheau
    Service de Néphrologie et de transplantation rénale, Hopital Saint Louis, Paris, France
    Transplantation 78:311-5. 2004
    ..Present challenges are to determine the genes of interest and to validate such determination prospectively in clinical practice...
  71. ncbi request reprint [mTOR inhibitors: pleiotropic antiproliferative drugs]
    Nicolas Pallet
    Service de transplantation rénale, Hopital Necker, AP HP, université Paris V René Descartes, 149, rue de Sevres, 75015 Paris, France
    Med Sci (Paris) 22:947-52. 2006
    ..Finally, rapamycine is now evaluated in various diseases characterized by cell growth disorders such as phacomatosis and autosomal dominant polycystic kidney disease...
  72. ncbi request reprint Corticosteroid-free immunosuppression with tacrolimus, mycophenolate mofetil, and daclizumab induction in renal transplantation
    Lionel Rostaing
    Multiorgan Transplant Unit, Rangueil University Hospital, 31059 Toulouse, France
    Transplantation 79:807-14. 2005
    ..We investigated whether a corticosteroid-free tacrolimus (Tac)/mycophenolate mofetil (MMF) regimen, in combination with daclizumab (Dac) induction therapy, provides adequate immunosuppression after renal transplantation...
  73. ncbi request reprint Renal function with delayed or immediate cyclosporine microemulsion in combination with enteric-coated mycophenolate sodium and steroids: results of follow up to 30 months post-transplant
    Georges Mourad
    Department of Nephrology Transplantation, Hopital Lapeyronie, Montpellier, France
    Clin Transplant 21:295-300. 2007
    ..One-yr results have been published previously. We now report the results of an extension study in which patients were followed up for a period of three yr post-transplant...
  74. ncbi request reprint Sequential protocols using basiliximab versus antithymocyte globulins in renal-transplant patients receiving mycophenolate mofetil and steroids
    Georges Mourad
    Service de Nephrologie, Hopital Lapeyronie, 191, avenue du Doyen Gaston Giraud, 34295 Montpellier 5, France
    Transplantation 78:584-90. 2004
    ....
  75. ncbi request reprint Association of the multidrug resistance-1 gene single-nucleotide polymorphisms with the tacrolimus dose requirements in renal transplant recipients
    Dany Anglicheau
    Unité INSERM UMR S490, Molecular Toxicology, Centre Universitaire des Saints Peres, Universite Rene Descartes, 45 Rue des Saints Peres, 75006 Paris, France univ paris5 fr
    J Am Soc Nephrol 14:1889-96. 2003
    ..Genotype monitoring of the MDR1 gene reliably predicts the optimal dose of tacrolimus in renal transplant recipients and may predict the initial daily dose needed by individual patients to obtain adequate immunosuppression...
  76. ncbi request reprint High sirolimus levels may induce focal segmental glomerulosclerosis de novo
    Emmanuel Letavernier
    Service de Transplantation Adulte Hôpital Necker, 149 rue de Sèvres 75743 Paris, France
    Clin J Am Soc Nephrol 2:326-33. 2007
    ..Moreover, a decrease in vascular endothelial growth factor expression was observed in some glomeruli. In conclusion, sirolimus induces FSGS that is responsible for proteinuria in some transplant patients...
  77. ncbi request reprint Superior outcomes in renal transplantation after early cyclosporine withdrawal and sirolimus maintenance therapy, regardless of baseline renal function
    Graeme Russ
    The Queen Elizabeth Hospital, Woodville, South Australia, Australia, and Hospitais da Universidade de Coimbra, Coimbra, Portugal
    Transplantation 80:1204-11. 2005
    ..We evaluated the long-term impact of renal function at the time of withdrawing cyclosporine (CsA) in renal allograft recipients receiving sirolimus (SRL), CsA, and steroids (ST)...
  78. ncbi request reprint A three-arm study comparing immediate tacrolimus therapy with antithymocyte globulin induction therapy followed by tacrolimus or cyclosporine A in adult renal transplant recipients
    Bernard Charpentier
    Service de Nephrologie, Hopital de Bicetre, Le Kremlin Bicetre, France
    Transplantation 75:844-51. 2003
    ..A study was undertaken to assess the efficacy and safety of ATG induction on tacrolimus-based and cyclosporine A (CsA)-based therapies compared with immediate tacrolimus triple therapy in kidney transplant recipients...
  79. doi request reprint [First acute rejection episode after renal transplantation: study of the histopathological characteristics according to the immunological risk]
    Lidia Ghisdal
    Service de Nephrologie, hôpital académique ULB Erasme, 808, Route de Lennik, 1070 Bruxelles, Belgique
    Nephrol Ther 4:173-80. 2008
    ..In conclusion, half of the immunized patients had a humoral rejection, patients with a C4d positive rejection had more early graft loss and more severe histological lesions...
  80. doi request reprint B cell survival in intragraft tertiary lymphoid organs after rituximab therapy
    Olivier Thaunat
    Renal Transplantation and Clinical Immunology Department, Edouard Herriot Hospital, HCL, Universite Claude Bernard Lyon I, INSERM U851, Lyon, France
    Transplantation 85:1648-53. 2008
    ..In the present study, we evaluated the impact of rituximab therapy on TLOs associated with chronic active antibody-mediated rejection, a prototypic humoral chronic inflammatory condition...
  81. ncbi request reprint The economic value of valacyclovir prophylaxis in transplantation
    Jean Paul Squifflet
    University Clinic Saint Luc, 1200 Brussels, Belgium
    J Infect Dis 186:S116-22. 2002
    ..Benefits of valacyclovir in transplantation extend beyond CMV to other herpesviruses and may be increased in some clinical situations by prolonging prophylaxis beyond 3 months...
  82. ncbi request reprint Sirolimus-based therapy following early cyclosporine withdrawal provides significantly improved renal histology and function at 3 years
    Alfredo Mota
    Hospitais da Universidade de Coimbra, Coimbra, Portugal
    Am J Transplant 4:953-61. 2004
    ..8 vs. 68.2 mL/min, p = 0.009). In conclusion, withdrawing CsA from the SRL-CsA-ST regimen resulted in improved renal histology and function...
  83. ncbi request reprint Complications of protocol renal biopsy
    Lazaro Capote Fereira
    Transplantation 77:1475-6. 2004
  84. ncbi request reprint Rapamycin-induced oligospermia
    Lynda Bererhi
    Transplantation 76:885-6. 2003
  85. ncbi request reprint [Use of a previously transplanted kidney for second transplantation]
    Edouard Tariel
    Service d Urologie, Hopital Saint Louis, 1, place Claude Vellefaux, 75475 Paris
    Prog Urol 13:121-2. 2003
    ..To our knowledge, this constitutes the first case of retransplantation of the same organ after long-term implantation in a first recipient...
  86. ncbi request reprint New-onset diabetes after transplantation: 2003 International consensus guidelines. Proceedings of an international expert panel meeting. Barcelona, Spain, 19 February 2003
    Jaime Davidson
    Endocrine and Diabetes Association of Texas, Dallas, TX, USA
    Transplantation 75:SS3-24. 2003
  87. ncbi request reprint Prevalence and management of anemia in renal transplant recipients: a European survey
    Yves Vanrenterghem
    Department of Nephrology, University Hospital Gasthuisberg, Leuven, Belgium
    Am J Transplant 3:835-45. 2003
    ..Further studies should be carried out to interpret whether appropriate management of anemia after kidney transplantation may improve long-term outcome...
  88. ncbi request reprint Improving estimates of event incidence over time in populations exposed to other events: application to three large databases
    Corinne Alberti
    Departement de Biostatistique et Informatique Medicale, Hopital Saint Louis, 1 avenue Claude Vellefaux, 75475 Paris, France
    J Clin Epidemiol 56:536-45. 2003
    ..A competing-risk approach must be used to analyze the risk of events other than death in cohort studies, particularly when mortality rates are high...
  89. ncbi request reprint Problems of cytomegalovirus: how to measure and how to treat
    Christophe Legendre
    Service de Néphrologie Hôpital Saint Louis Paris, France
    Transplantation 77:1640. 2004
  90. pmc Central nervous system cryptococcosis in solid organ transplant recipients: clinical relevance of abnormal neuroimaging findings
    Nina Singh
    University of Pittsburgh, Pittsburgh, PA, USA
    Transplantation 86:647-51. 2008
    ..Prognostic implications of cryptococcal antigen and outcomes associated with central nervous system (CNS) cryptococcal lesions in solid organ transplant recipients have not been fully defined...
  91. doi request reprint Immune-mediated pure red cell aplasia in renal transplant recipients
    Julien Zuber
    Haematologica 93:1750-2. 2008
  92. ncbi request reprint Differences in the frequency and function of HHV8-specific CD8 T cells between asymptomatic HHV8 infection and Kaposi sarcoma
    Marion Lambert
    INSERM U561, Hopital St Vincent de Paul, 75014 Paris, France
    Blood 108:3871-80. 2006
    ..They may also have important implications for the design of prophylactic and therapeutic HHV8 vaccines, and for adoptive immunotherapy of KS...