Leger D, Quera Salva M, Vecchierini M, Ogrizek P, Perry C, Dressman M. Safety profile of tasimelteon, a melatonin MT1 and MT2 receptor agonist: pooled safety analyses from six clinical studies. Expert Opin Drug Saf. 2015;14:1673-85 pubmed publisher
..Long-term tasimelteon administration was safe and well-tolerated. This is supported by placebo-controlled data in both Non-24 and insomnia patients. ..
Leger D, Partinen M, Hirshkowitz M, Chokroverty S, Hedner J. Characteristics of insomnia in a primary care setting: EQUINOX survey of 5293 insomniacs from 10 countries. Sleep Med. 2010;11:987-98 pubmed publisher
..Patients visiting PCPs with insomnia are likely to present with severe and poly-symptomatic insomnia. ..
Leger D, Beck F, Richard J, Godeau E. Total sleep time severely drops during adolescence. PLoS ONE. 2012;7:e45204 pubmed publisher
..6% of the 11 yo vs. 24.6% of the 15 yo (p<0.001). Despite the obvious need for sleep in adolescence, TST drastically decreases with age among children from 11 to 15 yo which creates significant sleep debt increasing with age. ..
Leger D, Bayon V, De Sanctis A. The role of sleep in the regulation of body weight. Mol Cell Endocrinol. 2015;418 Pt 2:101-7 pubmed publisher
..Third, we provide some recent data on how sleep may be disturbed by sleep disorders or reduced by sleep debt with consequences on weight. Finally, we explore the relationships between sleep debt and obesity. ..
Bougard C, Davenne D, Espie S, Moussay S, LÃ©ger D. Sleepiness, attention and risk of accidents in powered two-wheelers. Sleep Med Rev. 2016;25:40-51 pubmed publisher
..Finally we provide some suggestions as to how this question may be better approached in the future. ..
Leger D, Morin C, Uchiyama M, Hakimi Z, Cure S, Walsh J. Chronic insomnia, quality-of-life, and utility scores: comparison with good sleepers in a cross-sectional international survey. Sleep Med. 2012;13:43-51 pubmed publisher
..67 in France, and 0.67 versus 0.77 in Japan, P<.0001). This survey suggests that chronic insomnia is associated with significant impairment of HRQoL and decreased utilities across the different geographical regions studied. ..
LÃ©ger D, Ement P. [Sleepiness and accidental risk]. Presse Med. 2015;44:1022-8 pubmed publisher
..Road safety and information to the drivers have now to focus on better informing drivers on the rules of preventing sleepiness at the wheel in order to avoiding hundred of accidents in the next future. ..
Leger D, Partinen M, Hirshkowitz M, Chokroverty S, Touchette E, Hedner J. Daytime consequences of insomnia symptoms among outpatients in primary care practice: EQUINOX international survey. Sleep Med. 2010;11:999-1009 pubmed publisher
..To assess the daytime consequences in outpatients suffering from different insomnia symptoms in primary care practice...
Chennaoui M, Arnal P, Dorey R, Sauvet F, Ciret S, Gallopin T, et al
. Changes of Cerebral and/or Peripheral Adenosine A? Receptor and IGF-I Concentrations under Extended Sleep Duration in Rats. Int J Mol Sci. 2017;18: pubmed publisher
..An extension of sleep duration might favor cerebral and peripheral anabolism, which may help attentional and physical capacities. ..