Marie Paule Lefranc

Summary

Country: France

Publications

  1. ncbi request reprint Immunoinformatics of the V, C, and G Domains: IMGT(®) Definitive System for IG, TR and IgSF, MH, and MhSF
    Marie Paule Lefranc
    IMGT, the international ImMunoGeneTics information system, Laboratoire d Immunogenetique moleculaire, LIGM, Institut de Genetique Humaine IGH, UPR CNRS 1142, Universite Montpellier 2, 141 rue de la Cardonille, 34396, Montpellier Cedex 5, France
    Methods Mol Biol 1184:59-107. 2014
  2. pmc Imgt-ontology 2012
    Veronique Giudicelli
    IMGT, the international ImMunoGeneTics information system, Universite Montpellier 2, Laboratoire d Immunogenetique moleculaire, Institut de Genetique Humaine, UPR CNRS Montpellier, France
    Front Genet 3:79. 2012
  3. pmc IMGT/3Dstructure-DB and IMGT/DomainGapAlign: a database and a tool for immunoglobulins or antibodies, T cell receptors, MHC, IgSF and MhcSF
    François Ehrenmann
    IMGT, the international ImMunoGeneTics information system, Universite Montpellier 2, Laboratoire d ImmunoGenetique Moleculaire LIGM, Institut de Genetique Humaine IGH, UPR CNRS 1142, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France
    Nucleic Acids Res 38:D301-7. 2010
  4. pmc IMGT/V-QUEST: the highly customized and integrated system for IG and TR standardized V-J and V-D-J sequence analysis
    Xavier Brochet
    IMGT, the international ImMunoGeneTics information system, Laboratoire d ImmunoGenetique Moleculaire LIGM, Universite Montpellier 2, Institut de Genetique Humaine IGH, UPR CNRS 1142, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France
    Nucleic Acids Res 36:W503-8. 2008
  5. pmc IMGT/HighV QUEST paradigm for T cell receptor IMGT clonotype diversity and next generation repertoire immunoprofiling
    Shuo Li
    Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria 3052, Australia
    Nat Commun 4:2333. 2013
  6. ncbi request reprint Use of IMGT(®) databases and tools for antibody engineering and humanization
    Marie Paule Lefranc
    Laboratoire d ImmunoGenetique Moleculaire LIGM, IMGT, Institut de Genetique Humaine IGH, UPR CNRS 1142, the international ImMunoGeneTics information system, Montpellier, France
    Methods Mol Biol 907:3-37. 2012
  7. ncbi request reprint Human Gm, Km, and Am allotypes and their molecular characterization: a remarkable demonstration of polymorphism
    Marie Paule Lefranc
    IMGT, the international ImMunoGeneTics information system, Universite Montpellier 2, Laboratoire d ImmunoGenetique Moleculaire LIGM, Institut de Genetique Humaine IGH, UPR CNRS1142, Montpellier, France
    Methods Mol Biol 882:635-80. 2012
  8. ncbi request reprint IMGT/HighV-QUEST: the IMGT® web portal for immunoglobulin (IG) or antibody and T cell receptor (TR) analysis from NGS high throughput and deep sequencing
    Eltaf Alamyar
    IMGT, the international ImMunoGeneTics information system, Laboratoire d ImmunoGenetique Moleculaire LIGM, Universite Montpellier 2, Institut de Genetique Humaine IGH, UPR CNRS 1142
    Immunome Res 8:26. 2012
  9. pmc A novel paradigm for cell and molecule interaction ontology: from the CMM model to IMGT-ONTOLOGY
    Francesco Pappalardo
    Institute for Computing Applications M, Picone, National Research Council CNR, Rome, Italy
    Immunome Res 6:1. 2010
  10. pmc Annotation and classification of the bovine T cell receptor delta genes
    Carolyn T A Herzig
    Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA 01003, USA
    BMC Genomics 11:100. 2010

Collaborators

Detail Information

Publications67

  1. ncbi request reprint Immunoinformatics of the V, C, and G Domains: IMGT(®) Definitive System for IG, TR and IgSF, MH, and MhSF
    Marie Paule Lefranc
    IMGT, the international ImMunoGeneTics information system, Laboratoire d Immunogenetique moleculaire, LIGM, Institut de Genetique Humaine IGH, UPR CNRS 1142, Universite Montpellier 2, 141 rue de la Cardonille, 34396, Montpellier Cedex 5, France
    Methods Mol Biol 1184:59-107. 2014
    ..In this chapter, we review the IMGT(®) definitive system for the V, C, and G domains, based on the IMGT-ONTOLOGY concepts of IMGT unique numbering and IMGT Collier de Perles. ..
  2. pmc Imgt-ontology 2012
    Veronique Giudicelli
    IMGT, the international ImMunoGeneTics information system, Universite Montpellier 2, Laboratoire d Immunogenetique moleculaire, Institut de Genetique Humaine, UPR CNRS Montpellier, France
    Front Genet 3:79. 2012
    ....
  3. pmc IMGT/3Dstructure-DB and IMGT/DomainGapAlign: a database and a tool for immunoglobulins or antibodies, T cell receptors, MHC, IgSF and MhcSF
    François Ehrenmann
    IMGT, the international ImMunoGeneTics information system, Universite Montpellier 2, Laboratoire d ImmunoGenetique Moleculaire LIGM, Institut de Genetique Humaine IGH, UPR CNRS 1142, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France
    Nucleic Acids Res 38:D301-7. 2010
    ..IMGT/3Dstructure-DB and IMGT/DomainGapAlign are freely available at http://www.imgt.org...
  4. pmc IMGT/V-QUEST: the highly customized and integrated system for IG and TR standardized V-J and V-D-J sequence analysis
    Xavier Brochet
    IMGT, the international ImMunoGeneTics information system, Laboratoire d ImmunoGenetique Moleculaire LIGM, Universite Montpellier 2, Institut de Genetique Humaine IGH, UPR CNRS 1142, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France
    Nucleic Acids Res 36:W503-8. 2008
    ..The 'Advanced parameters' allow to modify default parameters used by IMGT/V-QUEST and IMGT/JunctionAnalysis according to the users' interest. IMGT/V-QUEST is freely available for academic research at http://imgt.cines.fr...
  5. pmc IMGT/HighV QUEST paradigm for T cell receptor IMGT clonotype diversity and next generation repertoire immunoprofiling
    Shuo Li
    Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria 3052, Australia
    Nat Commun 4:2333. 2013
    ....
  6. ncbi request reprint Use of IMGT(®) databases and tools for antibody engineering and humanization
    Marie Paule Lefranc
    Laboratoire d ImmunoGenetique Moleculaire LIGM, IMGT, Institut de Genetique Humaine IGH, UPR CNRS 1142, the international ImMunoGeneTics information system, Montpellier, France
    Methods Mol Biol 907:3-37. 2012
    ....
  7. ncbi request reprint Human Gm, Km, and Am allotypes and their molecular characterization: a remarkable demonstration of polymorphism
    Marie Paule Lefranc
    IMGT, the international ImMunoGeneTics information system, Universite Montpellier 2, Laboratoire d ImmunoGenetique Moleculaire LIGM, Institut de Genetique Humaine IGH, UPR CNRS1142, Montpellier, France
    Methods Mol Biol 882:635-80. 2012
    ..Knowledge of allotypes is important in antibody engineering and humanization of monoclonal antibodies to improve immunotherapy...
  8. ncbi request reprint IMGT/HighV-QUEST: the IMGT® web portal for immunoglobulin (IG) or antibody and T cell receptor (TR) analysis from NGS high throughput and deep sequencing
    Eltaf Alamyar
    IMGT, the international ImMunoGeneTics information system, Laboratoire d ImmunoGenetique Moleculaire LIGM, Universite Montpellier 2, Institut de Genetique Humaine IGH, UPR CNRS 1142
    Immunome Res 8:26. 2012
    ..They will also contribute to characterize potential therapeutic antibodies from combinatorial libraries...
  9. pmc A novel paradigm for cell and molecule interaction ontology: from the CMM model to IMGT-ONTOLOGY
    Francesco Pappalardo
    Institute for Computing Applications M, Picone, National Research Council CNR, Rome, Italy
    Immunome Res 6:1. 2010
    ..With the increasing use of models in biology and medicine, the need to link different levels, from molecules to cells to tissues and organs, is increasingly important...
  10. pmc Annotation and classification of the bovine T cell receptor delta genes
    Carolyn T A Herzig
    Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA 01003, USA
    BMC Genomics 11:100. 2010
    ..Prior to the onset of the studies described here, there was limited information regarding the genes that code for the T cell receptor delta chains of this gammadelta T cell high species...
  11. pmc Isolation of a human-like antibody fragment (scFv) that neutralizes ricin biological activity
    Thibaut Pelat
    Groupe de Biotechnologie des Anticorps, Département de Biologie des Agents Transmissibles, Centre de Recherche du Service de Sante des Armees, La Tronche, France
    BMC Biotechnol 9:60. 2009
    ..It is easily extracted from a ubiquitously grown plant, Ricinus communis, and thus readily available for use as a bioweapon (BW). Anti-ricin antibodies provide the only known therapeutic against ricin intoxication...
  12. pmc Recovering probabilities for nucleotide trimming processes for T cell receptor TRA and TRG V-J junctions analyzed with IMGT tools
    Kevin Bleakley
    Institut Curie, Centre de Recherche, Paris, F 75248, France
    BMC Bioinformatics 9:408. 2008
    ..However, as trimmed nucleotides can potentially be replaced by identical N region nucleotides during the process, the observed "output" represents a biased estimate of the "true trimming process."..
  13. ncbi request reprint WHO-IUIS Nomenclature Subcommittee for immunoglobulins and T cell receptors report August 2007, 13th International Congress of Immunology, Rio de Janeiro, Brazil
    Marie Paule Lefranc
    the international ImMunoGeneTics information system, Institut de Genetique Humaine, 34396 Montpellier Cedex 5, France
    Dev Comp Immunol 32:461-3. 2008
  14. ncbi request reprint WHO-IUIS Nomenclature Subcommittee for immunoglobulins and T cell receptors report
    Marie Paule Lefranc
    IMGT, the international ImMunoGeneTics information system, Laboratoire d Immunogenetique moleculaire, Institut de Genetique Humaine, IGH, UPR CNRS 1142, 141 rue de la Cardonille, 34396, Montpellier Cedex 5, France
    Immunogenetics 59:899-902. 2007
  15. doi request reprint [Antibody databases: IMGT, a French platform of world-wide interest]
    Marie Paule Lefranc
    Universite Montpellier 2, IMGT, LIGM, Institut de Genetique Humaine, UPR CNRS 1142, 141, rue de la Cardonille, 34396 Montpellier Cedex 5, France
    Med Sci (Paris) 25:1020-3. 2009
    ..IMGT is to-day the international reference system in immunogenetics and immunoinformatics, used in fundamental, medical and biotechnological research and, in particular, in antibody -engineering and humanization...
  16. ncbi request reprint IMGT, the International ImMunoGeneTics Information System for Immunoinformatics : methods for querying IMGT databases, tools, and web resources in the context of immunoinformatics
    Marie Paule Lefranc
    the international ImMunoGeneTics information system, Laboratoire d Immunogenetique moleculaire, Universite Montpellier 2, Institut de Genetique Humaine, Montpellier Cedex 5, France
    Mol Biotechnol 40:101-11. 2008
    ..IMGT Web resources comprise 10,000 HTML pages of synthesis and knowledge (IMGT Scientific chart, IMGT Repertoire, IMGT Education, etc.) and external links (IMGT Bloc-notes and IMGT other accesses)...
  17. ncbi request reprint IMGT, a system and an ontology that bridge biological and computational spheres in bioinformatics
    Marie Paule Lefranc
    IMGT, Laboratoire d Immunogenetique moleculaire, LIGM, UPR CNRS 1142, IGH, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France
    Brief Bioinform 9:263-75. 2008
    ..In that way the Formal IMGT-ONTOLOGY represents a paradigm for the elaboration of ontologies in system biology...
  18. pmc IMGT, the international ImMunoGeneTics information system
    Marie Paule Lefranc
    IMGT, the international ImMunoGeneTics information system, Universite Montpellier 2, Laboratoire d ImmunoGenetique Moleculaire LIGM, UPR CNRS 1142, Institut de Genetique Humaine IGH, 34396 Montpellier Cedex 5, France
    Nucleic Acids Res 37:D1006-12. 2009
    ..IMGT is freely available at http://www.imgt.org...
  19. pmc IMGT, the international ImMunoGeneTics information system
    Marie Paule Lefranc
    IMGT, the international ImMunoGeneTics information system Universite Montpellier II, Laboratoire d ImmunoGenetique Moleculaire LIGM, UPR CNRS 1142, Institut de Genetique Humaine IGH, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France
    Nucleic Acids Res 33:D593-7. 2005
    ..IMGT is freely available at http://imgt.cines.fr...
  20. pmc IMGT/LIGM-DB, the IMGT comprehensive database of immunoglobulin and T cell receptor nucleotide sequences
    Veronique Giudicelli
    IMGT, the international ImMunoGeneTics information system, Laboratoire d Immunogenetique moleculaire, LIGM, Universite Montpellier II, Institut de Genetique Humaine IGH, UPR CNRS 1142, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France
    Nucleic Acids Res 34:D781-4. 2006
    ..They represent the main source of IG and TR gene and allele knowledge stored in IMGT/GENE-DB and in the IMGT reference directory. IMGT/LIGM-DB is freely available at http://imgt.cines.fr...
  21. ncbi request reprint IMGT-Choreography for immunogenetics and immunoinformatics
    Marie Paule Lefranc
    Universite Montpellier II, Laboratoire d ImmunoGenetique Moleculaire LIGM, UPR CNRS 1142, Institut de Genetique Humaine IGH, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France
    In Silico Biol 5:45-60. 2005
    ..IMGT is freely available at http://imgt.cines.fr...
  22. ncbi request reprint IMGT-Kaleidoscope, the formal IMGT-ONTOLOGY paradigm
    Patrice Duroux
    the international ImMunoGeneTics information system, Universite Montpellier 2, 34396 Montpellier Cedex 5, France
    Biochimie 90:570-83. 2008
    ..In that way the Formal IMGT-ONTOLOGY represents a paradigm for the elaboration of ontologies in system biology...
  23. pmc IMGT/V-QUEST, an integrated software program for immunoglobulin and T cell receptor V-J and V-D-J rearrangement analysis
    Veronique Giudicelli
    IMGT, the international ImMunoGeneTics information system, Laboratoire d Immunogenetique moleculaire, LIGM, Institut de Genetique Humaine IGH, UPR CNRS 1142, 141 rue de la Cardonille, F 34396 Montpellier Cedex 5, France
    Nucleic Acids Res 32:W435-40. 2004
    ..IMGT/V-QUEST is currently available for human and mouse, and partly for non-human primates, sheep, chondrichthyes and teleostei. IMGT/V-QUEST is freely available at http://imgt.cines.fr...
  24. ncbi request reprint IMGT-ONTOLOGY for immunogenetics and immunoinformatics
    Marie Paule Lefranc
    IMGT, the international ImMunoGeneTics information system Universite Montpellier II, Laboratoire d ImmunoGenetique Moleculaire LIGM UPR CNRS 1142, Institut de Genetique Humaine IGH, Montpellier Cedex 5, France
    In Silico Biol 4:17-29. 2004
    ..IMGT is freely available at http://imgt.cines.fr...
  25. ncbi request reprint IMGT unique numbering for immunoglobulin and T cell receptor variable domains and Ig superfamily V-like domains
    Marie Paule Lefranc
    IMGT, Laboratoire d ImmunoGenetique Moleculaire LIGM, Universite Montpellier II, UPR CNRS 1142, IGH, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France
    Dev Comp Immunol 27:55-77. 2003
    ..The IMGT numbering has been extended to the V-like domain and is, therefore, highly valuable for comparative analysis and evolution studies of proteins belonging to the IG superfamily...
  26. ncbi request reprint IMGT unique numbering for MHC groove G-DOMAIN and MHC superfamily (MhcSF) G-LIKE-DOMAIN
    Marie Paule Lefranc
    IMGT, the international ImMunoGeneTics information system, Laboratoire d Immunogenetique moleculaire, LIGM, Universite Montpellier II, Institut de Genetique Humaine, IGH UPR CNRS 1142, 34396 Montpellier Cedex 5, France
    Dev Comp Immunol 29:917-38. 2005
    ....
  27. pmc IMGT/3Dstructure-DB and IMGT/StructuralQuery, a database and a tool for immunoglobulin, T cell receptor and MHC structural data
    Quentin Kaas
    IMGT, the international ImMunoGeneTics information system, Laboratoire d Immunogenetique moleculaire, LIGM, Institut de Genetique Humaine IGH, UPR CNRS 1142, 141 rue de la Cardonille, F 34396 Montpellier Cedex 5, France
    Nucleic Acids Res 32:D208-10. 2004
    ..The IMGT/StructuralQuery tool allows search of this database based on specific structural characteristics. IMGT/3Dstructure-DB and IMGT/StructuralQuery are freely available at http://imgt. cines.fr...
  28. ncbi request reprint IMGT/JunctionAnalysis: the first tool for the analysis of the immunoglobulin and T cell receptor complex V-J and V-D-J JUNCTIONs
    Mehdi Yousfi Monod
    Laboratoire d ImmunoGenetique Moleculaire LIGM, Universite Montpellier II, UPR CNRS 1142, Institut de Genetique Humaine IGH, Montpellier Cedex 5, France
    Bioinformatics 20:i379-85. 2004
    ..We developed IMGT/JunctionAnalysis to analyse automatically in detail the IG and TR junctions, according to the IMGT Scientific chart rules, based on the IMGT-ONTOLOGY concepts...
  29. pmc IMGT, the international ImMunoGeneTics database
    Marie Paule Lefranc
    Universite Montpellier II, Laboratoire d Immunogenetique moleculaire, LIGM, UPR CNRS 1142, Institut de Genetique Humaine, Montpellier, France
    Nucleic Acids Res 31:307-10. 2003
    ..IMGT is freely available at http://imgt.cines.fr...
  30. ncbi request reprint IMGT(®) tools for the nucleotide analysis of immunoglobulin (IG) and T cell receptor (TR) V-(D)-J repertoires, polymorphisms, and IG mutations: IMGT/V-QUEST and IMGT/HighV-QUEST for NGS
    Eltaf Alamyar
    IMGT, the international ImMunoGeneTics information system, Universite Montpellier 2, Laboratoire d ImmunoGenetique Moleculaire LIGM, Institut de Genetique Humaine IGH, UPR CNRS 1142, Montpellier, France
    Methods Mol Biol 882:569-604. 2012
    ..IMGT/V-QUEST and IMGT/HighV-QUEST are available at the IMGT(®) Home page, http://www.imgt.org...
  31. pmc From IMGT-ONTOLOGY to IMGT/LIGMotif: the IMGT standardized approach for immunoglobulin and T cell receptor gene identification and description in large genomic sequences
    Jerome Lane
    Universite Montpellier 2, Laboratoire d ImmunoGenetique Moleculaire LIGM, UPR CNRS 1142, Institut de Genetique Humaine IGH, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France
    BMC Bioinformatics 11:223. 2010
    ..This tool is based on standardized rules defined in IMGT-ONTOLOGY, the first ontology in immunogenetics and immunoinformatics...
  32. doi request reprint Using bioinformatics tools for the sequence analysis of immunoglobulins and T cell receptors
    Marie Paule Lefranc
    IMGT, Universite Montpellier II, CNRS, Montpellier, France
    Curr Protoc Immunol . 2006
    ..IMGT/JunctionAnalysis is the first tool that automatically analyzes the complex junctions in detail. These interactive tools are easy to use and freely available on the Web (http://imgt.cines.fr), either separately or integrated...
  33. ncbi request reprint T cell receptor/peptide/MHC molecular characterization and standardized pMHC contact sites in IMGT/3Dstructure-DB
    Quentin Kaas
    IMGT, the international ImMunoGeneTics information system, Universite Montpellier II, Laboratoire d ImmunoGénétique Moléculaire LIGMUPR CNRS 1142, Institut de Genetique Humaine IGH, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France
    In Silico Biol 5:505-28. 2005
    ..The TR/pMHC contact description, based on the IMGT numbering, can be queried in the IMGT/StucturalQuery tool, at http://imgt.cines.fr...
  34. ncbi request reprint IMGT standardized criteria for statistical analysis of immunoglobulin V-REGION amino acid properties
    Christelle Pommie
    IMGT, Laboratoire d ImmunoGenetique Moleculaire LIGM, Universite Montpellier II, UPR CNRS 1142 Institut de Génétique Humaine IGH, 141 rue de la Cardonille, F 34396 Montpellier Cedex 5, France
    J Mol Recognit 17:17-32. 2004
    ....
  35. pmc IMGT/GENE-DB: a comprehensive database for human and mouse immunoglobulin and T cell receptor genes
    Veronique Giudicelli
    IMGT, the international ImMunoGeneTics information system, Laboratoire d Immunogenetique moleculaire, LIGM, Universite Montpellier II, Institut de Genetique Humaine, IGH, UPR CNRS 1142, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France
    Nucleic Acids Res 33:D256-61. 2005
    ..IMGT/GENE-DB is freely available at http://imgt.cines.fr...
  36. ncbi request reprint IMGT gene identification and Colliers de Perles of human immunoglobulins with known 3D structures
    Manuel Ruiz
    Laboratoire d ImmunoGenetique Moleculaire LIGM, Universite Montpellier II, UPR CNRS 1142, IGH, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France
    Immunogenetics 53:857-83. 2002
    ..A query Web interface allows interactive search of the IMGT/3D structure-DB data. In this article, IMGT gene identification and Colliers de Perles of human immunoglobulins with known 3D structures in the Protein Data Bank are presented...
  37. ncbi request reprint IMGT, the international ImMunoGeneTics database: a high-quality information system for comparative immunogenetics and immunology
    Marie Paule Lefranc
    Laboratoire d Immunogenetique moleculaire, LIGM, Universite Montpellier II, UPR CNRS 1142, IGH, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France
    Dev Comp Immunol 26:697-705. 2002
    ..These expertly annotated data on the genome, proteome, genetics and structure of the IG, TR and MHC are of high value for comparative genome evolution studies of the adaptative immune response...
  38. ncbi request reprint IMGT unique numbering for immunoglobulin and T cell receptor constant domains and Ig superfamily C-like domains
    Marie Paule Lefranc
    IMGT, the international ImMunoGeneTics information system, LIGM, Laboratoire d Immunogenetique moleculaire, Universite Montpellier II, UPR CNRS 1142, IGH, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France
    Dev Comp Immunol 29:185-203. 2005
    ....
  39. ncbi request reprint IMGT, the international ImMunoGeneTics information system, http://imgt.cines.fr: the reference in immunoinformatics
    Marie Paule Lefranc
    Laboratoire d ImmunoGenetique Moleculaire LIGM, Universite Montpellier II, UPR CNRS 1142, Institut de Genetique Humaine, IGH, Montpellier, France
    Stud Health Technol Inform 95:74-9. 2003
    ..IMGT is freely available at http://imgt.cines.fr...
  40. ncbi request reprint IMGT, the international ImMunoGeneTics information system, http://imgt.cines.fr
    Marie Paule Lefranc
    Universite Montpellier II, Laboratoire d Immunogenetique moleculaire, LIGM, UPR CNRS 1142, Institut de Genetique Humaine, Montpellier, France
    Novartis Found Symp 254:126-36; discussion 136-42, 216-22, 250-2. 2003
    ..IMGT is freely available at http://imgt.cines.fr...
  41. ncbi request reprint IMGT/DomainGapAlign: the IMGT® tool for the analysis of IG, TR, MH, IgSF, and MhSF domain amino acid polymorphism
    François Ehrenmann
    IMGT, the international ImMunoGeneTics information system, Universite Montpellier 2, Laboratoire d ImmunoGenetique Moleculaire LIGM, Institut de Genetique Humaine IGH, UPR CNRS 1142, Montpellier, France
    Methods Mol Biol 882:605-33. 2012
    ..IMGT/DomainGapAlign is freely available at http://www.imgt.org...
  42. doi request reprint IMGT, the international ImMunoGeneTics information system for Immunoinformatics. Methods for querying IMGT databases, tools, and Web resources in the context of immunoinformatics
    Marie Paule Lefranc
    Institut Universitaire de France, Laboratoire d Immunogenetique moleculaire, Universite Montpellier II, UPR CNRS 1142, France
    Methods Mol Biol 409:19-42. 2007
    ..IMGT Web resources comprise 8,000 HTML pages of synthesis and knowledge (IMGT Scientific chart, IMGT Repertoire, IMGT Education, etc.) and external links (IMGT Bloc-notes and IMGT other accesses)...
  43. ncbi request reprint IMGT standardization for statistical analyses of T cell receptor junctions: the TRAV-TRAJ example
    Kevin Bleakley
    Institut de Mathématiques et de Modélisation de Montpellier, UMR CNRS 5149, Equipe de Probabilités et Statistique, Universite Montpellier II, Montpellier, France
    In Silico Biol 6:573-88. 2006
    ..Using statistical learning, we constructed an automatic warning system to predict if new, automatically analysed TRAV-TRAJ sequences should be manually re-checked. We estimated the robustness of this automatic warning system...
  44. ncbi request reprint IMGT-ONTOLOGY and IMGT databases, tools and Web resources for immunogenetics and immunoinformatics
    Marie Paule Lefranc
    Laboratoire d Immunogenetique moleculaire, LIGM, Institut de Genetique Humaine IGH, Universite Montpellier II, UPR CNRS 1142, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France
    Mol Immunol 40:647-60. 2004
    ..IMGT is freely available at http://imgt.cines.fr...
  45. ncbi request reprint A simple method to predict protein-binding from aligned sequences--application to MHC superfamily and beta2-microglobulin
    Elodie Duprat
    Laboratoire d ImmunoGénétique Moléculaire IGH UPR CNRS 1142, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France
    Bioinformatics 22:453-9. 2006
    ..IMGT standardization of MhcSF protein domains provides a unique numbering of the multiple alignment positions, and conditions to develop such predictive tool...
  46. doi request reprint Web sites of interest to immunologists
    Marie Paule Lefranc
    Universite Montpellier II, CNRS, Montpellier, France
    Curr Protoc Immunol . 2006
    ..Three other sections (Molecular Biology Servers, Resources, and Universities and Institutes) offer their own lists of useful links...
  47. doi request reprint Antibody V and C domain sequence, structure, and interaction analysis with special reference to IMGT®
    Eltaf Alamyar
    the international ImMunoGeneTics information system, Laboratoire d Immunogenetique moleculaire, Institut de Genetique Humaine IGH, Universite Montpellier 2, Montpellier, France
    Methods Mol Biol 1131:337-81. 2014
    ..These IMGT(®) tools and databases, and the IMGT/mAb-DB interface with access to therapeutical antibody data, provide an invaluable help for antibody engineering and antibody humanization...
  48. ncbi request reprint IMGT, The International ImMunoGeneTics Information System, http://imgt.cines.fr
    Marie Paule Lefranc
    IMGT, Laboratoire d Immunogenetique moleculaire, LIGM, Universite Montpellier II, UPR CNRS 1142, Institut de Genetique Humaine, IGH, Montpellier, France
    Methods Mol Biol 248:27-49. 2004
  49. pmc Restricted V gene usage and VH/VL pairing of mouse humoral response against the N-terminal immunodominant epitope of the amyloid β peptide
    Remy Robert
    CSIRO Molecular and Health Technologies, 343 Royal Parade, Parkville, Victoria 3052, Australia
    Mol Immunol 48:59-72. 2010
    ..These findings may have important implications in designing more effective therapeutic antibodies against Aβ...
  50. ncbi request reprint The mouse (Mus musculus) T cell receptor alpha (TRA) and delta (TRD) variable genes
    Nathalie Bosc
    IMGT, Laboratoire d ImmunoGenetique Moleculaire LIGM, Universite Montpellier II, Institut de Genetique Humaine, UPR CNRS 1142, 141 rue de la Cardonille, 34396 5, Montpellier Cedex, France
    Dev Comp Immunol 27:465-97. 2003
    ..The international ImMunoGeneTics information system (http://imgt.cines.fr) created by Marie-Paule Lefranc, Université Montpellier II, CNRS, France...
  51. ncbi request reprint IMGT Colliers de Perles and IgSF domain standardization for T cell costimulatory activatory (CD28, ICOS) and inhibitory (CTLA4, PDCD1 and BTLA) receptors
    Vijay Phani Garapati
    IMGT, the international ImMunoGeneTics information system, Laboratoire d Immunogenetique moleculaire, LIGM, Institut de Genetique Humaine, IGH, UPR CNRS 1142, 141 Rue de la Cardonille 34396 Montpellier CEDEX 5, France
    Dev Comp Immunol 31:1050-72. 2007
    ..cines.fr)...
  52. ncbi request reprint IMGT/PhyloGene: an on-line tool for comparative analysis of immunoglobulin and T cell receptor genes
    Olivier Elemento
    IMGT, the international ImMunoGeneTics information system, Laboratoire d ImmunoGenetique Moleculaire LIGM, Universite Montpellier II, UPR CNRS 1142, Institut de Genetique Humaine IGH, 141 rue de la Cardonille, 34396 Cedex 5, Montpellier, France
    Dev Comp Immunol 27:763-79. 2003
    ..IMGT/PhyloGene is freely available at http://imgt.cines.fr...
  53. doi request reprint IG, TR and IgSF, MHC and MhcSF: what do we learn from the IMGT Colliers de Perles?
    Quentin Kaas
    University of Queensland, Brisbane, Australia
    Brief Funct Genomic Proteomic 6:253-64. 2007
    ..These IMGT Colliers de Perles are particularly useful for antibody engineering, sequence-structure analysis, visualization and comparison of positions for mutations, polymorphisms and contact analysis...
  54. pmc IMGT/GeneInfo: enhancing V(D)J recombination database accessibility
    Thierry Pascal Baum
    Laboratoire TIMC IMAG CNRS UMR 5525, Techniques de l Imagerie, de la Modélisation et de la Cognition, Universite Joseph Fourier, Grenoble 1, Faculte de Medecine, Domaine de la Merci, 38706 La Tronche, France
    Nucleic Acids Res 32:D51-4. 2004
    ..Access to IMGT/GeneInfo is free and can be found at http://imgt.cines.fr/GeneInfo...
  55. ncbi request reprint The genomic sequence of the bovine T cell receptor gamma TRG loci and localization of the TRGC5 cassette
    Melanie L Conrad
    University of Victoria, Centre for Biomedical Research, Victoria, British Columbia, Canada V8W 3N5
    Vet Immunol Immunopathol 115:346-56. 2007
    ..The location of the TRGC5 cassette is conclusively described in 5' of the TRG1 locus. Analysis of 17 TRGV belonging to 10 different subgroups, 8 TRGJ and 6 TRGC genes is conducted which comprises the most comprehensive list to date...
  56. ncbi request reprint Diversity in the complementarity-determining region 3 (CDR3) of antibodies from mice with evolving anti-thyroid-stimulating hormone receptor antibody responses
    Osvaldo Martinez
    Department of Microbiology and Immunology M C 790, Room E 709, Building 935, 835 South Wolcott Avenue, Chicago, Illinois 60612, USA
    Endocrinology 148:752-61. 2007
    ..Collectively, our results suggest that higher somatic mutations within the CDR3 may correlate with pathogenic antibodies against the TSHR...
  57. pmc IMGT/GeneInfo: T cell receptor gamma TRG and delta TRD genes in database give access to all TR potential V(D)J recombinations
    Thierry Pascal Baum
    Laboratoire TIMC IMAG CNRS UMR 5525, Techniques de l Imagerie, de la Modélisation et de la Cognition, Universite Joseph Fourier, Grenoble 1, Faculte de Medecine, Domaine de la Merci, 38706 La Tronche, France
    BMC Bioinformatics 7:224. 2006
    ..Whereas many data exist, they are scattered in non specialized resources with different nomenclatures (eg. flat files) and are difficult to extract...
  58. ncbi request reprint A high-affinity macaque antibody Fab with human-like framework regions obtained from a small phage display immune library
    Stéphanie Chassagne
    Immunobiologie, Département de biologie des agents transmissibles DBAT, Centre de Recherche du Service de Sante des Armees, 24, av des Maquis du Grésivaudan, La Tronche, P O box 38702, France
    Mol Immunol 41:539-46. 2004
    ..This strategy could be used for the isolation of high-affinity, human-like Fab fragments directed against numerous antigens...
  59. ncbi request reprint PenBase, the shrimp antimicrobial peptide penaeidin database: sequence-based classification and recommended nomenclature
    Yannick Gueguen
    Ifremer CNRS University of Montpellier 2, UMR 5171 Génome Population Interaction Adaptation, 2 Place E Bataillon, CC80, F 34095 Montpellier Cedex 5, France
    Dev Comp Immunol 30:283-8. 2006
    ..A specialized database, PenBase, which is freely available at , has been developed for the penaeidin family of antimicrobial peptides, to provide comprehensive information about their properties, diversity and nomenclature...
  60. ncbi request reprint Bovine T cell receptor gamma variable and constant genes: combinatorial usage by circulating gammadelta T cells
    Carolyn Herzig
    Paige Laboratory, Department of Veterinary and Animal Sciences and Program in Molecular and Cellular Biology, University of Massachusetts, Amherst, MA 01003, USA
    Immunogenetics 58:138-51. 2006
    ..Cattle are useful models for gammadelta T cell biology because they have gammadelta T cells that respond to isopentenylpyrophosphate (IPP) antigens, while mice do not, and some bovine TRGV genes cluster closely with human genes...
  61. ncbi request reprint Chemiluminescent detection of clonal immunoglobulin and T cell receptor gene rearrangements in Tunisian lymphoid malignancies, leukemias and lymphomas
    Rym El Abed
    Laboratoire de Biochimie, Faculte de Medecine, Sousse, Tunisia
    Leuk Lymphoma 47:1129-37. 2006
    ....
  62. ncbi request reprint Costimulatory receptors in jawed vertebrates: conserved CD28, odd CTLA4 and multiple BTLAs
    David Bernard
    Institut National de la Recherche Agronomique, Unite de Virologie et Immunologie Moleculaires, 78352 Jouy en Josas Cedex, France
    Dev Comp Immunol 31:255-71. 2007
    ..The genomic localization of these genes in vertebrate genomes supports the split between the BTLA and CD28 families...
  63. ncbi request reprint Reconstructing the duplication history of tandemly repeated genes
    Olivier Elemento
    Département d Informatique Fondamentale et Applications, LIRMM, 161 rue Ada, 34392 Montpellier, France
    Mol Biol Evol 19:278-88. 2002
    ....
  64. pmc High-affinity, human antibody-like antibody fragment (single-chain variable fragment) neutralizing the lethal factor (LF) of Bacillus anthracis by inhibiting protective antigen-LF complex formation
    Thibaut Pelat
    Groupe de Biotechnologie des Anticorps, Département de Biologie des Agents Transmissibles, La Tronche, France
    Antimicrob Agents Chemother 51:2758-64. 2007
    ..These results, and others formerly published, demonstrate that our approach can generate antibody fragments suitable for prophylaxis and therapeutics...
  65. ncbi request reprint Structure-function relationships of the variable domains of monoclonal antibodies approved for cancer treatment
    Charlotte Magdelaine-Beuzelin
    Universite Francois Rabelais de Tours, EA 3853 Immuno Pharmaco Génétique des Anticorps thérapeutiques, France
    Crit Rev Oncol Hematol 64:210-25. 2007
    ..Overall, the IMGT standards appear as a first and crucial step in the evaluation of recombinant antibodies...
  66. ncbi request reprint The human anti-thyroid peroxidase autoantibody repertoire in Graves' and Hashimoto's autoimmune thyroid diseases
    Thierry Chardes
    INRA CNRS UMR 5087, Laboratoire de Pathologie Comparée, 30380 Saint Christol Lez Alès, France
    Immunogenetics 54:141-57. 2002
    ..The aim of this review is to provide new insights into aAb generation against TPO, a major autoantigen involved in AITD...