M P Lefranc

Summary

Country: France

Publications

  1. pmc IMGT/LIGM-DB, the IMGT comprehensive database of immunoglobulin and T cell receptor nucleotide sequences
    Veronique Giudicelli
    IMGT, the international ImMunoGeneTics information system, Laboratoire d Immunogenetique moleculaire, LIGM, Universite Montpellier II, Institut de Genetique Humaine IGH, UPR CNRS 1142, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France
    Nucleic Acids Res 34:D781-4. 2006
  2. pmc IMGT/GENE-DB: a comprehensive database for human and mouse immunoglobulin and T cell receptor genes
    Veronique Giudicelli
    IMGT, the international ImMunoGeneTics information system, Laboratoire d Immunogenetique moleculaire, LIGM, Universite Montpellier II, Institut de Genetique Humaine, IGH, UPR CNRS 1142, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France
    Nucleic Acids Res 33:D256-61. 2005
  3. pmc IMGT, the international ImMunoGeneTics information system
    Marie Paule Lefranc
    IMGT, the international ImMunoGeneTics information system Universite Montpellier II, Laboratoire d ImmunoGenetique Moleculaire LIGM, UPR CNRS 1142, Institut de Genetique Humaine IGH, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France
    Nucleic Acids Res 33:D593-7. 2005
  4. pmc IMGT/GeneInfo: T cell receptor gamma TRG and delta TRD genes in database give access to all TR potential V(D)J recombinations
    Thierry Pascal Baum
    Laboratoire TIMC IMAG CNRS UMR 5525, Techniques de l Imagerie, de la Modélisation et de la Cognition, Universite Joseph Fourier, Grenoble 1, Faculte de Medecine, Domaine de la Merci, 38706 La Tronche, France
    BMC Bioinformatics 7:224. 2006
  5. pmc IMGT, the international ImMunoGeneTics database
    M P Lefranc
    Laboratoire d Immunogenetique moleculaire, LIGM, Universite Montpellier II, UPR CNRS 1142, IGH, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France
    Nucleic Acids Res 29:207-9. 2001
  6. ncbi IMGT-ONTOLOGY for immunogenetics and immunoinformatics
    Marie Paule Lefranc
    IMGT, the international ImMunoGeneTics information system Universite Montpellier II, Laboratoire d ImmunoGenetique Moleculaire LIGM UPR CNRS 1142, Institut de Genetique Humaine IGH, Montpellier Cedex 5, France
    In Silico Biol 4:17-29. 2004
  7. ncbi IMGT, the international ImMunoGeneTics information system, http://imgt.cines.fr: the reference in immunoinformatics
    Marie Paule Lefranc
    Laboratoire d ImmunoGenetique Moleculaire LIGM, Universite Montpellier II, UPR CNRS 1142, Institut de Genetique Humaine, IGH, Montpellier, France
    Stud Health Technol Inform 95:74-9. 2003
  8. ncbi IMGT-ONTOLOGY and IMGT databases, tools and Web resources for immunogenetics and immunoinformatics
    Marie Paule Lefranc
    Laboratoire d Immunogenetique moleculaire, LIGM, Institut de Genetique Humaine IGH, Universite Montpellier II, UPR CNRS 1142, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France
    Mol Immunol 40:647-60. 2004
  9. ncbi Nomenclature of the human immunoglobulin heavy (IGH) genes
    M P Lefranc
    IMGT Nomenclature Committee, CNRS, Universite Montpellier II, Montpellier, France
    Exp Clin Immunogenet 18:100-16. 2001
  10. ncbi Nomenclature of the human immunoglobulin kappa (IGK) genes
    M P Lefranc
    IMGT Nomenclature Committee, CNRS, Universite Montpellier II, Montpellier, France
    Exp Clin Immunogenet 18:161-74. 2001

Collaborators

Detail Information

Publications76

  1. pmc IMGT/LIGM-DB, the IMGT comprehensive database of immunoglobulin and T cell receptor nucleotide sequences
    Veronique Giudicelli
    IMGT, the international ImMunoGeneTics information system, Laboratoire d Immunogenetique moleculaire, LIGM, Universite Montpellier II, Institut de Genetique Humaine IGH, UPR CNRS 1142, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France
    Nucleic Acids Res 34:D781-4. 2006
    ..They represent the main source of IG and TR gene and allele knowledge stored in IMGT/GENE-DB and in the IMGT reference directory. IMGT/LIGM-DB is freely available at http://imgt.cines.fr...
  2. pmc IMGT/GENE-DB: a comprehensive database for human and mouse immunoglobulin and T cell receptor genes
    Veronique Giudicelli
    IMGT, the international ImMunoGeneTics information system, Laboratoire d Immunogenetique moleculaire, LIGM, Universite Montpellier II, Institut de Genetique Humaine, IGH, UPR CNRS 1142, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France
    Nucleic Acids Res 33:D256-61. 2005
    ..IMGT/GENE-DB is freely available at http://imgt.cines.fr...
  3. pmc IMGT, the international ImMunoGeneTics information system
    Marie Paule Lefranc
    IMGT, the international ImMunoGeneTics information system Universite Montpellier II, Laboratoire d ImmunoGenetique Moleculaire LIGM, UPR CNRS 1142, Institut de Genetique Humaine IGH, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France
    Nucleic Acids Res 33:D593-7. 2005
    ..IMGT is freely available at http://imgt.cines.fr...
  4. pmc IMGT/GeneInfo: T cell receptor gamma TRG and delta TRD genes in database give access to all TR potential V(D)J recombinations
    Thierry Pascal Baum
    Laboratoire TIMC IMAG CNRS UMR 5525, Techniques de l Imagerie, de la Modélisation et de la Cognition, Universite Joseph Fourier, Grenoble 1, Faculte de Medecine, Domaine de la Merci, 38706 La Tronche, France
    BMC Bioinformatics 7:224. 2006
    ..Whereas many data exist, they are scattered in non specialized resources with different nomenclatures (eg. flat files) and are difficult to extract...
  5. pmc IMGT, the international ImMunoGeneTics database
    M P Lefranc
    Laboratoire d Immunogenetique moleculaire, LIGM, Universite Montpellier II, UPR CNRS 1142, IGH, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France
    Nucleic Acids Res 29:207-9. 2001
    ..This information is of high value for medical and veterinary research, biotechnology related to antibody and T cell receptor engineering, genome diversity and evolution studies of the immune response...
  6. ncbi IMGT-ONTOLOGY for immunogenetics and immunoinformatics
    Marie Paule Lefranc
    IMGT, the international ImMunoGeneTics information system Universite Montpellier II, Laboratoire d ImmunoGenetique Moleculaire LIGM UPR CNRS 1142, Institut de Genetique Humaine IGH, Montpellier Cedex 5, France
    In Silico Biol 4:17-29. 2004
    ..IMGT is freely available at http://imgt.cines.fr...
  7. ncbi IMGT, the international ImMunoGeneTics information system, http://imgt.cines.fr: the reference in immunoinformatics
    Marie Paule Lefranc
    Laboratoire d ImmunoGenetique Moleculaire LIGM, Universite Montpellier II, UPR CNRS 1142, Institut de Genetique Humaine, IGH, Montpellier, France
    Stud Health Technol Inform 95:74-9. 2003
    ..IMGT is freely available at http://imgt.cines.fr...
  8. ncbi IMGT-ONTOLOGY and IMGT databases, tools and Web resources for immunogenetics and immunoinformatics
    Marie Paule Lefranc
    Laboratoire d Immunogenetique moleculaire, LIGM, Institut de Genetique Humaine IGH, Universite Montpellier II, UPR CNRS 1142, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France
    Mol Immunol 40:647-60. 2004
    ..IMGT is freely available at http://imgt.cines.fr...
  9. ncbi Nomenclature of the human immunoglobulin heavy (IGH) genes
    M P Lefranc
    IMGT Nomenclature Committee, CNRS, Universite Montpellier II, Montpellier, France
    Exp Clin Immunogenet 18:100-16. 2001
    ..The tables are available at the IMGT Marie-Paule page of IMGT, the international ImMunoGeneTics database (http://imgt.cines.fr:8104) created by Marie-Paule Lefranc, Université Montpellier II, CNRS, France...
  10. ncbi Nomenclature of the human immunoglobulin kappa (IGK) genes
    M P Lefranc
    IMGT Nomenclature Committee, CNRS, Universite Montpellier II, Montpellier, France
    Exp Clin Immunogenet 18:161-74. 2001
    ..The tables are available at the IMGT Marie-Paule page from IMGT, the international ImMunoGeneTics database (http://imgt.cines.fr:8104) created by Marie-Paule Lefranc, Université Montpellier II, CNRS, France...
  11. pmc IMGT, the international ImMunoGeneTics database
    Marie Paule Lefranc
    Universite Montpellier II, Laboratoire d Immunogenetique moleculaire, LIGM, UPR CNRS 1142, Institut de Genetique Humaine, Montpellier, France
    Nucleic Acids Res 31:307-10. 2003
    ..IMGT is freely available at http://imgt.cines.fr...
  12. ncbi Nomenclature of the human immunoglobulin lambda (IGL) genes
    M P Lefranc
    IMGT Nomenclature Committee, CNRS, Universite Montpellier II, Montpellier, France
    Exp Clin Immunogenet 18:242-54. 2001
    ..The tables are available at the IMGT Marie-Paule page of IMGT, the international ImMunoGeneTics database (http://imgt.cines.fr) created by Marie-Paule Lefranc, Université Montpellier II, CNRS, France...
  13. ncbi IMGT unique numbering for immunoglobulin and T cell receptor variable domains and Ig superfamily V-like domains
    Marie Paule Lefranc
    IMGT, Laboratoire d ImmunoGenetique Moleculaire LIGM, Universite Montpellier II, UPR CNRS 1142, IGH, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France
    Dev Comp Immunol 27:55-77. 2003
    ..The IMGT numbering has been extended to the V-like domain and is, therefore, highly valuable for comparative analysis and evolution studies of proteins belonging to the IG superfamily...
  14. ncbi IMGT unique numbering for immunoglobulin and T cell receptor constant domains and Ig superfamily C-like domains
    Marie Paule Lefranc
    IMGT, the international ImMunoGeneTics information system, LIGM, Laboratoire d Immunogenetique moleculaire, Universite Montpellier II, UPR CNRS 1142, IGH, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France
    Dev Comp Immunol 29:185-203. 2005
    ....
  15. pmc IMGT, the international ImMunoGeneTics database
    M P Lefranc
    Laboratoire d Immunogenetique moleculaire, Universite Montpellier II, UPR CNRS 1142 IGH, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France
    Nucleic Acids Res 27:209-12. 1999
    ..IMGT is freely available at http://imgt.cnusc. fr:8104..
  16. ncbi IMGT, the international ImMunoGeneTics database: a high-quality information system for comparative immunogenetics and immunology
    Marie Paule Lefranc
    Laboratoire d Immunogenetique moleculaire, LIGM, Universite Montpellier II, UPR CNRS 1142, IGH, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France
    Dev Comp Immunol 26:697-705. 2002
    ..These expertly annotated data on the genome, proteome, genetics and structure of the IG, TR and MHC are of high value for comparative genome evolution studies of the adaptative immune response...
  17. ncbi IMGT-Choreography for immunogenetics and immunoinformatics
    Marie Paule Lefranc
    Universite Montpellier II, Laboratoire d ImmunoGenetique Moleculaire LIGM, UPR CNRS 1142, Institut de Genetique Humaine IGH, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France
    In Silico Biol 5:45-60. 2005
    ..IMGT is freely available at http://imgt.cines.fr...
  18. ncbi IMGT unique numbering for MHC groove G-DOMAIN and MHC superfamily (MhcSF) G-LIKE-DOMAIN
    Marie Paule Lefranc
    IMGT, the international ImMunoGeneTics information system, Laboratoire d Immunogenetique moleculaire, LIGM, Universite Montpellier II, Institut de Genetique Humaine, IGH UPR CNRS 1142, 34396 Montpellier Cedex 5, France
    Dev Comp Immunol 29:917-38. 2005
    ....
  19. ncbi Exon duplication and triplication in the human T-cell receptor gamma constant region genes and RFLP in French, Lebanese, Tunisian, and black African populations
    C Buresi
    Laboratoire d Immunogénétique, URA CNRS 1191, Universite des Sciences et Techniques du Languedoc, Montpellier, France
    Immunogenetics 29:161-72. 1989
    ..Moreover, we analyze the TCRG haplotypes in four different populations (French, Lebanese, Tunisian, and Black African) to underline their interest for population genetics...
  20. ncbi IMGT/LIGM-DB: a systematized approach for ImMunoGeneTics database coherence and data distribution improvement
    V Giudicelli
    Laboratoire d Immunogenetique moleculaire, LIGM, UMR 5535 CNRS, Universite Montpellier II, France
    Proc Int Conf Intell Syst Mol Biol 6:59-68. 1998
    ..Recently, we have developed an API which allows Java programmers to remotely access and integrate LIGM-DB data in other computer environments...
  21. ncbi Genomic organisation of 34 kb of the human immunoglobulin lambda locus (IGLV): restriction map and sequences of new V lambda III genes
    J P Frippiat
    Laboratoire d Immunogenetique moleculaire, LIGM, Institut de Genetique Moleculaire, UMR 9942 CNRS, Université Montpellier I France
    Mol Immunol 31:657-70. 1994
    ..All these genes share the same orientation of transcription. Pulsed field gel electrophoresis analysis of the IGLV locus shows that most of the V lambda I subgroup genes are located at the 5' end of the locus...
  22. pmc Human immunoglobulin C lambda 6 gene encodes the Kern+Oz-lambda chain and C lambda 4 and C lambda 5 are pseudogenes
    P Dariavach
    Laboratoire d Immunogénétique, Universite des Sciences et Techniques du Languedoc, Montpellier, France
    Proc Natl Acad Sci U S A 84:9074-8. 1987
    ..Allotypic and isotypic differences confirm the polymorphism and complexity of the human C lambda locus...
  23. ncbi IMGT databases, web resources and tools for immunoglobulin and T cell receptor sequence analysis, http://imgt.cines.fr
    M P Lefranc
    Laboratoire d Immunogenetique moleculaire, LIGM, Universite Montpellier II, UPR CNRS 1142, Institut de Genetique Humaine, IGH, Montpellier, France
    Leukemia 17:260-6. 2003
    ..IMGT is freely available at http://imgt.cines.fr...
  24. doi Using bioinformatics tools for the sequence analysis of immunoglobulins and T cell receptors
    Marie Paule Lefranc
    IMGT, Universite Montpellier II, CNRS, Montpellier, France
    Curr Protoc Immunol . 2006
    ..IMGT/JunctionAnalysis is the first tool that automatically analyzes the complex junctions in detail. These interactive tools are easy to use and freely available on the Web (http://imgt.cines.fr), either separately or integrated...
  25. pmc Variable region genes in the human T-cell rearranging gamma (TRG) locus: V-J junction and homology with the mouse genes
    S Huck
    UA CNRS 1191 Génétique Moléculaire, Universite des Sciences et Techniques du Languedoc, Montpellier, France
    EMBO J 7:719-26. 1988
    ..Our results bring the number of human V gamma genes whose sequence is known to 13 and reveal unexpected homology with the mouse V gamma genes...
  26. ncbi Human Ig superfamily CTLA-4 gene: chromosomal localization and identity of protein sequence between murine and human CTLA-4 cytoplasmic domains
    P Dariavach
    Laboratoire d Immunogénétique, UA CNRS 1191, Universite des Sciences et Techniques du Languedoc, Montpellier, France
    Eur J Immunol 18:1901-5. 1988
    ..This complete interspecies conservation comes in support of an important role for this domain in CTLA-4 function...
  27. ncbi IMGT (ImMunoGeneTics) locus on focus. A new section of Experimental and Clinical Immunogenetics
    M P Lefranc
    Laboratoire d Immunogenetique moleculaire, CNRS, Universite Montpellier II, France
    Exp Clin Immunogenet 15:1-7. 1998
    ....
  28. ncbi The promoter regions of the T-cell receptor V9 gamma (TRGV9) and V2 delta (TRDV2) genes display short direct repeats but no TATA box
    P Dariavach
    Laboratoire d Immunogenetique moleculaire, URA CNRS 199, Universite Montpellier II, France
    FEBS Lett 256:185-91. 1989
    ..Of interest is the presence of a characteristic decanucleotide AGGTGGT(T)GAG in the promoter regions of both the TRDV2 and TRGV9 genes...
  29. ncbi Nomenclature and overview of the mouse (Mus musculus and Mus sp.) immunoglobulin kappa (IGK) genes
    C Martinez-Jean
    IMGT Nomenclature Committee, CNRS, Universite Montpellier II, Montpellier, France
    Exp Clin Immunogenet 18:255-79. 2001
    ..These tables and figures are available at the IMGT Marie-Paule page of IMGT, the international ImMunoGeneTics database (http://imgt.cines.fr) created by Marie-Paule Lefranc, Université Montpellier II, CNRS, France...
  30. ncbi Characterization of human FCGR3B*02 (HNA-1b, NA2) cDNAs and IMGT standardized description of FCGR3B alleles
    G Bertrand
    Laboratoire R and D, Agents Transmissibles par transfusion, Établissement français du sang Pyrénées Méditerranée, Montpellier, France
    Tissue Antigens 64:119-31. 2004
    ..The standardized description of FCGR3B allele polymorphisms was approved by the IMGT Nomenclature Committee (IMGT-NC) and is freely available in IMGT repertoire at IMGT, http://imgt.cines.fr...
  31. ncbi IMGT, the international ImMunoGeneTics information system, http://imgt.cines.fr
    Marie Paule Lefranc
    Universite Montpellier II, Laboratoire d Immunogenetique moleculaire, LIGM, UPR CNRS 1142, Institut de Genetique Humaine, Montpellier, France
    Novartis Found Symp 254:126-36; discussion 136-42, 216-22, 250-2. 2003
    ..IMGT is freely available at http://imgt.cines.fr...
  32. pmc IMGT/3Dstructure-DB and IMGT/StructuralQuery, a database and a tool for immunoglobulin, T cell receptor and MHC structural data
    Quentin Kaas
    IMGT, the international ImMunoGeneTics information system, Laboratoire d Immunogenetique moleculaire, LIGM, Institut de Genetique Humaine IGH, UPR CNRS 1142, 141 rue de la Cardonille, F 34396 Montpellier Cedex 5, France
    Nucleic Acids Res 32:D208-10. 2004
    ..The IMGT/StructuralQuery tool allows search of this database based on specific structural characteristics. IMGT/3Dstructure-DB and IMGT/StructuralQuery are freely available at http://imgt. cines.fr...
  33. pmc IMGT/V-QUEST, an integrated software program for immunoglobulin and T cell receptor V-J and V-D-J rearrangement analysis
    Veronique Giudicelli
    IMGT, the international ImMunoGeneTics information system, Laboratoire d Immunogenetique moleculaire, LIGM, Institut de Genetique Humaine IGH, UPR CNRS 1142, 141 rue de la Cardonille, F 34396 Montpellier Cedex 5, France
    Nucleic Acids Res 32:W435-40. 2004
    ..IMGT/V-QUEST is currently available for human and mouse, and partly for non-human primates, sheep, chondrichthyes and teleostei. IMGT/V-QUEST is freely available at http://imgt.cines.fr...
  34. doi IMGT, the international ImMunoGeneTics information system for Immunoinformatics. Methods for querying IMGT databases, tools, and Web resources in the context of immunoinformatics
    Marie Paule Lefranc
    Institut Universitaire de France, Laboratoire d Immunogenetique moleculaire, Universite Montpellier II, UPR CNRS 1142, France
    Methods Mol Biol 409:19-42. 2007
    ..IMGT Web resources comprise 8,000 HTML pages of synthesis and knowledge (IMGT Scientific chart, IMGT Repertoire, IMGT Education, etc.) and external links (IMGT Bloc-notes and IMGT other accesses)...
  35. ncbi T cell receptor/peptide/MHC molecular characterization and standardized pMHC contact sites in IMGT/3Dstructure-DB
    Quentin Kaas
    IMGT, the international ImMunoGeneTics information system, Universite Montpellier II, Laboratoire d ImmunoGénétique Moléculaire LIGMUPR CNRS 1142, Institut de Genetique Humaine IGH, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France
    In Silico Biol 5:505-28. 2005
    ..The TR/pMHC contact description, based on the IMGT numbering, can be queried in the IMGT/StucturalQuery tool, at http://imgt.cines.fr...
  36. ncbi IMGT-Kaleidoscope, the formal IMGT-ONTOLOGY paradigm
    Patrice Duroux
    the international ImMunoGeneTics information system, Universite Montpellier 2, 34396 Montpellier Cedex 5, France
    Biochimie 90:570-83. 2008
    ..In that way the Formal IMGT-ONTOLOGY represents a paradigm for the elaboration of ontologies in system biology...
  37. ncbi The human T cell receptor alpha joining (TRAJ) genes
    D Scaviner
    Laboratoire d Immunogenetique moleculaire, CNRS, Universite Montpellier II, Montpellier, France
    Exp Clin Immunogenet 17:97-106. 2000
    ..These tables are available on the IMGT Marie-Paule page from IMGT, the international ImMunoGeneTics database (http://imgt. cines.fr:8104) created in 1989 by Marie-Paule Lefranc, Université Montpellier II, CNRS, France...
  38. ncbi Organization of the human T-cell receptor genes
    M P Lefranc
    URA CNRS 1191, Universite Montpellier II, France
    Eur Cytokine Netw 1:121-30. 1990
    ..In this review, we summarize the recent findings on the genomic organization of the alpha, beta, gamma and delta T-cell receptor loci in human...
  39. ncbi WHO-IUIS Nomenclature Subcommittee for immunoglobulins and T cell receptors report August 2007, 13th International Congress of Immunology, Rio de Janeiro, Brazil
    Marie Paule Lefranc
    the international ImMunoGeneTics information system, Institut de Genetique Humaine, 34396 Montpellier Cedex 5, France
    Dev Comp Immunol 32:461-3. 2008
  40. doi IMGT, the International ImMunoGeneTics Information System for Immunoinformatics : methods for querying IMGT databases, tools, and web resources in the context of immunoinformatics
    Marie Paule Lefranc
    the international ImMunoGeneTics information system, Laboratoire d Immunogenetique moleculaire, Universite Montpellier 2, Institut de Genetique Humaine, Montpellier Cedex 5, France
    Mol Biotechnol 40:101-11. 2008
    ..IMGT Web resources comprise 10,000 HTML pages of synthesis and knowledge (IMGT Scientific chart, IMGT Repertoire, IMGT Education, etc.) and external links (IMGT Bloc-notes and IMGT other accesses)...
  41. ncbi IMGT gene identification and Colliers de Perles of human immunoglobulins with known 3D structures
    Manuel Ruiz
    Laboratoire d ImmunoGenetique Moleculaire LIGM, Universite Montpellier II, UPR CNRS 1142, IGH, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France
    Immunogenetics 53:857-83. 2002
    ..A query Web interface allows interactive search of the IMGT/3D structure-DB data. In this article, IMGT gene identification and Colliers de Perles of human immunoglobulins with known 3D structures in the Protein Data Bank are presented...
  42. ncbi IMGT, a system and an ontology that bridge biological and computational spheres in bioinformatics
    Marie Paule Lefranc
    IMGT, Laboratoire d Immunogenetique moleculaire, LIGM, UPR CNRS 1142, IGH, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France
    Brief Bioinform 9:263-75. 2008
    ..In that way the Formal IMGT-ONTOLOGY represents a paradigm for the elaboration of ontologies in system biology...
  43. pmc IMGT/V-QUEST: the highly customized and integrated system for IG and TR standardized V-J and V-D-J sequence analysis
    Xavier Brochet
    IMGT, the international ImMunoGeneTics information system, Laboratoire d ImmunoGenetique Moleculaire LIGM, Universite Montpellier 2, Institut de Genetique Humaine IGH, UPR CNRS 1142, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France
    Nucleic Acids Res 36:W503-8. 2008
    ..The 'Advanced parameters' allow to modify default parameters used by IMGT/V-QUEST and IMGT/JunctionAnalysis according to the users' interest. IMGT/V-QUEST is freely available for academic research at http://imgt.cines.fr...
  44. ncbi WHO-IUIS Nomenclature Subcommittee for immunoglobulins and T cell receptors report
    Marie Paule Lefranc
    IMGT, the international ImMunoGeneTics information system, Laboratoire d Immunogenetique moleculaire, Institut de Genetique Humaine, IGH, UPR CNRS 1142, 141 rue de la Cardonille, 34396, Montpellier Cedex 5, France
    Immunogenetics 59:899-902. 2007
  45. ncbi Molecular analysis of the IGHA and MHC class III region genes in one family with IgA and C4 deficiencies
    G Keyeux
    Laboratoire d Immunogenetique moleculaire, URA CNRS 1191, Universite Montpellier II, France
    Exp Clin Immunogenet 7:170-80. 1990
    ..These data were further supported by another molecular study in a patient with a recurrent Landry-Guillain-Barre syndrome who showed total absence of serum IgA and sIgA+B cells with no major structural defect of the IGHA region...
  46. ncbi Rearrangements to the JP1, JP and JP2 segments in the human T-cell rearranging gamma gene (TRG gamma) locus
    S Huck
    Laboratoire d Immunogénétique, UA CNRS 1191 Génétique Moléculaire, Montpellier, France
    FEBS Lett 224:291-6. 1987
    ..6, 1945-1950], our results show that a unique probe can detect all the TRG gamma rearrangements and be particularly useful for assessing the preferential usage of V gamma and J gamma segments in the TRG gamma-expressing cells...
  47. ncbi The mouse (Mus musculus) T cell receptor delta variable (TRDV), diversity (TRDD) and joining (TRDJ) genes
    N Bosc
    , , CNRS, , Montpellier, France
    Exp Clin Immunogenet 18:51-8. 2001
    ..These tables are available at the IMGT Marie-Paule page from IMGT, the international ImMunoGeneTics database (http://imgt.cines. fr:8104) created by Marie-Paule Lefranc, Université Montpellier II, CNRS, Montpellier, France...
  48. ncbi Organization of the human immunoglobulin lambda light-chain locus on chromosome 22q11.2
    J P Frippiat
    Laboratoire d Immunogenetique moleculaire, LIGM, Institut de Genetique Moleculaire, UMR 9942 CNRS, Universites Montpellier I et II, France
    Hum Mol Genet 4:983-91. 1995
    ..The VpreB gene, encoding part of the surrogate light chain, the GGT2 gene and the BCRL4 pseudogene were also mapped within the lambda locus...
  49. ncbi IMGT/JunctionAnalysis: the first tool for the analysis of the immunoglobulin and T cell receptor complex V-J and V-D-J JUNCTIONs
    Mehdi Yousfi Monod
    Laboratoire d ImmunoGenetique Moleculaire LIGM, Universite Montpellier II, UPR CNRS 1142, Institut de Genetique Humaine IGH, Montpellier Cedex 5, France
    Bioinformatics 20:i379-85. 2004
    ..We developed IMGT/JunctionAnalysis to analyse automatically in detail the IG and TR junctions, according to the IMGT Scientific chart rules, based on the IMGT-ONTOLOGY concepts...
  50. ncbi IMGT standardized criteria for statistical analysis of immunoglobulin V-REGION amino acid properties
    Christelle Pommie
    IMGT, Laboratoire d ImmunoGenetique Moleculaire LIGM, Universite Montpellier II, UPR CNRS 1142 Institut de Génétique Humaine IGH, 141 rue de la Cardonille, F 34396 Montpellier Cedex 5, France
    J Mol Recognit 17:17-32. 2004
    ....
  51. doi Web sites of interest to immunologists
    Marie Paule Lefranc
    Universite Montpellier II, CNRS, Montpellier, France
    Curr Protoc Immunol . 2006
    ..Three other sections (Molecular Biology Servers, Resources, and Universities and Institutes) offer their own lists of useful links...
  52. ncbi The human T cell receptor beta variable (TRBV) genes
    G Folch
    , CNRS, , Montpellier, France
    Exp Clin Immunogenet 17:42-54. 2000
    ..These tables are available at the IMGT Marie-Paule page from IMGT, the international ImMunoGeneTics database (http://imgt.cines. fr: 8104) created by Marie-Paule Lefranc, Université Montpellier II, CNRS, France...
  53. ncbi Nomenclature of the human immunoglobulin genes
    M P Lefranc
    , CNRS, Montpellier, France
    Curr Protoc Immunol . 2001
    ..Three additional tables list corresponding nomenclatures for these genes...
  54. ncbi IMGT standardization for statistical analyses of T cell receptor junctions: the TRAV-TRAJ example
    Kevin Bleakley
    Institut de Mathématiques et de Modélisation de Montpellier, UMR CNRS 5149, Equipe de Probabilités et Statistique, Universite Montpellier II, Montpellier, France
    In Silico Biol 6:573-88. 2006
    ..Using statistical learning, we constructed an automatic warning system to predict if new, automatically analysed TRAV-TRAJ sequences should be manually re-checked. We estimated the robustness of this automatic warning system...
  55. ncbi Molecular mapping of the human T cell receptor gamma (TRG) genes and linkage of the variable and constant regions
    M P Lefranc
    Laboratoire d Immunogenetique moleculaire, URA CNRS 199, Universite des Sciences et Techniques du Languedoc, Montpellier, France
    Eur J Immunol 19:989-94. 1989
    ....
  56. ncbi Genetic organization of the human T cell receptor gamma locus
    M P Lefranc
    Laboratoire d Immunogenetique moleculaire, URA CNRS 1191, Universite Montpellier II, France
    Curr Top Microbiol Immunol 173:3-9. 1991
  57. ncbi Protein displays of the human T cell receptor alpha, beta, gamma and delta variable and joining regions
    G Folch
    Laboratoire d Immunogenetique moleculaire, Institut de Genetique Humaine, CNRS, Universite Montpellier II, Montpellier, France
    Exp Clin Immunogenet 17:205-15. 2000
    ..These figures and tables are available at the IMGT Marie-Paule page from IMGT, the international ImMunoGeneTics database (http:// imgt.cines.fr:8104) created by Marie-Paule Lefranc, Université Montpellier II, CNRS, Montpellier, France...
  58. ncbi Nomenclature of the human T cell receptor genes
    M P Lefranc
    , CNRS, Montpellier, France
    Curr Protoc Immunol . 2001
    ..Two additional tables list corresponding nomenclatures for these genes...
  59. ncbi A simple method to predict protein-binding from aligned sequences--application to MHC superfamily and beta2-microglobulin
    Elodie Duprat
    Laboratoire d ImmunoGénétique Moléculaire IGH UPR CNRS 1142, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France
    Bioinformatics 22:453-9. 2006
    ..IMGT standardization of MhcSF protein domains provides a unique numbering of the multiple alignment positions, and conditions to develop such predictive tool...
  60. ncbi IMGT, The International ImMunoGeneTics Information System, http://imgt.cines.fr
    Marie Paule Lefranc
    IMGT, Laboratoire d Immunogenetique moleculaire, LIGM, Universite Montpellier II, UPR CNRS 1142, Institut de Genetique Humaine, IGH, Montpellier, France
    Methods Mol Biol 248:27-49. 2004
  61. ncbi IMGT Colliers de Perles and IgSF domain standardization for T cell costimulatory activatory (CD28, ICOS) and inhibitory (CTLA4, PDCD1 and BTLA) receptors
    Vijay Phani Garapati
    IMGT, the international ImMunoGeneTics information system, Laboratoire d Immunogenetique moleculaire, LIGM, Institut de Genetique Humaine, IGH, UPR CNRS 1142, 141 Rue de la Cardonille 34396 Montpellier CEDEX 5, France
    Dev Comp Immunol 31:1050-72. 2007
    ..cines.fr)...
  62. ncbi The mouse (Mus musculus) T cell receptor alpha (TRA) and delta (TRD) variable genes
    Nathalie Bosc
    IMGT, Laboratoire d ImmunoGenetique Moleculaire LIGM, Universite Montpellier II, Institut de Genetique Humaine, UPR CNRS 1142, 141 rue de la Cardonille, 34396 5, Montpellier Cedex, France
    Dev Comp Immunol 27:465-97. 2003
    ..The international ImMunoGeneTics information system (http://imgt.cines.fr) created by Marie-Paule Lefranc, Université Montpellier II, CNRS, France...
  63. doi IG, TR and IgSF, MHC and MhcSF: what do we learn from the IMGT Colliers de Perles?
    Quentin Kaas
    University of Queensland, Brisbane, Australia
    Brief Funct Genomic Proteomic 6:253-64. 2007
    ..These IMGT Colliers de Perles are particularly useful for antibody engineering, sequence-structure analysis, visualization and comparison of positions for mutations, polymorphisms and contact analysis...
  64. ncbi The genomic sequence of the bovine T cell receptor gamma TRG loci and localization of the TRGC5 cassette
    Melanie L Conrad
    University of Victoria, Centre for Biomedical Research, Victoria, British Columbia, Canada V8W 3N5
    Vet Immunol Immunopathol 115:346-56. 2007
    ..The location of the TRGC5 cassette is conclusively described in 5' of the TRG1 locus. Analysis of 17 TRGV belonging to 10 different subgroups, 8 TRGJ and 6 TRGC genes is conducted which comprises the most comprehensive list to date...
  65. ncbi Diversity in the complementarity-determining region 3 (CDR3) of antibodies from mice with evolving anti-thyroid-stimulating hormone receptor antibody responses
    Osvaldo Martinez
    Department of Microbiology and Immunology M C 790, Room E 709, Building 935, 835 South Wolcott Avenue, Chicago, Illinois 60612, USA
    Endocrinology 148:752-61. 2007
    ..Collectively, our results suggest that higher somatic mutations within the CDR3 may correlate with pathogenic antibodies against the TSHR...
  66. pmc IMGT/GeneInfo: enhancing V(D)J recombination database accessibility
    Thierry Pascal Baum
    Laboratoire TIMC IMAG CNRS UMR 5525, Techniques de l Imagerie, de la Modélisation et de la Cognition, Universite Joseph Fourier, Grenoble 1, Faculte de Medecine, Domaine de la Merci, 38706 La Tronche, France
    Nucleic Acids Res 32:D51-4. 2004
    ..Access to IMGT/GeneInfo is free and can be found at http://imgt.cines.fr/GeneInfo...
  67. ncbi Bovine T cell receptor gamma variable and constant genes: combinatorial usage by circulating gammadelta T cells
    Carolyn Herzig
    Paige Laboratory, Department of Veterinary and Animal Sciences and Program in Molecular and Cellular Biology, University of Massachusetts, Amherst, MA 01003, USA
    Immunogenetics 58:138-51. 2006
    ..Cattle are useful models for gammadelta T cell biology because they have gammadelta T cells that respond to isopentenylpyrophosphate (IPP) antigens, while mice do not, and some bovine TRGV genes cluster closely with human genes...
  68. ncbi Reconstructing the duplication history of tandemly repeated genes
    Olivier Elemento
    Département d Informatique Fondamentale et Applications, LIRMM, 161 rue Ada, 34392 Montpellier, France
    Mol Biol Evol 19:278-88. 2002
    ....
  69. ncbi The human anti-thyroid peroxidase autoantibody repertoire in Graves' and Hashimoto's autoimmune thyroid diseases
    Thierry Chardes
    INRA CNRS UMR 5087, Laboratoire de Pathologie Comparée, 30380 Saint Christol Lez Alès, France
    Immunogenetics 54:141-57. 2002
    ..The aim of this review is to provide new insights into aAb generation against TPO, a major autoantigen involved in AITD...
  70. ncbi Structure-function relationships of the variable domains of monoclonal antibodies approved for cancer treatment
    Charlotte Magdelaine-Beuzelin
    Universite Francois Rabelais de Tours, EA 3853 Immuno Pharmaco Génétique des Anticorps thérapeutiques, France
    Crit Rev Oncol Hematol 64:210-25. 2007
    ..Overall, the IMGT standards appear as a first and crucial step in the evaluation of recombinant antibodies...
  71. ncbi A high-affinity macaque antibody Fab with human-like framework regions obtained from a small phage display immune library
    Stéphanie Chassagne
    Immunobiologie, Département de biologie des agents transmissibles DBAT, Centre de Recherche du Service de Sante des Armees, 24, av des Maquis du Grésivaudan, La Tronche, P O box 38702, France
    Mol Immunol 41:539-46. 2004
    ..This strategy could be used for the isolation of high-affinity, human-like Fab fragments directed against numerous antigens...
  72. ncbi PenBase, the shrimp antimicrobial peptide penaeidin database: sequence-based classification and recommended nomenclature
    Yannick Gueguen
    Ifremer CNRS University of Montpellier 2, UMR 5171 Génome Population Interaction Adaptation, 2 Place E Bataillon, CC80, F 34095 Montpellier Cedex 5, France
    Dev Comp Immunol 30:283-8. 2006
    ..A specialized database, PenBase, which is freely available at , has been developed for the penaeidin family of antimicrobial peptides, to provide comprehensive information about their properties, diversity and nomenclature...
  73. pmc High-affinity, human antibody-like antibody fragment (single-chain variable fragment) neutralizing the lethal factor (LF) of Bacillus anthracis by inhibiting protective antigen-LF complex formation
    Thibaut Pelat
    Groupe de Biotechnologie des Anticorps, Département de Biologie des Agents Transmissibles, La Tronche, France
    Antimicrob Agents Chemother 51:2758-64. 2007
    ..These results, and others formerly published, demonstrate that our approach can generate antibody fragments suitable for prophylaxis and therapeutics...
  74. ncbi Chemiluminescent detection of clonal immunoglobulin and T cell receptor gene rearrangements in Tunisian lymphoid malignancies, leukemias and lymphomas
    Rym El Abed
    Laboratoire de Biochimie, Faculte de Medecine, Sousse, Tunisia
    Leuk Lymphoma 47:1129-37. 2006
    ....
  75. ncbi Costimulatory receptors in jawed vertebrates: conserved CD28, odd CTLA4 and multiple BTLAs
    David Bernard
    Institut National de la Recherche Agronomique, Unite de Virologie et Immunologie Moleculaires, 78352 Jouy en Josas Cedex, France
    Dev Comp Immunol 31:255-71. 2007
    ..The genomic localization of these genes in vertebrate genomes supports the split between the BTLA and CD28 families...