Agnes Lefort

Summary

Country: France

Publications

  1. ncbi request reprint Activity of fosfomycin alone or combined with cefoxitin in vitro and in vivo in a murine model of urinary tract infection due to Escherichia coli harbouring CTX-M-15-type extended-spectrum β-lactamase
    Agnes Lefort
    EA3964, Faculte de Medecine Xavier Bichat, Universite Paris Diderot, Paris, France Electronic address
    Int J Antimicrob Agents 43:366-9. 2014
  2. doi request reprint [Why should antibiotic therapy be avoided in case of acute infectious diarrhea?]
    Agnes Lefort
    AP HP, Universite Paris Diderot, Faculté Bichat, Hopital Beaujon, Service de Medecine Interne, EA3964, 75870 Paris Cedex 18, France
    Presse Med 42:82-3. 2013
  3. pmc Host factors and portal of entry outweigh bacterial determinants to predict the severity of Escherichia coli bacteremia
    Agnes Lefort
    AP HP, Hopital Beaujon, Service de Medecine Interne, 92110 Clichy Cedex, France
    J Clin Microbiol 49:777-83. 2011
  4. pmc Influence of reduced susceptibility to glycopeptides on activities of vancomycin and teicoplanin against Staphylococcus aureus in experimental endocarditis
    Juliette Pavie
    INSERM EMI U 9933, Faculte de Medecine Xavier Bichat, 75018 Paris, France
    Antimicrob Agents Chemother 47:2018-21. 2003
  5. pmc Influence of VanD type resistance on activities of glycopeptides in vitro and in experimental endocarditis due to Enterococcus faecium
    Agnes Lefort
    Institut National de la Sante et de la Recherche Medicale, EMI U 9933, Hôpital Bichat Claude Bernard Unité des Agents Antibactériens, Institut Pasteur, Paris, France
    Antimicrob Agents Chemother 47:3515-8. 2003
  6. doi request reprint Do case vignettes accurately reflect antibiotic prescription?
    Jean Christophe Lucet
    Infection Control Unit, Bichat Claude Bernard Hospital, Assistance Publique Hopitaux de Paris, Paris, and Université Paris Diderot, Sorbonne Paris Cité, France
    Infect Control Hosp Epidemiol 32:1003-9. 2011
  7. ncbi request reprint Complexity of Escherichia coli bacteremia pathophysiology evidenced by comparison of isolates from blood and portal of entry within single patients
    Olivier Clermont
    UMR S 722, INSERM and Université Paris Diderot, Sorbonne Paris Cité, Paris, France
    Int J Med Microbiol 303:529-32. 2013
  8. pmc The in vitro contribution of autolysins to bacterial killing elicited by amoxicillin increases with inoculum size in Enterococcus faecalis
    Vincent Dubée
    EA3964, Universite Paris Diderot, Faculte de Medecine, Paris, France
    Antimicrob Agents Chemother 55:910-2. 2011
  9. pmc Efficacies of quinupristin-dalfopristin combined with vancomycin in vitro and in experimental endocarditis due to methicillin-resistant Staphylococcus aureus in relation to cross-resistance to macrolides, lincosamides, and streptogramin B- type antibiotic
    Juliette Pavie
    Institut National de la Santé et de la Recherche Médicale EMI 9933, Faculte de Medecine Xavier Bichat, Paris
    Antimicrob Agents Chemother 46:3061-4. 2002
  10. pmc Activity and diffusion of tigecycline (GAR-936) in experimental enterococcal endocarditis
    Agnes Lefort
    Hopital Bichat, Institut National de la Sante et de la Recherche Medicale, EMI U 9933, Paris, France
    Antimicrob Agents Chemother 47:216-22. 2003

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Activity of fosfomycin alone or combined with cefoxitin in vitro and in vivo in a murine model of urinary tract infection due to Escherichia coli harbouring CTX-M-15-type extended-spectrum β-lactamase
    Agnes Lefort
    EA3964, Faculte de Medecine Xavier Bichat, Universite Paris Diderot, Paris, France Electronic address
    Int J Antimicrob Agents 43:366-9. 2014
    ..In vivo, the combination conferred an advantage in terms of kidney sterilisation of mice infected with either strain compared with fosfomycin monotherapy. ..
  2. doi request reprint [Why should antibiotic therapy be avoided in case of acute infectious diarrhea?]
    Agnes Lefort
    AP HP, Universite Paris Diderot, Faculté Bichat, Hopital Beaujon, Service de Medecine Interne, EA3964, 75870 Paris Cedex 18, France
    Presse Med 42:82-3. 2013
    ..Antibiotic prescriptions may thus be limited to patients with entero-invasive or severe choleriform diarrhea...
  3. pmc Host factors and portal of entry outweigh bacterial determinants to predict the severity of Escherichia coli bacteremia
    Agnes Lefort
    AP HP, Hopital Beaujon, Service de Medecine Interne, 92110 Clichy Cedex, France
    J Clin Microbiol 49:777-83. 2011
    ..46 [95% CI, 0.30 to 0.70] and OR = 0.53 [95% CI, 0.30 to 0.91], respectively). In summary, host factors and the portal of entry outweigh bacterial determinants for predicting E. coli bacteremia severity...
  4. pmc Influence of reduced susceptibility to glycopeptides on activities of vancomycin and teicoplanin against Staphylococcus aureus in experimental endocarditis
    Juliette Pavie
    INSERM EMI U 9933, Faculte de Medecine Xavier Bichat, 75018 Paris, France
    Antimicrob Agents Chemother 47:2018-21. 2003
    ..While vancomycin was similarly active against both strains, teicoplanin was approximately 100-fold less active against the resistant strain and selected for the emergence of more resistant subpopulations...
  5. pmc Influence of VanD type resistance on activities of glycopeptides in vitro and in experimental endocarditis due to Enterococcus faecium
    Agnes Lefort
    Institut National de la Sante et de la Recherche Medicale, EMI U 9933, Hôpital Bichat Claude Bernard Unité des Agents Antibactériens, Institut Pasteur, Paris, France
    Antimicrob Agents Chemother 47:3515-8. 2003
    ..These results suggest that detection of VanD type resistance is of major importance because it abolishes in vivo glycopeptide activity and allows the emergence of mutants highly resistant to glycopeptides...
  6. doi request reprint Do case vignettes accurately reflect antibiotic prescription?
    Jean Christophe Lucet
    Infection Control Unit, Bichat Claude Bernard Hospital, Assistance Publique Hopitaux de Paris, Paris, and Université Paris Diderot, Sorbonne Paris Cité, France
    Infect Control Hosp Epidemiol 32:1003-9. 2011
    ..Antibiotic prescription is frequently inappropriate in hospitals. Our objective was to evaluate whether the quality of antibiotic prescription could be measured using case vignettes to assess physicians' knowledge...
  7. ncbi request reprint Complexity of Escherichia coli bacteremia pathophysiology evidenced by comparison of isolates from blood and portal of entry within single patients
    Olivier Clermont
    UMR S 722, INSERM and Université Paris Diderot, Sorbonne Paris Cité, Paris, France
    Int J Med Microbiol 303:529-32. 2013
    ..8%) (p=0.09). These data highlight the complexity of pathophysiology of E. coli bacteremia and should be taken into consideration when strain antibiotic susceptibility is tested, especially in bacteremia of pus origin. ..
  8. pmc The in vitro contribution of autolysins to bacterial killing elicited by amoxicillin increases with inoculum size in Enterococcus faecalis
    Vincent Dubée
    EA3964, Universite Paris Diderot, Faculte de Medecine, Paris, France
    Antimicrob Agents Chemother 55:910-2. 2011
    ..We have assessed the contribution of the second mechanism by using an autolysin-deficient mutant of Enterococcus faecalis and shown that it contributes to amoxicillin-induced cell lysis only at a high bacterial density...
  9. pmc Efficacies of quinupristin-dalfopristin combined with vancomycin in vitro and in experimental endocarditis due to methicillin-resistant Staphylococcus aureus in relation to cross-resistance to macrolides, lincosamides, and streptogramin B- type antibiotic
    Juliette Pavie
    Institut National de la Santé et de la Recherche Médicale EMI 9933, Faculte de Medecine Xavier Bichat, Paris
    Antimicrob Agents Chemother 46:3061-4. 2002
    ....
  10. pmc Activity and diffusion of tigecycline (GAR-936) in experimental enterococcal endocarditis
    Agnes Lefort
    Hopital Bichat, Institut National de la Sante et de la Recherche Medicale, EMI U 9933, Paris, France
    Antimicrob Agents Chemother 47:216-22. 2003
    ..d. regimen in rabbits...
  11. ncbi request reprint Expression of glycopeptide-resistance gene in response to vancomycin and teicoplanin in the cardiac vegetations of rabbits infected with VanB-type Enterococcus faecalis
    Agnes Lefort
    Institut National de la Sante et de la Recherche Medicale, Equipe Mixté INSERM Université 9933, Paris, France
    J Infect Dis 189:90-7. 2004
    ..Teicoplanin-resistant mutants were detected as fluorescent bacteria in rabbits treated with teicoplanin. Thus, the reporter system monitored expression of a glycopeptide-resistance gene in vivo at a single-cell level...
  12. pmc Cefoxitin as an alternative to carbapenems in a murine model of urinary tract infection due to Escherichia coli harboring CTX-M-15-type extended-spectrum β-lactamase
    Raphaël Lepeule
    Universite Paris Diderot, Paris, France
    Antimicrob Agents Chemother 56:1376-81. 2012
    ..In conclusion, FOX appears to be an effective therapeutic alternative to carbapenems for the treatment of UTIs due to CTX-M-producing E. coli...
  13. pmc Flow cytometry as a tool to determine the effects of cell wall-active antibiotics on vancomycin-susceptible and -resistant Enterococcus faecalis strains
    Françoise Chau
    EA3964, Faculte de Medecine Xavier Bichat, Universite Paris 7, Paris, France
    Antimicrob Agents Chemother 55:395-8. 2011
    ..Daptomycin exerted the most pronounced effects on bacterial size and bacterial permeability against susceptible and resistant strains...
  14. doi request reprint Safety and immunogenicity of 4 intramuscular double doses and 4 intradermal low doses vs standard hepatitis B vaccine regimen in adults with HIV-1: a randomized controlled trial
    Odile Launay
    Paris Descartes University, France
    JAMA 305:1432-40. 2011
    ..Alternative schedules more immunogenic than the standard hepatitis B vaccine regimen are needed in patients with human immunodeficiency virus 1 (HIV-1) infection...
  15. doi request reprint Technetium 99m-labeled annexin V scintigraphy of platelet activation in vegetations of experimental endocarditis
    Francois Rouzet
    AP HP, Groupe Hospitalier Bichat Claude Bernard, Service de Medecine Nucleaire, Paris, France
    Circulation 117:781-9. 2008
    ..This ability was assessed in rabbits and rats because of the different interest of these 2 species in preclinical analysis...
  16. doi request reprint Bacteraemia caused by third-generation cephalosporin-resistant Escherichia coli in France: prevalence, molecular epidemiology and clinical features
    A Courpon-Claudinon
    AP HP, Hopital Louis Mourier, Service de Microbiologie Hygiène, Colombes, France
    Clin Microbiol Infect 17:557-65. 2011
    ..The fact that the molecular support of 3GC resistance is mainly plasmid-mediated represents a potentially epidemic threat...
  17. doi request reprint Antibiotic use: knowledge and perceptions in two university hospitals
    Jean Christophe Lucet
    Infection Control Unit, Bichat Claude Bernard Hospital, Assistance Publique Hopitaux de Paris, and Denis Diderot University, Paris, France
    J Antimicrob Chemother 66:936-40. 2011
    ..To investigate knowledge and perceptions about antibiotic prescription in two university hospitals...
  18. pmc Contribution of the autolysin AtlA to the bactericidal activity of amoxicillin against Enterococcus faecalis JH2-2
    Anne Lise Bravetti
    Faculte de Medecine Xavier Bichat, Universite Paris 7, Paris, France
    Antimicrob Agents Chemother 53:1667-9. 2009
    ..Comparison of the two strains indicated that this autolysin contributes to killing by amoxicillin both in vitro and in a rabbit model of experimental endocarditis...