Tony Lefebvre

Summary

Country: France

Publications

  1. ncbi request reprint Does O-GlcNAc play a role in neurodegenerative diseases?
    Tony Lefebvre
    UMR 8576, Centre National de la Recherche Scientifique, Laboratoire de Chimie Biologique, Batiment C9, 59655 Villeneuve d Ascq, France
    Expert Rev Proteomics 2:265-75. 2005
  2. ncbi request reprint Evidence of a balance between phosphorylation and O-GlcNAc glycosylation of Tau proteins--a role in nuclear localization
    Tony Lefebvre
    Laboratoire de Chimie Biologique, Unité Mixte de Recherches 8576 du CNRS, Université des Sciences et Technologies de Lille I, F 59655 Villeneuve d Ascq, France
    Biochim Biophys Acta 1619:167-76. 2003
  3. ncbi request reprint O-GlcNAc glycosylation and neurological disorders
    Tony Lefebvre
    UMR 8576, UGSF CNRS, Cite Scientifique, 59655 Villeneuve d Ascq, France
    Adv Exp Med Biol 535:189-202. 2003
  4. ncbi request reprint Identification of O-linked N-acetylglucosamine proteins in rat skeletal muscle using two-dimensional gel electrophoresis and mass spectrometry
    Caroline Cieniewski-Bernard
    Unite Mixte de Recherche, Centre National de la Recherche Scientifique 8576, Glycobiologie Structurale et Fonctionnelle, IFR118, Villeneuve d Ascc, France
    Mol Cell Proteomics 3:577-85. 2004
  5. ncbi request reprint The tumor suppressor HIC1 (hypermethylated in cancer 1) is O-GlcNAc glycosylated
    Tony Lefebvre
    UMR 8526 du CNRS, Institut de Biologie de Lille, Institut Pasteur de Lille, Lille Cédex BP447, France
    Eur J Biochem 271:3843-54. 2004
  6. doi request reprint Dysregulation of the nutrient/stress sensor O-GlcNAcylation is involved in the etiology of cardiovascular disorders, type-2 diabetes and Alzheimer's disease
    Tony Lefebvre
    CNRS UMR 8576, Unit of Structural and Functional Glycobiology, IFR 147, University of Lille 1, Villeneuve d Ascq, France
    Biochim Biophys Acta 1800:67-79. 2010
  7. ncbi request reprint Modulation of O-GlcNAc glycosylation during Xenopus oocyte maturation
    Tony Lefebvre
    Unité Mixte de Recherches 8576 du CNRS, Glycobiologie Structurale et Fonctionnelle, IFR 118, USTL, Batiment C9, 59655 Villeneuve d Ascq, France
    J Cell Biochem 93:999-1010. 2004
  8. doi request reprint Survey of O-GlcNAc level variations in Xenopus laevis from oogenesis to early development
    Vanessa Dehennaut
    UMR CNRS 8576, Unite de Glycobiologie Structurale et Fonctionnelle, IFR 147, USTL, 59655, Villeneuve d Ascq, France
    Glycoconj J 26:301-11. 2009
  9. ncbi request reprint O-linked N-acetylglucosaminyltransferase inhibition prevents G2/M transition in Xenopus laevis oocytes
    Vanessa Dehennaut
    Laboratoire de Régulation des Signaux de Division, EA 4020, Universite des Sciences et Technologies de Lille, SN3, IFR147, 59655 Villeneuve d Ascq, France
    J Biol Chem 282:12527-36. 2007
  10. doi request reprint Protein ubiquitination is modulated by O-GlcNAc glycosylation
    Céline Guinez
    UMR USTL CNRS 8576, Laboratoire de Glycobiologie Structurale et Fonctionnelle, IFR 147, 59655 Villeneuve d Ascq, France
    FASEB J 22:2901-11. 2008

Collaborators

  • Willy Morelle
  • Anne Sophie Vercoutter-Edouart
  • Jean Francois Bodart
  • Francois Foulquier
  • Anne Harduin-Lepers
  • Isabelle Landrieu
  • Gerard Vergoten
  • Xavier Hanoulle
  • Françoise Debierre-Grockiego
  • G Lippens
  • Andre Delacourte
  • Jean Claude Michalski
  • Vanessa Dehennaut
  • Céline Guinez
  • Yobana Perez-Cervera
  • Anne Marie Mir
  • Stéphanie Olivier-Van Stichelen
  • Jean Pierre Vilain
  • René Cacan
  • Yves Leroy
  • Ali Mehdy
  • Ludivine Drougat
  • Stéphanie Olivier
  • Axel Vicart
  • Jérôme Lemoine
  • Caroline Cieniewski-Bernard
  • Christelle Cebo
  • Moyira Aquino Gil
  • Katia Guedri
  • Carlos Josué Solórzano Mata
  • Chunming Liu
  • Marlene Mortuaire
  • Anne Sophie Lacoste
  • Claire Rosnoblet
  • Sandrine Duvet
  • Dominique Legrand
  • Edwige Meurice
  • Ulrike Bieker
  • Grégoire Harichaux
  • Jörg Schmidt
  • Ralph T Schwarz
  • Dominique Leprince
  • Nathalie Martin
  • Adeline Page
  • Marie Christine Slomianny
  • Catherine Jessus
  • Suzanne Walker
  • Chantal Sellier
  • Benjamin Gross
  • Marie Estelle Losfeld
  • Anne Fernandez
  • Brigitte Kahn-Perles
  • Jean Imbert
  • Bruno Bastide
  • Yvonne Mounier
  • Gerard Strecker
  • Jean Pierre Zanetta
  • Doina Florea
  • Philippe Lagant
  • Viviane Durier
  • Emmanuel Maes

Detail Information

Publications29

  1. ncbi request reprint Does O-GlcNAc play a role in neurodegenerative diseases?
    Tony Lefebvre
    UMR 8576, Centre National de la Recherche Scientifique, Laboratoire de Chimie Biologique, Batiment C9, 59655 Villeneuve d Ascq, France
    Expert Rev Proteomics 2:265-75. 2005
    ..The data presented in this review strongly suggest that O-GlcNAc could play an active role in neurodegenerative diseases...
  2. ncbi request reprint Evidence of a balance between phosphorylation and O-GlcNAc glycosylation of Tau proteins--a role in nuclear localization
    Tony Lefebvre
    Laboratoire de Chimie Biologique, Unité Mixte de Recherches 8576 du CNRS, Université des Sciences et Technologies de Lille I, F 59655 Villeneuve d Ascq, France
    Biochim Biophys Acta 1619:167-76. 2003
    ..Hence, this paper establishes a direct relationship between O-GlcNAc glycosylation, phosphorylation and cellular localization of Tau proteins...
  3. ncbi request reprint O-GlcNAc glycosylation and neurological disorders
    Tony Lefebvre
    UMR 8576, UGSF CNRS, Cite Scientifique, 59655 Villeneuve d Ascq, France
    Adv Exp Med Biol 535:189-202. 2003
  4. ncbi request reprint Identification of O-linked N-acetylglucosamine proteins in rat skeletal muscle using two-dimensional gel electrophoresis and mass spectrometry
    Caroline Cieniewski-Bernard
    Unite Mixte de Recherche, Centre National de la Recherche Scientifique 8576, Glycobiologie Structurale et Fonctionnelle, IFR118, Villeneuve d Ascc, France
    Mol Cell Proteomics 3:577-85. 2004
    ..These results strongly suggest that O-GlcNAc modification may serve as an important regulation system in skeletal muscle physiology...
  5. ncbi request reprint The tumor suppressor HIC1 (hypermethylated in cancer 1) is O-GlcNAc glycosylated
    Tony Lefebvre
    UMR 8526 du CNRS, Institut de Biologie de Lille, Institut Pasteur de Lille, Lille Cédex BP447, France
    Eur J Biochem 271:3843-54. 2004
    ..Thus, the O-GlcNAc modification of HIC1 does not affect its specific DNA-binding activity and is highly sensitive to conformational effects, notably its dimerization through the BTB/POZ domain...
  6. doi request reprint Dysregulation of the nutrient/stress sensor O-GlcNAcylation is involved in the etiology of cardiovascular disorders, type-2 diabetes and Alzheimer's disease
    Tony Lefebvre
    CNRS UMR 8576, Unit of Structural and Functional Glycobiology, IFR 147, University of Lille 1, Villeneuve d Ascq, France
    Biochim Biophys Acta 1800:67-79. 2010
    ..Lastly, the finding that AD may correspond to a type-3 diabetes offers new perspectives into the knowledge of the neuropathology and into the search for new therapeutic avenues...
  7. ncbi request reprint Modulation of O-GlcNAc glycosylation during Xenopus oocyte maturation
    Tony Lefebvre
    Unité Mixte de Recherches 8576 du CNRS, Glycobiologie Structurale et Fonctionnelle, IFR 118, USTL, Batiment C9, 59655 Villeneuve d Ascq, France
    J Cell Biochem 93:999-1010. 2004
    ..Our results suggest that O-GlcNAc glycosylation could regulate protein-protein interactions required for the cell cycle kinetic...
  8. doi request reprint Survey of O-GlcNAc level variations in Xenopus laevis from oogenesis to early development
    Vanessa Dehennaut
    UMR CNRS 8576, Unite de Glycobiologie Structurale et Fonctionnelle, IFR 147, USTL, 59655, Villeneuve d Ascq, France
    Glycoconj J 26:301-11. 2009
    ..Our results show that O-GlcNAc is regulated throughout oogenesis and development within a complex pattern and suggest that dysfunctions in the dynamics of this glycosylation could lead to developmental abnormalities...
  9. ncbi request reprint O-linked N-acetylglucosaminyltransferase inhibition prevents G2/M transition in Xenopus laevis oocytes
    Vanessa Dehennaut
    Laboratoire de Régulation des Signaux de Division, EA 4020, Universite des Sciences et Technologies de Lille, SN3, IFR147, 59655 Villeneuve d Ascq, France
    J Biol Chem 282:12527-36. 2007
    ..The present work underlines a crucial role for O-GlcNAc in G(2)/M transition and strongly suggests that its function is required for cell cycle regulation...
  10. doi request reprint Protein ubiquitination is modulated by O-GlcNAc glycosylation
    Céline Guinez
    UMR USTL CNRS 8576, Laboratoire de Glycobiologie Structurale et Fonctionnelle, IFR 147, 59655 Villeneuve d Ascq, France
    FASEB J 22:2901-11. 2008
    ....
  11. ncbi request reprint Hsp70-GlcNAc-binding activity is released by stress, proteasome inhibition, and protein misfolding
    Céline Guinez
    UMR CNRS 8576, UGSF, IFR 147, 59655 Villeneuve d Ascq, France
    Biochem Biophys Res Commun 361:414-20. 2007
    ..Finally, HGBA could be triggered by proteasome inhibition and by L-azetidine-2-carboxylic acid (a proline analogue) incorporation demonstrating that protein misfolding is one of the key-activator of this Hsp70 property...
  12. doi request reprint Microinjection of recombinant O-GlcNAc transferase potentiates Xenopus oocytes M-phase entry
    Vanessa Dehennaut
    UMR CNRS 8576, UGSF, USTL, IFR 147, 59655 Villeneuve d Ascq, France
    Biochem Biophys Res Commun 369:539-46. 2008
    ..Microinjection of anti-OGT antibodies leads to a delay of the GVBD kinetics. Our results hence demonstrate that OGT is a key molecule for the timely progression of the cell cycle...
  13. doi request reprint Characterization of O-GlcNAc cycling and proteomic identification of differentially O-GlcNAcylated proteins during G1/S transition
    Ludivine Drougat
    Universite des Sciences et Technologies de Lille, Villeneuve d Ascq, France
    Biochim Biophys Acta 1820:1839-48. 2012
    ..Despite increasing evidences showing that O-GlcNAcylation regulates mitotic events, the impact of this PTM in the early steps of the cell cycle remains poorly understood...
  14. doi request reprint Identification of structural and functional O-linked N-acetylglucosamine-bearing proteins in Xenopus laevis oocyte
    Vanessa Dehennaut
    UMR CNRS 8576, Unite de Glycobiologie Structurale et Fonctionnelle, Universite des Sciences et Technologies de Lille, IFR 147, 59655 Villeneuve d Ascq, France
    Mol Cell Proteomics 7:2229-45. 2008
    ....
  15. ncbi request reprint Modulation of HSP70 GlcNAc-directed lectin activity by glucose availability and utilization
    Céline Guinez
    UMR 8576 CNRS, Glycobiologie Structurale et Fonctionnelle, IFR 118, Batiment C9, 59655 Villeneuve d Ascq, France
    Glycobiology 16:22-8. 2006
    ..This work also demonstrates that HSP70 does not regulate its GlcNAc-binding properties through its own O-GlcNAc glycosylation...
  16. doi request reprint Proteomics and PUGNAcity will overcome questioning of insulin resistance induction by nonselective inhibition of O-GlcNAcase
    Vanessa Dehennaut
    CNRS UMR 8576, Unit of Structural and Functional Glycobiology, IFR 147, University of Lille 1, Villeneuve d Ascq, France
    Proteomics 13:2944-6. 2013
    ....
  17. doi request reprint Antibodies and activity measurements for the detection of O-GlcNAc transferase and assay of its substrate, UDP-GlcNAc
    Tony Lefebvre
    Unit of Structural and Functional Glycobiology, University of Lille 1, Villeneuve d Ascq, France
    Methods Mol Biol 1022:147-59. 2013
    ..Finally, a sensitive HPAEC-based technique to measure the cellular content of UDP-GlcNAc, the donor substrate of OGT, is described in detail...
  18. ncbi request reprint O-GlcNAc glycosylation: a signal for the nuclear transport of cytosolic proteins?
    Céline Guinez
    Unité Mixte de Recherches 8576 du CNRS, Glycobiologie Structurale et Fonctionnelle, IFR 118, USTL, Batiment C9, 59655 Villeneuve d Ascq, France
    Int J Biochem Cell Biol 37:765-74. 2005
    ..The action of the chaperone in nuclear translocation was put forward 10 years ago, but new findings suggest that this mechanism could be linked to O-GlcNAc glycosylation...
  19. ncbi request reprint 70-kDa-heat shock protein presents an adjustable lectinic activity towards O-linked N-acetylglucosamine
    Céline Guinez
    UMR 8576 du CNRS, IFR 118, Unite de Glycobiologie Structurale et Fonctionnelle, Batiment C9, Cite Scientifique, 59655 Villeneuve d Ascq cedex, France
    Biochem Biophys Res Commun 319:21-6. 2004
    ..These results strongly suggest that O-GlcNAc influences protein stability through specific interaction with 70-kDa-heat shock protein members...
  20. doi request reprint The hexosamine biosynthetic pathway and O-GlcNAcylation drive the expression of β-catenin and cell proliferation
    Stéphanie Olivier-Van Stichelen
    CNRS UMR 8576, Unit of Structural and Functional Glycobiology, University of Lille 1, Villeneuve d Ascq, France
    Am J Physiol Endocrinol Metab 302:E417-24. 2012
    ..In accordance with our findings, we propose that metabolic disorders correlate to CRC via an upregulation of HBP that reverberates on high O-GlcNAcylation levels including modification of β-catenin...
  21. doi request reprint [Signaling and metabolic predispositions linked to the colorectal cancer]
    Stéphanie Olivier
    CNRS UMR 8576, Unite de Glycobiologie Structurale et Fonctionnelle, IFR 147, Batiment C9, Universite de Lille 1, avenue Mendeleiev, Cite Scientifique, 59655 Villeneuve d Ascq, France
    Med Sci (Paris) 27:514-20. 2011
    ..We propose that, since it is implicated in the control of the insulin pathway among other actions, the nutritional sensor O-GlcNAcylation may be the element linking these metabolic disorders to CCR...
  22. doi request reprint Arginine 469 is a pivotal residue for the Hsc70-GlcNAc-binding property
    Céline Guinez
    CNRS UMR 8576, Unit of Structural and Functional Glycobiology, IFR 147, Universite de Lille 1, Cite Scientifique, 59655 Villeneuve d Ascq, France
    Biochem Biophys Res Commun 400:537-42. 2010
    ..SPORT6 vector and we showed that the mutation R469A decreased the GlcNAc-binding property of the chaperone of around 70%. This is the first work reporting the localization of the GlcNAc-binding domain of a member of the HSP70 family...
  23. doi request reprint Insulin signaling controls the expression of O-GlcNAc transferase and its interaction with lipid microdomains
    Yobana Perez-Cervera
    Centre National de la Recherche Scientifique CNRS Unité Mixte de Recherche UMR 8576, Institut Fédératif de Recherche IFR 147, University of Lille 1, Villeneuve d Ascq, France
    FASEB J 27:3478-86. 2013
    ..Taken together, these findings indicate that O-GlcNAcylation, lipid rafts, and signaling pathways are spatiotemporally coordinated to enable fundamental cellular functions...
  24. doi request reprint PUGNAc treatment leads to an unusual accumulation of free oligosaccharides in CHO cells
    Ali Mehdy
    IFR147, UMR8576 CNRS Laboratoire de Glycobiologie Structurale et Fonctionnelle, USTL, Villeneuve d Ascq, France
    J Biochem 151:439-46. 2012
    ..This study clearly points out another off target effects of PUGNAc that need to be taken into account in the use of this drug...
  25. doi request reprint Direct evidence of O-GlcNAcylation in the apicomplexan Toxoplasma gondii: a biochemical and bioinformatic study
    Yobana Perez-Cervera
    Unit of Structural and Functional Glycobiology, CNRS UMR 8576, IFR 147, Universite de Lille 1, Cite Scientifique, Villeneuve d Ascq, France
    Amino Acids 40:847-56. 2011
    ..gondii and suspected in P. falciparum. Since the O-GlcNAcylation is implicated in many biological fundamental processes this study opens a new research track in the knowledge of apicomplexans' life cycle and pathogenic potential...
  26. ncbi request reprint O-glycosylation of the nuclear forms of Pax-6 products in quail neuroretina cells
    Tony Lefebvre
    Unité Mixte de Recherche 8576 du CNRS, Laboratoire de Chimie Biologique, 59655 Villeneuve d Ascq, France
    J Cell Biochem 85:208-18. 2002
    ....
  27. ncbi request reprint Increased chromatin association of Sp1 in interphase cells by PP2A-mediated dephosphorylations
    Axel Vicart
    INSERM, UMR 599, Centre de Recherches en Cancérologie de Marseille, Marseille, F 13009, France
    J Mol Biol 364:897-908. 2006
    ..We propose that the coordinated dephosphorylation of several Sp1 residues, a general feature of dividing cells, is a required post-translational mechanism for Sp1-dependent transcription of genes related to cell division...
  28. ncbi request reprint Function and molecular modeling of the interaction between human interleukin 6 and its HNK-1 oligosaccharide ligands
    Christelle Cebo
    CNRS Unité Mixte de Recherche 8576, Laboratoire de Glycobiologie Structurale et Fonctionnelle, Université des Sciences et Technologie de Lille Bâtiment C9, 59655 Villeneuve d Ascq cedex, France
    J Biol Chem 277:12246-52. 2002
    ..Stahl, M., and Seehra, J. S. (1997) EMBO J. 16, 989-997), already known to be involved in interactions with gp130...