Tony Lefebvre


Country: France


  1. request reprint
    Lefebvre T, Guinez C, Dehennaut V, Beseme Dekeyser O, Morelle W, Michalski J. Does O-GlcNAc play a role in neurodegenerative diseases?. Expert Rev Proteomics. 2005;2:265-75 pubmed
    ..The data presented in this review strongly suggest that O-GlcNAc could play an active role in neurodegenerative diseases. ..
  2. Olivier Van Stichelen S, Dehennaut V, Buzy A, Zachayus J, Guinez C, Mir A, et al. O-GlcNAcylation stabilizes ?-catenin through direct competition with phosphorylation at threonine 41. FASEB J. 2014;28:3325-38 pubmed publisher
    ..Accordingly, we propose that O-GlcNAcylation of ?-catenin is a missing link between the glucose metabolism deregulation observed in metabolic disorders and the development of cancer. ..
  3. Gatta E, Lefebvre T, Gaetani S, Dos Santos M, Marrocco J, Mir A, et al. Evidence for an imbalance between tau O-GlcNAcylation and phosphorylation in the hippocampus of a mouse model of Alzheimer's disease. Pharmacol Res. 2016;105:186-97 pubmed publisher
    ..These data demonstrate that an imbalance between tau phosphorylation and O-GlcNAcylation exists in AD mice, and strengthens the hypothesis that O-GlcNAcylation might be targeted by disease modifying drugs in AD. ..
  4. Baldini S, Wavelet C, Hainault I, Guinez C, Lefebvre T. The Nutrient-Dependent O-GlcNAc Modification Controls the Expression of Liver Fatty Acid Synthase. J Mol Biol. 2016;428:3295-3304 pubmed publisher
    ..Together, these results reveal a new type of regulation of FAS, linked to O-GlcNAcylation status, and advance our knowledge on deregulation of lipogenesis in diverse forms of liver diseases. ..
  5. Kupferschmid M, Aquino Gil M, Shams Eldin H, Schmidt J, Yamakawa N, Krzewinski F, et al. Identification of O-GlcNAcylated proteins in Plasmodium falciparum. Malar J. 2017;16:485 pubmed publisher
    ..Blocking biosynthesis of UDP-GlcNAc in the parasites is another promising option to reduce Plasmodium life cycle. ..