Thomas Lecuit

Summary

Country: France

Publications

  1. ncbi request reprint Cell adhesion: sorting out cell mixing with echinoid?
    Thomas Lecuit
    Laboratoire de Genetique et de Physiologie du Developpement, UMR 6545, CNRS Université de la Méditerrannée, Institut de Biologie du Developpement de Marseille, France
    Curr Biol 15:R505-7. 2005
  2. ncbi request reprint Spatial control of actin organization at adherens junctions by a synaptotagmin-like protein Btsz
    Fanny Pilot
    Institut de Biologie du Développement de Marseille Luminy IBDML UMR 6216, CNRS Université de la Méditerrannée Campus de Luminy, Case 907, 13288 Marseille Cedex 09, France
    Nature 442:580-4. 2006
  3. doi request reprint Breaking down EMT
    Romain Levayer
    IBDML, UMR6216 CNRS Université de la Méditerranée, Campus de Luminy, 13288 Marseille Cedex 09, France
    Nat Cell Biol 10:757-9. 2008
  4. ncbi request reprint Junctions as organizing centers in epithelial cells? A fly perspective
    Thomas Lecuit
    Howard Hughes Medical Institute, Molecular Biology Department, Washington Road, Princeton University, Princeton, New Jersey 08544, USA
    Traffic 3:92-7. 2002
  5. ncbi request reprint Adhesion remodeling underlying tissue morphogenesis
    Thomas Lecuit
    Laboratoire de Genetique et de Physiologie du Developpement, UMR 6545 CNRS Université de la Méditerranée, Institut de Biologie du Developpement de Marseille, Campus de Luminy Case 907, 13288 Marseille Cedex 09, France
    Trends Cell Biol 15:34-42. 2005
  6. ncbi request reprint Cell surface mechanics and the control of cell shape, tissue patterns and morphogenesis
    Thomas Lecuit
    Institute of Developmental Biology of Marseille Luminy, UMR6216 CNRS Université de la Méditerranée, Campus de Luminy Case 907, 13288 Marseille Cedex 09, France
    Nat Rev Mol Cell Biol 8:633-44. 2007
  7. ncbi request reprint Developmental control of cell morphogenesis: a focus on membrane growth
    Thomas Lecuit
    Laboratoire de Genetique et de Physiologie du Developpement, Institut de Biologie du Developpement de Marseille, CNRS Université de la Méditerrannée, Campus de Luminy, Case 907 13288 Marseille Cedex 09, France
    Nat Cell Biol 5:103-8. 2003
  8. ncbi request reprint slam encodes a developmental regulator of polarized membrane growth during cleavage of the Drosophila embryo
    Thomas Lecuit
    Howard Hughes Medical Institute, Molecular Biology Department, Washington Road, Princeton University, Princeton, NJ 08544, USA
    Dev Cell 2:425-36. 2002
  9. doi request reprint Spatial regulation of Dia and Myosin-II by RhoGEF2 controls initiation of E-cadherin endocytosis during epithelial morphogenesis
    Romain Levayer
    IBDML, UMR6216 CNRS Université de la Méditerranée, Campus de Luminy, Case 907 13288 Marseille Cedex 09, France
    Nat Cell Biol 13:529-40. 2011
  10. doi request reprint Repression of Wasp by JAK/STAT signalling inhibits medial actomyosin network assembly and apical cell constriction in intercalating epithelial cells
    Claire Bertet
    IBDML, UMR6216 CNRS Université de la Méditerranée, Campus de Luminy, Case 907, 13288 Marseille Cedex 09, France
    Development 136:4199-212. 2009

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Cell adhesion: sorting out cell mixing with echinoid?
    Thomas Lecuit
    Laboratoire de Genetique et de Physiologie du Developpement, UMR 6545, CNRS Université de la Méditerrannée, Institut de Biologie du Developpement de Marseille, France
    Curr Biol 15:R505-7. 2005
    ..A recent study shows that Echinoid, a member of the immunoglobulin domain containing protein family, is a modulator of intercellular adhesion in Drosophila that controls cell sorting...
  2. ncbi request reprint Spatial control of actin organization at adherens junctions by a synaptotagmin-like protein Btsz
    Fanny Pilot
    Institut de Biologie du Développement de Marseille Luminy IBDML UMR 6216, CNRS Université de la Méditerrannée Campus de Luminy, Case 907, 13288 Marseille Cedex 09, France
    Nature 442:580-4. 2006
    ..These results provide a mechanism for the spatial order of actin organization underlying junction stabilization in primary embryonic epithelia...
  3. doi request reprint Breaking down EMT
    Romain Levayer
    IBDML, UMR6216 CNRS Université de la Méditerranée, Campus de Luminy, 13288 Marseille Cedex 09, France
    Nat Cell Biol 10:757-9. 2008
    ..Most studies of this process have focused on the disassembly of adherens junctions, but regulation of basement membrane breakdown by a pathway involving RhoA and microtubules may be equally important...
  4. ncbi request reprint Junctions as organizing centers in epithelial cells? A fly perspective
    Thomas Lecuit
    Howard Hughes Medical Institute, Molecular Biology Department, Washington Road, Princeton University, Princeton, New Jersey 08544, USA
    Traffic 3:92-7. 2002
    ....
  5. ncbi request reprint Adhesion remodeling underlying tissue morphogenesis
    Thomas Lecuit
    Laboratoire de Genetique et de Physiologie du Developpement, UMR 6545 CNRS Université de la Méditerranée, Institut de Biologie du Developpement de Marseille, Campus de Luminy Case 907, 13288 Marseille Cedex 09, France
    Trends Cell Biol 15:34-42. 2005
    ..Recent studies show that the understanding of adhesion will benefit from studies of developing organisms in which adhesion is regulated...
  6. ncbi request reprint Cell surface mechanics and the control of cell shape, tissue patterns and morphogenesis
    Thomas Lecuit
    Institute of Developmental Biology of Marseille Luminy, UMR6216 CNRS Université de la Méditerranée, Campus de Luminy Case 907, 13288 Marseille Cedex 09, France
    Nat Rev Mol Cell Biol 8:633-44. 2007
    ..In this context, a range of developmental phenomena can be explained by the regulation of cell surface tension...
  7. ncbi request reprint Developmental control of cell morphogenesis: a focus on membrane growth
    Thomas Lecuit
    Laboratoire de Genetique et de Physiologie du Developpement, Institut de Biologie du Developpement de Marseille, CNRS Université de la Méditerrannée, Campus de Luminy, Case 907 13288 Marseille Cedex 09, France
    Nat Cell Biol 5:103-8. 2003
    ..We suggest that tubulogenesis, tissue spreading and cell intercalation stem mostly from a remarkably small number of cell intrinsic surface remodelling events that confer on cells different modes of migratory behaviours...
  8. ncbi request reprint slam encodes a developmental regulator of polarized membrane growth during cleavage of the Drosophila embryo
    Thomas Lecuit
    Howard Hughes Medical Institute, Molecular Biology Department, Washington Road, Princeton University, Princeton, NJ 08544, USA
    Dev Cell 2:425-36. 2002
    ..Our results suggest that developmental induction of Slam organizes the polarized growth of membrane via the recruitment of membrane-targeting proteins at adherens junctions...
  9. doi request reprint Spatial regulation of Dia and Myosin-II by RhoGEF2 controls initiation of E-cadherin endocytosis during epithelial morphogenesis
    Romain Levayer
    IBDML, UMR6216 CNRS Université de la Méditerranée, Campus de Luminy, Case 907 13288 Marseille Cedex 09, France
    Nat Cell Biol 13:529-40. 2011
    ..Finally, we provide evidence that Dia and Myo-II control the initiation of E-cadherin endocytosis by regulating the lateral clustering of E-cadherin...
  10. doi request reprint Repression of Wasp by JAK/STAT signalling inhibits medial actomyosin network assembly and apical cell constriction in intercalating epithelial cells
    Claire Bertet
    IBDML, UMR6216 CNRS Université de la Méditerranée, Campus de Luminy, Case 907, 13288 Marseille Cedex 09, France
    Development 136:4199-212. 2009
    ..We discuss possible models for the role of Wasp activity in the regulation of Myo-II distribution...
  11. ncbi request reprint Junctions and vesicular trafficking during Drosophila cellularization
    Thomas Lecuit
    Laboratoire de Genetique et de Physiologie du Developpement, UMR 6545 CNRS Université de la Méditerranée, Institut de Biologie du Developpement de Marseille, Campus de Luminy, Case 907, 13288 Marseille Cedex 09, France
    J Cell Sci 117:3427-33. 2004
    ..The novel proteins Nullo and Slam, which are specifically induced during cellularization, represent developmental regulators of membrane growth during cellularization...
  12. doi request reprint Planar polarized actomyosin contractile flows control epithelial junction remodelling
    Matteo Rauzi
    IBDML, UMR6216 CNRS Université de la Méditerranée, Campus de Luminy, Case 907, 13288 Marseille Cedex 09, France
    Nature 468:1110-4. 2010
    ..Thus, epithelial morphogenesis is not properly reflected by Myosin II steady state distribution but by polarized contractile actomyosin flows that emerge from interactions between E-cadherin and actomyosin networks...
  13. doi request reprint A two-tiered mechanism for stabilization and immobilization of E-cadherin
    Matthieu Cavey
    Institut de Biologie du Développment de Marseille Luminy, UMR 6216 CNRS Université de la Méditerranée, Campus de Luminy Case 907, 13288 Marseille Cedex 09, France
    Nature 453:751-6. 2008
    ..Uncoupling stability and mobility of E-cadherin complexes suggests that stable epithelia may remodel through the regulated mobility of very stable adhesive foci...
  14. doi request reprint Adhesion disengagement uncouples intrinsic and extrinsic forces to drive cytokinesis in epithelial tissues
    Charlène Guillot
    Aix Marseille Universite, CNRS UMR 7288, IBDM, Campus de Luminy, Case 907, 13288 Marseille Cedex 09, France
    Dev Cell 24:227-41. 2013
    ..We uncover intrinsic and extrinsic forces necessary for cytokinesis and present a framework for understanding how tissue cohesion is preserved during epithelial division...
  15. ncbi request reprint Myosin-dependent junction remodelling controls planar cell intercalation and axis elongation
    Claire Bertet
    Laboratoire de Genetique et de Physiologie du Developpement, Institut de Biologie du Developpement de Marseille, CNRS Inserm Université de la Méditerranée, Campus de Luminy, Case 907, 13288 Marseille Cedex 9, France
    Nature 429:667-71. 2004
    ..This simple cellular mechanism provides a general model for polarized morphogenesis in epithelial organs...
  16. doi request reprint Oscillation and polarity of E-cadherin asymmetries control actomyosin flow patterns during morphogenesis
    Romain Levayer
    IBDM, Aix Marseille Universite, CNRS UMR 7288, Campus de Luminy, Marseille, France
    Dev Cell 26:162-75. 2013
    ..This work suggests that fluctuations and mechanical instability are not the consequences of limited control over the systems key parameters, but rather that they define the axis of symmetry breaking. ..
  17. ncbi request reprint Compartmentalized morphogenesis in epithelia: from cell to tissue shape
    Fanny Pilot
    Laboratoire de génétique et de physiologie du développement LGPD, UMR 6545 CNRS Université de la Méditerranée, Institut de Biologie du Développement de Marseille IBDM, Marseille, France
    Dev Dyn 232:685-94. 2005
    ..Some signals define a local change in cell behavior (e.g., apical constriction), others orient a dynamic process in the plane of the tissue (e.g., junction remodeling)...
  18. doi request reprint Mechanics of epithelial tissue homeostasis and morphogenesis
    Charlène Guillot
    Aix Marseille Universite, CNRS UMR 7288, IBDM, Campus de Luminy, Marseille, France
    Science 340:1185-9. 2013
    ..Tissue fluidity emerges from local active stresses acting at cell interfaces and allows the maintenance of epithelial organization during morphogenesis and tissue renewal...
  19. ncbi request reprint Trafficking through Rab11 endosomes is required for cellularization during Drosophila embryogenesis
    Anne Pelissier
    Laboratoire de Genetique et de Physiologie du Developpement, Institut de Biologie du Developpement de Marseille, France
    Curr Biol 13:1848-57. 2003
    ..In Drosophila, the process is specialized and called cellularization. The trafficking pathways that underlie this process and that are responsible for the mobilization of membrane pools, however, remain poorly understood...
  20. doi request reprint alpha-catenin mechanosensing for adherens junctions
    Thomas Lecuit
    Thomas Lecuit is in IBDML, UMR6216 CNRS Université de la Méditerranée, Campus de Luminy, Case 907 13288 Marseille Cedex 09, France
    Nat Cell Biol 12:522-4. 2010
    ..The finding that actomyosin tension reinforces mechanical coupling of actin to E-cadherin through alpha-catenin reveals similarities with integrin regulation...
  21. doi request reprint A global pattern of mechanical stress polarizes cell divisions and cell shape in the growing Drosophila wing disc
    Loic Legoff
    IBDML, UMR7288 CNRS Université d Aix Marseille Campus de Luminy, Case 907, 13288 Marseille Cedex 09, France
    Development 140:4051-9. 2013
    ..Ectopic perturbations of tissue growth by the Hippo signaling pathway reorganize this pattern in a non-autonomous manner, suggesting a synergy between tissue mechanics and growth control during wing disc morphogenesis. ..
  22. doi request reprint Lighting up developmental mechanisms: how fluorescence imaging heralded a new era
    Manos Mavrakis
    IBDML Institut de Biologie du Développement de Marseille Luminy, UMR6216 CNRS Université de la Méditerranée, Parc Scientifique de Luminy BP 907, 13009 Marseille, France
    Development 137:373-87. 2010
    ..We review how the study of patterning, cell polarization and morphogenesis has benefited from this technology and discuss the possibilities offered by fluorescence imaging and by the contributions of quantitative disciplines...
  23. doi request reprint Microtubule-induced nuclear envelope fluctuations control chromatin dynamics in Drosophila embryos
    Bernhard Hampoelz
    IBDML, UMR6216 CNRS Université de la Méditerranée, Campus de Luminy, Case 907, 13288 Marseille Cedex 09, France
    Development 138:3377-86. 2011
    ..Thus, the NE is a dynamic organelle, fluctuations of which increase chromatin dynamics. We propose that such mechanical regulation of chromatin dynamics by MTs might be important for gene regulation...
  24. doi request reprint Planar polarity and short-range polarization in Drosophila embryos
    Claire Bertet
    IBDML, UMR6216 CNRS Université de la Méditerranée, Campus de Luminy Case 907, 13288 Marseille Cedex 09, France
    Semin Cell Dev Biol 20:1006-13. 2009
    ..We contrast these with other systems, such as the adult Drosophila wing where planar cell polarity occurs at longer range...
  25. ncbi request reprint Orchestrating size and shape during morphogenesis
    Thomas Lecuit
    Universite de la Mediterranee, Institut de Biologie du Developpement de Marseille Luminy IBDML, Marseille Cedex 09, France
    Nature 450:189-92. 2007
    ..New models integrate how specific signals and mechanical forces shape tissues and may also control their size...
  26. doi request reprint Biomechanical regulation of contractility: spatial control and dynamics
    Romain Levayer
    Institut de Biologie du Developpement de Marseille Luminy, Unite Mixte de Recherche 6216, Case 907, Campus de Luminy, 13009 Marseille, France
    Trends Cell Biol 22:61-81. 2012
    ..Through the comparison of cytokinesis, cell migration and epithelial morphogenesis, we delineate emergent properties of contractile activity, including self-organization, adaptability and robustness...
  27. doi request reprint Closing in on mechanisms of tissue morphogenesis
    Matteo Rauzi
    IBDML, UMR6216 CNRS Université de la Méditerranée, Campus de Luminy Case 907, 13288 Marseille Cedex 09, France
    Cell 137:1183-5. 2009
    ..Solon et al. (2009) now report that a ratchet-like mechanism drives the movement of epithelial sheets during dorsal closure in embryos of the fruit fly Drosophila...
  28. doi request reprint Imaging cellular and molecular dynamics in live embryos using fluorescent proteins
    Matthieu Cavey
    IBDML, Campus de Luminy, Marseille, France
    Methods Mol Biol 420:219-38. 2008
    ..4) Finally, we focus on pitfalls and how to overcome a variety of possible problems encountered during live imaging...
  29. pmc Transcriptional and epigenetic signatures of zygotic genome activation during early Drosophila embryogenesis
    Elodie Darbo
    Technological Advances for Genomics and Clinics TAGC, INSERM U1090, Universite de la Mediterranee, Campus de Luminy, 13288 Marseille Cedex 9, France
    BMC Genomics 14:226. 2013
    ..The regulatory mechanisms underlying these drastic transcriptional changes remain largely unknown...
  30. doi request reprint Nuclear mechanics in differentiation and development
    Bernhard Hampoelz
    IBDML, UMR6216 CNRS Université de la Méditerranée, Campus de Luminy, Case 907, 13288 Marseille Cedex 09, France
    Curr Opin Cell Biol 23:668-75. 2011
    ..Thus it is likely that the mechanical characteristics of nuclei significantly contribute to proper differentiation...
  31. ncbi request reprint Regulation of membrane dynamics in developing epithelia
    Thomas Lecuit
    Institut de Biologie du Developpement de Marseille, Laboratoire de Genetique et de Physiologie du Developpement, Campus de Luminy, Case 907, 13288 Marseille, Cedex 09, France
    Curr Opin Genet Dev 13:351-7. 2003
    ..It is now possible to identify signalling pathways that provide the temporal triggers and/or spatial cues to regulate core cellular effectors during migration, morphogenesis and the formation of epithelia...
  32. ncbi request reprint Developmental control of nuclear size and shape by Kugelkern and Kurzkern
    Annely Brandt
    Zentrum für Molekulare Biologie der Universität Heidelberg ZMBH, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany
    Curr Biol 16:543-52. 2006
    ..We investigated this question in early Drosophila embryos, where the nuclear shape changes from spherical to ellipsoidal together with a 2.5-fold increase in nuclear length during cellularization...
  33. ncbi request reprint Developmental control of nuclear morphogenesis and anchoring by charleston, identified in a functional genomic screen of Drosophila cellularisation
    Fanny Pilot
    Institut de Biologie du Développement de Marseille IBDM de Génétique et de Physiologie du Développement LGPD, UMR6545 CNRS Université de la Méditerrannée Campus de Luminy case 907, Marseille 13288 cedex9, France
    Development 133:711-23. 2006
    ..The upregulation of Char during cellularisation and gastrulation reveals the existence of an as yet unknown developmental control of nuclear morphology and anchoring in embryonic epithelia...
  34. ncbi request reprint Developmental biology: Flowers' wings, fruitflies' petals
    Claude Desplan
    Nature 422:123-4. 2003
  35. pmc The fly Olympics: faster, higher and stronger answers to developmental questions. Conference on the Molecular and Developmental Biology of Drosophila
    Amy Bejsovec
    Department of Biology, Duke University, Durham, North Carolina 27708, USA
    EMBO Rep 5:1037-40. 2004