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Genomes and GenesSpecies | Thomas LecuitSummaryCountry: France Publications
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Publications
Orchestrating size and shape during morphogenesisThomas Lecuit
Universite de la Mediterranee, Institut de Biologie du Developpement de Marseille Luminy IBDML, Marseille Cedex 09, France
Nature 450:189-92. 2007..New models integrate how specific signals and mechanical forces shape tissues and may also control their size...
alpha-catenin mechanosensing for adherens junctionsThomas Lecuit
Thomas Lecuit is in IBDML, UMR6216 CNRS Université de la Méditerranée, Campus de Luminy, Case 907 13288 Marseille Cedex 09, France
Nat Cell Biol 12:522-4. 2010..The finding that actomyosin tension reinforces mechanical coupling of actin to E-cadherin through alpha-catenin reveals similarities with integrin regulation...- Repression of Wasp by JAK/STAT signalling inhibits medial actomyosin network assembly and apical cell constriction in intercalating epithelial cellsClaire Bertet
IBDML, UMR6216 CNRS Université de la Méditerranée, Campus de Luminy, Case 907, 13288 Marseille Cedex 09, France
Development 136:4199-212. 2009..We discuss possible models for the role of Wasp activity in the regulation of Myo-II distribution... - Spatial regulation of Dia and Myosin-II by RhoGEF2 controls initiation of E-cadherin endocytosis during epithelial morphogenesisRomain Levayer
IBDML, UMR6216 CNRS Université de la Méditerranée, Campus de Luminy, Case 907 13288 Marseille Cedex 09, France
Nat Cell Biol 13:529-40. 2011..Finally, we provide evidence that Dia and Myo-II control the initiation of E-cadherin endocytosis by regulating the lateral clustering of E-cadherin... - Planar polarized actomyosin contractile flows control epithelial junction remodellingMatteo Rauzi
IBDML, UMR6216 CNRS Université de la Méditerranée, Campus de Luminy, Case 907, 13288 Marseille Cedex 09, France
Nature 468:1110-4. 2010..Thus, epithelial morphogenesis is not properly reflected by Myosin II steady state distribution but by polarized contractile actomyosin flows that emerge from interactions between E-cadherin and actomyosin networks... - Junctions and vesicular trafficking during Drosophila cellularizationThomas Lecuit
Laboratoire de Genetique et de Physiologie du Developpement, UMR 6545 CNRS Université de la Méditerranée, Institut de Biologie du Developpement de Marseille, Campus de Luminy, Case 907, 13288 Marseille Cedex 09, France
J Cell Sci 117:3427-33. 2004..The novel proteins Nullo and Slam, which are specifically induced during cellularization, represent developmental regulators of membrane growth during cellularization... - Force generation, transmission, and integration during cell and tissue morphogenesisThomas Lecuit
Developmental Biology Institute of Marseilles Luminy, Centre National de la Recherche Scientifique, Universite de la Mediterranee, 13288 Marseille Cedex 9, France
Annu Rev Cell Dev Biol 27:157-84. 2011..A new era is opening that emphasizes the similarities of and allows comparisons between distant dynamic biological phenomena because they rely on core machineries that control universal features of cytomechanics... - Myosin-dependent junction remodelling controls planar cell intercalation and axis elongationClaire Bertet
Laboratoire de Genetique et de Physiologie du Developpement, Institut de Biologie du Developpement de Marseille, CNRS Inserm Université de la Méditerranée, Campus de Luminy, Case 907, 13288 Marseille Cedex 9, France
Nature 429:667-71. 2004..This simple cellular mechanism provides a general model for polarized morphogenesis in epithelial organs... - Lighting up developmental mechanisms: how fluorescence imaging heralded a new eraManos Mavrakis
IBDML Institut de Biologie du Développement de Marseille Luminy, UMR6216 CNRS Université de la Méditerranée, Parc Scientifique de Luminy BP 907, 13009 Marseille, France
Development 137:373-87. 2010..We review how the study of patterning, cell polarization and morphogenesis has benefited from this technology and discuss the possibilities offered by fluorescence imaging and by the contributions of quantitative disciplines... - Biomechanical regulation of contractility: spatial control and dynamicsRomain Levayer
Institut de Biologie du Developpement de Marseille Luminy, Unite Mixte de Recherche 6216, Case 907, Campus de Luminy, 13009 Marseille, France
Trends Cell Biol 22:61-81. 2012..Through the comparison of cytokinesis, cell migration and epithelial morphogenesis, we delineate emergent properties of contractile activity, including self-organization, adaptability and robustness... - Planar polarity and short-range polarization in Drosophila embryosClaire Bertet
IBDML, UMR6216 CNRS Université de la Méditerranée, Campus de Luminy Case 907, 13288 Marseille Cedex 09, France
Semin Cell Dev Biol 20:1006-13. 2009..We contrast these with other systems, such as the adult Drosophila wing where planar cell polarity occurs at longer range... - Breaking down EMTRomain Levayer
IBDML, UMR6216 CNRS Université de la Méditerranée, Campus de Luminy, 13288 Marseille Cedex 09, France
Nat Cell Biol 10:757-9. 2008..Most studies of this process have focused on the disassembly of adherens junctions, but regulation of basement membrane breakdown by a pathway involving RhoA and microtubules may be equally important... - Regulation of membrane dynamics in developing epitheliaThomas Lecuit
, , Campus de Luminy, Case 907, 13288 Marseille, Cedex 09, France
Curr Opin Genet Dev 13:351-7. 2003..It is now possible to identify signalling pathways that provide the temporal triggers and/or spatial cues to regulate core cellular effectors during migration, morphogenesis and the formation of epithelia... - Junctions as organizing centers in epithelial cells? A fly perspectiveThomas Lecuit
Howard Hughes Medical Institute, Molecular Biology Department, Washington Road, Princeton University, Princeton, New Jersey 08544, USA
Traffic 3:92-7. 2002.... - Adhesion remodeling underlying tissue morphogenesisThomas Lecuit
Laboratoire de Genetique et de Physiologie du Developpement, UMR 6545 CNRS Université de la Méditerranée, Institut de Biologie du Developpement de Marseille, Campus de Luminy Case 907, 13288 Marseille Cedex 09, France
Trends Cell Biol 15:34-42. 2005..Recent studies show that the understanding of adhesion will benefit from studies of developing organisms in which adhesion is regulated... - slam encodes a developmental regulator of polarized membrane growth during cleavage of the Drosophila embryoThomas Lecuit
Howard Hughes Medical Institute, Molecular Biology Department, Washington Road, Princeton University, Princeton, NJ 08544, USA
Dev Cell 2:425-36. 2002..Our results suggest that developmental induction of Slam organizes the polarized growth of membrane via the recruitment of membrane-targeting proteins at adherens junctions... - Cell adhesion: sorting out cell mixing with echinoid?Thomas Lecuit
Laboratoire de Genetique et de Physiologie du Developpement, UMR 6545, CNRS Université de la Méditerrannée, Institut de Biologie du Developpement de Marseille, France
Curr Biol 15:R505-7. 2005..A recent study shows that Echinoid, a member of the immunoglobulin domain containing protein family, is a modulator of intercellular adhesion in Drosophila that controls cell sorting... - Microtubule-induced nuclear envelope fluctuations control chromatin dynamics in Drosophila embryosBernhard Hampoelz
IBDML, UMR6216 CNRS Université de la Méditerranée, Campus de Luminy, Case 907, 13288 Marseille Cedex 09, France
Development 138:3377-86. 2011..Thus, the NE is a dynamic organelle, fluctuations of which increase chromatin dynamics. We propose that such mechanical regulation of chromatin dynamics by MTs might be important for gene regulation... - Cell surface mechanics and the control of cell shape, tissue patterns and morphogenesisThomas Lecuit
Institute of Developmental Biology of Marseille Luminy, UMR6216 CNRS Université de la Méditerranée, Campus de Luminy Case 907, 13288 Marseille Cedex 09, France
Nat Rev Mol Cell Biol 8:633-44. 2007..In this context, a range of developmental phenomena can be explained by the regulation of cell surface tension... - Nuclear mechanics in differentiation and developmentBernhard Hampoelz
IBDML, UMR6216 CNRS Université de la Méditerranée, Campus de Luminy, Case 907, 13288 Marseille Cedex 09, France
Curr Opin Cell Biol 23:668-75. 2011..Thus it is likely that the mechanical characteristics of nuclei significantly contribute to proper differentiation... - Imaging cellular and molecular dynamics in live embryos using fluorescent proteinsMatthieu Cavey
IBDML, Campus de Luminy, Marseille, France
Methods Mol Biol 420:219-38. 2008..4) Finally, we focus on pitfalls and how to overcome a variety of possible problems encountered during live imaging... - Closing in on mechanisms of tissue morphogenesisMatteo Rauzi
IBDML, UMR6216 CNRS Université de la Méditerranée, Campus de Luminy Case 907, 13288 Marseille Cedex 09, France
Cell 137:1183-5. 2009..Solon et al. (2009) now report that a ratchet-like mechanism drives the movement of epithelial sheets during dorsal closure in embryos of the fruit fly Drosophila... - Developmental control of cell morphogenesis: a focus on membrane growthThomas Lecuit
Laboratoire de Genetique et de Physiologie du Developpement, Institut de Biologie du Developpement de Marseille, CNRS Université de la Méditerrannée, Campus de Luminy, Case 907 13288 Marseille Cedex 09, France
Nat Cell Biol 5:103-8. 2003..We suggest that tubulogenesis, tissue spreading and cell intercalation stem mostly from a remarkably small number of cell intrinsic surface remodelling events that confer on cells different modes of migratory behaviours... - Developmental control of nuclear size and shape by Kugelkern and KurzkernAnnely Brandt
Zentrum für Molekulare Biologie der Universität Heidelberg ZMBH, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany
Curr Biol 16:543-52. 2006..We investigated this question in early Drosophila embryos, where the nuclear shape changes from spherical to ellipsoidal together with a 2.5-fold increase in nuclear length during cellularization... - Developmental control of nuclear morphogenesis and anchoring by charleston, identified in a functional genomic screen of Drosophila cellularisationFanny Pilot
, , Marseille 13288 cedex9, France
Development 133:711-23. 2006..The upregulation of Char during cellularisation and gastrulation reveals the existence of an as yet unknown developmental control of nuclear morphology and anchoring in embryonic epithelia... - Spatial control of actin organization at adherens junctions by a synaptotagmin-like protein BtszFanny Pilot
Institut de Biologie du Développement de Marseille Luminy IBDML UMR 6216, CNRS Université de la Méditerrannée Campus de Luminy, Case 907, 13288 Marseille Cedex 09, France
Nature 442:580-4. 2006..These results provide a mechanism for the spatial order of actin organization underlying junction stabilization in primary embryonic epithelia... - Trafficking through Rab11 endosomes is required for cellularization during Drosophila embryogenesisAnne Pelissier
Laboratoire de Genetique et de Physiologie du Developpement, Institut de Biologie du Developpement de Marseille, France
Curr Biol 13:1848-57. 2003..In Drosophila, the process is specialized and called cellularization. The trafficking pathways that underlie this process and that are responsible for the mobilization of membrane pools, however, remain poorly understood... - A two-tiered mechanism for stabilization and immobilization of E-cadherinMatthieu Cavey
Institut de Biologie du Développment de Marseille Luminy, UMR 6216 CNRS Université de la Méditerranée, Campus de Luminy Case 907, 13288 Marseille Cedex 09, France
Nature 453:751-6. 2008..Uncoupling stability and mobility of E-cadherin complexes suggests that stable epithelia may remodel through the regulated mobility of very stable adhesive foci... - Compartmentalized morphogenesis in epithelia: from cell to tissue shapeFanny Pilot
, , , Marseille, France
Dev Dyn 232:685-94. 2005..Some signals define a local change in cell behavior (e.g., apical constriction), others orient a dynamic process in the plane of the tissue (e.g., junction remodeling)... 
The fly Olympics: faster, higher and stronger answers to developmental questions. Conference on the Molecular and Developmental Biology of DrosophilaAmy Bejsovec
Department of Biology, Duke University, Durham, North Carolina 27708, USA
EMBO Rep 5:1037-40. 2004- Developmental biology: Flowers' wings, fruitflies' petalsClaude Desplan
Nature 422:123-4. 2003