Christine Lebrun

..All of them were seizure-free. Progression free survival was not reached at 5 Years. Up-front chemotherapy for low-grade astrocytomas may be useful and has to be prospectively evaluated...

..It is unknown whether pregnancy impacts the risk of clinical conversion in those within the presymptomatic period...

..For 63% of patients treated with immunosuppressive or immunomodulatory therapies, oral levocarnitine adjunction decreased fatigue intensity, especially in patients treated with cyclophosphamide and interferon beta...

..A prospective study is in progress in French MS centers on behalf the Club Francophone de la SEP (CARIMS Project)...

..These results suggest that radiotherapy could be postponed until the malignant transformation occurs to delay cognitive side effects of irradiation...

..The subsequent molecular characterization may contribute to the appropriate care of affected patients and asymptomatic gene carriers...

..3 years. To our knowledge, this is the first cohort of CIS with preclinical follow-up. Early treatment should be discussed in view of the predictive value on conversion of the MRI burden of the disease...

..From 1 January 1995 to 30 June 2006, we collected and studied the profile of 7,418 MS patients gathered from nine French MS centers. We evaluated the incidence of cancer in a Cancer Risk In MS Cohort...

..0 and 6.0. We collected data and studied the impact of disease-modifying therapies (DMT) in NA patients with MS, among the 4144 MS patients treated in our MS clinics...

..Many therapeutic options can be ruled, such as thymectomy, corticosteroids, azathioprine, cyclophosphamide, mycophenolate mofetil, methotrexate, intravenous immunoglobulin (IVIg) or less frequently plasmapheresis must be ruled...

..Subclinical demyelinating lesions may occur in the brains of asymptomatic individuals...

..Neuroprotective agents are still evaluated. The neurologic complications of the more commonly used chemotherapeutic agents, hormones and targeted molecular agents are discussed...

..This result could influence the attitude of the medical profession with respect to the benefit to risk ratio when proposing DMT to MS patients...

..Non-steroid antiinflammatory gels, local corticosteroids or endermology can help patients to resolve side-effects and to continue immunomodulatory treatment...

..To evaluate sessions of endermology (LPG) on patients with lipoatrophy, due to GA injections in an open-labelled study...

..There are many sources of error when comparing successive images which can be overcome to some extent with repositioning and image processing techniques...

..In previous studies, it was demonstrated that visual evoked potential and cerebrospinal fluid help to identify pejorative markers in converting to MS...

..Brain MRI showed giant plaques in eight cases (40%). A full recovery was observed in 14 patients (64%). Furthermore, acute aphasia did not appear to be a criterion for poor prognosis...

..We suggest that tear OCB detection may replace CSF OCB detection as a diagnostic tool in patients with CIS. This would circumvent the practice of invasive lumbar punctures currently used in MS diagnosis...

..To date, cognitive functions have never been investigated in NMO...

..CONCLUSION: Relevant personal and familial history can provide the clue to the diagnosis of Turcot's syndrome. Molecular diagnosis may contribute to appropriate care of affected patients...

..Favorable prognostic factors for oligodendroglial tumors include age younger than 40 years, low tumor grade, and extent of resection...

..Few data are available about the effect of rituximab (RTX) on refractory (RM) and non-refractory (NRM) myasthenia...

..The objective of this study was to determine if there was an increased risk of developing exacerbations in women with MS after in vitro fertilisation (IVF)...

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..In addition, a few patients with progressive cerebellar ataxia show high titres of GAD-Ab, suggesting an auto-immune origin...

..This syndrome is of uncertain nosological status, and is supposedly due to unilateral primary degeneration of corticospinal pathway. Some authors have suggested that it could represent a variant of primary lateral sclerosis...

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..MS patients respond well to treatment, either psychotherapy or antidepressants...

..We applied these criteria to 14 patients who presented a first severe acute demyelinating event and whose later clinical course enabled clear identification of the neurological diagnosis...

..In the European multiple sclerosis (MS) database registered in Nice, about 8p.cent of the patients have a North African ethnic background...

..ChAc patients exhibit involuntary movements, psychiatric abnormalities and progressive cognitive deterioration. We report a case of ChAc in which blood smears failed to demonstrate acanthocytes...

..To date, no treatment is approved for PPMS and we therefore propose a trial to test the use of CYC treatment early in the course of the disease in PPMS patients with disability progression...

..To compare the clinical disease progression in European (E) and North African (NA) patients with multiple sclerosis (MS) patients in France...

..Health related quality of life (HRQOL) is often affected in multiple sclerosis (MS). Nevertheless, to our knowledge, there is no longitudinal study in the literature about the correlation between MRI parameters and HRQOL in MS patients...

..In patients with a history of recent infection or vaccination, especially for adolescents or young adults, the differential diagnosis with acute disseminated encephalomyelitis can be difficult...

..Haematologic side-effects decrease after AED modification during the continued chemotherapy. This adverse event should be managed with caution...

..CONCLUSION: Cyclophosphamide appears to be more efficient in early stage of progressive multiple sclerosis independently of age, relapses or neurological disability scale...

..Depressive states are twice frequent and usual antidepressant drugs seems to demonstrate some efficacy...

..In a retrospective study of 288 patients with ATM, 45 cases (15.6%) met the criteria for idiopathic ATM. The patients formed a relatively homogeneous group in terms of clinical and MRI data, but the prognosis was highly variable...

..CONCLUSION: During the initial phase of the disease, most of the relapsing remitting patients present a mild cognitive impairment. Early detection, therapeutic propositions, and recognition of disorders are necessary...

..It points out the need for continuous clinical evaluation to detect their appearance. When neurological complications are diagnosed late, they are rarely reversible. Neuroprotective agents are still under evaluation...

..MMF is efficient and well tolerated, but there is no case-report about neurosarcoidosis...

..This report suggests that benefits of CT on symptoms, survival, and quality of life should be prospectively compared with RT...

..Surprisingly, some patients had partial improvement of neurological functions which were considered as sequelae. Indications for intravenous immunoglobulins in the treatment of the multiple sclerosis need to be evaluated...

..The probability of relapse was significantly lower in the IS Group (P =0.0007). From our results, interferon beta is not recommended, and one of the best current therapeutic options for NMO appears to be immunosuppressants...

..The respective criteria for NMO and MS were able to distinguish these two pathologies but only when MRI data were applied. This finding could have implications for future therapeutic trials...

..To our knowledge, this is the first case reported in literature...

..We reviewed the correlations between the radiological and clinical findings and the methodology of published trials on beta interferons in remitting, secondarily progressive and early onset multiple sclerosis...

..We report a case of FXTAS with isolated cerebellar ataxia...

..ii) Ligands other than insulin, such as antibodies, which perturb the extracellular domain, can function as alternative ways to restore the mutant receptor kinase...

..A variety of oral and parenteral medications are available. Review of comparative efficacy and tolerability of anti-spastic agents is performed in order to guide rational prescribing...

..Future surveillance after vaccination will be needed to detect emerging serogroups and resistance among S. pneumoniae...

..To determine the electroclinical characteristics and causative factors of nonconvulsive status epilepticus (NCSE) of frontal origin...

..Intermittent catheterization, surgical treatment, or electrostimulation are proposed in most severe cases. Therapies for intestinal disorders are more limited. Management of symptoms and different therapies are reviewed...

..The elevated level of urinary methoxylated metabolites is statistically correlated to clinical dysautonomia and can be used as a biological marker to monitoring demyelinating polyradiculoneuritis...

..To date, no clear criteria exist for ADEM, and the risk of subsequent evolution to multiple sclerosis (MS) remains unknown...