Christine Lebrun

Summary

Country: France

Publications

  1. ncbi request reprint [Neoadjuvant chemotherapy for symptomatic non operable grade II fibrillary astrocytoma in adults]
    C Lebrun
    Service de Neurologie, Hopital Pasteur, Nice, France
    Rev Neurol (Paris) 160:533-7. 2004
  2. ncbi request reprint Impact of pregnancy on conversion to clinically isolated syndrome in a radiologically isolated syndrome cohort
    C Lebrun
    Club Francophone de Sclerose en Plaques, CHU Nice et CHU Rennes, Nice, France
    Mult Scler 18:1297-302. 2012
  3. ncbi request reprint [The contribution of automatic anatomical matching of sequential brain MRI scans in the monitoring of multiple sclerosis lesions]
    C Lebrun
    Service de Neurologie, CHU, Nice
    Rev Neurol (Paris) 160:805-10. 2004
  4. doi request reprint Association between clinical conversion to multiple sclerosis in radiologically isolated syndrome and magnetic resonance imaging, cerebrospinal fluid, and visual evoked potential: follow-up of 70 patients
    Christine Lebrun
    Departments of Neurology, University of Nice Sophia Antipolis, 06002 Nice, France
    Arch Neurol 66:841-6. 2009
  5. doi request reprint Cancer risk and impact of disease-modifying treatments in patients with multiple sclerosis
    Christine Lebrun
    Service de Neurologie, CHU Pasteur, 06002 Nice, France
    Mult Scler 14:399-405. 2008
  6. doi request reprint Successful treatment of refractory generalized myasthenia gravis with rituximab
    C Lebrun
    Department of Neurology, Universitary Hospital, Nice, France
    Eur J Neurol 16:246-50. 2009
  7. ncbi request reprint Turcot syndrome confirmed with molecular analysis
    C Lebrun
    Service de Neurologie, Hopital Pasteur, Nice, France
    Eur J Neurol 14:470-2. 2007
  8. ncbi request reprint Treatment of newly diagnosed symptomatic pure low-grade oligodendrogliomas with PCV chemotherapy
    C Lebrun
    Department of Neurology, Hopital Pasteur, Nice, France
    Eur J Neurol 14:391-8. 2007
  9. ncbi request reprint Levocarnitine administration in multiple sclerosis patients with immunosuppressive therapy-induced fatigue
    C Lebrun
    Department of Neurology, Hopital Pasteur, 30 Voie Romaine, 06002 Nice, France
    Mult Scler 12:321-4. 2006
  10. doi request reprint Impact of disease-modifying treatments in North African migrants with multiple sclerosis in France
    C Lebrun
    MS Clinic, Neurology, University Hospital Pasteur, Nice, France
    Mult Scler 14:933-9. 2008

Detail Information

Publications59

  1. ncbi request reprint [Neoadjuvant chemotherapy for symptomatic non operable grade II fibrillary astrocytoma in adults]
    C Lebrun
    Service de Neurologie, Hopital Pasteur, Nice, France
    Rev Neurol (Paris) 160:533-7. 2004
    ..All of them were seizure-free. Progression free survival was not reached at 5 Years. Up-front chemotherapy for low-grade astrocytomas may be useful and has to be prospectively evaluated...
  2. ncbi request reprint Impact of pregnancy on conversion to clinically isolated syndrome in a radiologically isolated syndrome cohort
    C Lebrun
    Club Francophone de Sclerose en Plaques, CHU Nice et CHU Rennes, Nice, France
    Mult Scler 18:1297-302. 2012
    ..It is unknown whether pregnancy impacts the risk of clinical conversion in those within the presymptomatic period...
  3. ncbi request reprint [The contribution of automatic anatomical matching of sequential brain MRI scans in the monitoring of multiple sclerosis lesions]
    C Lebrun
    Service de Neurologie, CHU, Nice
    Rev Neurol (Paris) 160:805-10. 2004
    ..There are many sources of error when comparing successive images which can be overcome to some extent with repositioning and image processing techniques...
  4. doi request reprint Association between clinical conversion to multiple sclerosis in radiologically isolated syndrome and magnetic resonance imaging, cerebrospinal fluid, and visual evoked potential: follow-up of 70 patients
    Christine Lebrun
    Departments of Neurology, University of Nice Sophia Antipolis, 06002 Nice, France
    Arch Neurol 66:841-6. 2009
    ..Subclinical demyelinating lesions may occur in the brains of asymptomatic individuals...
  5. doi request reprint Cancer risk and impact of disease-modifying treatments in patients with multiple sclerosis
    Christine Lebrun
    Service de Neurologie, CHU Pasteur, 06002 Nice, France
    Mult Scler 14:399-405. 2008
    ..From 1 January 1995 to 30 June 2006, we collected and studied the profile of 7,418 MS patients gathered from nine French MS centers. We evaluated the incidence of cancer in a Cancer Risk In MS Cohort...
  6. doi request reprint Successful treatment of refractory generalized myasthenia gravis with rituximab
    C Lebrun
    Department of Neurology, Universitary Hospital, Nice, France
    Eur J Neurol 16:246-50. 2009
    ..Many therapeutic options can be ruled, such as thymectomy, corticosteroids, azathioprine, cyclophosphamide, mycophenolate mofetil, methotrexate, intravenous immunoglobulin (IVIg) or less frequently plasmapheresis must be ruled...
  7. ncbi request reprint Turcot syndrome confirmed with molecular analysis
    C Lebrun
    Service de Neurologie, Hopital Pasteur, Nice, France
    Eur J Neurol 14:470-2. 2007
    ..The subsequent molecular characterization may contribute to the appropriate care of affected patients and asymptomatic gene carriers...
  8. ncbi request reprint Treatment of newly diagnosed symptomatic pure low-grade oligodendrogliomas with PCV chemotherapy
    C Lebrun
    Department of Neurology, Hopital Pasteur, Nice, France
    Eur J Neurol 14:391-8. 2007
    ..These results suggest that radiotherapy could be postponed until the malignant transformation occurs to delay cognitive side effects of irradiation...
  9. ncbi request reprint Levocarnitine administration in multiple sclerosis patients with immunosuppressive therapy-induced fatigue
    C Lebrun
    Department of Neurology, Hopital Pasteur, 30 Voie Romaine, 06002 Nice, France
    Mult Scler 12:321-4. 2006
    ..For 63% of patients treated with immunosuppressive or immunomodulatory therapies, oral levocarnitine adjunction decreased fatigue intensity, especially in patients treated with cyclophosphamide and interferon beta...
  10. doi request reprint Impact of disease-modifying treatments in North African migrants with multiple sclerosis in France
    C Lebrun
    MS Clinic, Neurology, University Hospital Pasteur, Nice, France
    Mult Scler 14:933-9. 2008
    ..0 and 6.0. We collected data and studied the impact of disease-modifying therapies (DMT) in NA patients with MS, among the 4144 MS patients treated in our MS clinics...
  11. ncbi request reprint [CARIMS (Cancer Risk In Multiple Sclerosis) project: impact of long-term treatment]
    C Lebrun
    Service de Neurologie, CHU Pasteur, Nice
    Rev Neurol (Paris) 163:38-46. 2007
    ..A prospective study is in progress in French MS centers on behalf the Club Francophone de la SEP (CARIMS Project)...
  12. doi request reprint Endermology: a treatment for injection-induced lipoatrophy in multiple sclerosis patients treated with sub cutaneous glatiramer acetate
    Christine Lebrun
    Service de Neurologie, Hopital Pasteur, Nice, France
    Clin Neurol Neurosurg 113:721-4. 2011
    ..To evaluate sessions of endermology (LPG) on patients with lipoatrophy, due to GA injections in an open-labelled study...
  13. doi request reprint [Neurologic side effects of cytotoxic drugs]
    C Lebrun
    Service de Neurologie, CHU de Nice, 30, avenue de la Voie Romaine, Nice Cedex, France
    Rev Med Interne 31:295-304. 2010
    ..Neuroprotective agents are still evaluated. The neurologic complications of the more commonly used chemotherapeutic agents, hormones and targeted molecular agents are discussed...
  14. doi request reprint Cognitive function in radiologically isolated syndrome
    Christine Lebrun
    Department of Neurology of Nice University, France
    Mult Scler 16:919-25. 2010
    ..In previous studies, it was demonstrated that visual evoked potential and cerebrospinal fluid help to identify pejorative markers in converting to MS...
  15. ncbi request reprint Cutaneous Side-effects of Immunomodulators in MS
    C Lebrun
    Christine Lebrun Service de Neurologie Hopital Pasteur 30 voie romaine 06002 Nice France Tel 33 4 92 03 78 96 Fax 33 4 92 03 79 97 E mail
    Int MS J 17:88-94. 2011
    ..Non-steroid antiinflammatory gels, local corticosteroids or endermology can help patients to resolve side-effects and to continue immunomodulatory treatment...
  16. doi request reprint Unexpected multiple sclerosis: follow-up of 30 patients with magnetic resonance imaging and clinical conversion profile
    C Lebrun
    Neurology, CHU de Nice, France
    J Neurol Neurosurg Psychiatry 79:195-8. 2008
    ..3 years. To our knowledge, this is the first cohort of CIS with preclinical follow-up. Early treatment should be discussed in view of the predictive value on conversion of the MRI burden of the disease...
  17. doi request reprint Cancer and multiple sclerosis in the era of disease-modifying treatments
    Christine Lebrun
    Service de Neurologie, CHU Pasteur, 30 Voie Romaine, 06002 Nice, France
    J Neurol 258:1304-11. 2011
    ..This result could influence the attitude of the medical profession with respect to the benefit to risk ratio when proposing DMT to MS patients...
  18. ncbi request reprint Acute aphasia in multiple sclerosis: A multicenter study of 22 patients
    A Lacour
    Department of Neurology, University of Lille, University of Besancon, Lille Cedex, France
    Neurology 62:974-7. 2004
    ..Brain MRI showed giant plaques in eight cases (40%). A full recovery was observed in 14 patients (64%). Furthermore, acute aphasia did not appear to be a criterion for poor prognosis...
  19. ncbi request reprint Switching from natalizumab to fingolimod in multiple sclerosis: a French prospective study
    Mikael Cohen
    Department of Neurology, University Hospital of Nice, Nice, France
    JAMA Neurol 71:436-41. 2014
    ..The safety and efficacy of switching from natalizumab to fingolimod have not yet been evaluated in a large cohort of patients with multiple sclerosis (MS) to our knowledge...
  20. doi request reprint Cognitive functions in neuromyelitis optica
    Frederic Blanc
    Department of Neurology, Strasbourg University, Alsace, France
    Arch Neurol 65:84-8. 2008
    ..To date, cognitive functions have never been investigated in NMO...
  21. doi request reprint Tear analysis in clinically isolated syndrome as new multiple sclerosis criterion
    Gauthier Calais
    Groupe Hospitalier de l Institut Catholique de Lille, Service de Neurologie, Lille, France
    Mult Scler 16:87-92. 2010
    ..We suggest that tear OCB detection may replace CSF OCB detection as a diagnostic tool in patients with CIS. This would circumvent the practice of invasive lumbar punctures currently used in MS diagnosis...
  22. ncbi request reprint [Turcot's syndrome confirmed by molecular biological tests]
    S Jeannin
    Service de Neurologie, Hopital Pasteur, Nice
    Rev Neurol (Paris) 162:741-6. 2006
    ..Turcot's syndrome is characterized clinically by the concurrence of a primary brain tumor and a familial adenomatous polyposis or a hereditary nonpolyposis colorectal cancer...
  23. ncbi request reprint Long-term outcome of oligodendrogliomas
    C Lebrun
    Department of Neurology, Hopital Pasteur, Nice, France
    Neurology 62:1783-7. 2004
    ..Favorable prognostic factors for oligodendroglial tumors include age younger than 40 years, low tumor grade, and extent of resection...
  24. doi request reprint Rituximab in refractory and non-refractory myasthenia: a retrospective multicenter study
    Nicolas Collongues
    Department of Neurology, University of Strasbourg, University Hospital of Hautepierre, 1 Avenue Moliere, 67000 Strasbourg, France
    Muscle Nerve 46:687-91. 2012
    ..Few data are available about the effect of rituximab (RTX) on refractory (RM) and non-refractory (NRM) myasthenia...
  25. doi request reprint Increased risk of multiple sclerosis relapse after in vitro fertilisation
    Laure Michel
    Service de Neurologie, Centre Hospitalier Universitaire de Nantes, Hopital Laennec, Nantes Cedex, France
    J Neurol Neurosurg Psychiatry 83:796-802. 2012
    ..The objective of this study was to determine if there was an increased risk of developing exacerbations in women with MS after in vitro fertilisation (IVF)...
  26. ncbi request reprint [Mills' syndrome: a rare clinical entity]
    S Lachaud
    Service d EFSN, Hopital Pasteur, Nice, France
    Rev Neurol (Paris) 163:335-40. 2007
    ..This syndrome is of uncertain nosological status, and is supposedly due to unilateral primary degeneration of corticospinal pathway. Some authors have suggested that it could represent a variant of primary lateral sclerosis...
  27. ncbi request reprint [Diagnostic and prognostic values of 1p and 19q deletions in adult gliomas: critical review of the literature and implications in daily clinical practice]
    D Fontaine
    Service de Neurochirurgie, Hopital Pasteur, CHU de Nice, UNSA, 30, avenue de la Voie Romaine, 06000 Nice, France
    Rev Neurol (Paris) 164:595-604. 2008
    ....
  28. doi request reprint Auto-immune cerebellar ataxia with anti-GAD antibodies accompanied by de novo late-onset type 1 diabetes mellitus
    C Bayreuther
    Neurology Department, Pasteur Hospital, 30, Voie Romaine, 06002 Nice, France
    Diabetes Metab 34:386-8. 2008
    ..In addition, a few patients with progressive cerebellar ataxia show high titres of GAD-Ab, suggesting an auto-immune origin...
  29. doi request reprint [De Seze et al. criteria: application to a series of 14 patients presenting a first severe acute demyelinating event]
    E Bozzolo
    Service de Neurologie, Pavillon F, CHU de Nice, Hopital Pasteur, 30, avenue de la Voie Romaine, BP 69, 06002 Nice cedex 1, France
    Rev Neurol (Paris) 165:38-47. 2009
    ..We applied these criteria to 14 patients who presented a first severe acute demyelinating event and whose later clinical course enabled clear identification of the neurological diagnosis...
  30. doi request reprint [Chorea-acanthocytosis without acanthocytes]
    C Bayreuther
    Service de Neurologie, Hopital Pasteur, CHU de Nice, 30, Voie Romaine, 06002 Nice, France
    Rev Neurol (Paris) 166:100-3. 2010
    ..ChAc patients exhibit involuntary movements, psychiatric abnormalities and progressive cognitive deterioration. We report a case of ChAc in which blood smears failed to demonstrate acanthocytes...
  31. doi request reprint [Depression in multiple sclerosis]
    C Lebrun
    Service de Neurologie, Hopital Pasteur, Nice
    Rev Neurol (Paris) 165:S156-62. 2009
    ..MS patients respond well to treatment, either psychotherapy or antidepressants...
  32. doi request reprint [Natalizumab (Tysabri) prescription practices of neurologists in southern France]
    F Rocher
    Service de Neurologie, Hopital Pasteur, CHU de Nice, 30 Venue de la Voie Romaine, BP 69, 06002 Nice Cedex 01, France
    Rev Neurol (Paris) 166:412-8. 2010
    ....
  33. ncbi request reprint [Contribution of cognitive evoked potentials for detecting early cognitive disorders in multiple sclerosis]
    M N Magnie
    Service d Explorations Fonctionnelles du Système Nerveux, CHU de Nice
    Rev Neurol (Paris) 163:1065-74. 2007
    ....
  34. ncbi request reprint [Relapsing remitting multiple sclerosis or multiphasic disseminated encephalomyelitis?]
    C Lebrun
    Service de Neurologie, Hopital Pasteur, CHU de Nice, 06002 Nice
    Rev Neurol (Paris) 161:228-33. 2005
    ..In patients with a history of recent infection or vaccination, especially for adolescents or young adults, the differential diagnosis with acute disseminated encephalomyelitis can be difficult...
  35. ncbi request reprint [Phenotypical aspects and clinical course of multiple sclerosis in 76 patients with a North African ethnic background followed at the Nice University Hospital]
    S Jeannin
    Service de Neurologie, CHRU Nice, Hopital Pasteur, 30 Voie Romaine, Nice
    Rev Neurol (Paris) 163:440-7. 2007
    ..In the European multiple sclerosis (MS) database registered in Nice, about 8p.cent of the patients have a North African ethnic background...
  36. ncbi request reprint Treatment of progressive forms of multiple sclerosis by cyclophosphamide: a cohort study of 490 patients
    H Zephir
    Department of Neurology, Hopital R Salengro, CHRU of Lille, 59037, Lille, Cedex, France
    J Neurol Sci 218:73-7. 2004
    ..To date, no treatment is approved for PPMS and we therefore propose a trial to test the use of CYC treatment early in the course of the disease in PPMS patients with disability progression...
  37. doi request reprint [Longitudinal study of health related quality of life in multiple sclerosis: correlation with MRI parameters]
    M Cohen
    Service de Neurologie, Hopital Pasteur, CHU de Nice, 30, Voie Romaine, BP69, 06002 Nice Cedex, France
    Rev Neurol (Paris) 166:894-900. 2010
    ..Health related quality of life (HRQOL) is often affected in multiple sclerosis (MS). Nevertheless, to our knowledge, there is no longitudinal study in the literature about the correlation between MRI parameters and HRQOL in MS patients...
  38. ncbi request reprint More severe disability of North Africans vs Europeans with multiple sclerosis in France
    M Debouverie
    Department of Neurology, Central Hospital, Nancy, France
    Neurology 68:29-32. 2007
    ..To compare the clinical disease progression in European (E) and North African (NA) patients with multiple sclerosis (MS) patients in France...
  39. ncbi request reprint [Treatment of progressive multiple sclerosis with monthly pulsed cyclophosphamide-methylprednisolone: predictive factors of treatment response]
    E Delmont
    Service de Neurologie, CHU de Nice
    Rev Neurol (Paris) 160:659-65. 2004
    ..Cyclophospamide is used in the treatment of progressive multiple sclerosis. We were looking for predictive indicators of treatment response...
  40. ncbi request reprint [Chemotherapeutic neurotoxicity]
    C Lebrun
    Service de Neurologie, CHU de Nice
    Rev Neurol (Paris) 159:741-54. 2003
    ..It points out the need for continuous clinical evaluation to detect their appearance. When neurological complications are diagnosed late, they are rarely reversible. Neuroprotective agents are still under evaluation...
  41. ncbi request reprint Idiopathic acute transverse myelitis: application of the recent diagnostic criteria
    J de Seze
    Department of Neurology, University of Lille, France
    Neurology 65:1950-3. 2005
    ..In a retrospective study of 288 patients with ATM, 45 cases (15.6%) met the criteria for idiopathic ATM. The patients formed a relatively homogeneous group in terms of clinical and MRI data, but the prognosis was highly variable...
  42. ncbi request reprint [Early detection of cognitive impairment in relapsing-remitting multiple sclerosis: functional-anatomical correlations and longitudinal follow-up]
    C Bensa
    Service de Neurologie, Hopital Pasteur, CHU Nice
    Rev Neurol (Paris) 162:1221-31. 2006
    ..Cognitive impairment is frequent in relapsing remitting Multiple Sclerosis and is often diagnosed after disruption of occupational and social relations...
  43. ncbi request reprint [Therapeutic indications in symptomatic cognitive and psychopathological disorders in multiple sclerosis]
    C Lebrun
    Service de Neurologie, , 30, Voie Romaine, BP69, 06002 Nice
    Rev Neurol (Paris) 157:1085-90. 2001
    ..Depressive states are twice frequent and usual antidepressant drugs seems to demonstrate some efficacy...
  44. ncbi request reprint Nitroso-urea-cisplatin-based chemotherapy associated with valproate: increase of haematologic toxicity
    V Bourg
    Service de Neurologie, H pital Pasteur, Nice, France
    Ann Oncol 12:217-9. 2001
    ..Haematologic side-effects decrease after AED modification during the continued chemotherapy. This adverse event should be managed with caution...
  45. ncbi request reprint Is Devic's neuromyelitis optica a separate disease? A comparative study with multiple sclerosis
    J de Seze
    Department of Neurology, Hopital R Salengro, University of Lille, France
    Mult Scler 9:521-5. 2003
    ..The respective criteria for NMO and MS were able to distinguish these two pathologies but only when MRI data were applied. This finding could have implications for future therapeutic trials...
  46. ncbi request reprint [Intravenous immunoglobulins for relapsing-remitting multiple sclerosis after failure of treatment with other immuno-modulators]
    C Lebrun
    Service de Neurologie, Hopital Pasteur, Nice, France
    Rev Neurol (Paris) 159:648-51. 2003
    ..Surprisingly, some patients had partial improvement of neurological functions which were considered as sequelae. Indications for intravenous immunoglobulins in the treatment of the multiple sclerosis need to be evaluated...
  47. ncbi request reprint First-line nitrosourea-based chemotherapy in symptomatic non-resectable supratentorial pure low-grade astrocytomas
    M P Frenay
    Service de Neurologie, Hopital Pasteur, Nice, France
    Eur J Neurol 12:685-90. 2005
    ..This report suggests that benefits of CT on symptoms, survival, and quality of life should be prospectively compared with RT...
  48. ncbi request reprint Immunosuppressive therapy is more effective than interferon in neuromyelitis optica
    C Papeix
    Department of Neurology, Hopital de la Salpetriere, Paris, France
    Mult Scler 13:256-9. 2007
    ..The probability of relapse was significantly lower in the IS Group (P =0.0007). From our results, interferon beta is not recommended, and one of the best current therapeutic options for NMO appears to be immunosuppressants...
  49. ncbi request reprint [Neurosarcoidosis treated with mycophenolate mofetil: two cases]
    A Chaussenot
    Service de Neurologie, Hopital Pasteur, Nice
    Rev Neurol (Paris) 163:471-5. 2007
    ..MMF is efficient and well tolerated, but there is no case-report about neurosarcoidosis...
  50. ncbi request reprint [Recurrent aseptic meningitis associated with primary biliary cirrhosis]
    C Bensa
    Service de Neurologie, Hopital Pasteur, Nice
    Rev Neurol (Paris) 161:87-91. 2005
    ..The etiological diagnosis of recurrent aseptic meningitis often requires difficult investigations. We report a case of recurrent aseptic meningitis associated with a primary biliary cirrhosis...
  51. doi request reprint [Late cerebellar ataxia associated with fragile X premutation]
    A Chaussenot
    Service de Neurologie, Hopital Pasteur, 30, Voie Romaine, 06002, Nice, France
    Rev Neurol (Paris) 164:957-63. 2008
    ..We report a case of FXTAS with isolated cerebellar ataxia...
  52. ncbi request reprint [Beta-interferon clinical trials using MRI in patients with multiple sclerosis]
    C Lebrun
    Service de Neurologie, , 30, Voie Romaine, BP 69, 06002 Nice Cedex, France
    Rev Neurol (Paris) 157:761-7. 2001
    ..We reviewed the correlations between the radiological and clinical findings and the methodology of published trials on beta interferons in remitting, secondarily progressive and early onset multiple sclerosis...
  53. ncbi request reprint Nonconvulsive status epilepticus of frontal origin
    P Thomas
    Service de Neurologie, Hopital Pasteur, Nice, France
    Neurology 52:1174-83. 1999
    ..To determine the electroclinical characteristics and causative factors of nonconvulsive status epilepticus (NCSE) of frontal origin...
  54. ncbi request reprint [Acute polyradiculoneuritis and dysautonomia: contribution of assaying catecholamines and their methoxylated metabolites]
    C Lebrun
    Service de Neurologie, Hopital Pasteur, Nice Cedex, France
    Rev Neurol (Paris) 157:304-8. 2001
    ..The elevated level of urinary methoxylated metabolites is statistically correlated to clinical dysautonomia and can be used as a biological marker to monitoring demyelinating polyradiculoneuritis...
  55. ncbi request reprint [Therapeutic indications in spasticity symptoms of multiple sclerosis]
    C Lebrun
    Service de Neurologie, , 30 Voie Romaine, BP69, 06002 Nice
    Rev Neurol (Paris) 157:1045-50. 2001
    ..A variety of oral and parenteral medications are available. Review of comparative efficacy and tolerability of anti-spastic agents is performed in order to guide rational prescribing...
  56. ncbi request reprint [Therapeutic indications in symptoms of bladder and sphincter disorders in multiple sclerosis]
    C Lebrun
    Service de Neurologie, , 30, Voie Romaine, BP69, 06002 Nice
    Rev Neurol (Paris) 157:1060-5. 2001
    ..Intermittent catheterization, surgical treatment, or electrostimulation are proposed in most severe cases. Therapies for intestinal disorders are more limited. Management of symptoms and different therapies are reviewed...
  57. ncbi request reprint Antibodies to the extracellular receptor domain restore the hormone-insensitive kinase and conformation of the mutant insulin receptor valine 382
    C Lebrun
    Institut National de la Sante et de la Recherche Medicale, Unité 145, Faculte de Medecine, Nice, France
    J Biol Chem 268:11272-7. 1993
    ..ii) Ligands other than insulin, such as antibodies, which perturb the extracellular domain, can function as alternative ways to restore the mutant receptor kinase...
  58. ncbi request reprint [Evolution of antibiotic resistance and serogroups of Streptococcus pneumoniae over the 1997-2003 period in Brittany]
    S Mignard
    Département de Bactériologie Virologie et Hygiène Hospitalière, CHU, 35033 Rennes, France
    Pathol Biol (Paris) 53:457-62. 2005
    ..Future surveillance after vaccination will be needed to detect emerging serogroups and resistance among S. pneumoniae...
  59. ncbi request reprint Acute fulminant demyelinating disease: a descriptive study of 60 patients
    Jerome De Seze
    Departement de Neurologie, Hopital Civil, 1 Place de l Hopital, BP 426, 67091 Strasbourg Cedex, France
    Arch Neurol 64:1426-32. 2007
    ..To date, no clear criteria exist for ADEM, and the risk of subsequent evolution to multiple sclerosis (MS) remains unknown...