Didier Lebrec

Summary

Country: France

Publications

  1. ncbi request reprint Review article: future indications for terlipressin therapy
    D Lebrec
    Laboratoire d Hémodynamique Splanchnique et de Biologie Vasculaire, INSERM U 481, Hopital Beaujon, Clichy, France
    Aliment Pharmacol Ther 20:65-7; discussion 68. 2004
  2. ncbi request reprint Complications of portal hypertension in adults: a French consensus
    Didier Lebrec
    Laboratoire d Hémodynamique Splanchnique et de Biologie Vasculaire, INSERM U 481 and Service d Hépatologie, Hopital Beaujon, Clichy, France
    Eur J Gastroenterol Hepatol 17:403-10. 2005
  3. doi request reprint Pentoxifylline does not decrease short-term mortality but does reduce complications in patients with advanced cirrhosis
    Didier Lebrec
    INSERM, Unité 773, Centre de Recherche Biomédicle Bichat Beaujon CRB3, Paris, France and Service d Hépatologie, Hopital Beaujon, Clichy, France
    Gastroenterology 138:1755-62. 2010
  4. doi request reprint Bleeding in patients with Budd-Chiari syndrome
    Pierre Emmanuel Rautou
    Pôle des Maladies de l Appareil Digestif, Service d Hepatologie, Hopital Beaujon, AP HP, Clichy, France
    J Hepatol 54:56-63. 2011
  5. doi request reprint Ex vivo effects of high-density lipoprotein exposure on the lipopolysaccharide-induced inflammatory response in patients with severe cirrhosis
    Arnaud Galbois
    INSERM, U773, Centre de Recherche Biomedicale Bichat Beaujon CRB3, Hopital Beaujon, Clichy, France
    Hepatology 49:175-84. 2009
  6. ncbi request reprint Discrepant effects of inducible nitric oxide synthase modulation on systemic and splanchnic endothelial nitric oxide synthase activity and expression in cirrhotic rats
    Eugene Malyshev
    INSERM U773, Research Center Bichat Beaujon CRB3, Beaujon Hospital, Clichy, France
    J Gastroenterol Hepatol 22:2195-201. 2007
  7. ncbi request reprint Comparison of outcome in patients with cirrhosis and ascites following treatment with albumin or a synthetic colloid: a randomised controlled pilot trail
    Richard Moreau
    Service d Hépatologie and INSERM Unité 481, Hopital Beaujon, Clichy, France
    Liver Int 26:46-54. 2006
  8. doi request reprint Severe hyponatremia is a better predictor of mortality than MELDNa in patients with cirrhosis and refractory ascites
    Thomas Sersté
    Service d Hepatologie, Hopital Beaujon, Clichy, France
    J Hepatol 57:274-80. 2012
  9. ncbi request reprint Norfloxacin reduces aortic NO synthases and proinflammatory cytokine up-regulation in cirrhotic rats: role of Akt signaling
    Khalid A Tazi
    Laboratoire d Hémodynamique Splanchnique et de Biologie Vasculaire, INSERM, Hopital Beaujon, Clichy, France
    Gastroenterology 129:303-14. 2005
  10. ncbi request reprint Terlipressin inhibits in vivo aortic iNOS expression induced by lipopolysaccharide in rats with biliary cirrhosis
    Richard Moreau
    Laboratoire d Hémodynamique Splanchnique et de Biologie Vasculaire, INSERM U 481, Hopital Beaujon, Paris, France
    Hepatology 36:1070-8. 2002

Detail Information

Publications66

  1. ncbi request reprint Review article: future indications for terlipressin therapy
    D Lebrec
    Laboratoire d Hémodynamique Splanchnique et de Biologie Vasculaire, INSERM U 481, Hopital Beaujon, Clichy, France
    Aliment Pharmacol Ther 20:65-7; discussion 68. 2004
    ..A positive effect has also been demonstrated with vasopressin in cardiopulmonary resuscitation...
  2. ncbi request reprint Complications of portal hypertension in adults: a French consensus
    Didier Lebrec
    Laboratoire d Hémodynamique Splanchnique et de Biologie Vasculaire, INSERM U 481 and Service d Hépatologie, Hopital Beaujon, Clichy, France
    Eur J Gastroenterol Hepatol 17:403-10. 2005
    ..The conclusions of a French consensus conference on the prevention and treatments of the main complications of portal hypertension in adults are reported...
  3. doi request reprint Pentoxifylline does not decrease short-term mortality but does reduce complications in patients with advanced cirrhosis
    Didier Lebrec
    INSERM, Unité 773, Centre de Recherche Biomédicle Bichat Beaujon CRB3, Paris, France and Service d Hépatologie, Hopital Beaujon, Clichy, France
    Gastroenterology 138:1755-62. 2010
    ..We performed a randomized, placebo-controlled, double-blind trial of its effects in patients with cirrhosis...
  4. doi request reprint Bleeding in patients with Budd-Chiari syndrome
    Pierre Emmanuel Rautou
    Pôle des Maladies de l Appareil Digestif, Service d Hepatologie, Hopital Beaujon, AP HP, Clichy, France
    J Hepatol 54:56-63. 2011
    ..This study aimed to assess the incidence, severity, and risk factors of major bleeding in patients with Budd-Chiari syndrome (BCS) receiving anticoagulation therapy...
  5. doi request reprint Ex vivo effects of high-density lipoprotein exposure on the lipopolysaccharide-induced inflammatory response in patients with severe cirrhosis
    Arnaud Galbois
    INSERM, U773, Centre de Recherche Biomedicale Bichat Beaujon CRB3, Hopital Beaujon, Clichy, France
    Hepatology 49:175-84. 2009
    ..These results were confirmed in isolated monocytes from these patients. This suggests that administration of rHDL might be a useful strategy for the treatment of cirrhosis to limit LPS-induced cytokine overproduction...
  6. ncbi request reprint Discrepant effects of inducible nitric oxide synthase modulation on systemic and splanchnic endothelial nitric oxide synthase activity and expression in cirrhotic rats
    Eugene Malyshev
    INSERM U773, Research Center Bichat Beaujon CRB3, Beaujon Hospital, Clichy, France
    J Gastroenterol Hepatol 22:2195-201. 2007
    ..The aim of this study was to evaluate the effects of modulating aortic and superior mesenteric arteries (SMA) iNOS on arterial eNOS activity and expression in rats with cirrhosis...
  7. ncbi request reprint Comparison of outcome in patients with cirrhosis and ascites following treatment with albumin or a synthetic colloid: a randomised controlled pilot trail
    Richard Moreau
    Service d Hépatologie and INSERM Unité 481, Hopital Beaujon, Clichy, France
    Liver Int 26:46-54. 2006
    ..The question of which colloid (albumin or synthetic colloids) used for plasma expansion following paracentesis or other complications requiring fluid loading in patients with cirrhosis remains controversial...
  8. doi request reprint Severe hyponatremia is a better predictor of mortality than MELDNa in patients with cirrhosis and refractory ascites
    Thomas Sersté
    Service d Hepatologie, Hopital Beaujon, Clichy, France
    J Hepatol 57:274-80. 2012
    ..This study assessed the prognostic value of severe hyponatremia and the MELDNa score in these patients...
  9. ncbi request reprint Norfloxacin reduces aortic NO synthases and proinflammatory cytokine up-regulation in cirrhotic rats: role of Akt signaling
    Khalid A Tazi
    Laboratoire d Hémodynamique Splanchnique et de Biologie Vasculaire, INSERM, Hopital Beaujon, Clichy, France
    Gastroenterology 129:303-14. 2005
    ..In this study, we investigated the signal transduction pathway of bacterial translocation-induced aortic NOS up-regulation in cirrhotic rats...
  10. ncbi request reprint Terlipressin inhibits in vivo aortic iNOS expression induced by lipopolysaccharide in rats with biliary cirrhosis
    Richard Moreau
    Laboratoire d Hémodynamique Splanchnique et de Biologie Vasculaire, INSERM U 481, Hopital Beaujon, Paris, France
    Hepatology 36:1070-8. 2002
    ..Terlipressin administration may be a novel approach for the treatment of arterial hypotension and hyporeactivity to alpha(1)-adrenergic constrictors in patients with cirrhosis and septic shock...
  11. doi request reprint Possible mechanisms involved in the discrepancy of hepatic and aortic endothelial nitric oxide synthases during the development of cirrhosis in rats
    Morvarid Shir Mohammadi
    INSERM, U773, Centre de Recherche Biomédical Bichat Beaujon, Hopital Beaujon, Clichy, France
    Liver Int 29:692-700. 2009
    ..The aim of this study was to evaluate the regulation of eNOS and its major modulators in the liver and aorta during the development of cirrhosis in rats...
  12. ncbi request reprint Diagnosis of portopulmonary hypertension in candidates for liver transplantation: a prospective study
    Isabelle O Colle
    Service d Hépatologie and INSERM U481, Hopital Beaujon, Clichy, France
    Hepatology 37:401-9. 2003
    ..In addition, the absence of portopulmonary hypertension at evaluation does not exclude the occasional occurrence of acquired portopulmonary hypertension profile after listing...
  13. doi request reprint Levels and initial course of serum alanine aminotransferase can predict outcome of patients with Budd-Chiari syndrome
    Pierre Emmanuel Rautou
    Pôle des Maladies de l Appareil Digestif, Service d Hepatologie, Hopital Beaujon, AP HP, Clichy, France
    Clin Gastroenterol Hepatol 7:1230-5. 2009
    ..An increased level of serum alanine aminotransferase (ALT) is an objective marker for acute liver injury. We analyzed the significance of changes in ALT levels in Budd-Chiari syndrome patients...
  14. doi request reprint The spectrum of renal lesions in patients with cirrhosis: a clinicopathological study
    Jean Marie Trawalé
    Service d Hepatologie, Hopital Beaujon, Assistance Publique Hopitaux de Paris, Clichy, France
    Liver Int 30:725-32. 2010
    ..This retrospective, one-point-in-time study aimed to report the results of the analysis of renal biopsy specimens obtained in patients with cirrhosis...
  15. ncbi request reprint Upregulation of TNF-alpha production signaling pathways in monocytes from patients with advanced cirrhosis: possible role of Akt and IRAK-M
    Khalid A Tazi
    INSERM, U773, Centre de Recherche Biomedicale Bichat Beaujon CRB3, Hopital Beaujon, Clichy, France
    J Hepatol 45:280-9. 2006
    ..Thus, we investigated ex vivo the signaling pathways of TNF-alpha production before and after LPS incubation in monocytes from noninfected Child-Pugh C patients with advanced cirrhosis and healthy subjects...
  16. ncbi request reprint The quest for new therapies in patients with cirrhosis and sepsis. Time to move from the lab to the bedside
    Jean Jacques Quioc
    INSERM, U 773, Centre de Recherche Biomédicale Bichat Beaujon CRB 3, Hopital Beaujon, Clichy
    Gastroenterol Clin Biol 30:819-22. 2006
  17. ncbi request reprint Evolution of hypoxemia in patients with severe cirrhosis
    Isabelle Colle
    Laboratoire d Hémodynamique Splanchnique et de Biologie Vasculaire, INSERM U 481 and Service d Hépatologie, Hopital Beaujon, Clichy, France
    J Gastroenterol Hepatol 17:1106-9. 2002
    ..The aim of this study was to follow a series of patients with cirrhosis and to compare patients with and without hypoxemia to determine their risk of complications and survival rate...
  18. ncbi request reprint Role of shear stress in aortic eNOS up-regulation in rats with biliary cirrhosis
    Khalid A Tazi
    Laboratoire d Hémodynamique Splanchnique et de Biologie Vasculaire, INSERM U 481, Hopital Beaujon, Clichy, France
    Gastroenterology 122:1869-77. 2002
    ....
  19. ncbi request reprint The use of vasoconstrictors in patients with cirrhosis: type 1 HRS and beyond
    Richard Moreau
    INSERM, U773, Centre de Recherche Biomedicale Bichat Beaujon CRB3, and Service d Hépatologie, Hopital Beaujon, Clichy, France
    Hepatology 43:385-94. 2006
    ..Further studies are needed in all these fields...
  20. doi request reprint Autophagy in liver diseases
    Pierre Emmanuel Rautou
    Service d Hepatologie, Hopital Beaujon, Assistance Publique Hopitaux de Paris, Clichy, France
    J Hepatol 53:1123-34. 2010
    ..This decrease in autophagy contributes to the formation of Mallory-Denk bodies and to liver cell death. Hepatic autophagy is defective in the liver in obesity and its upregulation improves insulin sensitivity...
  21. doi request reprint Detection of bacterial DNA in serum and ascitic fluid of asymptomatic outpatients with cirrhosis and non-neutrocytic ascites
    Thomas Sersté
    Service d Hepatologie, Hôpital AP HP Beaujon, Clichy, France
    Liver Int 31:494-8. 2011
    ..The aim of this prospective study was to investigate the presence of bactDNA in AF and serum among cirrhotic outpatients with non-neutrocytic ascites...
  22. pmc Changes in autophagic response in patients with chronic hepatitis C virus infection
    Pierre Emmanuel Rautou
    Service d Hepatologie, Hopital Beaujon, Assistance Publique Hopitaux de Paris, Clichy, France
    Am J Pathol 178:2708-15. 2011
    ..Neither genotype nor viral load influenced the autophagy level. In conclusion, autophagy is altered in hepatocytes from CHC patients, likely due to a blockade of the last step of the autophagic process...
  23. ncbi request reprint Clinicopathological forms and prognostic index in Budd-Chiari syndrome
    Philippe Langlet
    Service d Hepatologie, Hopital Beaujon, Clichy, France
    J Hepatol 39:496-501. 2003
    ..A recent study in patients with Budd-Chiari syndrome showed the value of a prognostic index including age, Pugh score, ascites and serum creatinine. Surgical portosystemic shunt did not appear to improve survival...
  24. doi request reprint Acute liver cell damage in patients with anorexia nervosa: a possible role of starvation-induced hepatocyte autophagy
    Pierre Emmanuel Rautou
    Pôle des Maladies de l Appareil Digestif, Service d Hepatologie, Hopital Beaujon, AP HP, Clichy, France
    Gastroenterology 135:840-8, 848.e1-3. 2008
    ..Acute liver insufficiency is a rare complication of anorexia nervosa. The mechanisms for this complication are unclear. The aim of this study was to describe patient characteristics and clarify the mechanisms involved...
  25. ncbi request reprint Cyclic AMP-phosphodiesterases inhibitor improves sodium excretion in rats with cirrhosis and ascites
    Mina Ahloulay
    Laboratoire d Hémodynamique Splanchnique et de Biologie Vasculaire, INSERM U 481, Hopital Beaujon, 92118 Clichy, France
    Liver Int 25:403-9. 2005
    ..Cyclic AMP (cAMP) regulates sodium reabsorption in the proximal nephron. This study investigates the role of cAMP metabolism in renal dysfunction in cirrhosis...
  26. doi request reprint Acute kidney injury: new concepts. Hepatorenal syndrome: the role of vasopressors
    Richard Moreau
    INSERM U773, Centre de Recherche Biomedicale Bichat Beaujon CRB3, Service d Hepatologie, Hopital Beaujon, Clichy, France
    Nephron Physiol 109:p73-9. 2008
    ..Vasopressor therapy with terlipressin plus intravenous albumin is the medical treatment of choice for type 1 HRS...
  27. ncbi request reprint Clinical characteristics and outcome of patients with cirrhosis and refractory ascites
    Richard Moreau
    Service d Hépatologie and INSERM U 481, 92118 Clichy, France
    Liver Int 24:457-64. 2004
    ..In patients with cirrhosis, refractory ascites is associated with a poor prognosis and is an indication for liver transplantation. However, factors that determine prognosis remain unclear...
  28. ncbi request reprint In vitro and in vivo vascular responses to the L-type calcium channel activator, Bay K 8644, in rats with cirrhosis
    R Moreau
    Laboratoire d Hémodynamique Splanchnique et de Biologie Vasculaire, INSERM, Hopital Beaujon, Clichy, France
    J Gastroenterol Hepatol 13:1254-8. 1998
    ..This study also shows that Bay K 8644-induced vascular contraction was less marked in cirrhotic than in normal rats, in systemic and splanchnic vascular beds...
  29. ncbi request reprint Pathogenesis of portal hypertension
    D Lebrec
    Laboratoire d Hémodynamique Splanchnique et de Biologie Vasculaire, INSERM U 481, Hopital Beaujon, Clichy, France
    Eur J Gastroenterol Hepatol 13:309-11. 2001
    ..In this review, the main results and their mechanisms of the splanchnic and systemic haemodynamic alterations in portal hypertension are discussed...
  30. ncbi request reprint Role of small-conductance Ca2+-dependent K+ channels in in vitro nitric oxide-mediated aortic hyporeactivity to alpha-adrenergic vasoconstriction in rats with cirrhosis
    E Barriere
    Laboratoire d Hémodynamique Splanchnique et de Biologie Vasculaire, INSERM U 481, Hĵpital Beaujon, Clichy, France
    J Hepatol 35:350-7. 2001
    ..Thus, the aim of the present study was to investigate the role of endothelial SK(Ca) channels in cirrhosis-induced, NO-mediated, in vitro aortic hyporeactivity to alpha1-adrenergic vasoconstrictors...
  31. doi request reprint [Progress in portal hypertension]
    D Lebrec
    INSERM U773, Centre de Recherche Bichat Beaujon CRB3, 75018 Paris, France
    Gastroenterol Clin Biol 33:799-810. 2009
    ..The combination of both types of substances is probably the best pharmacological treatment of portal hypertension but further hemodynamic and clinical studies are needed...
  32. pmc Comparison of the effect of terlipressin and albumin on arterial blood volume in patients with cirrhosis and tense ascites treated by paracentesis: a randomised pilot study
    R Moreau
    Laboratoire d Hémodynamique Splanchnique et de Biologie Vasculaire, INSERM U 481, Clichy, France
    Gut 50:90-4. 2002
    ....
  33. ncbi request reprint Relationship between protein kinase C alterations and nitric oxide overproduction in cirrhotic rat aortas
    Khalid A Tazi
    Laboratoire d Hémodynamique Splanchnique et de Biologie Vasculaire, INSERM U 481, Hopital Beaujon, Clichy, France
    Liver 22:178-83. 2002
    ..Therefore, the relationships between NOS and PKC activities were studied in cirrhotic rat aortas...
  34. ncbi request reprint Coagulation disorders in patients with cirrhosis and severe sepsis
    Aurelie Plessier
    Laboratoire d Hémodynamique Splanchnique et de Biologie Vasculaire, INSERM U 481, et Service d Hepatologie, Hopital Beaujon, Clichy, France
    Liver Int 23:440-8. 2003
    ..In patients with cirrhosis, severe sepsis may stimulate the extrinsic coagulation pathway resulting in thrombin generation and fibrin formation...
  35. ncbi request reprint Molecular and structural basis of portal hypertension
    Richard Moreau
    INSERM, U773, Centre de Recherche Biomedicale Bichat Beaujon CRB3, Hopital Beaujon, Clichy 92118, France
    Clin Liver Dis 10:445-57, vii. 2006
    ....
  36. ncbi request reprint Diagnosis and treatment of acute renal failure in patients with cirrhosis
    Richard Moreau
    INSERM, U773, Centre de Recherche Biomedicale Bichat Beaujon CRB3, and Service d Hépatologie, Hopital Beaujon, 92118 Clichy, France
    Best Pract Res Clin Gastroenterol 21:111-23. 2007
    ..Studies are needed on the natural course and treatment (e.g., renal-replacement therapy) of acute tubular necrosis in patients with cirrhosis...
  37. ncbi request reprint Acute renal failure in patients with cirrhosis: perspectives in the age of MELD
    Richard Moreau
    Laboratoire d Hémodynamique Splanchnique et de Biologie Vasculaire, INSERM U 481, Clichy, France
    Hepatology 37:233-43. 2003
    ..Little is known about the natural course and treatment (i.e., renal replacement therapy) of cirrhosis-associated acute tubular necrosis...
  38. ncbi request reprint Pulmonary hemodynamics and gas exchange after liver transplantation in patients with cirrhosis
    Emmanuel Rassiat
    Laboratoire d Hémodynamique Splanchnique et de Biologie Vasculaire, INSERM U 481, Hopital Beaujon, Clichy, France
    Dig Dis Sci 47:746-9. 2002
    ..Moreover, it has no major effect on gas exchange in patients with cirrhosis without hypoxemia...
  39. ncbi request reprint Aortic hyporeactivity to norepinephrine induced by lipopolysaccharide in cirrhotic rats: beneficial effects of a non-steroidal anti-inflammatory drug coupled with a nitric oxide donor
    P Lefilliatre
    , , H pital Beaujon, Clichy, France
    J Gastroenterol Hepatol 16:70-8. 2001
    ..CONCLUSIONS: These findings suggest that NO-flurbiprofen has a beneficial hemodynamic effect in cirrhotic rats and may help to prevent LPS aortic hyporeactivity...
  40. ncbi request reprint Lack of prognostic usefulness of hepatic venous pressures and hemodynamic values in a select group of patients with severe alcoholic cirrhosis
    Pierre Deltenre
    Laboratoire d Hémodynamique Splanchnique et de Biologie Vasculaire, INSERM 481 and Service d Hépatologie, Hopital Beaujon, Clichy, France
    Am J Gastroenterol 97:1187-90. 2002
    ..Prognostic assessment of patients with alcoholic cirrhosis is still controversial. A prospective study was performed to evaluate hemodynamic values as prognostic factors of death in a group of patients with severe alcoholic cirrhosis...
  41. ncbi request reprint Spectrum of portal vein thrombosis in the West
    Dominique Charles Valla
    Laboratoire d Hémodynamique Splanchnique et de Biologie Vasculaire, INSERM U 481 and Service d Hépatologie, Hopital Beaujon, Clichy, France
    J Gastroenterol Hepatol 17:S224-7. 2002
  42. doi request reprint Abnormal plasma microparticles impair vasoconstrictor responses in patients with cirrhosis
    Pierre Emmanuel Rautou
    INSERM Unité 970, Paris Cardiovascular Research Center PARCC, Paris, France
    Gastroenterology 143:166-76.e6. 2012
    ..We investigated the cellular origins of MPs in plasma from patients with cirrhosis and assessed the contribution of MPs to arterial vasodilation, a mechanism that contributes to portal hypertension...
  43. ncbi request reprint [Angiotensin II receptor antagonists and portal hypertension]
    Didier Lebrec
    Laboratoire d Hémodynamique Splanchnique et de Biologie Vasculaire, INSERM U 481, Service d Hepatologie, Hopital Beaujon, Clichy, France
    Gastroenterol Clin Biol 26:254-5. 2002
  44. ncbi request reprint Terlipressin in patients with cirrhosis and type 1 hepatorenal syndrome: a retrospective multicenter study
    Richard Moreau
    INSERM U 481 et Service d Hépatologie, Hopital Beaujon, Clichy, France
    Gastroenterology 122:923-30. 2002
    ..Although the administration of terlipressin improves renal function, its effect on survival is unknown. This study investigated predictive factors of survival in patients with type 1 HRS treated with terlipressin...
  45. ncbi request reprint Incidence and characteristics of type 2 hepatorenal syndrome in patients with cirrhosis and refractory ascites
    T Sersté
    Service d Hepatologie, Hopital Beaujon, Clichy, France
    Acta Gastroenterol Belg 71:9-14. 2008
    ..The aim of this study was to assess the incidence, predictive factors and outcome of type 2 HRS in patients with cirrhosis and refractory ascites...
  46. pmc Tezosentan, an endothelin receptor antagonist, limits liver injury in endotoxin challenged cirrhotic rats
    W Urbanowicz
    INSERM U 481, Hopital Beaujon, 100 Boulevard du General Leclerc, 92118 Clichy, France
    Gut 53:1844-9. 2004
    ..The aim of this study was to investigate the effects of tezosentan, a non-selective ETA and ETB receptor antagonist, in LPS challenged rats with cirrhosis...
  47. ncbi request reprint Relationships between haemodynamic alterations and the development of ascites or refractory ascites in patients with cirrhosis
    I Colle
    , INSERM U-481, , Clichy, France
    Eur J Gastroenterol Hepatol 13:251-6. 2001
    ..The development of ascites or refractory ascites was not associated with any alteration in systemic haemodynamics...
  48. ncbi request reprint Regulation of splanchnic perfusion
    R Moreau
    Splanchnic Haemodynamic and Vascular Biology Laboratory, INSERM U-481, Clichy, 92118, France
    Best Pract Res Clin Gastroenterol 15:15-20. 2001
    ..Activation of G proteins, inositol trisphosphate, diacylglycerol and membrane depolarization are important mediators of the increase in [Ca(2+)]i...
  49. pmc Idiopathic non-cirrhotic intrahepatic portal hypertension in the West: a re-evaluation in 28 patients
    S Hillaire
    Service d Hépatologie and INSERM U 481, Hopital Beaujon, 92118 Clichy, France
    Gut 51:275-80. 2002
    ..Non-cirrhotic portal hypertension of unknown cause is a poorly understood condition attributed to obstructive portal venopathy...
  50. ncbi request reprint Hemodynamic, metabolic and hormonal responses to oral glibenclamide in patients with cirrhosis receiving glucose
    R Moreau
    , INSERM U-481 and Hopital Beaujon, Clichy, France
    Scand J Gastroenterol 36:303-8. 2001
    ..In addition, glibenclamide per se induced a decrease in cardiac index. These findings should be taken into account when glibenclamide is administered to patients with cirrhosis and type 2 diabetes...
  51. ncbi request reprint Review article: hepatorenal syndrome--definitions and diagnosis
    R Moreau
    Laboratoire d Hémodynamique Splanchnique et de Biologie Vasculaire, INSERM U 481, Hopital Beaujon, Clichy, France
    Aliment Pharmacol Ther 20:24-8; discussion 29-30. 2004
    ..Furthermore, uncontrolled HRS may lead to ischaemic tubular necrosis; thus, these patients must be managed as soon as possible in an intensive care unit...
  52. ncbi request reprint Clinical course, predictive factors and prognosis in patients with cirrhosis and type 1 hepatorenal syndrome treated with Terlipressin: a retrospective analysis
    Isabelle Colle
    Laboratoire d Hémodynamique Splanchmique et de Biologie Vasculaire, Institut National de la Santé et de la Recherge Médicale, Clinchy, France
    J Gastroenterol Hepatol 17:882-8. 2002
    ..The aim of the present retrospective study was to investigate the predictive factors and prognosis of patients with type 1 HRS treated with terlipressin...
  53. ncbi request reprint Prevention of gram-negative translocation reduces the severity of hepatopulmonary syndrome
    Anne Rabiller
    Laboratoire de Chirurgie Expérimentale UPRES, Centre Chirurgical Marie Lannelongue, Universite Paris Sud, 133 avenue de la Resistance, 92350 Le Plessis Robinson, Paris, France
    Am J Respir Crit Care Med 166:514-7. 2002
    ..Norfloxacin may reduce HPS severity by inhibiting Gram-negative bacterial translocation, thereby decreasing NO production by pulmonary intravascular macrophages. Bacterial translocation may be the key to the pathogenesis of HPS...
  54. doi request reprint Portopulmonary hypertension: survival and prognostic factors
    Jerome Le Pavec
    Universite Paris Sud 11, UPRES 2705, Service de Pneumologie, Hopital Antoine Beclere, 157 rue de la Porte de Trivaux, 92140 Clamart, France
    Am J Respir Crit Care Med 178:637-43. 2008
    ..Survival results in PoPH are contrasting, and prognostic factors need to be identified...
  55. ncbi request reprint Model for end-stage liver disease score and systemic inflammatory response are major prognostic factors in patients with cirrhosis and acute functional renal failure
    Dominique Thabut
    AP HP Service d Hépato Gastroentérologie, Groupe Hospitalier Pitie Salpetriere, Paris, France
    Hepatology 46:1872-82. 2007
    ..This suggests that preventing and treating SIRS could decrease mortality in patients with cirrhosis and acute renal failure...
  56. ncbi request reprint Cirrhotic rats with bacterial translocation have higher incidence and severity of hepatopulmonary syndrome
    Benjamin Sztrymf
    Surgical Laboratory UPRES EA 2705, Marie Lannelongue Surgical Center, Paris South University, Le Plessis Robinson, France
    J Gastroenterol Hepatol 20:1538-44. 2005
    ....
  57. ncbi request reprint High-density lipoprotein administration attenuates liver proinflammatory response, restores liver endothelial nitric oxide synthase activity, and lowers portal pressure in cirrhotic rats
    Dominique Thabut
    INSERM, U773, Centre de Recherche Biomedicale Bichat Beaujon CRB3, Paris 75018, France
    Hepatology 46:1893-906. 2007
    ..This suggests that the decrease in circulating HDL in cirrhosis plays a role in the excessive proinflammatory response and intrahepatic eNOS down-regulation...
  58. ncbi request reprint The future treatment of portal hypertension
    Jurg Reichen
    Institute of Clinical Pharmacology, University of Berne, Murtenstrasse 31 POB 49, 3010 Berne, Switzerland
    Best Pract Res Clin Gastroenterol 21:191-202. 2007
    ..This role needs to be further defined but it appears likely that this phenomenon is yet another target for therapeutic intervention...
  59. ncbi request reprint Relationship between the degree of portal hypertension and the onset of spontaneous bacterial peritonitis in patients with cirrhosis
    Thomas Sersté
    Department of Gastroenterology, ULB Erasme University Hospital, Brussels, Belgium
    Acta Gastroenterol Belg 69:355-60. 2006
    ..The aim of this study was to test the hypothesis that an association exists between the degree of portal hypertension and the occurrence of SBP...
  60. ncbi request reprint [Are the diagnosis and measurement of portal hypertension of interest?]
    Didier Lebrec
    Gastroenterol Clin Biol 29:967-8. 2005
  61. ncbi request reprint Deleterious effects of beta-blockers on exercise capacity and hemodynamics in patients with portopulmonary hypertension
    Steeve Provencher
    Centre des Maladies Vasculaires Pulmonaires UPRES EA 2705, Service de Pneumologie, Hopital Antoine Beclere, Clamart, France
    Gastroenterology 130:120-6. 2006
    ..The aim of this study was to investigate the effect of beta-blockers on exercise capacity and pulmonary hemodynamics in patients with portopulmonary hypertension receiving beta-blockers for the prophylaxis of variceal bleeding...
  62. ncbi request reprint In vivo altered unfolded protein response and apoptosis in livers from lipopolysaccharide-challenged cirrhotic rats
    Khalid A Tazi
    INSERM U773, Centre de Recherche Bichat Beaujon CRB3, Paris 75018, France
    J Hepatol 46:1075-88. 2007
    ..We hypothesized that an altered UPR in the liver may sensitize cirrhotic livers to LPS-induced, TNFalpha-mediated apoptosis. Thus, we examined in vivo UPR and NF-kappaB activity in livers from cirrhotic and normal LPS-challenged rats...
  63. pmc Meta-analyses of FibroTest diagnostic value in chronic liver disease
    Thierry Poynard
    Service d Hepato Gastroenterologie, Groupe Hospitalier Pitie Salpetriere, Universite Paris VI, CNRS ESA 8067 Paris, France
    BMC Gastroenterol 7:40. 2007
    ....
  64. doi request reprint Recombinant factor VIIa for variceal bleeding in patients with advanced cirrhosis: A randomized, controlled trial
    Jaime Bosch
    Hepatic Hemodynamic Laboratory, Hospital Clinic and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas CIBEREHD, University of Barcelona, Spain
    Hepatology 47:1604-14. 2008
    ..A marked heterogeneity in the failure rate in all treatment groups was observed across participating centers. Adverse events, including overall thromboembolic events, were comparable between groups...
  65. ncbi request reprint Screening for esophageal varices: Endoscopy, other tools, or endoscopy and other tools?
    Dominique Thabut
    Hepatology 47:1434-6. 2008
  66. ncbi request reprint Uncovered transjugular intrahepatic portosystemic shunt for refractory ascites
    Pierre Deltenre
    Gastroenterology 130:1372-3; author reply 1373. 2006