Y Lebranchu

Summary

Country: France

Publications

  1. ncbi request reprint Simultaneous estimation of cyclosporin and mycophenolic acid areas under the curve in stable renal transplant patients using a limited sampling strategy
    Chantal Le Guellec
    Department of Pharmacology, Tours University Hospital, France
    Eur J Clin Pharmacol 57:805-11. 2002
  2. ncbi request reprint [Organ transplantation: epidemiological and immunological aspects; principles of treatment and surveillance; complications and prognosis; ethical and legal aspects]
    Yvon Lebranchu
    Service de Nephrologie, Immunologie Clinique, CHU hôpital Bretonneau, 37044 Tours Cedex
    Rev Prat 54:2295-304; quiz 2304. 2004
  3. doi request reprint Five-year results of a randomized trial comparing de novo sirolimus and cyclosporine in renal transplantation: the SPIESSER study
    Y Lebranchu
    Department of Nephrology and Clinical Immunology, Bretonneau Hospital, University Hospital, Tours, France
    Am J Transplant 12:1801-10. 2012
  4. doi request reprint Efficacy and safety of early cyclosporine conversion to sirolimus with continued MMF-four-year results of the Postconcept study
    Y Lebranchu
    Department of Nephrology, Clinical Immunology, University Hospital, Francois Rabelais University, Tours, France
    Am J Transplant 11:1665-75. 2011
  5. doi request reprint Can we eliminate both calcineurin inhibitors and steroids?
    Y Lebranchu
    University Hospital of Tours, François Rabelais University of Tours, Tours, France
    Transplant Proc 42:S25-8. 2010
  6. ncbi request reprint New approaches to de novo immunosuppression and steroid elimination
    Y Lebranchu
    University Hospital of Tours, Tours, France
    Transplant Proc 41:S39-41. 2009
  7. ncbi request reprint Immunoprophylaxis with basiliximab compared with antithymocyte globulin in renal transplant patients receiving MMF-containing triple therapy
    Yvon Lebranchu
    Service Nephrologie Immunologie Clinique Hĵpital Bretonneau Tours, France
    Am J Transplant 2:48-56. 2002
  8. ncbi request reprint Delayed graft function: risk factors, consequences and parameters affecting outcome-results from MOST, A Multinational Observational Study
    Y Lebranchu
    CHU Tours, Hopital Bretonneau, Tours, France
    Transplant Proc 37:345-7. 2005
  9. doi request reprint New approaches to de novo immunosuppression and steroid elimination
    Y Lebranchu
    University Hospital of Tours, Tours, France
    Transplant Proc 40:S57-9. 2008
  10. doi request reprint Efficacy on renal function of early conversion from cyclosporine to sirolimus 3 months after renal transplantation: concept study
    Y Lebranchu
    Service Nephrologie Immunologie Clinique, CHRU Tours, EA 4245, University Francois Rabelais, Tours, France
    Am J Transplant 9:1115-23. 2009

Detail Information

Publications72

  1. ncbi request reprint Simultaneous estimation of cyclosporin and mycophenolic acid areas under the curve in stable renal transplant patients using a limited sampling strategy
    Chantal Le Guellec
    Department of Pharmacology, Tours University Hospital, France
    Eur J Clin Pharmacol 57:805-11. 2002
    ..It is the method of choice for mycophenolic acid (MPA). The objective of this study was to develop a limited sampling strategy for simultaneous estimation of CsA and MPA AUCs in long-term renal transplant patients...
  2. ncbi request reprint [Organ transplantation: epidemiological and immunological aspects; principles of treatment and surveillance; complications and prognosis; ethical and legal aspects]
    Yvon Lebranchu
    Service de Nephrologie, Immunologie Clinique, CHU hôpital Bretonneau, 37044 Tours Cedex
    Rev Prat 54:2295-304; quiz 2304. 2004
  3. doi request reprint Five-year results of a randomized trial comparing de novo sirolimus and cyclosporine in renal transplantation: the SPIESSER study
    Y Lebranchu
    Department of Nephrology and Clinical Immunology, Bretonneau Hospital, University Hospital, Tours, France
    Am J Transplant 12:1801-10. 2012
    ..60%, p = 0.015). Results confirmed the high SRL discontinuation rate due to adverse events. Nevertheless, a benefit was evidenced on renal function in patients (more than 50%) still on treatment at 5 years...
  4. doi request reprint Efficacy and safety of early cyclosporine conversion to sirolimus with continued MMF-four-year results of the Postconcept study
    Y Lebranchu
    Department of Nephrology, Clinical Immunology, University Hospital, Francois Rabelais University, Tours, France
    Am J Transplant 11:1665-75. 2011
    ..42 ± 0.44 vs. 0.26 ± 0.37; p = 0.018). In summary, the renal benefits associated with conversion of CsA to SRL, at 3 months posttransplantation, in combination with MMF were maintained for 4 years posttransplantation...
  5. doi request reprint Can we eliminate both calcineurin inhibitors and steroids?
    Y Lebranchu
    University Hospital of Tours, François Rabelais University of Tours, Tours, France
    Transplant Proc 42:S25-8. 2010
    ..At 30 months, steroids had been withdrawn in 72% of SRL-treated patients and in 70% of CsA-treated patients...
  6. ncbi request reprint New approaches to de novo immunosuppression and steroid elimination
    Y Lebranchu
    University Hospital of Tours, Tours, France
    Transplant Proc 41:S39-41. 2009
    ..In both studies, a significant improvement in renal function was observed at 12 months in patients receiving a maintenance regimen with SRL and MMF. In addition, steroids could be withdrawn in 70% of these patients...
  7. ncbi request reprint Immunoprophylaxis with basiliximab compared with antithymocyte globulin in renal transplant patients receiving MMF-containing triple therapy
    Yvon Lebranchu
    Service Nephrologie Immunologie Clinique Hĵpital Bretonneau Tours, France
    Am J Transplant 2:48-56. 2002
    ..12%). Both strategies give excellent results, despite the differences in patterns, in nonhyperimmunized patients receiving their first cadaveric renal allograft...
  8. ncbi request reprint Delayed graft function: risk factors, consequences and parameters affecting outcome-results from MOST, A Multinational Observational Study
    Y Lebranchu
    CHU Tours, Hopital Bretonneau, Tours, France
    Transplant Proc 37:345-7. 2005
    ..Logistic regression was used to evaluate the risk factors for DGF occurrence, and multifactorial analysis of variance (ANCOVA) to assess the relevance of different factors for GFR at 1 year...
  9. doi request reprint New approaches to de novo immunosuppression and steroid elimination
    Y Lebranchu
    University Hospital of Tours, Tours, France
    Transplant Proc 40:S57-9. 2008
    ..017). In both studies, a significant improvement in renal function was observed at 12 months among patients receiving a maintenance regimen with SRL plus MMF. Furthermore, steroids could be withdrawn in three quarters of the patients...
  10. doi request reprint Efficacy on renal function of early conversion from cyclosporine to sirolimus 3 months after renal transplantation: concept study
    Y Lebranchu
    Service Nephrologie Immunologie Clinique, CHRU Tours, EA 4245, University Francois Rabelais, Tours, France
    Am J Transplant 9:1115-23. 2009
    ..Significantly, more patients in the SRL group reported aphthous, diarrhea, acne and high triglyceride levels. Conversion CsA to SRL 3 months after transplantation combined with MMF is associated with improvement in renal function...
  11. ncbi request reprint Sirolimus versus cyclosporine in kidney recipients receiving thymoglobulin, mycophenolate mofetil and a 6-month course of steroids
    M Buchler
    Francois Rabelais University, Department of Nephrology and Clinical Immunology, Bretonneau Hospital, CHU Tours, France
    Am J Transplant 7:2522-31. 2007
    ..23%, p < 0.01). A CNI-free regimen using sirolimus-MMF can achieve excellent renal function, but patients on sirolimus experienced a high rate of adverse events and study drug discontinuation...
  12. doi request reprint CMV infection in the donor and increased kidney graft loss: impact of full HLA-I mismatch and posttransplantation CD8(+) cell reduction
    P Gatault
    EA4245 Cellules Dendritiques et Greffes, Universite Francois Rabelais, Tours, France
    Am J Transplant 13:2119-29. 2013
    ..This study identifies HLA-I full mismatch and a decrease of CD8(+) cell count at 2 years as important determinants of CMV-associated graft loss. ..
  13. ncbi request reprint Urinary albumin excretion and the risk of graft loss and death in proteinuric and non-proteinuric renal transplant recipients
    J M Halimi
    Francois Rabelais University, Department of Nephrology and Clinical Immunology, CHU Tours, Tours, France
    Am J Transplant 7:618-25. 2007
    ..Whether microalbuminuria (especially in non-proteinuric patients) and macroalbuminuria constitute risk factors for graft loss and death is presently unknown in renal transplantation...
  14. doi request reprint Early pulse pressure and low-grade proteinuria as independent long-term risk factors for new-onset diabetes mellitus after kidney transplantation
    M Roland
    Service de néphrologie immunologie clinique, Hopital Bretonneau, CHRU Tours, Tours, France
    Am J Transplant 8:1719-28. 2008
    ..Early low-grade proteinuria and pulse pressure (in addition to beta-blockers) constitute independent risk factors for NODAT; they may be markers of the metabolic syndrome and/or vascular damage in renal transplant recipients...
  15. doi request reprint Impact of a polymorphism in the IL-12p40 gene on the outcome of kidney transplantation
    T W Hoffmann
    Universite Francois Rabelais de Tours, EA4245 Cellules Dendritiques, Immunomodulation et Greffes, Tours, France
    Transplant Proc 41:654-6. 2009
    ..77; P = .027). In conclusion, IL12B 3'UTR polymorphism did not affect graft survival, DGF, or acute rejection episodes, but had an impact on the occurrence of cytomegalovirus infection...
  16. ncbi request reprint Long-term results of monoclonal anti-Il2-receptor antibody versus polyclonal antilymphocyte antibodies as induction therapy in renal transplantation
    A Al Najjar
    Departments of Nephrology and Clinical Immunology, CHU Tours, Hopital Bretonneau, 2 boulevard Tonnelle, 37044 Tours cedex 9, France
    Transplant Proc 38:2298-9. 2006
    ..Our results showed that the choice of the induction therapy seemed to not have a major impact on long-term outcomes among renal recipients at low immunological risk...
  17. doi request reprint Prognostic value of absent end-diastolic flow within the first week following renal transplantation
    S Ba
    Department of Imaging, INSERM U930 CNRS 2448, Francois Rabelais University, CHU Tours, France
    Transplant Proc 41:645-7. 2009
    ..Doppler sonogram of the graft is used as a routine assessment in renal transplantation. When the resistance index (RI) equals 1, absent end-diastolic flow (AEDF) is observed; the prognostic value of AEDF is presently unknown...
  18. ncbi request reprint Relationship between calcineurin inhibition and plasma endothelin concentrations in cyclosporine-A-treated kidney transplant patients
    M Buchler
    Department of Nephrology and Clinical Immunology, Tours University Hospital, Tours, France
    Eur J Clin Pharmacol 60:703-8. 2004
    ..However, there is obviously also an inter-individual pharmacodynamic variability, which might be explored by the measurement of biomarkers of CsA effects...
  19. doi request reprint Renal function of renal transplantation patients after hospitalization in an intensive care unit
    J Badin
    Service de Reanimation Medicale, CHU Bretonneau, Tours, France
    Transplant Proc 44:2792-4. 2012
    ..We have herein reported the evolution of renal function among kidney graft recipients after an ICU stay...
  20. doi request reprint New sampling strategy using a Bayesian approach to assess iohexol clearance in kidney transplant recipients
    I Benz-de Bretagne
    Laboratory of Biochemistry and Molecular Biology, University Hospital of Tours, Tours, France
    Ther Drug Monit 34:289-97. 2012
    ..The aim of this study was to develop and validate a Bayesian model with fewer samples for reliable prediction of GFR in kidney transplant recipients...
  21. doi request reprint Induction of porcine regulatory cells by mycophenolic Acid-treated dendritic cells
    C Pilon
    Universite Francois Rabelais, EA 4245 Cellules Dendritiques et Greffes, IFR 136, UFR de Medecine, Tours, France
    Transplant Proc 41:700-2. 2009
    ..These preliminary results suggested induction of a regulatory T-cell population that we are currently seeking to characterize...
  22. doi request reprint Mycophenolate mofetil in patients with systemic lupus erythematosus: a prospective pharmacokinetic study
    M Roland
    Service de néphrologie immunologie clinique, Hopital Bretonneau, CHRU Tours, France
    Lupus 18:441-7. 2009
    ..This suggests that MPA exposure may be unpredictable with a fixed MMF dose. There was a concentration-effect relationship between MPA exposure (C(0)) and immunological disease activity parameters...
  23. ncbi request reprint Recipient TNFRSF6 (FAS) gene polymorphism and acute renal allograft rejection
    S Cappellesso
    Centre Hospitalier Universitaire de Tours et EA Cellules Hématopolétiques, Hémostase et Greffe, Faculte de Medecine de Tours, Tours, France
    Transplant Proc 34:803-4. 2002
  24. ncbi request reprint Effects of current smoking and smoking discontinuation on renal function and proteinuria in the general population
    J M Halimi
    Center de Recherche Clinique, Faculte de Medecine, and Service de Néphrologie Immunologie Clinique, Hopital Bretonneau, Tours, France
    Kidney Int 58:1285-92. 2000
    ..Smoking may adversely affect the progression of renal diseases. However, it is unknown whether smoking affects renal function in subjects without nephropathy...
  25. ncbi request reprint Estimation of the glomerular filtration rate through different methods in kidney transplant recipients: correlation with the creatinine clearance measurement
    M Buchler
    Francois Rabelais University, Department of Nephrology and Clinical Immunology, CHU Tours, Hopital Bretonneau, 2 boulevard Tonnelle, 37044 Tours cedex 9, France
    Transplant Proc 38:2289-91. 2006
    ..Further studies are required to compare the estimated GFR with better reference methods, such as the use of isotopic markers in kidney graft recipients...
  26. ncbi request reprint Disappearance of tophi in familial juvenile hyperuricemic nephropathy after kidney transplantation
    E Merieau
    Department of Nephrology and Clinical Immunology, Bretonneau Hospital, Francois Rabelais University, CHU Tours, Cedex, France
    Am J Transplant 7:2634-6. 2007
    ..Serum uric acid level decreased slowly from 650 mumol/L before transplantation to 300 mumol/L. Reduction of tophi was probably due to the absence of the mutated UMOD gene in the transplanted kidney...
  27. doi request reprint Mothers without HLA antibodies before transplantation have a low risk of alloimmunization post-transplantation
    P Gatault
    Service de néphrologie immunologie clinique, Hopital Bretonneau, CHRU Tours, Tours, France
    Tissue Antigens 78:241-8. 2011
    ..027) remained significantly lower after adjustment on donor age, acute rejection and number of class I/II HLA mismatches. In conclusion, we show that parous women non-immunized are at low risk of HLA Ab production after transplantation...
  28. ncbi request reprint Early proteinuria is a strong indicator of donor renal lesions, ischemia-reperfusion injury and immunological aggression
    J Halimi
    Francois Rabelais University, Department of Nephrology and Clinical Immunology, Hopital Bretonneau, 2 boulevard Tonnelle, 37044 Tours cedex 9, France
    Transplant Proc 38:2319-20. 2006
    ..Early proteinuria is associated with reduced long-term graft survival. However, the determinants and mechanisms of proteinuria early after transplantation have not been identified...
  29. doi request reprint Mycophenolic Acid Inhibits p38 Mitogen-Activated Protein Kinase in Human Monocyte-Derived Dendritic Cells Stimulated by Lipopolysaccharide
    D Faugaret
    Universite Francois Rabelais, EA 4245 Cellules Dendritiques et Greffes, IFR 136, UFR de Medecine, Tours, France
    Transplant Proc 41:698-9. 2009
    ..Our results suggested that MPA inhibits p38MAPK activity independent of IMPDH in human DCs. This effect of MPA may explain its capacity to inhibit maturation marker expression on DCs...
  30. ncbi request reprint A three-arm study comparing immediate tacrolimus therapy with antithymocyte globulin induction therapy followed by tacrolimus or cyclosporine A in adult renal transplant recipients
    Bernard Charpentier
    Service de Nephrologie, Hopital de Bicetre, Le Kremlin Bicetre, France
    Transplantation 75:844-51. 2003
    ..A study was undertaken to assess the efficacy and safety of ATG induction on tacrolimus-based and cyclosporine A (CsA)-based therapies compared with immediate tacrolimus triple therapy in kidney transplant recipients...
  31. doi request reprint Anti-CD25 antibodies decrease the ability of human dendritic cells to prime allogeneic CD4 T cells
    K Mnasria
    JE 2448, Faculte de Medecine, Universite Francois Rabelais, Tours, France
    Transplant Proc 41:695-7. 2009
    ..This study supported previously unrecognized effects of anti-CD25 monoclonal antibodies on DCs that may contribute to their clinical efficacy...
  32. doi request reprint Immunosuppressive medications, clinical and metabolic parameters in new-onset diabetes mellitus after kidney transplantation
    Mélanie Roland
    Service de néphrologie immunologie clinique, Hopital Bretonneau, CHRU Tours, Tours, France
    Transpl Int 21:523-30. 2008
    ..However, main independent risk factors were age, BMI, initial glucose and triglycerides...
  33. ncbi request reprint Induction therapy by anti-thymocyte globulin (rabbit) in renal transplantation: a 1-yr follow-up of safety and efficacy
    Matthias Buchler
    Service Nephrologie et Immunologie Clinique, CHU Bretonneau, Tours, France
    Clin Transplant 17:539-45. 2003
    ..Two hundred and forty cadaveric renal transplant recipients given anti-thymocyte globulin (Thymoglobulin) as induction immunotherapy were followed up prospectively to review safety and efficacy...
  34. ncbi request reprint Mycophenolate mofetil in patients with anti-neutrophil cytoplasmic antibody-associated vasculitis: a prospective pharmacokinetics and clinical study
    B Chaigne
    Department of Immunology and Nephrology, Tours University Hospital, Tours, France Department of Internal Medicine, Tours University Hospital, Tours, France Université François Rabelais, Tours, France
    Clin Exp Immunol 176:172-9. 2014
    ..Our results confirm the interindividual variability of MPA AUC in patients treated with MMF in AAV and support a personalized therapy according to blood levels of MPA...
  35. ncbi request reprint Microalbuminuria in hypertensive nonproteinuric renal transplant recipients: influence of previous acute rejection episodes and sodium intake
    J M Halimi
    Service de néphrologie immunologie clinique, Hopital Bretonneau, Tours, France
    Transplant Proc 34:801-2. 2002
  36. ncbi request reprint Renal artery aneurysm secondary to Candida albicans in four kidney allograft recipients
    I Laouad
    Department of Nephrology and Clinical Immunology, University Hospital, Tours, France
    Transplant Proc 37:2834-6. 2005
    ..It may occur at different periods after transplantation. We report four cases of mycotic aneurysms due to Candida albicans (CA) in renal transplant recipients occurring early after kidney transplantation...
  37. ncbi request reprint [Cyclosporin-induced toxic neuromyopathy]
    A M Guennoc
    Clinique Neurologique, CHU Bretoneau, 37044 Tours
    Rev Neurol (Paris) 161:221-3. 2005
    ..Among neurological side effects, neuropathies or myopathies have been reported, specially inpatients given combinations of cyclosporine with co-enzyme A reductase inhibitors...
  38. doi request reprint Revisiting the effects of CMV on long-term transplant outcome
    Christophe Baron
    UPRES EA 4245 Cellules Dendritiques, Immunomodulation et Greffes, UFR de Medecine, Universite Francois Rabelais, Tours Cedex, France
    Curr Opin Organ Transplant 15:492-8. 2010
    ..This review will fuel the discussion and review some of the recent data...
  39. ncbi request reprint Higher exposure to mycophenolic acid with sirolimus than with cyclosporine cotreatment
    Matthias Buchler
    Department of Nephrology, Tours University Hospital, 37044 Tours, France
    Clin Pharmacol Ther 78:34-42. 2005
    ..However, most of the pharmacokinetic studies involved patients cotreated with cyclosporine (INN, ciclosporin)...
  40. ncbi request reprint Living with a functioning kidney transplant at 74 yr or older: a national epidemiological study
    Matthias Buchler
    Department of Nephrology and Clinical Immunology, CHU Bretonneau, Tours, France
    Clin Transplant 18:681-5. 2004
    ..Renal function in this group of patients was good and quality of life seemed excellent. Cardiovascular disease and malignancies were the main co-morbid conditions...
  41. ncbi request reprint Early low-grade proteinuria: causes, short-term evolution and long-term consequences in renal transplantation
    Jean Michel Halimi
    Department of Nephrology and Clinical Immunology, Francois Rabelais University, Tours, France
    Am J Transplant 5:2281-8. 2005
    ..Early low-grade proteinuria due to pre-transplant renal lesions, ischemia-reperfusion and immunologic injuries is a potent predictor of graft loss. Short-term reduction in proteinuria is associated with improved long-term graft survival...
  42. pmc Supernatant from bifidobacterium differentially modulates transduction signaling pathways for biological functions of human dendritic cells
    Cyrille Hoarau
    UPRES EA 4245 Cellules Dendritiques and Greffes, Universite Francois Rabelais, Tours, France
    PLoS ONE 3:e2753. 2008
    ..We therefore studied the roles of mitogen-activated protein kinases (MAPK), glycogen synthase kinase-3 (GSK3) and phosphatidylinositol 3-kinase (PI3K) pathways on biological functions of human monocyte-derived DCs treated with BbC50sn...
  43. pmc Bayesian estimation of cyclosporin exposure for routine therapeutic drug monitoring in kidney transplant patients
    Hélène Bourgoin
    Department of Pharmacology, University Hospital of Tours, 2 boulevard Tonnelle, 37044 Tours cedex 9, France
    Br J Clin Pharmacol 59:18-27. 2005
    ..We developed a population pharmacokinetic model to describe dose-exposure relationships for CsA in renal transplant patients and applied it to the Bayesian estimation of AUCs using three blood concentrations...
  44. ncbi request reprint Enalapril/amlodipine combination in cyclosporine-treated renal transplant recipients: a prospective randomized trial
    Jean Michel Halimi
    Department of Nephrology and Clinical Immunology, Francois Rabelais University, CHRU Bretonneau, Tours, France
    Clin Transplant 21:277-84. 2007
    ..Most hypertensive renal transplant recipients require two or more antihypertensive medications to achieve blood pressure control. However, which medications must be combined is still a matter of debate...
  45. ncbi request reprint Population pharmacokinetics and Bayesian estimation of mycophenolic acid concentrations in stable renal transplant patients
    Chantal Le Guellec
    Department of Pharmacology, Tours University Hospital, Tours, France
    Clin Pharmacokinet 43:253-66. 2004
    ..Area under the curve (AUC) rather than trough concentration-based monitoring is recommended and models for AUC estimation are needed...
  46. ncbi request reprint Respective predictive role of urinary albumin excretion and nonalbumin proteinuria on graft loss and death in renal transplant recipients
    Jean Michel Halimi
    Department of Nephrology and Clinical Immunology, Francois Rabelais University, CHU Tours, Tours, France
    Am J Transplant 7:2775-81. 2007
    ..12 [1.65-10.29], p = 0.0024) were risk factors for death. Proteinuria is made of various proportions of UAE and NAP in renal transplantation; these two parameters provide different information on graft/patient survival...
  47. doi request reprint Association between a polymorphism in the IL-12p40 gene and cytomegalovirus reactivation after kidney transplantation
    Thomas W Hoffmann
    JE2448 Cellules Dendritiques et Greffes, UFR de Medecine, Universite Francois Rabelais, Tours, France
    Transplantation 85:1406-11. 2008
    ..However, the impact of this single nucleotide polymorphism on events after organ transplantation has never been reported...
  48. pmc Interferon gamma licensing of human dendritic cells in T-helper-independent CD8+ alloimmunity
    Roxane Lemoine
    Unité Propre de Recherche de l Enseignement Supérieur Equipe d Accueil 4245 Cellules Dendritiques, Immunomodulation et Greffes, Unité Formation et de Recherch UFR de Médecine, Institut Fédératif de Recherche 136, Universite Francois Rabelais, Tours, France
    Blood 116:3089-98. 2010
    ..However, adding IL-12 or tumor necrosis factor-α had no effect. These results suggest that IFN-γ has an important role in licensing DCs to prime CD4-independent CD8 allogeneic T cells via an autocrine loop...
  49. doi request reprint Association between a polymorphism in the human programmed death-1 (PD-1) gene and cytomegalovirus infection after kidney transplantation
    Thomas W Hoffmann
    Universite Francois Rabelais de Tours, EA 4245 Cellules Dendritiques Immunomodulation et Greffes, UFR de Medecine, Tours, France
    J Med Genet 47:54-8. 2010
    ..3, has recently been reported to be clinically relevant in several immune disorders. However, its association with CMV infection has never been reported...
  50. pmc Interindividual variability in the concentration-effect relationship of antilymphocyte globulins - a possible influence of FcgammaRIIIa genetic polymorphism
    David Ternant
    Universite Francois Rabelais, Tours, UPRES EA 3853 Immuno Pharmaco Genetics of therapeutic Antibodies, Tours, France
    Br J Clin Pharmacol 65:60-8. 2008
    ..Moreover, the genetic polymorphism of FcgammaRIIIa, a receptor for the Fc portion of immunoglobulins involved in antibody-dependent cellular cytotoxicity (ADCC), may influence their concentration-effect relationship...
  51. doi request reprint CD40 engagement strongly induces CD25 expression on porcine dendritic cells and polarizes the T cell immune response toward Th1
    Caroline Pilon
    Universite Francois Rabelais, EA 4245 Cellules Dendritiques, Immunomodulation et Greffes, IFR 136, UFR de Medecine, Tours, France
    Mol Immunol 46:437-47. 2009
    ..This study therefore underlines that the nature of the stimulus strongly influences the capacity of DC to steer the immune response in the pig...
  52. doi request reprint Induction of human CD4+ regulatory T cells by mycophenolic acid-treated dendritic cells
    Christine Lagaraine
    Cellules Dendritiques et Greffes, Universite Francois Rabelais de Tours, Tours, France
    J Leukoc Biol 84:1057-64. 2008
    ..These results obtained in vitro demonstrate that human MPA-DC can induce allospecific Tregs that may be exploited in cell therapy to induce allograft tolerance...
  53. ncbi request reprint Recipient age and mycophenolate mofetil as the main determinants of outcome after steroid withdrawal: analysis of long-term follow-up in renal transplantation
    Inass Laouad
    Department of Nephrology and Clinical Immunology, Tours University Hospital, Tours, France
    Transplantation 80:872-4. 2005
    ..1%). Our findings indicate that late steroid withdrawal results in excellent long-term outcome in most low-risk patients, but it should be attempted with caution in younger patients and when MMF is not used...
  54. ncbi request reprint [Difficulties in the management of localised pulmonary Goodpasture's syndrome]
    J Buret
    Service de Pneumologie, Hopital Bretonneau, CHU de Tours, France
    Rev Mal Respir 25:323-7. 2008
    ..Treatment for the pulmonary-renal form combining corticosteroids, cyclophosphamide and plasmapheresis should be applied to the pulmonary form to control haemorrhage and prevent relapse...
  55. ncbi request reprint TLR9 activation induces normal neutrophil responses in a child with IRAK-4 deficiency: involvement of the direct PI3K pathway
    Cyrille Hoarau
    Unité de Formation et de Recherche de Médecine, Cellules Dendritiques et Greffes, Universite Francois Rabelais, Tours, France
    J Immunol 179:4754-65. 2007
    ..This alternative pathway may play a key role in PMN control of infections by microorganisms other than pyogenic bacteria in inherited IRAK-4 deficiency...
  56. ncbi request reprint Effects of immunosuppressive drugs on dendritic cells and tolerance induction
    Christine Lagaraine
    EA 3249, Cellules hématopoïetiques, Hémostase et Greffe, Laboratoire d Immunologie, Faculte de Medecine, Tours, France
    Transplantation 75:37S-42S. 2003
    ..However, these molecules all appear to interfere with DC functions...
  57. doi request reprint Autosomal dominant polycystic kidney disease: risk factor for nonmelanoma skin cancer following kidney transplantation
    Anne Bretagnol
    Department of Nephrology and Clinical Immunology, CHRU Tours, Universite Francois Rabelais, Tours, France
    Transpl Int 23:878-86. 2010
    ..96; P = 0.89). Our findings suggest that ADPKD is an independent risk factor for developing NMSC after kidney transplantation...
  58. ncbi request reprint Association of donor TNFRSF6 (FAS) gene polymorphism with acute rejection in renal transplant patients: a case-control study
    Sandrine Cappellesso
    UPRES EA 3249 Cellules Hématopoïétiques, Hémostase et Greffe, Universite de Tours, Faculte de Medecine, and Laboratoire d Immunologie and Service de Néphrologie et Immunologie Clinique, CHRU de Tours, Tours Cedex, France
    Nephrol Dial Transplant 19:439-43. 2004
    ....
  59. ncbi request reprint Mycophenolic acid-treated human dendritic cells have a mature migratory phenotype and inhibit allogeneic responses via direct and indirect pathways
    Christine Lagaraine
    JE 2448, Cellules Dendritiques et Greffes, IFR 135, Imagerie et exploration fonctionnelles, Universite Francois Rabelais, 2 bis Bd Tonnelle, 37032 Tours, France
    Int Immunol 17:351-63. 2005
    ..All these characteristics suggest that MPA-DCs may be used in cell therapy to induce allograft tolerance...
  60. ncbi request reprint Renal function with delayed or immediate cyclosporine microemulsion in combination with enteric-coated mycophenolate sodium and steroids: results of follow up to 30 months post-transplant
    Georges Mourad
    Department of Nephrology Transplantation, Hopital Lapeyronie, Montpellier, France
    Clin Transplant 21:295-300. 2007
    ..One-yr results have been published previously. We now report the results of an extension study in which patients were followed up for a period of three yr post-transplant...
  61. ncbi request reprint Supernatant of Bifidobacterium breve induces dendritic cell maturation, activation, and survival through a Toll-like receptor 2 pathway
    Cyrille Hoarau
    Universite Francois Rabelais de Tours, JE2448 Cellules Dendritiques and Greffes, France
    J Allergy Clin Immunol 117:696-702. 2006
    ..However, the interactions between these commensal bacteria and the immune system are largely unknown...
  62. ncbi request reprint Follow-up after renal transplantation with organs from donors after cardiac death
    Jeremy Chapman
    Renal Unit, Westmead Hospital, Westmead, NSW, Australia
    Transpl Int 19:715-9. 2006
    ....
  63. ncbi request reprint [Renal transplantation in patients with autosomal dominant polycystic kidney disease: pre-transplantation evaluation and follow-up]
    Anne Bretagnol
    Service de néphrologie immunologie clinique, CHU de Bretonneau, 2, boulevard Tonnelle, 37044 Tours, France
    Nephrol Ther 3:449-55. 2007
    ..Altogether, it apears that a specific approach is needed for ADPKD patients when considering renal transplantation...
  64. doi request reprint Quantification of interstitial fibrosis by image analysis on routine renal biopsy in patients receiving cyclosporine
    Aude Servais
    Department of Renal Transplantation, Universite Paris 5 Rene Descartes, Necker Hospital, Paris, France
    Transplantation 84:1595-601. 2007
    ..We performed a retrospective analysis to calculate IF on routine renal biopsies performed at 1 year posttransplant...
  65. ncbi request reprint Estimated one-year glomerular filtration rate is the best predictor of long-term graft function following renal transplant
    Maurizio Salvadori
    Renal Unit, Careggi University Hospital, Florence, Tuscany, Italy
    Transplantation 81:202-6. 2006
    ..The objective of this study was to assess the effect of various demographic and transplant-related parameters on renal function via GFR at 1 year and 5 years post transplantation, using univariate and multivariate data analysis...
  66. ncbi request reprint A double absorption-phase model adequately describes mycophenolic acid plasma profiles in de novo renal transplant recipients given oral mycophenolate mofetil
    Aurélie Prémaud
    Department of Pharmacology Toxicology, University Hospital, 2 Avenue Martin Luther King, 87042 Limoges, France
    Clin Pharmacokinet 44:837-47. 2005
    ..Mycophenolic acid (MPA) shows complex plasma concentration-time profiles, particularly in the immediate (first month) post-transplantation phase for which no relevant pharmacokinetic model has been proposed thus far...
  67. doi request reprint Anti CD25 treatment of human dendritic cells modulates both their cytokine synthesis profiles and their capacity to activate allogeneic CD4 T cells: a potential tolerogenic effect
    Kaouther Mnasria
    JE 2448, Cellules Dendritiques et Greffes, Faculté de médecine Université François Rabelais, 2 bis Bd Tonnelle, 37032 Tours, France
    Int Immunopharmacol 8:414-22. 2008
    ..All these characteristics suggest that DCs may be used in cellular therapy either to induce allograft tolerance (anti CD25 treated DCs) or to restore immunity against tumors (IL-2 treated DCs)...
  68. ncbi request reprint Acute septic arthritis after kidney transplantation due to Acremonium
    Severine Beaudreuil
    Nephrol Dial Transplant 18:850-1. 2003
  69. ncbi request reprint Analysis of human CD4 T lymphocyte proliferation induced by porcine lymphoblastoid B cell lines
    Christine Bonenfant
    EA 3249 Cellules Hématoponaïétiques, Hémostase et Greffe and IFR 120 Imagerie et Exploration Fonctionnelles, Universite Francois Rabelais, Tours Cedex, France
    Xenotransplantation 10:107-19. 2003
    ..This study was undertaken to characterize the two porcine lymphoblastoid cell lines L23 and L35, derived from a pig inoculated by the retrovirus Tsukuba-1, and to determine how they induce a strong human lymphocyte proliferation...
  70. ncbi request reprint FasL-transfected endothelial cells decrease the proliferative response of allogeneic PBL
    Sandrine Cappellesso
    UPRES EA 3249 Cellules Hématopoïétiques, Hémostase et Greffe, Faculte de Medecine, 2 bis boulevard Tonnelĺe 37032 Tours, France
    Transpl Immunol 10:293-302. 2002
    ..These results suggest that endothelial cells could be interesting candidates to convey a death signal and induce hyporesponsiveness of alloreactive T cells during organ transplantation...
  71. ncbi request reprint Replacement kidney lipomatosis after renal transplantation
    Inass Laouad
    Department of Nephrology and Renal Transplantation, Necker Hospital, 149 rue de Sevres, 75015 Paris, France
    Transplantation 79:496-8. 2005
    ..We describe three cases of replacement kidney lipomatosis that occurred after cadaveric renal transplantation and discuss the possible differential diagnosis of this condition...
  72. ncbi request reprint Efficacy and safety of rituximab in B-cell post-transplantation lymphoproliferative disorders: results of a prospective multicenter phase 2 study
    Sylvain Choquet
    Hematology Unit, CHU La Pitié Salpêtrière Hospital, 47 bd de l Hopital, 75651 Paris Cedex 14, France
    Blood 107:3053-7. 2006
    ..We conclude that rituximab is effective and safe in PTLD, with stable responses at 1 year. The response rate and overall survival might be improved by combining rituximab with other treatments...