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Publications
Simultaneous estimation of cyclosporin and mycophenolic acid areas under the curve in stable renal transplant patients using a limited sampling strategyChantal Le Guellec
Department of Pharmacology, Tours University Hospital, France
Eur J Clin Pharmacol 57:805-11. 2002..It is the method of choice for mycophenolic acid (MPA). The objective of this study was to develop a limited sampling strategy for simultaneous estimation of CsA and MPA AUCs in long-term renal transplant patients...
Five-year results of a randomized trial comparing de novo sirolimus and cyclosporine in renal transplantation: the SPIESSER studyY Lebranchu
Department of Nephrology and Clinical Immunology, Bretonneau Hospital, University Hospital, Tours, France
Am J Transplant 12:1801-10. 2012..60%, p = 0.015). Results confirmed the high SRL discontinuation rate due to adverse events. Nevertheless, a benefit was evidenced on renal function in patients (more than 50%) still on treatment at 5 years...- [Organ transplantation: epidemiological and immunological aspects; principles of treatment and surveillance; complications and prognosis; ethical and legal aspects]Yvon Lebranchu
, Immunologie Clinique, , 37044 Tours Cedex
Rev Prat 54:2295-304; quiz 2304. 2004 - New approaches to de novo immunosuppression and steroid eliminationY Lebranchu
University Hospital of Tours, Tours, France
Transplant Proc 41:S39-41. 2009..In both studies, a significant improvement in renal function was observed at 12 months in patients receiving a maintenance regimen with SRL and MMF. In addition, steroids could be withdrawn in 70% of these patients... - New approaches to de novo immunosuppression and steroid eliminationY Lebranchu
University Hospital of Tours, Tours, France
Transplant Proc 40:S57-9. 2008..017). In both studies, a significant improvement in renal function was observed at 12 months among patients receiving a maintenance regimen with SRL plus MMF. Furthermore, steroids could be withdrawn in three quarters of the patients... - Can we eliminate both calcineurin inhibitors and steroids?Y Lebranchu
University Hospital of Tours, François Rabelais University of Tours, Tours, France
Transplant Proc 42:S25-8. 2010..At 30 months, steroids had been withdrawn in 72% of SRL-treated patients and in 70% of CsA-treated patients... - Efficacy and safety of early cyclosporine conversion to sirolimus with continued MMF-four-year results of the Postconcept studyY Lebranchu
Department of Nephrology, Clinical Immunology, University Hospital, Francois Rabelais University, Tours, France
Am J Transplant 11:1665-75. 2011..42 ± 0.44 vs. 0.26 ± 0.37; p = 0.018). In summary, the renal benefits associated with conversion of CsA to SRL, at 3 months posttransplantation, in combination with MMF were maintained for 4 years posttransplantation... - Delayed graft function: risk factors, consequences and parameters affecting outcome-results from MOST, A Multinational Observational StudyY Lebranchu
CHU Tours, Hopital Bretonneau, Tours, France
Transplant Proc 37:345-7. 2005..Logistic regression was used to evaluate the risk factors for DGF occurrence, and multifactorial analysis of variance (ANCOVA) to assess the relevance of different factors for GFR at 1 year... - Immunoprophylaxis with basiliximab compared with antithymocyte globulin in renal transplant patients receiving MMF-containing triple therapyYvon Lebranchu
Service Nephrologie Immunologie Clinique Hĵpital Bretonneau Tours, France
Am J Transplant 2:48-56. 2002..12%). Both strategies give excellent results, despite the differences in patterns, in nonhyperimmunized patients receiving their first cadaveric renal allograft... - Efficacy on renal function of early conversion from cyclosporine to sirolimus 3 months after renal transplantation: concept studyY Lebranchu
Service Nephrologie Immunologie Clinique, CHRU Tours, EA 4245, University Francois Rabelais, Tours, France
Am J Transplant 9:1115-23. 2009..Significantly, more patients in the SRL group reported aphthous, diarrhea, acne and high triglyceride levels. Conversion CsA to SRL 3 months after transplantation combined with MMF is associated with improvement in renal function... - Sirolimus versus cyclosporine in kidney recipients receiving thymoglobulin, mycophenolate mofetil and a 6-month course of steroidsM Buchler
Francois Rabelais University, Department of Nephrology and Clinical Immunology, Bretonneau Hospital, CHU Tours, France
Am J Transplant 7:2522-31. 2007..23%, p < 0.01). A CNI-free regimen using sirolimus-MMF can achieve excellent renal function, but patients on sirolimus experienced a high rate of adverse events and study drug discontinuation... - Urinary albumin excretion and the risk of graft loss and death in proteinuric and non-proteinuric renal transplant recipientsJ M Halimi
Francois Rabelais University, Department of Nephrology and Clinical Immunology, CHU Tours, Tours, France
Am J Transplant 7:618-25. 2007..Whether microalbuminuria (especially in non-proteinuric patients) and macroalbuminuria constitute risk factors for graft loss and death is presently unknown in renal transplantation... - Early pulse pressure and low-grade proteinuria as independent long-term risk factors for new-onset diabetes mellitus after kidney transplantationM Roland
Service de néphrologie immunologie clinique, Hopital Bretonneau, CHRU Tours, Tours, France
Am J Transplant 8:1719-28. 2008..Early low-grade proteinuria and pulse pressure (in addition to beta-blockers) constitute independent risk factors for NODAT; they may be markers of the metabolic syndrome and/or vascular damage in renal transplant recipients... - Impact of a polymorphism in the IL-12p40 gene on the outcome of kidney transplantationT W Hoffmann
Universite Francois Rabelais de Tours, EA4245 Cellules Dendritiques, Immunomodulation et Greffes, Tours, France
Transplant Proc 41:654-6. 2009..77; P = .027). In conclusion, IL12B 3'UTR polymorphism did not affect graft survival, DGF, or acute rejection episodes, but had an impact on the occurrence of cytomegalovirus infection... - Long-term results of monoclonal anti-Il2-receptor antibody versus polyclonal antilymphocyte antibodies as induction therapy in renal transplantationA Al Najjar
Departments of Nephrology and Clinical Immunology, CHU Tours, Hopital Bretonneau, 2 boulevard Tonnelle, 37044 Tours cedex 9, France
Transplant Proc 38:2298-9. 2006..Our results showed that the choice of the induction therapy seemed to not have a major impact on long-term outcomes among renal recipients at low immunological risk... - Relationship between calcineurin inhibition and plasma endothelin concentrations in cyclosporine-A-treated kidney transplant patientsM Buchler
Department of Nephrology and Clinical Immunology, Tours University Hospital, Tours, France
Eur J Clin Pharmacol 60:703-8. 2004..However, there is obviously also an inter-individual pharmacodynamic variability, which might be explored by the measurement of biomarkers of CsA effects... - Prognostic value of absent end-diastolic flow within the first week following renal transplantationS Ba
Department of Imaging, INSERM U930 CNRS 2448, Francois Rabelais University, CHU Tours, France
Transplant Proc 41:645-7. 2009..Doppler sonogram of the graft is used as a routine assessment in renal transplantation. When the resistance index (RI) equals 1, absent end-diastolic flow (AEDF) is observed; the prognostic value of AEDF is presently unknown... - Induction of porcine regulatory cells by mycophenolic Acid-treated dendritic cellsC Pilon
Universite Francois Rabelais, EA 4245 Cellules Dendritiques et Greffes, IFR 136, UFR de Medecine, Tours, France
Transplant Proc 41:700-2. 2009..These preliminary results suggested induction of a regulatory T-cell population that we are currently seeking to characterize... - Estimation of the glomerular filtration rate through different methods in kidney transplant recipients: correlation with the creatinine clearance measurementM Buchler
Francois Rabelais University, Department of Nephrology and Clinical Immunology, CHU Tours, Hopital Bretonneau, 2 boulevard Tonnelle, 37044 Tours cedex 9, France
Transplant Proc 38:2289-91. 2006..Further studies are required to compare the estimated GFR with better reference methods, such as the use of isotopic markers in kidney graft recipients... - Disappearance of tophi in familial juvenile hyperuricemic nephropathy after kidney transplantationE Merieau
Department of Nephrology and Clinical Immunology, Bretonneau Hospital, Francois Rabelais University, CHU Tours, Cedex, France
Am J Transplant 7:2634-6. 2007..Serum uric acid level decreased slowly from 650 mumol/L before transplantation to 300 mumol/L. Reduction of tophi was probably due to the absence of the mutated UMOD gene in the transplanted kidney... - Effects of current smoking and smoking discontinuation on renal function and proteinuria in the general populationJ M Halimi
Center de Recherche Clinique, Faculte de Medecine, and Service de Néphrologie Immunologie Clinique, Hopital Bretonneau, Tours, France
Kidney Int 58:1285-92. 2000..Smoking may adversely affect the progression of renal diseases. However, it is unknown whether smoking affects renal function in subjects without nephropathy... - Mycophenolate mofetil in patients with systemic lupus erythematosus: a prospective pharmacokinetic studyM Roland
Service de néphrologie immunologie clinique, Hopital Bretonneau, CHRU Tours, France
Lupus 18:441-7. 2009..This suggests that MPA exposure may be unpredictable with a fixed MMF dose. There was a concentration-effect relationship between MPA exposure (C(0)) and immunological disease activity parameters... - Recipient TNFRSF6 (FAS) gene polymorphism and acute renal allograft rejectionS Cappellesso
, , , Tours, France
Transplant Proc 34:803-4. 2002 - Mothers without HLA antibodies before transplantation have a low risk of alloimmunization post-transplantationP Gatault
Service de néphrologie immunologie clinique, Hopital Bretonneau, CHRU Tours, Tours, France
Tissue Antigens 78:241-8. 2011..027) remained significantly lower after adjustment on donor age, acute rejection and number of class I/II HLA mismatches. In conclusion, we show that parous women non-immunized are at low risk of HLA Ab production after transplantation... - Early proteinuria is a strong indicator of donor renal lesions, ischemia-reperfusion injury and immunological aggressionJ Halimi
Francois Rabelais University, Department of Nephrology and Clinical Immunology, Hopital Bretonneau, 2 boulevard Tonnelle, 37044 Tours cedex 9, France
Transplant Proc 38:2319-20. 2006..Early proteinuria is associated with reduced long-term graft survival. However, the determinants and mechanisms of proteinuria early after transplantation have not been identified... - Mycophenolic Acid Inhibits p38 Mitogen-Activated Protein Kinase in Human Monocyte-Derived Dendritic Cells Stimulated by LipopolysaccharideD Faugaret
Universite Francois Rabelais, EA 4245 Cellules Dendritiques et Greffes, IFR 136, UFR de Medecine, Tours, France
Transplant Proc 41:698-9. 2009..Our results suggested that MPA inhibits p38MAPK activity independent of IMPDH in human DCs. This effect of MPA may explain its capacity to inhibit maturation marker expression on DCs... - A three-arm study comparing immediate tacrolimus therapy with antithymocyte globulin induction therapy followed by tacrolimus or cyclosporine A in adult renal transplant recipientsBernard Charpentier
Service de Nephrologie, Hopital de Bicetre, Le Kremlin Bicetre, France
Transplantation 75:844-51. 2003..A study was undertaken to assess the efficacy and safety of ATG induction on tacrolimus-based and cyclosporine A (CsA)-based therapies compared with immediate tacrolimus triple therapy in kidney transplant recipients... - New sampling strategy using a Bayesian approach to assess iohexol clearance in kidney transplant recipientsI Benz-de Bretagne
Laboratory of Biochemistry and Molecular Biology, University Hospital of Tours, Tours, France
Ther Drug Monit 34:289-97. 2012..The aim of this study was to develop and validate a Bayesian model with fewer samples for reliable prediction of GFR in kidney transplant recipients... - Anti-CD25 antibodies decrease the ability of human dendritic cells to prime allogeneic CD4 T cellsK Mnasria
JE 2448, Faculte de Medecine, Universite Francois Rabelais, Tours, France
Transplant Proc 41:695-7. 2009..This study supported previously unrecognized effects of anti-CD25 monoclonal antibodies on DCs that may contribute to their clinical efficacy... - Induction therapy by anti-thymocyte globulin (rabbit) in renal transplantation: a 1-yr follow-up of safety and efficacyMatthias Buchler
Service Nephrologie et Immunologie Clinique, CHU Bretonneau, Tours, France
Clin Transplant 17:539-45. 2003..Two hundred and forty cadaveric renal transplant recipients given anti-thymocyte globulin (Thymoglobulin) as induction immunotherapy were followed up prospectively to review safety and efficacy... - Immunosuppressive medications, clinical and metabolic parameters in new-onset diabetes mellitus after kidney transplantationMélanie Roland
Service de néphrologie immunologie clinique, Hopital Bretonneau, CHRU Tours, Tours, France
Transpl Int 21:523-30. 2008..However, main independent risk factors were age, BMI, initial glucose and triglycerides... - Renal artery aneurysm secondary to Candida albicans in four kidney allograft recipientsI Laouad
Department of Nephrology and Clinical Immunology, University Hospital, Tours, France
Transplant Proc 37:2834-6. 2005..It may occur at different periods after transplantation. We report four cases of mycotic aneurysms due to Candida albicans (CA) in renal transplant recipients occurring early after kidney transplantation... - [Cyclosporin-induced toxic neuromyopathy]A M Guennoc
Clinique Neurologique, CHU Bretoneau, 37044 Tours
Rev Neurol (Paris) 161:221-3. 2005..Among neurological side effects, neuropathies or myopathies have been reported, specially inpatients given combinations of cyclosporine with co-enzyme A reductase inhibitors... - Respective predictive role of urinary albumin excretion and nonalbumin proteinuria on graft loss and death in renal transplant recipientsJean Michel Halimi
Department of Nephrology and Clinical Immunology, Francois Rabelais University, CHU Tours, Tours, France
Am J Transplant 7:2775-81. 2007..12 [1.65-10.29], p = 0.0024) were risk factors for death. Proteinuria is made of various proportions of UAE and NAP in renal transplantation; these two parameters provide different information on graft/patient survival... - Enalapril/amlodipine combination in cyclosporine-treated renal transplant recipients: a prospective randomized trialJean Michel Halimi
Department of Nephrology and Clinical Immunology, Francois Rabelais University, CHRU Bretonneau, Tours, France
Clin Transplant 21:277-84. 2007..Most hypertensive renal transplant recipients require two or more antihypertensive medications to achieve blood pressure control. However, which medications must be combined is still a matter of debate... - Revisiting the effects of CMV on long-term transplant outcomeChristophe Baron
UPRES EA 4245 Cellules Dendritiques, Immunomodulation et Greffes, UFR de Medecine, Universite Francois Rabelais, Tours Cedex, France
Curr Opin Organ Transplant 15:492-8. 2010..This review will fuel the discussion and review some of the recent data... - Population pharmacokinetics and Bayesian estimation of mycophenolic acid concentrations in stable renal transplant patientsChantal Le Guellec
Department of Pharmacology, Tours University Hospital, Tours, France
Clin Pharmacokinet 43:253-66. 2004..Area under the curve (AUC) rather than trough concentration-based monitoring is recommended and models for AUC estimation are needed... - Living with a functioning kidney transplant at 74 yr or older: a national epidemiological studyMatthias Buchler
Department of Nephrology and Clinical Immunology, CHU Bretonneau, Tours, France
Clin Transplant 18:681-5. 2004..Renal function in this group of patients was good and quality of life seemed excellent. Cardiovascular disease and malignancies were the main co-morbid conditions... - Higher exposure to mycophenolic acid with sirolimus than with cyclosporine cotreatmentMatthias Buchler
Department of Nephrology, Tours University Hospital, 37044 Tours, France
Clin Pharmacol Ther 78:34-42. 2005..However, most of the pharmacokinetic studies involved patients cotreated with cyclosporine (INN, ciclosporin)... - Early low-grade proteinuria: causes, short-term evolution and long-term consequences in renal transplantationJean Michel Halimi
Department of Nephrology and Clinical Immunology, Francois Rabelais University, Tours, France
Am J Transplant 5:2281-8. 2005..Early low-grade proteinuria due to pre-transplant renal lesions, ischemia-reperfusion and immunologic injuries is a potent predictor of graft loss. Short-term reduction in proteinuria is associated with improved long-term graft survival... 
Bayesian estimation of cyclosporin exposure for routine therapeutic drug monitoring in kidney transplant patientsHélène Bourgoin
Department of Pharmacology, University Hospital of Tours, 2 boulevard Tonnelle, 37044 Tours cedex 9, France
Br J Clin Pharmacol 59:18-27. 2005..We developed a population pharmacokinetic model to describe dose-exposure relationships for CsA in renal transplant patients and applied it to the Bayesian estimation of AUCs using three blood concentrations...- Supernatant from bifidobacterium differentially modulates transduction signaling pathways for biological functions of human dendritic cellsCyrille Hoarau
UPRES EA 4245 Cellules Dendritiques and Greffes, Universite Francois Rabelais, Tours, France
PLoS ONE 3:e2753. 2008..We therefore studied the roles of mitogen-activated protein kinases (MAPK), glycogen synthase kinase-3 (GSK3) and phosphatidylinositol 3-kinase (PI3K) pathways on biological functions of human monocyte-derived DCs treated with BbC50sn... - Renal function of renal transplantation patients after hospitalization in an intensive care unitJ Badin
Service de Reanimation Medicale, CHU Bretonneau, Tours, France
Transplant Proc 44:2792-4. 2012..We have herein reported the evolution of renal function among kidney graft recipients after an ICU stay... - Microalbuminuria in hypertensive nonproteinuric renal transplant recipients: influence of previous acute rejection episodes and sodium intakeJ-M Halimi
, , Tours, France
Transplant Proc 34:801-2. 2002 - Association between a polymorphism in the IL-12p40 gene and cytomegalovirus reactivation after kidney transplantationThomas W Hoffmann
JE2448 Cellules Dendritiques et Greffes, UFR de Medecine, Universite Francois Rabelais, Tours, France
Transplantation 85:1406-11. 2008..However, the impact of this single nucleotide polymorphism on events after organ transplantation has never been reported... - Recipient age and mycophenolate mofetil as the main determinants of outcome after steroid withdrawal: analysis of long-term follow-up in renal transplantationInass Laouad
Department of Nephrology and Clinical Immunology, Tours University Hospital, Tours, France
Transplantation 80:872-4. 2005..1%). Our findings indicate that late steroid withdrawal results in excellent long-term outcome in most low-risk patients, but it should be attempted with caution in younger patients and when MMF is not used... - Interindividual variability in the concentration-effect relationship of antilymphocyte globulins - a possible influence of FcgammaRIIIa genetic polymorphismDavid Ternant
Universite Francois Rabelais, Tours, UPRES EA 3853 Immuno Pharmaco Genetics of therapeutic Antibodies, Tours, France
Br J Clin Pharmacol 65:60-8. 2008..Moreover, the genetic polymorphism of FcgammaRIIIa, a receptor for the Fc portion of immunoglobulins involved in antibody-dependent cellular cytotoxicity (ADCC), may influence their concentration-effect relationship... - CD40 engagement strongly induces CD25 expression on porcine dendritic cells and polarizes the T cell immune response toward Th1Caroline Pilon
Universite Francois Rabelais, EA 4245 Cellules Dendritiques, Immunomodulation et Greffes, IFR 136, UFR de Medecine, Tours, France
Mol Immunol 46:437-47. 2009..This study therefore underlines that the nature of the stimulus strongly influences the capacity of DC to steer the immune response in the pig... - Association between a polymorphism in the human programmed death-1 (PD-1) gene and cytomegalovirus infection after kidney transplantationThomas W Hoffmann
Universite Francois Rabelais de Tours, EA 4245 Cellules Dendritiques Immunomodulation et Greffes, UFR de Medecine, Tours, France
J Med Genet 47:54-8. 2010..3, has recently been reported to be clinically relevant in several immune disorders. However, its association with CMV infection has never been reported... - Interferon gamma licensing of human dendritic cells in T-helper-independent CD8+ alloimmunityRoxane Lemoine
Unité Propre de Recherche de l Enseignement Supérieur Equipe d Accueil 4245 Cellules Dendritiques, Immunomodulation et Greffes, Unité Formation et de Recherch UFR de Médecine, Institut Fédératif de Recherche 136, Universite Francois Rabelais, Tours, France
Blood 116:3089-98. 2010..However, adding IL-12 or tumor necrosis factor-α had no effect. These results suggest that IFN-γ has an important role in licensing DCs to prime CD4-independent CD8 allogeneic T cells via an autocrine loop... - Induction of human CD4+ regulatory T cells by mycophenolic acid-treated dendritic cellsChristine Lagaraine
Cellules Dendritiques et Greffes, Universite Francois Rabelais de Tours, Tours, France
J Leukoc Biol 84:1057-64. 2008..These results obtained in vitro demonstrate that human MPA-DC can induce allospecific Tregs that may be exploited in cell therapy to induce allograft tolerance... - [Difficulties in the management of localised pulmonary Goodpasture's syndrome]J Buret
Service de Pneumologie, Hopital Bretonneau, CHU de Tours, France
Rev Mal Respir 25:323-7. 2008..Treatment for the pulmonary-renal form combining corticosteroids, cyclophosphamide and plasmapheresis should be applied to the pulmonary form to control haemorrhage and prevent relapse... - Effects of immunosuppressive drugs on dendritic cells and tolerance inductionChristine Lagaraine
EA 3249, , , Laboratoire d'Immunologie, , Tours, France
Transplantation 75:37S-42S. 2003..However, these molecules all appear to interfere with DC functions... - Autosomal dominant polycystic kidney disease: risk factor for nonmelanoma skin cancer following kidney transplantationAnne Bretagnol
Department of Nephrology and Clinical Immunology, CHRU Tours, Universite Francois Rabelais, Tours, France
Transpl Int 23:878-86. 2010..96; P = 0.89). Our findings suggest that ADPKD is an independent risk factor for developing NMSC after kidney transplantation... - TLR9 activation induces normal neutrophil responses in a child with IRAK-4 deficiency: involvement of the direct PI3K pathwayCyrille Hoarau
Unité de Formation et de Recherche de Médecine, Cellules Dendritiques et Greffes, Universite Francois Rabelais, Tours, France
J Immunol 179:4754-65. 2007..This alternative pathway may play a key role in PMN control of infections by microorganisms other than pyogenic bacteria in inherited IRAK-4 deficiency... - Supernatant of Bifidobacterium breve induces dendritic cell maturation, activation, and survival through a Toll-like receptor 2 pathwayCyrille Hoarau
, JE2448 Cellules Dendritiques and Greffes, France
J Allergy Clin Immunol 117:696-702. 2006..These properties might correspond to a regulatory DC profile, which could limit the excessive TH1 response and control the excessive TH2 polarization observed in atopic newborns... - Estimated one-year glomerular filtration rate is the best predictor of long-term graft function following renal transplantMaurizio Salvadori
Renal Unit, Careggi University Hospital, Florence, Tuscany, Italy
Transplantation 81:202-6. 2006..The objective of this study was to assess the effect of various demographic and transplant-related parameters on renal function via GFR at 1 year and 5 years post transplantation, using univariate and multivariate data analysis... - [Renal transplantation in patients with autosomal dominant polycystic kidney disease: pre-transplantation evaluation and follow-up]Anne Bretagnol
Service de néphrologie immunologie clinique, CHU de Bretonneau, 2, boulevard Tonnelle, 37044 Tours, France
Nephrol Ther 3:449-55. 2007..Altogether, it apears that a specific approach is needed for ADPKD patients when considering renal transplantation... - Association of donor TNFRSF6 (FAS) gene polymorphism with acute rejection in renal transplant patients: a case-control studySandrine Cappellesso
UPRES EA 3249 Cellules Hématopoïétiques, Hémostase et Greffe, Universite de Tours, Faculte de Medecine, and Laboratoire d Immunologie and Service de Néphrologie et Immunologie Clinique, CHRU de Tours, Tours Cedex, France
Nephrol Dial Transplant 19:439-43. 2004.... - Renal function with delayed or immediate cyclosporine microemulsion in combination with enteric-coated mycophenolate sodium and steroids: results of follow up to 30 months post-transplantGeorges Mourad
Department of Nephrology Transplantation, Hopital Lapeyronie, Montpellier, France
Clin Transplant 21:295-300. 2007..One-yr results have been published previously. We now report the results of an extension study in which patients were followed up for a period of three yr post-transplant... - Mycophenolic acid-treated human dendritic cells have a mature migratory phenotype and inhibit allogeneic responses via direct and indirect pathwaysChristine Lagaraine
JE 2448, Cellules Dendritiques et Greffes, IFR 135, Imagerie et exploration fonctionnelles, , 2 bis Bd Tonnelle, 37032 Tours, France
Int Immunol 17:351-63. 2005..All these characteristics suggest that MPA-DCs may be used in cell therapy to induce allograft tolerance... - A double absorption-phase model adequately describes mycophenolic acid plasma profiles in de novo renal transplant recipients given oral mycophenolate mofetilAurélie Prémaud
Department of Pharmacology Toxicology, University Hospital, 2 Avenue Martin Luther King, 87042 Limoges, France
Clin Pharmacokinet 44:837-47. 2005..Mycophenolic acid (MPA) shows complex plasma concentration-time profiles, particularly in the immediate (first month) post-transplantation phase for which no relevant pharmacokinetic model has been proposed thus far... - Follow-up after renal transplantation with organs from donors after cardiac deathJeremy Chapman
Renal Unit, Westmead Hospital, Westmead, NSW, Australia
Transpl Int 19:715-9. 2006.... - Quantification of interstitial fibrosis by image analysis on routine renal biopsy in patients receiving cyclosporineAude Servais
Department of Renal Transplantation, Universite Paris 5 Rene Descartes, Necker Hospital, Paris, France
Transplantation 84:1595-601. 2007..We performed a retrospective analysis to calculate IF on routine renal biopsies performed at 1 year posttransplant... - Replacement kidney lipomatosis after renal transplantationInass Laouad
Department of Nephrology and Renal Transplantation, Necker Hospital, , 75015 Paris, France
Transplantation 79:496-8. 2005..We describe three cases of replacement kidney lipomatosis that occurred after cadaveric renal transplantation and discuss the possible differential diagnosis of this condition... - Anti CD25 treatment of human dendritic cells modulates both their cytokine synthesis profiles and their capacity to activate allogeneic CD4 T cells: a potential tolerogenic effectKaouther Mnasria
JE 2448, Cellules Dendritiques et Greffes, Faculté de médecine Université François Rabelais, 2 bis Bd Tonnelle, 37032 Tours, France
Int Immunopharmacol 8:414-22. 2008..All these characteristics suggest that DCs may be used in cellular therapy either to induce allograft tolerance (anti CD25 treated DCs) or to restore immunity against tumors (IL-2 treated DCs)... - Acute septic arthritis after kidney transplantation due to AcremoniumSeverine Beaudreuil
Nephrol Dial Transplant 18:850-1. 2003 - Analysis of human CD4 T lymphocyte proliferation induced by porcine lymphoblastoid B cell linesChristine Bonenfant
, , , Tours Cedex, France
Xenotransplantation 10:107-19. 2003..By expressing major histocompatibility complex class II antigens and costimulatory molecules, they induce a vigorous proliferative response of human CD4+ lymphocytes through a direct presentation pathway... - FasL-transfected endothelial cells decrease the proliferative response of allogeneic PBLSandrine Cappellesso
, , , 2 bis boulevard Tonnelĺe 37032 Tours, France
Transpl Immunol 10:293-302. 2002..These results suggest that endothelial cells could be interesting candidates to convey a death signal and induce hyporesponsiveness of alloreactive T cells during organ transplantation... - Efficacy and safety of rituximab in B-cell post-transplantation lymphoproliferative disorders: results of a prospective multicenter phase 2 studySylvain Choquet
Hematology Unit, CHU La Pitié Salpêtrière Hospital, 47 bd de l Hopital, 75651 Paris Cedex 14, France
Blood 107:3053-7. 2006..We conclude that rituximab is effective and safe in PTLD, with stable responses at 1 year. The response rate and overall survival might be improved by combining rituximab with other treatments...