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Genomes and GenesSpecies | Marion LeboyerSummaryCountry: France Publications
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Publications
Can bipolar disorder be viewed as a multi-system inflammatory disease?Marion Leboyer
INSERM U955, University Paris Est, FondaMental Fondation, Fondation de cooperation scientifique, AP HP, Groupe hospitalier Mondor, 40, rue de Mesly, Creteil, F 94000, France
J Affect Disord 141:1-10. 2012..In this review, we explore comorbid medical disorders, highlighting evidence that bipolar disorder can be effectively conceptualized as a multi-systemic inflammatory disease...
[Can we identify biomarkers in bipolar depression? From imaging to biology]M Leboyer
Universite Paris Est, Faculte de Medecine, UMR S 955, Creteil, F 94010, France
Encephale 37:S185-90. 2011..The identification of biomarkers for bipolar depression seems to be an interesting field, but it still remains in the domain of research...
Psychiatric and psychosocial problems in adults with normal-intelligence autism spectrum disordersBjörn Hofvander
Forensic Psychiatry, Department of Clinical Sciences, Lund University, Lund, Sweden
BMC Psychiatry 9:35. 2009..The objective of this paper is to describe the clinical psychiatric presentation and important outcome measures of a large group of normal-intelligence adult patients with ASDs...
Mutation screening of ASMT, the last enzyme of the melatonin pathway, in a large sample of patients with intellectual disabilityCecile Pagan
Human Genetics and Cognitive Functions, Institut Pasteur, Paris, France
BMC Med Genet 12:17. 2011..Thus the aim of the study was to ascertain the genetic variability of ASMT in a large cohort of patients with ID and controls...
Mutation screening of NOS1AP gene in a large sample of psychiatric patients and controlsRichard Delorme
Human Genetics and Cognitive Functions, Institut Pasteur, Paris, France
BMC Med Genet 11:108. 2010..Previous genetic and functional studies explored the role of NOS1AP in these psychiatric conditions, but only a limited number explored the sequence variability of NOS1AP...
Bipolar disorder: new perspectives in health care and preventionMarion Leboyer
Department of Psychiatry, Hopital Albert Chenevier, University Paris Est, Assistance Publique Hopitaux de Paris, Creteil, France
J Clin Psychiatry 71:1689-95. 2010....
Factor analyses of the Suicidal Intent Scale (SIS) and the Risk-Rescue Rating Scale (RRRS): toward the identification of homogeneous subgroups of suicidal behaviorsHelene Misson
INSERM, Unit 955, IMRB, Psychiatry Genetics Team, Creteil, France
J Affect Disord 121:80-7. 2010..This heterogeneity has major implications for clinical management of patients and identification of risk factors. Our study aims at identifying homogeneous subgroups of patients with suicidal behavior...
Schizotypal dimensions: an intermediate phenotype associated with the COMT high activity alleleFranck Schurhoff
Département Hospitalo Universitaire de Psychiatrie, Hôpital Albert Chenevier et Henri Mondor, 40 rue Mesly, Creteil, France
Am J Med Genet B Neuropsychiatr Genet 144:64-8. 2007....
Shared executive dysfunctions in unaffected relatives of patients with autism and obsessive-compulsive disorderRichard Delorme
INSERM U513, Neurobiologie et Psychiatrie, Universite Paris XII, Creteil, France
Eur Psychiatry 22:32-8. 2007....
Admixture analysis of age at onset in obsessive-compulsive disorderRichard Delorme
INSERM U513, Faculte de Medecine, Creteil, France
Psychol Med 35:237-43. 2005..If AAO is a clinical indicator of different biological subtypes, then subgroups based on distinct AAOs should have separate normal distributions as well as different clinical characteristics...
Correlations between cognitive performances and psychotic or schizotypal dimensionsAndrei Szoke
INSERM U955, 94000 Creteil, France
Eur Psychiatry 24:244-50. 2009..To test if specific correlations exist between cognitive measures and psychotic dimensions in schizophrenic subjects and if similar correlations, between cognition and schizotypal dimensions, are present in non-psychotic subjects...
Reduced 3-O-methyl-dopa levels in OCD patients and their unaffected parents is associated with the low activity M158 COMT alleleRichard Delorme
INSERM U955, Institut Mondor de Recherche Biomedicale, Psychiatric Genetics, Creteil, France
Am J Med Genet B Neuropsychiatr Genet 153:542-8. 2010..These findings further support a role of COMT in the susceptibility to OCD and provide evidence that 3-OMD levels could represent an endophenotype in OCD...
No evidence for physical anhedonia as a candidate symptom or an endophenotype in bipolar affective disorderBruno Etain
AP HP, Hopital Albert Chenevier, Département Hospitalo Universitaire de Psychiatrie, Universite Paris XII, France
Bipolar Disord 9:706-12. 2007..Physical anhedonia (PA) is considered a possible candidate symptom and endophenotype in schizophrenia, but has never been specifically investigated in BPAD...
Lack of association between 5HT2A receptor gene haplotype, bipolar disorder and its clinical subtypes in a West European sampleBruno Etain
Department of Psychiatry, Henri Mondor Hospital, AP HP, Creteil, France
Am J Med Genet B Neuropsychiatr Genet 129:29-33. 2004..Our study suggests that the 5HT2AR gene is unlikely to be involved in genetic susceptibility to BPAD but should be further investigated in a pharmacogenetic study...
Search for copy number variants in chromosomes 15q11-q13 and 22q11.2 in obsessive compulsive disorderRichard Delorme
INSERM, U955, Institut Mondor de Recherche Biomedicale, PsychiatricGenetics, Creteil, France
BMC Med Genet 11:100. 2010..Therefore, the aim of this study was to search for microrearrangements in these two regions in OCD patients...
European collaborative study of early-onset bipolar disorder: Evidence for genetic heterogeneity on 2q14 according to age at onsetFlavie Mathieu
INSERM, U 955, IMRB, Department of Medical Genetics, Psychiatry Genetics, Creteil, France
Am J Med Genet B Neuropsychiatr Genet 153:1425-33. 2010..Our findings illustrate that stratification according to AAO may be valuable for the identification of genetic vulnerability polymorphisms. © 2010 Wiley-Liss, Inc...
Admixture analysis of age at first suicide attemptFrederic Slama
INSERM, U955, IMRB, Department of Genetics, Psychiatry Genetics Team, Creteil, France
J Psychiatr Res 43:895-900. 2009..The aim of this study was to try to define different subgroups according to age at first SA subtypes using admixture analysis...
Is processing speed a valid cognitive endophenotype for bipolar disorder?Claire Daban
INSERM, U955, Creteil, 94000, France
J Affect Disord 139:98-101. 2012..The current study investigated whether a single brief cognitive assessment, processing speed, could be considered as a valid endophenotype for bipolar disorder (BD)...
Platelet serotonergic markers as endophenotypes for obsessive-compulsive disorderRichard Delorme
INSERM U 513, Faculte de Medecine, Creteil, France
Neuropsychopharmacology 30:1539-47. 2005..These alterations may serve as endophenotypic markers in OCD, and could contribute to the study of the biological mechanisms and genetic underpinnings of the disorder...
Clinical expression of bipolar disorder type I as a function of age and polarity at onset: convergent findings in samples from France and the United StatesBruno Etain
Institut National de la Sante et de la Recherche Medicale INSERM, Creteil, France
J Clin Psychiatry 73:e561-6. 2012..Certain onset characteristics (eg, age and polarity at onset) may delineate subgroups differing in clinical expression and outcome...
Neuroimaging biomarkers in bipolar disorderJosselin Houenou
AP HP, University Paris East, Department of Psychiatry, Henri Mondor Albert Chenevier Hospitals, Creteil, F 94010, France
Front Biosci (Elite Ed) 4:593-606. 2012..Future research should include studies to validate biomarkers for the assessment of bipolar disorder and studies of large and well characterized samples of patients with bipolar disorder...
Exploratory analysis of obsessive compulsive symptom dimensions in children and adolescents: a prospective follow-up studyRichard Delorme
INSERM U513, Faculte de Medecine, Universite Paris XII, Creteil, France
BMC Psychiatry 6:1. 2006..Although a phenotypic continuum from childhood to adulthood has been hypothesized, no factor analytic studies have been performed in juvenile patients, and the stability of OC dimensions in children and adolescents has not been assessed...
Prefrontal cortex dysfunction in patients with suicidal behaviorAurelie Raust
Department of Psychiatry, Chenevier Mondor Hospital, Assistance Publique Hopitaux de Paris, Creteil Cedex, France
Psychol Med 37:411-9. 2007..We investigated PFC-related neuropsychological function in patients with suicidal behavior, separating dorsolateral PFC (DLPFC)- and orbitofrontal cortex (OFC)-related functions...
Beyond genetics: childhood affective trauma in bipolar disorderBruno Etain
INSERM, Unite 841, IMRB, Département de génétique, Equipe de Psychiatrie Génétique, Creteil, France
Bipolar Disord 10:867-76. 2008..The objectives are to review the arguments in favor of an association between childhood trauma and bipolar disorder and to discuss the interpretations of such an observation...
Longitudinal studies of cognition in schizophrenia: meta-analysisAndrei Szoke
Service de Psychiatrie Adulte, Hopital Albert Chenevier, Creteil, France
Br J Psychiatry 192:248-57. 2008..A wide range of cognitive deficits have been demonstrated in schizophrenia, but their longitudinal course remains unclear...
Selective attention impairment in Schizophrenia: can it explain source monitoring failure?Abdelaziz Ferchiou
INSERM, U 955, Institut Mondor de Recherches Biomédicales IMRB, Département de Génomique Médicale, Equipe de Psychiatrie Génétique, Creteil, France
J Nerv Ment Dis 198:779-81. 2010..Selective attention impairments do not explain source monitoring deficits observed in schizophrenia. Source monitoring deficits deserve continued efforts to elucidate their causes and consequences...
A French network of bipolar expert centres: a model to close the gap between evidence-based medicine and routine practiceChantal Henry
INSERM, U 995, IMRB, Psychiatry Genetics, Creteil, France
J Affect Disord 131:358-63. 2011....
Autism multiplex family with 16p11.2p12.2 microduplication syndrome in monozygotic twins and distal 16p11.2 deletion in their brotherAnne Claude Tabet
AP HP, Robert Debre Hospital, Department of Genetics, Cytogenetics Unit, Paris, France
Eur J Hum Genet 20:540-6. 2012..We discuss the clinical and genetic implications of two different 16p chromosomal rearrangements in this family, and suggest that the 16p11.2 deletion in the father predisposed to the formation of the duplication in his twin children...
Exploring the relationships between tobacco smoking and schizophrenia in first-degree relativesAziz Ferchiou
AP HP, Hôpital H Mondor A Chenevier, pôle de psychiatrie, Creteil 94000, France
Psychiatry Res 200:674-8. 2012..Our results support the hypothesis that the relationship between schizophrenia and smoking is largely mediated by common familial factors, which may be genetic...
Emotional dysfunction as a marker of bipolar disordersChantal Henry
INSERM, U955, IMRB, Département de génétique, Creteil, F 94000, France
Front Biosci (Elite Ed) 4:2722-30. 2012..This article reviews data showing the relevance of using emotional reactivity to better characterize bipolar mood episodes...
Neuroimaging-based markers of bipolar disorder: evidence from two meta-analysesJosselin Houenou
INSERM, U 955, IMRB, Department of Medical Genomic, Psychiatry Genetic Team, University Paris Est Creteil, Creteil, F 94000, France
J Affect Disord 132:344-55. 2011..The identification of objective biomarkers, such as functional and structural brain abnormalities of BD might improve diagnosis and help elucidate its pathophysiology...
Frequency and transmission of glutamate receptors GRIK2 and GRIK3 polymorphisms in patients with obsessive compulsive disorderRichard Delorme
INSERM U 513, Faculte de Medecine, 8 rue du General Sarrail, 94010 Creteil, France
Neuroreport 15:699-702. 2004..03), supporting a functional role for this variant. These findings suggest the need for further investigation of the role of GRIK2 in OCD...
Early-onset obsessive-compulsive disorder: a subgroup with a specific clinical and familial pattern?Nadia Chabane
Service de Psychopathologie de l Enfant et de l Adolescent, Assistance Publique Hopitaux de Paris, Hopital Robert Debre, Paris, France
J Child Psychol Psychiatry 46:881-7. 2005..In this study, the specificity of early-onset OCD was investigated, focusing on the effect of gender, comorbid conditions and familial risk of tics and OCD by studying a population consisting exclusively of patients with early-onset OCD...
Association between the PPP3CC gene, coding for the calcineurin gamma catalytic subunit, and bipolar disorderFlavie Mathieu
INSERM U 513, Faculte de Medecine, 8 rue de General Sarrail, 94000, Creteil, France
Behav Brain Funct 4:2. 2008..abstract:..
Apolipoprotein E in schizophrenia: a French association study and meta-analysisFranck Schurhoff
Service de Psychiatrie Adulte, Hopital Albert Chenevier, Creteil, France
Am J Med Genet B Neuropsychiatr Genet 119:18-23. 2003..However, ApoE may be associated with particular forms of schizophrenia...
MRI exploration of pineal volume in bipolar disorderSamuel Sarrazin
AP HP, University Paris East, Department of Psychiatry, Henri Mondor Albert Chenevier Hospitals, Creteil, F 94010, France
J Affect Disord 135:377-9. 2011..Melatonin is secreted by the pineal gland. We investigated pineal volume in patients with bipolar disorder, and expected to observe smaller than normal pineal glands in cases of bipolar disorder...
Mutation screening of the ARX gene in patients with autismPauline Chaste
INSERM U513, Universite Paris XII, Creteil, France
Am J Med Genet B Neuropsychiatr Genet 144:228-30. 2007..The mutation analysis was performed by direct sequencing of all exons and flanking regions. No ARX mutations were identified in any of the patients tested. These findings indicate that mutations in the ARX gene are very rare in autism...
Handedness and schizotypal features in healthy subjectsFranck Schurhoff
AP HP Groupe Henri Mondor Albert Chenevier, pôle de psychiatrie, Creteil, France
World J Biol Psychiatry 9:121-5. 2008..Several studies have attempted to identify correlations between handedness and dimensions of psychosis but the results obtained so far remain inconclusive...
Preferential association between childhood emotional abuse and bipolar disorderBruno Etain
INSERM, Unité 955 and Assistance Publique Hôpitaux de Paris AP HP, Groupe Henri Mondor Albert Chenevier, pôle de psychiatrie, Creteil Cedex, France
J Trauma Stress 23:376-83. 2010..Clinical practice should include systematic assessment of childhood trauma among bipolar patients with a particular focus on emotional abuse...
Association between the dopamine receptor D4 (DRD4) gene and obsessive-compulsive disorderBruno Millet
INSERM E0117 Paris V, University Department of Psychiatry, Sainte Anne Hospital, Paris, France
Am J Med Genet B Neuropsychiatr Genet 116:55-9. 2003..The results suggest that the 2 allele or a nearby genetic variation could have a protective effect against OCD symptoms...
Anxiety disorders in 318 bipolar patients: prevalence and impact on illness severity and response to mood stabilizerChantal Henry
Department of Adult Psychiatry, Charles Perrens Hospital, and INSERM U 394, Integrative Neurobiology, Bordeaux, France
J Clin Psychiatry 64:331-5. 2003..The aim of this study was to assess the frequency and impact of anxiety disorders on illness severity and response to mood stabilizers in bipolar disorders...
Lack of evidence for association between serotonin transporter gene (5-HTTLPR) and obsessive-compulsive disorder by case control and family association study in humansNadia Chabane
University Department of Psychiatry, INSERM E0 117, Sainte Anne Hospital, Paris, France
Neurosci Lett 363:154-6. 2004..We also performed a family association study on 116 trios including an OCD patient (73 French and 43 German). No association was detected between the 5-HTTLPR polymorphism and OCD in either the case control study or the family study...
No human tryptophan hydroxylase-2 gene R441H mutation in a large cohort of psychiatric patients and control subjectsRichard Delorme
Human Genetics and Cognitive Functions, Pasteur Institute, Paris, France
Biol Psychiatry 60:202-3. 2006..1.4% in control subjects)...
Emotional hyper-reactivity as a fundamental mood characteristic of manic and mixed statesChantal Henry
Service de Psychiatrie Adulte, Centre Hospitalier Charles Perrens, 121, rue de la Béchade, 33076 Bordeaux, France
Eur Psychiatry 18:124-8. 2003..It is possible that the fundamental mood characteristic of mania is not tonality of mood (e.g. euphoric, irritable or depressed mood), but rather the intensity of emotions...
A first national survey of knowledge, attitudes and behaviours towards schizophrenia, bipolar disorders and autism in FranceIsabelle Durand-Zaleski
Department of Public Health and Psychiatry, AP HP, URCEco and Henri Mondor Albert Chenevier Hospitals, 51 Avenue du Marechal de Lattre de Tassigny, Creteil, F 94000, France
BMC Psychiatry 12:128. 2012..This study explores public perceptions and quantifies stigma for three chronic mental disorders: autism, schizophrenia and bipolar disorders in France...
Immuno- inflammatory markers of bipolar disorder: a review of evidenceNora Hamdani
Universite Paris Est, Faculte de Medecine, Creteil, 94000, France
Front Biosci (Elite Ed) 4:2170-82. 2012....
Defining bipolar mood states with quantitative measurement of inhibition/activation and emotional reactivityChantal Henry
INSERM, U 995, IMRB, Département de génétique, Creteil, France
J Affect Disord 127:300-4. 2010..The aim of the study is to determine whether two dimensions (activation/inhibition and emotional reactivity) improve assessment of bipolar states in which both manic and depressive symptoms are associated...
A meta-analysis of whole-brain diffusion tensor imaging studies in bipolar disorderFrançois Eric Vederine
AP HP, University Paris East, Department of Psychiatry, Henri Mondor Albert Chenevier Hospitals, Creteil, F 94010, France
Prog Neuropsychopharmacol Biol Psychiatry 35:1820-6. 2011....
Age at onset in bipolar I affective disorder: further evidence for three subgroupsFrank Bellivier
Department of Psychiatry, Hôpital Henri Mondor et Albert Chenevier, Assistance Publique Hopitaux de Paris, 51 avenue du Mal de Lattre de Tassigny, 94010 Creteil Cedex, France
Am J Psychiatry 160:999-1001. 2003..Preliminary data suggested that there are three subgroups of bipolar affective disorder based on age at onset. The authors sought to replicate those findings and determine the cut-off age of each subgroup...
Serotonin transporter gene polymorphism influences age at onset in patients with bipolar affective disorderFrank Bellivier
Service de Psychiatrie, Hôpital Henri Mondor et Albert Chenevier, Assistance Publique Hopitaux de Paris, Creteil, France
Neurosci Lett 334:17-20. 2002....
Public and nonprofit funding for research on mental disorders in France, the United Kingdom, and the United StatesKarine Chevreul
Department of Public Health AP HP Henri Mondor Albert Chenevier Hospitals, Creteil, France
J Clin Psychiatry 73:e906-12. 2012..To document the investments made in research on mental disorders by both government and nonprofit nongovernmental organizations in France, the United Kingdom, and the United States...
Temperament in schizophrenia: a study of the tridimensional personality questionnaire (TPQ)Andrei Szoke
Service de Psychiatrie Adulte, Hôpital Henri Mondor et Albert Chenevier, 40, rue de Mesly, AP HP, 94000, Creteil, France
Eur Psychiatry 17:379-83. 2002..The aim of this study was to assess dimensions of temperament as defined by Cloninger's neurobiological model using the tridimensional personality questionnaire (TPQ) in a sample of consecutively recruited schizophrenic patients...
Screening for genomic rearrangements and methylation abnormalities of the 15q11-q13 region in autism spectrum disordersChristel Depienne
INSERM U679, AP HP, Groupe Hospitalier Pitie Salpetriere, Paris, France
Biol Psychiatry 66:349-59. 2009..However, the prevalence of these disorders in ASD is unknown. The aim of this study was to assess the frequency of 15q11-q13 rearrangements in a large sample of patients ascertained for ASD...
Human endogenous retrovirus type W (HERV-W) in schizophrenia: a new avenue of research at the gene-environment interfaceMarion Leboyer
AP HP, Henri Mondor Albert Chenevier Hospitals, Department of Psychiatry, Creteil, France
World J Biol Psychiatry 14:80-90. 2013..Provide a synthetic review of recent studies evidencing an association between human endogenous retrovirus-W (HERV-W) and schizophrenia...
Autism risk factors: genes, environment, and gene-environment interactionsPauline Chaste
INSERM U 955, IMRB, Psychiatry Genetics, Creteil, France
Dialogues Clin Neurosci 14:281-92. 2012..One aspect of this search that has been neglected so far is the study of interactions between genes and environmental factors...
Patients' health literacy in psychotic disordersGhassen Saba
AP HP, Groupe Henri Mondor Albert Chenevier, pôle de psychiatrie, Creteil, F 94000, France INSERM Unité 841, IMRB, Département de génétique, Equipe 15, Creteil, F 94000, France Université Paris 12, Faculte de Medecine, IFR10, Creteil, F 94000, France
Neuropsychiatr Dis Treat 3:511-7. 2007..Most of these interventions have been shown to increase compliance and to decrease the rate of relapse, but the most robust results have been achieved with cognitive behavioral therapy...
Suicidal disorders: a nosological entity per se?Marion Leboyer
Department of Psychiatry, Hôpital Albert Chenevier et Henri Mondor, Creteil, France
Am J Med Genet C Semin Med Genet 133:3-7. 2005....
Searching for alternative phenotypes in psychiatric geneticsMarion Leboyer
Service de psychiatrie (Pr Rouillon, , 94010 Creitel, France
Methods Mol Med 77:145-61. 2003
