Thibaud Lebouvier

Summary

Country: France

Publications

  1. ncbi [Dementia: Where are the Lewy bodies?]
    T Lebouvier
    CMRR des Pays de Loire, Hopital Laennec, CHU de Nantes, boulevard Professeur Jacques Monod, 44800 Saint Herblain, France Electronic address
    Rev Neurol (Paris) 169:844-57. 2013
  2. pmc Colonic biopsies to assess the neuropathology of Parkinson's disease and its relationship with symptoms
    Thibaud Lebouvier
    UMR 913, INSERM, Nantes, France
    PLoS ONE 5:e12728. 2010
  3. ncbi Colonic neuropathology is independent of olfactory dysfunction in Parkinson's disease
    Thibaud Lebouvier
    INSERM, U913, Nantes, France
    J Parkinsons Dis 1:389-94. 2011
  4. doi Analysis of colonic alpha-synuclein pathology in multiple system atrophy
    Hélène Pouclet
    INSERM, U913, Nantes F 44093, France INSERM, CIC 04, Nantes F 44093, France CHU Nantes, Department of Neurology, F 44093, France
    Parkinsonism Relat Disord 18:893-5. 2012
  5. doi A comparison between rectal and colonic biopsies to detect Lewy pathology in Parkinson's disease
    Hélène Pouclet
    INSERM, U913, Nantes, F 44093, France
    Neurobiol Dis 45:305-9. 2012
  6. doi [Autonomic nervous system as a source of biomarkers in Parkinson's disease]
    Hélène Pouclet
    INSERM U913, University Nantes, Nantes, France
    Presse Med 41:695-701. 2012
  7. doi Colonic inflammation in Parkinson's disease
    David Devos
    INSERM, U913, Nantes, F 44093, France
    Neurobiol Dis 50:42-8. 2013
  8. doi α-Synuclein expression is induced by depolarization and cyclic AMP in enteric neurons
    Sébastien Paillusson
    INSERM, U913, Nantes, France
    J Neurochem 115:694-706. 2010
  9. ncbi Prospective evaluation of behavioral scales in the behavioral variant of frontotemporal dementia
    Claire Boutoleau-Bretonnière
    Centre Mémoire Recherche et Ressources CMRR, Nantes, France
    Dement Geriatr Cogn Disord 34:75-82. 2012
  10. ncbi [Frontal variant of frontotemporal dementia]
    Claire Boutoleau-Bretonnière
    Centre mémoire ressources et recherche, Hopital Laennec, CHU de Nantes, France Labo EMC, EA3082, Université Lyon 2, Bron, France
    Geriatr Psychol Neuropsychiatr Vieil 12:63-73. 2014

Collaborators

Detail Information

Publications16

  1. ncbi [Dementia: Where are the Lewy bodies?]
    T Lebouvier
    CMRR des Pays de Loire, Hopital Laennec, CHU de Nantes, boulevard Professeur Jacques Monod, 44800 Saint Herblain, France Electronic address
    Rev Neurol (Paris) 169:844-57. 2013
    ..With the avenue of targeted therapies against the protein agregates, new clinical scales able to apprehend the coexistence of Lewy pathology in Alzheimer's disease are expected. ..
  2. pmc Colonic biopsies to assess the neuropathology of Parkinson's disease and its relationship with symptoms
    Thibaud Lebouvier
    UMR 913, INSERM, Nantes, France
    PLoS ONE 5:e12728. 2010
    ....
  3. ncbi Colonic neuropathology is independent of olfactory dysfunction in Parkinson's disease
    Thibaud Lebouvier
    INSERM, U913, Nantes, France
    J Parkinsons Dis 1:389-94. 2011
    ..This suggests that unlike colonic Lewy pathology, OD is unrelated to disease severity. ..
  4. doi Analysis of colonic alpha-synuclein pathology in multiple system atrophy
    Hélène Pouclet
    INSERM, U913, Nantes F 44093, France INSERM, CIC 04, Nantes F 44093, France CHU Nantes, Department of Neurology, F 44093, France
    Parkinsonism Relat Disord 18:893-5. 2012
    ..Aggregates of alpha-synuclein were detected in one out of 6 MSA patients and in 5 out of 9 PD patients. This demonstrates that, despite being less frequent than in PD, alpha-synuclein deposits can be observed in the ENS in MSA...
  5. doi A comparison between rectal and colonic biopsies to detect Lewy pathology in Parkinson's disease
    Hélène Pouclet
    INSERM, U913, Nantes, F 44093, France
    Neurobiol Dis 45:305-9. 2012
    ..Therefore, rectal biopsies have substantially lower sensitivity than ascending colon biopsies to detect Lewy pathology in the gut...
  6. doi [Autonomic nervous system as a source of biomarkers in Parkinson's disease]
    Hélène Pouclet
    INSERM U913, University Nantes, Nantes, France
    Presse Med 41:695-701. 2012
    ..An anatomopathologic PD biomarker would be interesting at different stages of PD: for the positive diagnosis, to follow the progression and to develop neuroprotective treatments...
  7. doi Colonic inflammation in Parkinson's disease
    David Devos
    INSERM, U913, Nantes, F 44093, France
    Neurobiol Dis 50:42-8. 2013
    ..Our findings provide evidence that enteric inflammation occurs in PD and further reinforce the role of peripheral inflammation in the initiation and/or the progression of the disease...
  8. doi α-Synuclein expression is induced by depolarization and cyclic AMP in enteric neurons
    Sébastien Paillusson
    INSERM, U913, Nantes, France
    J Neurochem 115:694-706. 2010
    ..In conclusion, we have identified stimuli leading to α-synuclein over-expression in the ENS, which could be critical in the initiation of the pathological process in PD...
  9. ncbi Prospective evaluation of behavioral scales in the behavioral variant of frontotemporal dementia
    Claire Boutoleau-Bretonnière
    Centre Mémoire Recherche et Ressources CMRR, Nantes, France
    Dement Geriatr Cogn Disord 34:75-82. 2012
    ..Yet, few data are available on the long-term relevance of these scales...
  10. ncbi [Frontal variant of frontotemporal dementia]
    Claire Boutoleau-Bretonnière
    Centre mémoire ressources et recherche, Hopital Laennec, CHU de Nantes, France Labo EMC, EA3082, Université Lyon 2, Bron, France
    Geriatr Psychol Neuropsychiatr Vieil 12:63-73. 2014
    ..The therapeutic hope relies today on potential disease modifying drugs which could ensue from genetic discoveries. ..
  11. doi The second brain and Parkinson's disease
    Thibaud Lebouvier
    INSERM U913, CHU Nantes, Nantes, France
    Eur J Neurosci 30:735-41. 2009
    ..We further discuss the strategies that will help in our understanding of the roles of the enteric nervous system, both in the pathophysiology of the disease and in the pathophysiology of the gastrointestinal symptoms...
  12. doi Diagnostic value of minor salivary glands biopsy for the detection of Lewy pathology
    Emmanuelle Folgoas
    CHU Nantes, Department of Neurology, Nantes, F 44093, France
    Neurosci Lett 551:62-4. 2013
    ..Two control subjects exhibited weak phosphorylated alpha-synuclein immunoreactivity. Our results do not support the use of minor salivary glands biopsy for the detection of Lewy pathology in living subjects. ..
  13. doi Peripheral autonomic nervous system involvement in Gaucher-related parkinsonism
    Thibaud Lebouvier
    INSERM, U913, Nantes, France INSERM, CIC 04, Nantes, France University Nantes, Nantes, France CHU Nantes, Department of Neurology, Nantes, France
    J Parkinsons Dis 4:29-32. 2014
    ..We discuss the consequence of these findings on the pathophysiology of the disease. ..
  14. pmc Biopsable neural tissues: toward new biomarkers for Parkinson's disease?
    Thibaud Lebouvier
    INSERM, U913 Nantes, France
    Front Psychiatry 1:128. 2010
    ..Some of these peripheral tissues, especially the enteric nervous system, by being assessable using routine biopsies, could represent a window to assess in vivo the neuropathological processes occurring in PD...
  15. doi The microtubule-associated protein tau is also phosphorylated on tyrosine
    Thibaud Lebouvier
    INSERM, U913, Nantes, France
    J Alzheimers Dis 18:1-9. 2009
    ..In contrast, there is mounting evidence suggesting that tau tyrosine phosphorylation is an early event in the pathophysiology of AD and that Fyn and c-Abl are critical in the neurodegenerative process which occurs in tauopathies...
  16. doi Value of neuropsychological testing, imaging, and CSF biomarkers for the differential diagnosis and prognosis of clinically ambiguous dementia
    Claire Boutoleau-Bretonnière
    CHU Nantes, Centre de Mémoire et de Ressource et Recherche CM2R, Nantes, France
    J Alzheimers Dis 28:323-36. 2012
    ..Imaging biomarkers mostly contribute to the differential diagnosis between non-AD dementias. Initial neuropsychological testing was poorly contributive in CAD diagnosis...