Lebon G, Edwards P, Leslie A, Tate C. Molecular Determinants of CGS21680 Binding to the Human Adenosine A2A Receptor. Mol Pharmacol. 2015;87:907-15 pubmed publisher
..Mutation of amino acid residues Ser67(2.65), Glu169(EL2), and His264(EL3), and analysis of receptor activation either in the presence or absence of ligands implicates this region in modulating the level of basal activity of A(2A)R. ..
Nasrallah C, Rottier K, Marcellin R, Compan V, Font J, Llebaria A, et al
. Direct coupling of detergent purified human mGlu5 receptor to the heterotrimeric G proteins Gq and Gs. Sci Rep. 2018;8:4407 pubmed publisher
..Our findings provide important mechanistic insights into mGlu5 G protein-dependent activity and selectivity. ..
Song O, Kim H, Jouny S, Ricard I, Vandeputte A, Deboosere N, et al
. A Bacterial Toxin with Analgesic Properties: Hyperpolarization of DRG Neurons by Mycolactone. Toxins (Basel). 2017;9: pubmed publisher
..This result points towards novel ATâ‚‚R-dependent signaling pathways in DRG neurons underlying the analgesic effect of mycolactone, with the perspective for the development of new types of nature-inspired analgesics. ..