Ronan Le Goffic

Summary

Publications:
Kechaou, N., Chain, F., Gratadoux, J.J., Blugeon, S., Bertho, N., Chevalier, C., Le Goffic, R., Molimard, P., Chatel, J.M., Langella, P. and Bermudez-Humaran, L.G.
"Identification of one Novel Candidate Probiotic Lactobacillus plantarum Strain Active Against Influenza Virus Infection in Mice using a Large Scale Screening." Appl Environ Microbiol (2013).

Leymarie, O., Jouvion, G., Hervé, P., Chevalier, C., Lorin, V., Lecardonnel, J., Da Costa, B., Delmas, B., Escriou, N. and Le Goffic, R.
"Kinetic characterization of PB1-F2-mediated immunopathology during highly pathogenic avian H5N1 influenza virus infection." PLoS One (2013) Sous presse.

Vidic, J., Stankic, S., Ciric, D., Haque, F., Le Goffic, R., Vidy, A., Jupille, J. and Delmas, B.
"Selective cytotoxic effects of mixed ZnMgO nanoparticles on bacterial cells." J Nanopart Res (2013) In Press.

Le Goffic, R., Arshad, M.I., Rauch, M., LHelgoualch, A., Delmas, B., Piquet-Pellorce, C. and Samson, M.
"Influenza Virus Infection Induces IL-33 in Mouse Lungs." Am J Respir Cell Mol Biol (2011).

Le Goffic, R., Leymarie, O., Chevalier, C., Rebours, E., Da Costa, B., Vidic, J., Descamps, D., Sallenave, J.M., Rauch, M., Samson, M. and Delmas, B.
"Transcriptomic Analysis of Host Immune and Cell Death Responses Associated with the Influenza A Virus PB1-F2 Protein." PLoS Pathog (2011) 7(8): e1002202.

Chevalier, C., Al Bazzal, A., Vidic, J., Fevrier, V., Bourdieu, C., Bouguyon, E., Le Goffic, R., Vautherot, J.F., Bernard, J., Moudjou, M., Noinville, S., Chich, J.F., Da Costa, B., Rezaei, H. and Delmas, B.
"PB1-F2 influenza A virus protein adopts a beta-sheet conformation and forms amyloid fibers in membrane environments." J Biol Chem (2010) 285(17): 13233-43.

Le Goffic, R., Bouguyon, E., Chevalier, C., Vidic, J., Da Costa, B., Leymarie, O., Bourdieu, C., Decamps, L., Dhorne-Pollet, S. and Delmas, B.
"Influenza A virus protein PB1-F2 exacerbates IFN-beta expression of human respiratory epithelial cells." J Immunol (2010) 185(8): 4812-23.

Ventura, G.M., Le Goffic, R., Balloy, V., Plotkowski, M.C., Chignard, M. and Si-Tahar, M.
"TLR 5, but neither TLR2 nor TLR4, is involved in lung epithelial cell response to Burkholderia cenocepacia." FEMS Immunol Med Microbiol (2008) 54(1): 37-44.

Le Goffic, R., Pothlichet, J., Vitour, D., Fujita, T., Meurs, E., Chignard, M. and Si-Tahar, M.
"Cutting Edge: Influenza A virus activates TLR3-dependent inflammatory and RIG-I-dependent antiviral responses in human lung epithelial cells." J Immunol (2007) 178(6): 3368-72.

Raymond, B., Leduc, D., Ravaux, L., Le Goffic, R., Candela, T., Raymondjean, M., Goossens, P.L. and Touqui, L.
"Edema toxin impairs anthracidal phospholipase A2 expression by alveolar macrophages." PLoS Pathog (2007) 3(12): e187.

Le Goffic, R., Balloy, V., Lagranderie, M., Alexopoulou, L., Escriou, N., Flavell, R., Chignard, M. and Si-Tahar, M.
"Detrimental contribution of the Toll-like receptor (TLR)3 to influenza A virus-induced acute pneumonia." PLoS Pathog (2006) 2(6): e53.

Guillot, L., Le Goffic, R., Bloch, S., Escriou, N., Akira, S., Chignard, M. and Si-Tahar, M.
"Involvement of toll-like receptor 3 in the immune response of lung epithelial cells to double-stranded RNA and influenza A virus." J Biol Chem (2005) 280(7): 5571-80.

Irla, M., Puthier, D., Le Goffic, R., Victorero, G., Freeman, T., Naquet, P., Samson, M. and Nguyen, C.
"Spatial, a new nuclear factor tightly regulated during mouse spermatogenesis." Gene Expr Patterns (2003) 3(2): 135-8.

Le Goffic, R., Mouchel, T., Ruffault, A., Patard, J.J., Jegou, B. and Samson, M.
"Mumps virus decreases testosterone production and gamma interferon-induced protein 10 secretion by human leydig cells." J Virol (2003) 77(5): 3297-300.

Oyhenart, J., Le Goffic, R., Samson, M., Jegou, B. and Raich, N.
"Phtf1 is an integral membrane protein localized in an endoplasmic reticulum domain in maturing male germ cells." Biol Reprod (2003) 68(3): 1044-53.

Le Goffic, R., Mouchel, T., Aubry, F., Patard, J.J., Ruffault, A., Jegou, B. and Samson, M.
"Production of the chemokines monocyte chemotactic protein-1, regulated on activation normal T cell expressed and secreted protein, growth-related oncogene, and interferon-gamma-inducible protein-10 is induced by the Sendai virus in human and rat testicular cells." Endocrinology (2002) 143(4): 1434-40.

Mouchel, T., Le Goffic, R., Patard, J.J. and Samson, M.
"[Mumps virus and orchitis: towards a physiopathologic approach]." Prog Urol (2002) 12(1): 124-8.


Publications

  1. ncbi request reprint [Mumps virus and orchitis: towards a physiopathologic approach]
    Thomas Mouchel
    INSERM U 435 GERM, Campus de Beaulieu, Universite de Rennes, France
    Prog Urol 12:124-8. 2002
  2. doi request reprint Influenza A virus protein PB1-F2 exacerbates IFN-beta expression of human respiratory epithelial cells
    Ronan Le Goffic
    Unite de Virologie et Immunologie Moleculaires, Unité de Recherche 892 Institut National de la Recherche Agronomique, Domaine de Vilvert, Jouy en Josas, France
    J Immunol 185:4812-23. 2010
  3. pmc PB1-F2 influenza A virus protein adopts a beta-sheet conformation and forms amyloid fibers in membrane environments
    Christophe Chevalier
    Institut National de la Recherche Agronomique, Unite de Virologie et Immunologie Moleculaires, UR892, Domaine de Vilvert, F 78350 Centre de Jouy en Josas, France
    J Biol Chem 285:13233-43. 2010
  4. doi request reprint TLR 5, but neither TLR2 nor TLR4, is involved in lung epithelial cell response to Burkholderia cenocepacia
    Grasiella M de C Ventura
    Institut Pasteur, Unité de Défense Innée et Inflammation, Paris, France
    FEMS Immunol Med Microbiol 54:37-44. 2008
  5. pmc Edema toxin impairs anthracidal phospholipase A2 expression by alveolar macrophages
    Benoit Raymond
    Institut Pasteur, Unité de Défense Innée et Inflammation, Paris, France
    PLoS Pathog 3:e187. 2007
  6. ncbi request reprint Cutting Edge: Influenza A virus activates TLR3-dependent inflammatory and RIG-I-dependent antiviral responses in human lung epithelial cells
    Ronan Le Goffic
    Unité de Défense Innée et Inflammation, INSERM Unité 874, Institut Pasteur, 25 rue du Dr Roux, 75015 Paris, France
    J Immunol 178:3368-72. 2007
  7. pmc Detrimental contribution of the Toll-like receptor (TLR)3 to influenza A virus-induced acute pneumonia
    Ronan Le Goffic
    Institut Pasteur, Unité de Défense Innée et Inflammation, Paris, France
    PLoS Pathog 2:e53. 2006
  8. ncbi request reprint Involvement of toll-like receptor 3 in the immune response of lung epithelial cells to double-stranded RNA and influenza A virus
    Loic Guillot
    Unité de Défense Innée et Inflammation, INSERM E336, Paris, France
    J Biol Chem 280:5571-80. 2005
  9. ncbi request reprint Spatial, a new nuclear factor tightly regulated during mouse spermatogenesis
    Magali Irla
    ERM 206 INSERM, faculté de science de Luminy, Universite de la Mediterranee, Case 906, Parc Scientifique de Luminy, F 13288 Marseille Cedex 9, IFR57, France
    Gene Expr Patterns 3:135-8. 2003
  10. ncbi request reprint Phtf1 is an integral membrane protein localized in an endoplasmic reticulum domain in maturing male germ cells
    J Oyhenart
    INSERM U 567 CNRS UMR 8104, Institut Cochin, Departement d Hematologie, Maternité de Port Royal, Universite Rene Descartes, 75014 Paris, France
    Biol Reprod 68:1044-53. 2003

Collaborators

Detail Information

Publications12

  1. ncbi request reprint [Mumps virus and orchitis: towards a physiopathologic approach]
    Thomas Mouchel
    INSERM U 435 GERM, Campus de Beaulieu, Universite de Rennes, France
    Prog Urol 12:124-8. 2002
    ....
  2. doi request reprint Influenza A virus protein PB1-F2 exacerbates IFN-beta expression of human respiratory epithelial cells
    Ronan Le Goffic
    Unite de Virologie et Immunologie Moleculaires, Unité de Recherche 892 Institut National de la Recherche Agronomique, Domaine de Vilvert, Jouy en Josas, France
    J Immunol 185:4812-23. 2010
    ....
  3. pmc PB1-F2 influenza A virus protein adopts a beta-sheet conformation and forms amyloid fibers in membrane environments
    Christophe Chevalier
    Institut National de la Recherche Agronomique, Unite de Virologie et Immunologie Moleculaires, UR892, Domaine de Vilvert, F 78350 Centre de Jouy en Josas, France
    J Biol Chem 285:13233-43. 2010
    ..All of these observations suggest that PB1-F2 could be involved in physiological processes through different pathways, permeabilization of cellular membranes, and amyloid fiber formation...
  4. doi request reprint TLR 5, but neither TLR2 nor TLR4, is involved in lung epithelial cell response to Burkholderia cenocepacia
    Grasiella M de C Ventura
    Institut Pasteur, Unité de Défense Innée et Inflammation, Paris, France
    FEMS Immunol Med Microbiol 54:37-44. 2008
    ..cenocepacia-induced lung epithelial inflammatory response...
  5. pmc Edema toxin impairs anthracidal phospholipase A2 expression by alveolar macrophages
    Benoit Raymond
    Institut Pasteur, Unité de Défense Innée et Inflammation, Paris, France
    PLoS Pathog 3:e187. 2007
    ..Our study, therefore, describes a new molecular mechanism implemented by B. anthracis to escape innate host defense. These pioneering data will provide new molecular targets for future intervention against this deadly pathogen...
  6. ncbi request reprint Cutting Edge: Influenza A virus activates TLR3-dependent inflammatory and RIG-I-dependent antiviral responses in human lung epithelial cells
    Ronan Le Goffic
    Unité de Défense Innée et Inflammation, INSERM Unité 874, Institut Pasteur, 25 rue du Dr Roux, 75015 Paris, France
    J Immunol 178:3368-72. 2007
    ..We demonstrate that the sensing of IAV by TLR3 primarily regulates a proinflammatory response, whereas RIG-I (but not MDA-5) mediates both a type I IFN-dependent antiviral signaling and a proinflammatory response...
  7. pmc Detrimental contribution of the Toll-like receptor (TLR)3 to influenza A virus-induced acute pneumonia
    Ronan Le Goffic
    Institut Pasteur, Unité de Défense Innée et Inflammation, Paris, France
    PLoS Pathog 2:e53. 2006
    ..Hence, to our knowledge, our findings show for the first time that TLR3-IAV interaction critically contributes to the debilitating effects of a detrimental host inflammatory response...
  8. ncbi request reprint Involvement of toll-like receptor 3 in the immune response of lung epithelial cells to double-stranded RNA and influenza A virus
    Loic Guillot
    Unité de Défense Innée et Inflammation, INSERM E336, Paris, France
    J Biol Chem 280:5571-80. 2005
    ....
  9. ncbi request reprint Spatial, a new nuclear factor tightly regulated during mouse spermatogenesis
    Magali Irla
    ERM 206 INSERM, faculté de science de Luminy, Universite de la Mediterranee, Case 906, Parc Scientifique de Luminy, F 13288 Marseille Cedex 9, IFR57, France
    Gene Expr Patterns 3:135-8. 2003
    ..Thus, this recently described nuclear factor constitutes a new marker of the round spermatid stage that may play a key role in the control of male germ cell development...
  10. ncbi request reprint Phtf1 is an integral membrane protein localized in an endoplasmic reticulum domain in maturing male germ cells
    J Oyhenart
    INSERM U 567 CNRS UMR 8104, Institut Cochin, Departement d Hematologie, Maternité de Port Royal, Universite Rene Descartes, 75014 Paris, France
    Biol Reprod 68:1044-53. 2003
    ..It could help to elucidate the morphogenic events connected with the transformation of spermatogenic cells...
  11. pmc Mumps virus decreases testosterone production and gamma interferon-induced protein 10 secretion by human leydig cells
    Ronan Le Goffic
    INSERM U 435 GERM, Universite de Rennes I, Campus de Beaulieu, 35042 Rennes, France
    J Virol 77:3297-300. 2003
    ..Moreover, we show that gamma interferon-induced protein 10 (IP-10) is highly expressed by mumps virus-infected Leydig cells and that ribavirin does not block IP-10 production...
  12. pmc Transcriptomic analysis of host immune and cell death responses associated with the influenza A virus PB1-F2 protein
    Ronan Le Goffic
    Unite de Virologie et Immunologie Moleculaires, UR 892 INRA, Jouy en Josas, France
    PLoS Pathog 7:e1002202. 2011
    ..Collectively, these data demonstrate that PB1-F2 strongly influences the early host response during IAV infection and provides new insights into the mechanisms by which PB1-F2 mediates virulence...