Research Topics
Species | Xavier PuechalSummaryAffiliation: Le Mans Country: France Publications
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Detail Information
Publications
Rituximab therapy for systemic vasculitis associated with rheumatoid arthritis: Results from the AutoImmunity and Rituximab RegistryX Puechal
Le Mans General Hospital, Le Mans, and Cochin Hospital, Paris, France
Arthritis Care Res (Hoboken) 64:331-9. 2012..We assessed the efficacy and safety of rituximab in a real-life clinical setting among patients with systemic rheumatoid vasculitis (SRV)...
CTLA-4 +49A/G and CT60 gene polymorphisms in primary Sjögren syndromeJacques Eric Gottenberg
Rhumatologie, Institut Pour la Santé et la Recherche Médicale U802, Universite Paris Sud 11, Hopital Bicetre, 78 rue du General Leclerc, Assistance Publique Hopitaux de Paris, 94275 Le Kremlin Bicetre, France
Arthritis Res Ther 9:R24. 2007..In fact, sampling bias may account for some contradictory results previously reported for CTLA-4 association studies in autoimmune diseases...
Whipple disease and arthritisX Puechal
Service de Rhumatologie, Centre Hospitalier du Mans, Le Mans, France
Curr Opin Rheumatol 13:74-9. 2001..It may also allow earlier diagnosis, thereby preventing the development of the severe systemic and sometimes fatal forms of the disease...- Antineutrophil cytoplasmic antibody-associated vasculitidesXavier Puechal
Rheumatology Department, Centre Hospitalier Le Mans, 194, avenue Rubillard, 72037 Le Mans Cedex 9, France
Joint Bone Spine 74:427-35. 2007..Biotherapies such as rituximab and TNFalpha antagonists are currently under evaluation as promising rescue agents for patients with refractory disease... - Anti-tumour necrosis factor treatment in patients with refractory systemic vasculitis associated with rheumatoid arthritisX Puechal
Department of Rheumatology, Le Mans General Hospital, Le Mans, France
Ann Rheum Dis 67:880-4. 2008..To assess anti-tumour necrosis factor (anti-TNF) agents in patients with refractory systemic rheumatoid vasculitis (SRV)... - Churg-Strauss syndrome associated with omalizumabXavier Puechal
Department of Rheumatology, Le Mans General Hospital, 194 avenue Rubillard, 72000 Le Mans, France
Eur J Intern Med 19:364-6. 2008..Given the possible role of omalizumab in the development of this vasculitis in our patient, we recommend careful monitoring of the appearance of Churg-Strauss symptoms and rising eosinophil count in patients treated with omalizumab... - [Whipple's disease]X Puechal
Service de Rhumatologie, Centre Hospitalier du Mans, 72037 Le Mans Cedex 9, France
Rev Med Interne 30:233-41. 2009.... - What should be done in case of persistent symptoms after adequate antibiotic treatment for Lyme disease?Xavier Puechal
Service de Rhumatologie, Centre Hospitalier du Mans, Le Mans, France
Curr Probl Dermatol 37:191-9. 2009..If a diagnosis is made for which no specific treatment can be proposed, emotional support and management of pain, fatigue and other symptoms is required... - Tocilizumab in refractory adult Still's diseaseXavier Puechal
Le Mans General Hospital, Le Mans, France
Arthritis Care Res (Hoboken) 63:155-9. 2011..We report the first series of patients with ASD treated with tocilizumab (TCZ), a humanized anti-IL-6 receptor antibody... - Mutations of the cystic fibrosis gene in patients with bronchiectasis associated with rheumatoid arthritisXavier Puechal
Center for Rare Systemic Auto immune Diseases, Department of Rheumatology, Centre Hospitalier du Mans, 194 avenue Rubillard, 72000 Le Mans, France
Ann Rheum Dis 70:653-9. 2011..DB is also associated with other diseases including rheumatoid arthritis (RA) in which the role of genetic factors in the predisposition to DB remains unclear... - Cultivation of Tropheryma whipplei from the synovial fluid in Whipple's arthritisXavier Puechal
Le Mans General Hospital, Le Mans, France
Arthritis Rheum 56:1713-8. 2007..Antibiotic treatment was instituted in the patient, after which his symptoms remitted. These findings show for the first time that Whipple's arthritis may be, at least in some cases, a septic arthritis... - [Non antibiotic treatments of Lyme borreliosis]X Puechal
Service de Rhumatologie, Centre Hospitalier du Mans, 194, avenue Rubillard, 72037 Le Mans cedex 09, France
Med Mal Infect 37:473-8. 2007..Corticosteroids are not indicated in Lyme's disease. In post Lyme's disease syndrome, patient complaints may lead to a multidisciplinary therapeutic management and the use of neuro-psychiatric drugs... - Thromboangiitis obliterans or Buerger's disease: challenges for the rheumatologistX Puechal
Rheumatology Department, Le Mans General Hospital, Le Mans, France
Rheumatology (Oxford) 46:192-9. 2007..Blockade with antagonists of cannabinoid or endothelin receptors and the use of gene- or cell-based therapy to induce therapeutic angiogenesis have opened up new possibilities for treatment... - Whipple's diseaseXavier Puechal
Department of Rheumatology, Centre Hospitalier du Mans, Le Mans, France
Joint Bone Spine 69:133-40. 2002..Another hope is that the diagnosis will be made earlier, before the development of potentially fatal systemic complications... - Evaluation of two strategies (initial methotrexate monotherapy vs its combination with adalimumab) in management of early active rheumatoid arthritis: data from the GUEPARD trialMartin Soubrier
Department of Rheumatology, Hopital G Montpied, 63003 Clermont Ferrand, France
Rheumatology (Oxford) 48:1429-34. 2009..To compare this strategy with an initial combination of MTX and adalimumab (ADA) given for 3 months and then adjusted based on the disease activity status... - Azathioprine or methotrexate maintenance for ANCA-associated vasculitisChristian Pagnoux
Universite Paris Descartes, Hopital Cochin, Assistance Publique Hopitaux de Paris, Paris, France
N Engl J Med 359:2790-803. 2008..However, azathioprine and methotrexate have not been compared with regard to safety and efficacy... - Treatment of Churg-Strauss syndrome without poor-prognosis factors: a multicenter, prospective, randomized, open-label study of seventy-two patientsCamillo Ribi
Hopital Cochin, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, Paris, France
Arthritis Rheum 58:586-94. 2008.... - Prediction of response to disease modifying antirheumatic drugs in rheumatoid arthritisJean Francis Maillefert
INSERM U887, Department of Rheumatology, Hopital General, Dijon University Hospital, University of Burgundy, 3, rue du Fb Raines, 21078 Dijon, France
Joint Bone Spine 77:558-63. 2010..To investigate potential predictors of response to conventional DMARDs in RA... - How to treat refractory arthritis in lupus?Mathieu Artifoni
Center for Rare Systemic Auto immune Diseases, Department of Rheumatology, Le Mans General Hospital, 194, avenue Rubillard, 72000 Le Mans, France
Joint Bone Spine 79:347-50. 2012..As a last resort, after having weighed up the individual benefit-risk ratio, leflunomide, belimumab, rituximab or abatacept may be considered, on a case-by-case basis, and anti-TNF antibodies may be considered in exceptional cases... - Pneumomediastinum in interstitial lung disease associated with dermatomyositis and polymyositisBenoit Le Goff
Le Mans General Hospital, Le Mans, France
Arthritis Rheum 61:108-18. 2009..Spontaneous pneumomediastinum is a rare complication of dermatomyositis (DM) and polymyositis (PM). The aim of this study was to characterize this complication and determine its prognostic factors... - TNF alpha antagonist therapy and safety monitoringThao Pham
Rheumatology Department, CHU Sainte Marguerite, Marseille, France
Joint Bone Spine 78:15-185. 2011..To develop and/or update fact sheets about TNFα antagonists treatments, in order to assist physicians in the management of patients with inflammatory joint disease... - Whipple disease revealed by lung involvement: a case report and literature reviewGeoffrey Urbanski
Center for Rare Systemic Auto immune Diseases, Le Mans General Hospital, Le Mans, France
Chest 141:1595-8. 2012..The association of mediastinal adenopathy or pleural effusion offers additional concern. Whipple disease may be fatal in the absence of treatment, but prolonged antibiotic treatment often leads to complete remission... - Recommendations of the French Society for Rheumatology. TNFalpha antagonist therapy in rheumatoid arthritisBruno Fautrel
Service de Rhumatologie, Groupe Hospitalier Pitie Salpetriere, UFR de Medecine, Universite Pierre et Marie Curie Paris VI, 83, Boulevard de l Hopital, 75651 Paris Cedex 13, France
Joint Bone Spine 73:433-41. 2006..To develop recommendations for TNFalpha-antagonist therapy in patients with rheumatoid arthritis (RA) seen in everyday practice, under the aegis of the French Society for Rheumatology... - Tocilizumab: therapy and safety managementThao Pham
Service de Rhumatologie, CHU Conception, Marseille, France
Joint Bone Spine 77:S3-100. 2010..To develop fact sheets about tocilizumab, in order to assist physicians in the management of patients with inflammatory joint disease... - Comparison of in vitro-specific blood tests with tuberculin skin test for diagnosis of latent tuberculosis before anti-TNF therapyJeremie Sellam
Service de Rhumatologie, Hopital de Bicetre, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre, France
Ann Rheum Dis 66:1610-5. 2007..We aimed to investigate in vitro blood assays with TB-specific antigens (CFP-10, ESAT-6), in immune-mediated inflammatory diseases (IMID) for LTBI screening... - Eosinophilic granulomatosis with polyangiitis (Churg-Strauss): clinical characteristics and long-term followup of the 383 patients enrolled in the French Vasculitis Study Group cohortCloé Comarmond
Hopital Cochin, AP HP, and Universite Paris Descartes, Paris 5, Paris, France
Arthritis Rheum 65:270-81. 2013..This study was undertaken to describe the main characteristics of a larger patient cohort and their long-term outcomes... - Inefficacy of infliximab in primary Sjögren's syndrome: results of the randomized, controlled Trial of Remicade in Primary Sjögren's Syndrome (TRIPSS)Xavier Mariette
Service de Rhumatologie, Hôpital de Bicêtre AP HP, and Université Paris Sud, Le Kremlin Bicetre, France
Arthritis Rheum 50:1270-6. 2004..Since tumor necrosis factor alpha (TNF alpha) could be a key element in the pathogenesis of primary SS, we conducted a multicenter, randomized, double-blind, placebo-controlled trial to evaluate the effect of infliximab in primary SS... - Antineutrophil cytoplasmic antibodies and the Churg-Strauss syndromeRégis Sablé-Fourtassou
Hopital Cochin, Assistance Publique Hopitaux de Paris, Universite Paris 5 Rene Descartes, Paris, France
Ann Intern Med 143:632-8. 2005..Since testing for antineutrophil cytoplasmic antibodies (ANCA) became available for routine evaluation, no large homogeneous cohort of patients with the Churg-Strauss syndrome has been studied... - Panton-Valentine leukocidin-producing Staphylococcus aureus infections: report of 4 French casesCarine Salliot
Service de Médecine Interne et Rhumatologie et, Groupe Hospitalier Diaconesses La Croix Saint Simon, Paris, France
Scand J Infect Dis 38:192-5. 2006..These cases highlight the need to screen for PVL in patients with serious staphylococcal infections. All patients were cured. Two of them received intravenous immunoglobulins in addition to antibiotics... - Cardiovascular risk and rheumatoid arthritis: clinical practice guidelines based on published evidence and expert opinionThao Pham
Service de Rhumatologie, CHU de la Conception, Marseille, France
Joint Bone Spine 73:379-87. 2006....