Philippe Le Bouteiller

Summary

Country: France

Publications

  1. ncbi request reprint [Immunity of pregnancy: novel concepts]
    Philippe Le Bouteiller
    INSERM U563, Centre de Physiopathologie de Toulouse Purpan, B and t A, CHU Purpan, B 3028 31024 Toulouse Cedex 3
    Bull Acad Natl Med 193:1029-41; discussion 1041-2, 1067-8. 2009
  2. pmc A novel antiangiogenic and vascular normalization therapy targeted against human CD160 receptor
    Sophie Chabot
    Institut National de la Santé et de la Recherche Médicale U1043, F 31300 Toulouse, France
    J Exp Med 208:973-86. 2011
  3. doi request reprint The human decidual NK-cell response to virus infection: what can we learn from circulating NK lymphocytes?
    Philippe Le Bouteiller
    Institut National de la Sante et de la Recherche Medicale, UMR 1043, Toulouse 31300, France
    J Reprod Immunol 88:170-5. 2011
  4. doi request reprint CD160: a unique activating NK cell receptor
    Philippe Le Bouteiller
    Institut National de la Sante et de la Recherche Medicale, UMR1043, Toulouse F 31300, France
    Immunol Lett 138:93-6. 2011
  5. ncbi request reprint Soluble HLA-G and control of angiogenesis
    Philippe Le Bouteiller
    INSERM U563, Centre de Physiopathologie de Toulouse Purpan, Toulouse F 31300, France
    J Reprod Immunol 76:17-22. 2007
  6. ncbi request reprint HLA class I/NK cell receptor interaction in early human decidua basalis: possible functional consequences
    Magali Rabot
    INSERM U563, Hopital Purpan, Toulouse, France
    Chem Immunol Allergy 89:72-83. 2005
  7. ncbi request reprint Soluble HLA-G1 inhibits angiogenesis through an apoptotic pathway and by direct binding to CD160 receptor expressed by endothelial cells
    Pierre Fons
    Institut de Pharmacologie et Biologie Structurale, Centre National de la Recherche Scientifique, UMR 5089, INSERM U563, Bat A, Hopital Purpan, BP3028, 31024 Toulouse Cedex 3, France
    Blood 108:2608-15. 2006
  8. pmc Human cytomegalovirus infection elicits new decidual natural killer cell effector functions
    Johan Siewiera
    Institut National de la Sante et de la Recherche Medicale, UMR 1043, Toulouse, France
    PLoS Pathog 9:e1003257. 2013
  9. ncbi request reprint Differential down-modulation of HLA-G and HLA-A2 or -A3 cell surface expression following human cytomegalovirus infection
    Nathalie Pizzato
    Centre de Physiopathologie Toulouse Purpan, INSERM U563, Hopital Purpan, 31059 Toulouse Cedex 3, France
    J Reprod Immunol 62:3-15. 2004
  10. ncbi request reprint HLA-G, pre-eclampsia, immunity and vascular events
    Philippe Le Bouteiller
    INSERM U563, Centre de Physiopathologie Toulouse Purpan, Bat A, Hopital Purpan, Cedex 3, 31059 Toulouse, France
    J Reprod Immunol 59:219-34. 2003

Collaborators

Detail Information

Publications23

  1. ncbi request reprint [Immunity of pregnancy: novel concepts]
    Philippe Le Bouteiller
    INSERM U563, Centre de Physiopathologie de Toulouse Purpan, B and t A, CHU Purpan, B 3028 31024 Toulouse Cedex 3
    Bull Acad Natl Med 193:1029-41; discussion 1041-2, 1067-8. 2009
    ....
  2. pmc A novel antiangiogenic and vascular normalization therapy targeted against human CD160 receptor
    Sophie Chabot
    Institut National de la Santé et de la Recherche Médicale U1043, F 31300 Toulouse, France
    J Exp Med 208:973-86. 2011
    ..These studies validate CD160 as a potential new target in cases of human pathological ocular and tumor neoangiogenesis that do not respond or become resistant to existing antiangiogenic drugs...
  3. doi request reprint The human decidual NK-cell response to virus infection: what can we learn from circulating NK lymphocytes?
    Philippe Le Bouteiller
    Institut National de la Sante et de la Recherche Medicale, UMR 1043, Toulouse 31300, France
    J Reprod Immunol 88:170-5. 2011
    ..viral-mediated signal(s) and molecular interactions may subvert inhibition of dNK cytotoxic potential? Does uterine viral infection promote decidual NK cell secretion of cytokines and chemokines that boost the anti-viral immune response?..
  4. doi request reprint CD160: a unique activating NK cell receptor
    Philippe Le Bouteiller
    Institut National de la Sante et de la Recherche Medicale, UMR1043, Toulouse F 31300, France
    Immunol Lett 138:93-6. 2011
    ..The level of CD160-mediated IFN-γ production is always higher than the one observed after engagement of the CD16 receptor...
  5. ncbi request reprint Soluble HLA-G and control of angiogenesis
    Philippe Le Bouteiller
    INSERM U563, Centre de Physiopathologie de Toulouse Purpan, Toulouse F 31300, France
    J Reprod Immunol 76:17-22. 2007
    ....
  6. ncbi request reprint HLA class I/NK cell receptor interaction in early human decidua basalis: possible functional consequences
    Magali Rabot
    INSERM U563, Hopital Purpan, Toulouse, France
    Chem Immunol Allergy 89:72-83. 2005
    ..Instead they are able to secrete cytokines which are likely to be beneficial for the placental development, maternal uterine spiral arteries remodeling, and the antiviral immune response...
  7. ncbi request reprint Soluble HLA-G1 inhibits angiogenesis through an apoptotic pathway and by direct binding to CD160 receptor expressed by endothelial cells
    Pierre Fons
    Institut de Pharmacologie et Biologie Structurale, Centre National de la Recherche Scientifique, UMR 5089, INSERM U563, Bat A, Hopital Purpan, BP3028, 31024 Toulouse Cedex 3, France
    Blood 108:2608-15. 2006
    ....
  8. pmc Human cytomegalovirus infection elicits new decidual natural killer cell effector functions
    Johan Siewiera
    Institut National de la Sante et de la Recherche Medicale, UMR 1043, Toulouse, France
    PLoS Pathog 9:e1003257. 2013
    ....
  9. ncbi request reprint Differential down-modulation of HLA-G and HLA-A2 or -A3 cell surface expression following human cytomegalovirus infection
    Nathalie Pizzato
    Centre de Physiopathologie Toulouse Purpan, INSERM U563, Hopital Purpan, 31059 Toulouse Cedex 3, France
    J Reprod Immunol 62:3-15. 2004
    ..Such limited down-modulation of HLA-G may have functional consequences in term of innate immunity against congenital HCMV infection...
  10. ncbi request reprint HLA-G, pre-eclampsia, immunity and vascular events
    Philippe Le Bouteiller
    INSERM U563, Centre de Physiopathologie Toulouse Purpan, Bat A, Hopital Purpan, Cedex 3, 31059 Toulouse, France
    J Reprod Immunol 59:219-34. 2003
    ..In view of these different HLA-G properties, we will briefly discuss how defective HLA-G function may contribute to the low trophoblast invasion and vascular abnormalities observed in pre-eclamptic placentas...
  11. doi request reprint Effector functions of human decidual NK cells in healthy early pregnancy are dependent on the specific engagement of natural cytotoxicity receptors
    Hicham El Costa
    Institut National de la Sante et de la Recherche Medicale, U563, Toulouse, F 31300, France
    J Reprod Immunol 82:142-7. 2009
    ..Whether such NKG2A-mediated inhibition is abolished during pregnancies complicated by pathologies including viral infection is an interesting hypothesis that remains to be tested...
  12. ncbi request reprint Down-regulation of HLA-G1 cell surface expression in human cytomegalovirus infected cells
    Nathalie Pizzato
    INSERM U563, Centre de Physiopathologie Toulouse Purpan, Toulouse, France
    Am J Reprod Immunol 50:328-33. 2003
    ..To explore the level of HLA-G1 cell surface expression after HCMV infection and to investigate the influence of US viral proteins, we infected HLA-G1 expressing cells by HCMV laboratory strains...
  13. ncbi request reprint The HLA-G*0105N null allele induces cell surface expression of HLA-E molecule and promotes CD94/NKG2A-mediated recognition in JAR choriocarcinoma cell line
    Frederic G Sala
    Institut National de la Santé et de la Recherche Médicale U 563, Centre de Physiopathologie de Toulouse Purpan, Hopital Purpan, BP 3028, 31024 Toulouse Cedex 3, France
    Immunogenetics 56:617-24. 2004
    ..Using the NKL cell line in a standard (51)Cr release assay, the HLA-E molecules were found to inhibit natural killer lysis, through a mechanism partially dependent on CD94/NKG2A-mediated recognition...
  14. doi request reprint Human NK cells in pregnant uterus: why there?
    Philippe Le Bouteiller
    INSERM, U563, Centre de Physiopathologie de Toulouse Purpan, Toulouse, France
    Am J Reprod Immunol 59:401-6. 2008
    ..Finally, uterine NK cells are likely to be an important component of the local maternal immune response to pathogen infections...
  15. ncbi request reprint Engagement of the CD160 activating NK cell receptor leads to its association with CD2 in circulating human NK cells
    Magali Rabot
    INSERM U563, CHU Purpan, Toulouse, France
    Transpl Immunol 17:36-8. 2006
    ..These results demonstrate that CD160 activating NK cell receptor, upon its specific engagement, physically associates to the CD2 co-activating receptor present in the lipid raft that might play a role as signaling molecule...
  16. ncbi request reprint Induction of HLA-G-restricted human cytomegalovirus pp65 (UL83)-specific cytotoxic T lymphocytes in HLA-G transgenic mice
    Francoise Lenfant
    INSERM U 563, Centre de Physiopathologie de Toulouse Purpan, Hopital Purpan, 31059 Toulouse Cedex 3, France
    J Gen Virol 84:307-17. 2003
    ..The weak HLA-G-restricted anti-HCMV response is probably due to HLA-G-mediated inhibitory signals on the development of an antiviral CTL response...
  17. ncbi request reprint BCR/ABL oncogene directly controls MHC class I chain-related molecule A expression in chronic myelogenous leukemia
    Nicolas Boissel
    Institut National de la Sante et de la Recherche Medicale, Unité 622, Centre d Investigations Biomedicales, Laboratoire d Immunologie et d Histocompatibilité, Hopital Saint Louis, Paris, France
    J Immunol 176:5108-16. 2006
    ..These data provide evidence for direct control of MICA expression by an oncogene in human malignancy and indicate that posttranscriptional mechanisms may participate in the regulation of MICA expression...
  18. ncbi request reprint Soluble HLA-G and embryo implantation: frequently asked questions
    Philippe Le Bouteiller
    INSERM U563, Hopital Purpan, Toulouse, France
    Gynecol Obstet Invest 64:134-7. 2007
    ..culture supernatants? (2) Where do these sHLA-G molecules come from? (3) Why are some preimplantation embryos 'HLA-G secretors' and others not? (4) How might the functions exerted by sHLA-G molecules influence embryonic implantation?..
  19. ncbi request reprint Human villous trophoblast and the lack of intron 4-retaining soluble HLA-G secretion: beware of possible methodological biases
    Philippe Le Bouteiller
    INSERM U563, Hopital Purpan, Toulouse, France
    Mol Hum Reprod 11:711-3. 2005
  20. ncbi request reprint [Immunology of pregnancy: renewed interest]
    Philippe Le Bouteiller
    Inserm U563 Université Paul Sabatier, Hopital Purpan, Batiment A, BP 3028, 31024 Toulouse Cedex 3, France
    Med Sci (Paris) 22:745-50. 2006
    ....
  21. ncbi request reprint Commentary. Major breakthrough in the HLA-G debate: occurrence of pregnancy in human depends on the HLA-G status of preimplantation embryos
    Philippe Le Bouteiller
    INSERM U395, CHU Purpan, BP 3028, 31024 Toulouse Cedex 3, France
    Eur J Immunol 32:309-10. 2002
  22. ncbi request reprint Secretion of pro-apoptotic intron 4-retaining soluble HLA-G1 by human villous trophoblast
    Corinne Solier
    INSERM U563, Hopital Purpan, Toulouse, France
    Eur J Immunol 32:3576-86. 2002
    ....