P Le Bouteiller

Summary

Country: France

Publications

  1. ncbi Soluble HLA-G and control of angiogenesis
    Philippe Le Bouteiller
    INSERM U563, Centre de Physiopathologie de Toulouse Purpan, Toulouse F 31300, France
    J Reprod Immunol 76:17-22. 2007
  2. ncbi Soluble HLA-G and embryo implantation: frequently asked questions
    Philippe Le Bouteiller
    INSERM U563, Hopital Purpan, Toulouse, France
    Gynecol Obstet Invest 64:134-7. 2007
  3. doi Human NK cells in pregnant uterus: why there?
    Philippe Le Bouteiller
    INSERM, U563, Centre de Physiopathologie de Toulouse Purpan, Toulouse, France
    Am J Reprod Immunol 59:401-6. 2008
  4. ncbi [HLA-G and local placental immunity]
    P Le Bouteiller
    INSERM U563, Centre de Physiopathologie de Toulouse Purpan, Hopital Purpan, 31059 Toulouse Cedex 3, Paris, France
    Gynecol Obstet Fertil 31:782-5. 2003
  5. ncbi [Immunology of pregnancy: renewed interest]
    Philippe Le Bouteiller
    Inserm U563 Université Paul Sabatier, Hopital Purpan, Batiment A, BP 3028, 31024 Toulouse Cedex 3, France
    Med Sci (Paris) 22:745-50. 2006
  6. ncbi Soluble HLA-G1 at the materno-foetal interface--a review
    P Le Bouteiller
    INSERM U563, Centre de Physiopathologie de Toulouse Purpan, France
    Placenta 24:S10-5. 2003
  7. ncbi Placental HLA-G protein expression in vivo: where and what for?
    P Le Bouteiller
    INSERM U395, CHU Purpan, Toulouse, France
    Hum Reprod Update 5:223-33. 1999
  8. ncbi Primary cultured human thymic epithelial cells express both membrane-bound and soluble HLA-G translated products
    V Mallet
    INSERM U395, CHU Purpan, Toulouse, France
    J Reprod Immunol 43:225-34. 1999
  9. ncbi Comparative reactivity of different HLA-G monoclonal antibodies to soluble HLA-G molecules
    S Fournel
    Institut National de la Santé et de la Recherche Médicale U395, Hopital de Purpan, Toulouse, France
    Tissue Antigens 55:510-8. 2000
  10. ncbi Cutting edge: soluble HLA-G1 triggers CD95/CD95 ligand-mediated apoptosis in activated CD8+ cells by interacting with CD8
    S Fournel
    Institut National de la Santé et de la Recherche Médicale INSERM U395, Hopital de Purpan, Toulouse, France
    J Immunol 164:6100-4. 2000

Collaborators

Detail Information

Publications48

  1. ncbi Soluble HLA-G and control of angiogenesis
    Philippe Le Bouteiller
    INSERM U563, Centre de Physiopathologie de Toulouse Purpan, Toulouse F 31300, France
    J Reprod Immunol 76:17-22. 2007
    ....
  2. ncbi Soluble HLA-G and embryo implantation: frequently asked questions
    Philippe Le Bouteiller
    INSERM U563, Hopital Purpan, Toulouse, France
    Gynecol Obstet Invest 64:134-7. 2007
    ..culture supernatants? (2) Where do these sHLA-G molecules come from? (3) Why are some preimplantation embryos 'HLA-G secretors' and others not? (4) How might the functions exerted by sHLA-G molecules influence embryonic implantation?..
  3. doi Human NK cells in pregnant uterus: why there?
    Philippe Le Bouteiller
    INSERM, U563, Centre de Physiopathologie de Toulouse Purpan, Toulouse, France
    Am J Reprod Immunol 59:401-6. 2008
    ..Finally, uterine NK cells are likely to be an important component of the local maternal immune response to pathogen infections...
  4. ncbi [HLA-G and local placental immunity]
    P Le Bouteiller
    INSERM U563, Centre de Physiopathologie de Toulouse Purpan, Hopital Purpan, 31059 Toulouse Cedex 3, Paris, France
    Gynecol Obstet Fertil 31:782-5. 2003
    ..HLA-G was also found to induce apoptosis of activated CD8(+) T cells. HLA-G also modulates cytokine secretion of NK cells upon interaction with specific receptors...
  5. ncbi [Immunology of pregnancy: renewed interest]
    Philippe Le Bouteiller
    Inserm U563 Université Paul Sabatier, Hopital Purpan, Batiment A, BP 3028, 31024 Toulouse Cedex 3, France
    Med Sci (Paris) 22:745-50. 2006
    ....
  6. ncbi Soluble HLA-G1 at the materno-foetal interface--a review
    P Le Bouteiller
    INSERM U563, Centre de Physiopathologie de Toulouse Purpan, France
    Placenta 24:S10-5. 2003
    ..Soluble HLA-G1 is an immunosuppressive molecule inducing apoptosis of activated CD8(+) T cells and down-modulating CD4(+) T cell proliferation. Soluble HLA-G1 may also contribute to the control of implantation...
  7. ncbi Placental HLA-G protein expression in vivo: where and what for?
    P Le Bouteiller
    INSERM U395, CHU Purpan, Toulouse, France
    Hum Reprod Update 5:223-33. 1999
    ..Finally, soluble HLA-G isoforms may act as specific immunosuppressors during pregnancy...
  8. ncbi Primary cultured human thymic epithelial cells express both membrane-bound and soluble HLA-G translated products
    V Mallet
    INSERM U395, CHU Purpan, Toulouse, France
    J Reprod Immunol 43:225-34. 1999
    ..1 and W6/32 mAbs. These results confirm and extent those previously described showing that HLA-G expressing cells were detectable by immunohistochemistry in thymic medullary epithelial cells...
  9. ncbi Comparative reactivity of different HLA-G monoclonal antibodies to soluble HLA-G molecules
    S Fournel
    Institut National de la Santé et de la Recherche Médicale U395, Hopital de Purpan, Toulouse, France
    Tissue Antigens 55:510-8. 2000
    ....
  10. ncbi Cutting edge: soluble HLA-G1 triggers CD95/CD95 ligand-mediated apoptosis in activated CD8+ cells by interacting with CD8
    S Fournel
    Institut National de la Santé et de la Recherche Médicale INSERM U395, Hopital de Purpan, Toulouse, France
    J Immunol 164:6100-4. 2000
    ..Finally, we show that such sHLA-G1-induced apoptosis depends on the interaction with CD8 molecules, with cell death being blocked by various CD8 mAbs...
  11. ncbi Detection of transcripts for a soluble form of the RT1-E MHC class Ib molecule in rat placenta
    C Solier
    INSERM U395, CHU Purpan, Toulouse, France
    Immunogenetics 53:351-6. 2001
  12. ncbi HLA-G in the human placenta: expression and potential functions
    P Le Bouteiller
    INSERM U 395, CHU Purpan, Toulouse, France
    Biochem Soc Trans 28:208-12. 2000
    ..The possible anti-viral function of HLA-G, its modulatory role of natural killer cell activity and its likely non-immunological functions are discussed...
  13. ncbi Human decidual NK cells: unique phenotype and functional properties -- a review
    J Tabiasco
    INSERM U563, Universite Paul Sabatier, Hopital Purpan, Toulouse, France
    Placenta 27:S34-9. 2006
    ....
  14. ncbi HLA-G unique promoter region: functional implications
    C Solier
    INSERM U395, CHU Purpan, BP3028, 31024 Toulouse Cedex 3, France
    Immunogenetics 53:617-25. 2001
    ..This suggests that once the placenta is fully formed, the functions of HLA-G might not be so crucial...
  15. ncbi [The role of HLA-G expression in the embryo during implantation]
    P Le Bouteiller
    INSERM U563, Centre de Physiopathologie de Toulouse Purpan, Hopital Purpan, Toulouse, France
    J Gynecol Obstet Biol Reprod (Paris) 33:S9-12. 2004
    ..HLA-G also modulates cytokine secretion of NK cells upon interaction with specific receptors. Soluble HLA-G1 may also contribute to the control of implantation...
  16. ncbi Soluble HLA-G1 inhibits angiogenesis through an apoptotic pathway and by direct binding to CD160 receptor expressed by endothelial cells
    Pierre Fons
    Institut de Pharmacologie et Biologie Structurale, Centre National de la Recherche Scientifique, UMR 5089, INSERM U563, Bat A, Hopital Purpan, BP3028, 31024 Toulouse Cedex 3, France
    Blood 108:2608-15. 2006
    ....
  17. ncbi The HLA-G*0105N null allele induces cell surface expression of HLA-E molecule and promotes CD94/NKG2A-mediated recognition in JAR choriocarcinoma cell line
    Frederic G Sala
    Institut National de la Santé et de la Recherche Médicale U 563, Centre de Physiopathologie de Toulouse Purpan, Hopital Purpan, BP 3028, 31024 Toulouse Cedex 3, France
    Immunogenetics 56:617-24. 2004
    ..Using the NKL cell line in a standard (51)Cr release assay, the HLA-E molecules were found to inhibit natural killer lysis, through a mechanism partially dependent on CD94/NKG2A-mediated recognition...
  18. ncbi HLA-G in the human thymus: a subpopulation of medullary epithelial but not CD83(+) dendritic cells expresses HLA-G as a membrane-bound and soluble protein
    V Mallet
    INSERM U395, CHU Purpan, BP 3028, 31024 Toulouse Cedex 3, France
    Int Immunol 11:889-98. 1999
    ....
  19. ncbi [HLA molecules, immunity and gestation]
    P Le Bouteiller
    Institut National de la Sante et de la Recherche Medicale, unité 395, centre hospitalo universitaire de Purpan, BP 3028, 31024 Toulouse, France
    Gynecol Obstet Fertil 29:523-31. 2001
    ..The functional consequences of such a particular pattern of HLA expression in gestation are examined here...
  20. ncbi Is antigen presentation the primary function of HLA-G?
    P Le Bouteiller
    INSERM U 395, CHU Purpan, BP 3028, 31024 Toulouse Cedex 3, France
    Microbes Infect 3:323-32. 2001
    ..HLA-G also down-modulates both CD8(+) and CD4(+) T-cell responsiveness...
  21. ncbi HLA class I/NK cell receptor interaction in early human decidua basalis: possible functional consequences
    Magali Rabot
    INSERM U563, Hopital Purpan, Toulouse, France
    Chem Immunol Allergy 89:72-83. 2005
    ..Instead they are able to secrete cytokines which are likely to be beneficial for the placental development, maternal uterine spiral arteries remodeling, and the antiviral immune response...
  22. ncbi [Immunity of pregnancy: novel concepts]
    Philippe Le Bouteiller
    INSERM U563, Centre de Physiopathologie de Toulouse Purpan, B and t A, CHU Purpan, B 3028 31024 Toulouse Cedex 3
    Bull Acad Natl Med 193:1029-41; discussion 1041-2, 1067-8. 2009
    ....
  23. ncbi Commentary. Major breakthrough in the HLA-G debate: occurrence of pregnancy in human depends on the HLA-G status of preimplantation embryos
    Philippe Le Bouteiller
    INSERM U395, CHU Purpan, BP 3028, 31024 Toulouse Cedex 3, France
    Eur J Immunol 32:309-10. 2002
  24. ncbi Induction of HLA-G-restricted human cytomegalovirus pp65 (UL83)-specific cytotoxic T lymphocytes in HLA-G transgenic mice
    Francoise Lenfant
    INSERM U 563, Centre de Physiopathologie de Toulouse Purpan, Hopital Purpan, 31059 Toulouse Cedex 3, France
    J Gen Virol 84:307-17. 2003
    ..The weak HLA-G-restricted anti-HCMV response is probably due to HLA-G-mediated inhibitory signals on the development of an antiviral CTL response...
  25. ncbi Differential down-modulation of HLA-G and HLA-A2 or -A3 cell surface expression following human cytomegalovirus infection
    Nathalie Pizzato
    Centre de Physiopathologie Toulouse Purpan, INSERM U563, Hopital Purpan, 31059 Toulouse Cedex 3, France
    J Reprod Immunol 62:3-15. 2004
    ..Such limited down-modulation of HLA-G may have functional consequences in term of innate immunity against congenital HCMV infection...
  26. ncbi Down-regulation of HLA-G1 cell surface expression in human cytomegalovirus infected cells
    Nathalie Pizzato
    INSERM U563, Centre de Physiopathologie Toulouse Purpan, Toulouse, France
    Am J Reprod Immunol 50:328-33. 2003
    ..To explore the level of HLA-G1 cell surface expression after HCMV infection and to investigate the influence of US viral proteins, we infected HLA-G1 expressing cells by HCMV laboratory strains...
  27. ncbi HLA-G, pre-eclampsia, immunity and vascular events
    Philippe Le Bouteiller
    INSERM U563, Centre de Physiopathologie Toulouse Purpan, Bat A, Hopital Purpan, Cedex 3, 31059 Toulouse, France
    J Reprod Immunol 59:219-34. 2003
    ..In view of these different HLA-G properties, we will briefly discuss how defective HLA-G function may contribute to the low trophoblast invasion and vascular abnormalities observed in pre-eclamptic placentas...
  28. ncbi The functionality of HLA-G is emerging
    P Le Bouteiller
    INSERM U395, CHU Purpan, Toulouse, France
    Immunol Rev 167:233-44. 1999
    ..Such functional properties, although incompletely understood, are likely to be important in the outcome of human pregnancies but also in normal adult life...
  29. ncbi Secretion of pro-apoptotic intron 4-retaining soluble HLA-G1 by human villous trophoblast
    Corinne Solier
    INSERM U563, Hopital Purpan, Toulouse, France
    Eur J Immunol 32:3576-86. 2002
    ....
  30. ncbi Engagement of the CD160 activating NK cell receptor leads to its association with CD2 in circulating human NK cells
    Magali Rabot
    INSERM U563, CHU Purpan, Toulouse, France
    Transpl Immunol 17:36-8. 2006
    ..These results demonstrate that CD160 activating NK cell receptor, upon its specific engagement, physically associates to the CD2 co-activating receptor present in the lipid raft that might play a role as signaling molecule...
  31. ncbi Cutting edge: engagement of CD160 by its HLA-C physiological ligand triggers a unique cytokine profile secretion in the cytotoxic peripheral blood NK cell subset
    Aliz Barakonyi
    Institut National de la Santé et de la Recherche Médicale INSERM Unité 563, Centre de Physiopathologie Toulouse Purpan, Toulouse, France
    J Immunol 173:5349-54. 2004
    ..Thus, the CD160 receptor represents a unique triggering surface molecule expressed by cytotoxic NK cells that participates in the inflammatory response and determines the type of subsequent specific immunity...
  32. ncbi BCR/ABL oncogene directly controls MHC class I chain-related molecule A expression in chronic myelogenous leukemia
    Nicolas Boissel
    Institut National de la Sante et de la Recherche Medicale, Unité 622, Centre d Investigations Biomedicales, Laboratoire d Immunologie et d Histocompatibilité, Hopital Saint Louis, Paris, France
    J Immunol 176:5108-16. 2006
    ..These data provide evidence for direct control of MICA expression by an oncogene in human malignancy and indicate that posttranscriptional mechanisms may participate in the regulation of MICA expression...
  33. ncbi Human villous trophoblast and the lack of intron 4-retaining soluble HLA-G secretion: beware of possible methodological biases
    Philippe Le Bouteiller
    INSERM U563, Hopital Purpan, Toulouse, France
    Mol Hum Reprod 11:711-3. 2005
  34. ncbi CD160-activating NK cell effector functions depend on the phosphatidylinositol 3-kinase recruitment
    Magali Rabot
    Institut National de la Santé et de la Recherche Médicale Unité 563 and Université Paul Sabatier de Toulouse, Hopital Purpan, 31024 Toulouse Cedex 3, France
    Int Immunol 19:401-9. 2007
    ..These data demonstrate that PI3K is a crucial signaling element for both effector functions of the CD160 NK cell-activating receptor...
  35. pmc Engagement of CD160 receptor by HLA-C is a triggering mechanism used by circulating natural killer (NK) cells to mediate cytotoxicity
    Philippe Le Bouteiller
    Institut National de la Sante et de la Recherche Medicale U563, Hopital Purpan, 31059 Toulouse Cedex 3, France
    Proc Natl Acad Sci U S A 99:16963-8. 2002
    ..Thus, CD160HLA-C interaction constitutes a unique pathway to trigger NK cell cytotoxic activity...
  36. doi Effector functions of human decidual NK cells in healthy early pregnancy are dependent on the specific engagement of natural cytotoxicity receptors
    Hicham El Costa
    Institut National de la Sante et de la Recherche Medicale, U563, Toulouse, F 31300, France
    J Reprod Immunol 82:142-7. 2009
    ..Whether such NKG2A-mediated inhibition is abolished during pregnancies complicated by pathologies including viral infection is an interesting hypothesis that remains to be tested...
  37. ncbi Soluble HLA-G in IVF/ICSI embryo culture supernatants does not always predict implantation success: a multicentre study
    Julie Tabiasco
    INSERM, U563, Centre de Physiopathologie de Toulouse Purpan, Toulouse, F 31300 France
    Reprod Biomed Online 18:374-81. 2009
    ..01 for two centres). These data demonstrate that substantial variations of sHLA-G content in ES occur between different ART centres, highlighting the influence of several technical parameters that differ from one centre to another...
  38. ncbi In situ hybridization localizes the human OTF3 to chromosome 6p21.3-->p22 and OTF3L to 12p13
    T Guillaudeux
    LIGHT INSERM CNRS, Toulouse, France
    Cytogenet Cell Genet 63:212-4. 1993
    ..We report the mapping of the human homologue: OTF3, to human chromosome 6p21.3-->p22 within or close to the human MHC class I region. Furthermore, one OTF3-like copy (OTF3L) is localized to 12p13...
  39. ncbi Critical and differential roles of NKp46- and NKp30-activating receptors expressed by uterine NK cells in early pregnancy
    Hicham El Costa
    Institut National de la Santé et de la Recherche Médicale U563 France
    J Immunol 181:3009-17. 2008
    ..These data demonstrate a differential, controlled role of NKp46- and NKp30-activating receptors expressed by dNK that could be critical for the outcome of pregnancy and the killing of uterine cells infected by pathogens...
  40. ncbi Perforin and Fas/FasL cytolytic pathways at the maternal-fetal interface
    Tatjana Bogovic Crncic
    Department of Physiology and Immunology, Medical Faculty, University of Rijeka, Rijeka, Croatia
    Am J Reprod Immunol 54:241-8. 2005
    ..This paper gives an overview of the recent findings on the complex immunological events that occur at the maternal-fetal interface...
  41. ncbi Human cytomegalovirus-encoded US2 differentially affects surface expression of MHC class I locus products and targets membrane-bound, but not soluble HLA-G1 for degradation
    Martine T Barel
    Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands
    J Immunol 171:6757-65. 2003
    ..This indicates that the cytoplasmic tail of the MHC class I H chain is not required for its dislocation to the cytosol by US2...
  42. ncbi Subtle sequence variation among MHC class I locus products greatly influences sensitivity to HCMV US2- and US11-mediated degradation
    Martine T Barel
    Department of Medical Microbiology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Int Immunol 18:173-82. 2006
    ..With this study we provide better insights into the features underlying the selectivity in MHC class I down-regulation by US2 and US11...
  43. ncbi Inhibition of term decidual NK cell cytotoxicity by soluble HLA-G1
    Tobias G Poehlmann
    Placenta Labor, Department of Obstetrics, Friedrich Schiller University, Jena, Germany
    Am J Reprod Immunol 56:275-85. 2006
    ..Soluble (s)HLA-G1 is produced by trophoblast cells. Aim was to analyze the capacities and mechanisms of sHLA-G1 to regulate interleukin (IL)-2-induced cytotoxicity of natural killer (NK) cells from human deciduas...
  44. ncbi Killers become builders during pregnancy
    Philippe Le Bouteiller
    Nat Med 12:991-2. 2006
  45. ncbi sHLA-G production by human IVF embryos: can it be measured reliably?
    Ian Sargent
    Oxford Fertility Unit, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, UK
    J Reprod Immunol 75:128-32. 2007
    ..Further collaboration between the research groups involved is required to establish robust reproducible systems that function identically in all laboratories...
  46. ncbi Physiological smooth muscle cell apoptosis contributes to the uterine vascular remodeling in human early pregnancy
    Jean Jacques Helwig
    Circ Res 100:754-6. 2007
  47. ncbi Short-term cytolytic mediators' expression in decidual lymphocytes is enhanced by interleukin-15
    Natasa Strbo
    Department of Physiology and Immunology, Medical Faculty, University of Rijeka, Rijeka, Croatia
    Am J Reprod Immunol 55:217-25. 2006
    ..We investigated whether decidual adherent cells (DAC) and interleukin (IL)-15, in comparison to interleukin (IL)-2 affect cytolytic potential of first trimester decidual lymphocytes (DL)...
  48. ncbi Early pregnancy decidual lymphocytes beside perforin use Fas ligand (FasL) mediated cytotoxicity
    Tatjana Bogovic Crncic
    Department of Physiology and Immunology, Medical Faculty, University of Rijeka, B Branchetta 20, HR 51000 Rijeka, Croatia
    J Reprod Immunol 73:108-17. 2007
    ..These results suggest that DL cultured in DMC for 18h, have the characteristics of lymphokine-activated killer (LAK) cells and are able to use efficiently both the perforin and the FasL cytolytic pathways...