Erwann Le Rouzic

Summary

Country: France

Publications

  1. pmc The Vpr protein from HIV-1: distinct roles along the viral life cycle
    Erwann Le Rouzic
    Institut Cochin, Department of Infectious Diseases, INSERM U567, CNRS UMR8104, Universite Paris 5, Paris, France
    Retrovirology 2:11. 2005
  2. doi Assembly with the Cul4A-DDB1DCAF1 ubiquitin ligase protects HIV-1 Vpr from proteasomal degradation
    Erwann Le Rouzic
    Institut Cochin, Universite Paris Descartes, Centre National de la Recherche Scientifique, UMR 8104, bâtiment Gustave Roussy, 27 rue du Faubourg Saint Jacques, Paris, France
    J Biol Chem 283:21686-92. 2008
  3. pmc Molecular insight into how HIV-1 Vpr protein impairs cell growth through two genetically distinct pathways
    Claire Maudet
    INSERM, U1016, Institut Cochin, Paris 75014, France
    J Biol Chem 286:23742-52. 2011
  4. pmc Regulated degradation of the HIV-1 Vpu protein through a betaTrCP-independent pathway limits the release of viral particles
    Emilie Estrabaud
    Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, Paris, France
    PLoS Pathog 3:e104. 2007
  5. pmc Localization of HIV-1 Vpr to the nuclear envelope: impact on Vpr functions and virus replication in macrophages
    Guillaume Jacquot
    Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, Paris, France
    Retrovirology 4:84. 2007
  6. pmc Characterization of the molecular determinants of primary HIV-1 Vpr proteins: impact of the Q65R and R77Q substitutions on Vpr functions
    Guillaume Jacquot
    Institut Cochin, Universite Paris Descartes, CNRS, UMR 8104, Paris, France
    PLoS ONE 4:e7514. 2009
  7. pmc Recruitment of the nuclear form of uracil DNA glycosylase into virus particles participates in the full infectivity of HIV-1
    Carolin A Guenzel
    INSERM, U1016, Institut Cochin, Paris, France
    J Virol 86:2533-44. 2012
  8. ncbi HIV1 Vpr arrests the cell cycle by recruiting DCAF1/VprBP, a receptor of the Cul4-DDB1 ubiquitin ligase
    Erwann Le Rouzic
    Institut Cochin, Département Maladies Infectieuses, INSERM, CNRS, Universite Paris 5, Paris, France
    Cell Cycle 6:182-8. 2007
  9. pmc The CDK inhibitor p21Cip1/WAF1 is induced by FcgammaR activation and restricts the replication of human immunodeficiency virus type 1 and related primate lentiviruses in human macrophages
    Anna Bergamaschi
    Institut Pasteur, Unité de Régulation des Infections Rétrovirales, Paris, France
    J Virol 83:12253-65. 2009
  10. ncbi RASSF1C, an isoform of the tumor suppressor RASSF1A, promotes the accumulation of beta-catenin by interacting with betaTrCP
    Emilie Estrabaud
    Institut Cochin, Département Maladies Infectieuses Institut National de la Sante et de la Recherche Medicale U567, 27 rue du Faubourg Saint Jacques, Bâtiment G Roussy, 75014 Paris, France
    Cancer Res 67:1054-61. 2007

Collaborators

Detail Information

Publications11

  1. pmc The Vpr protein from HIV-1: distinct roles along the viral life cycle
    Erwann Le Rouzic
    Institut Cochin, Department of Infectious Diseases, INSERM U567, CNRS UMR8104, Universite Paris 5, Paris, France
    Retrovirology 2:11. 2005
    ..In this review, we will mainly focus on vpr from HIV-1 and discuss the most recent developments in our understanding of Vpr functions and its role during the virus replication cycle...
  2. doi Assembly with the Cul4A-DDB1DCAF1 ubiquitin ligase protects HIV-1 Vpr from proteasomal degradation
    Erwann Le Rouzic
    Institut Cochin, Universite Paris Descartes, Centre National de la Recherche Scientifique, UMR 8104, bâtiment Gustave Roussy, 27 rue du Faubourg Saint Jacques, Paris, France
    J Biol Chem 283:21686-92. 2008
    ..Targeting the Vpr-DCAF1 interaction might therefore present therapeutic interest...
  3. pmc Molecular insight into how HIV-1 Vpr protein impairs cell growth through two genetically distinct pathways
    Claire Maudet
    INSERM, U1016, Institut Cochin, Paris 75014, France
    J Biol Chem 286:23742-52. 2011
    ..However, DCAF1 binding per se is not sufficient to confer cytopathicity. These data support a model in which Vpr recruits DCAF1 to induce the degradation of two host proteins independently required for proper cell growth...
  4. pmc Regulated degradation of the HIV-1 Vpu protein through a betaTrCP-independent pathway limits the release of viral particles
    Emilie Estrabaud
    Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, Paris, France
    PLoS Pathog 3:e104. 2007
    ..Conservation of the Vpu degradation determinant, despite its negative effect on virion release, argues for a role in overall HIV-1 fitness...
  5. pmc Localization of HIV-1 Vpr to the nuclear envelope: impact on Vpr functions and virus replication in macrophages
    Guillaume Jacquot
    Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, Paris, France
    Retrovirology 4:84. 2007
    ..In the present study, we have explored the contribution of Vpr accumulation at the NE to the Vpr functions, including G2-arrest and pro-apoptotic activities, and virus replication in primary macrophages...
  6. pmc Characterization of the molecular determinants of primary HIV-1 Vpr proteins: impact of the Q65R and R77Q substitutions on Vpr functions
    Guillaume Jacquot
    Institut Cochin, Universite Paris Descartes, CNRS, UMR 8104, Paris, France
    PLoS ONE 4:e7514. 2009
    ..In contradiction with published results, the R77Q substitution, found in LTNP alleles, did not influence Vpr proapoptotic activity...
  7. pmc Recruitment of the nuclear form of uracil DNA glycosylase into virus particles participates in the full infectivity of HIV-1
    Carolin A Guenzel
    INSERM, U1016, Institut Cochin, Paris, France
    J Virol 86:2533-44. 2012
    ....
  8. ncbi HIV1 Vpr arrests the cell cycle by recruiting DCAF1/VprBP, a receptor of the Cul4-DDB1 ubiquitin ligase
    Erwann Le Rouzic
    Institut Cochin, Département Maladies Infectieuses, INSERM, CNRS, Universite Paris 5, Paris, France
    Cell Cycle 6:182-8. 2007
    ..This in turn suggests that both proteins have evolved to preserve interaction with the same Cul4 ubiquitin ligase while diverging in the recognition of host substrates targeted for proteasomal degradation...
  9. pmc The CDK inhibitor p21Cip1/WAF1 is induced by FcgammaR activation and restricts the replication of human immunodeficiency virus type 1 and related primate lentiviruses in human macrophages
    Anna Bergamaschi
    Institut Pasteur, Unité de Régulation des Infections Rétrovirales, Paris, France
    J Virol 83:12253-65. 2009
    ..Our results point to a role of p21 as an inhibitory factor of lentiviral infection in macrophages and to its implication in FcgammaR-mediated restriction...
  10. ncbi RASSF1C, an isoform of the tumor suppressor RASSF1A, promotes the accumulation of beta-catenin by interacting with betaTrCP
    Emilie Estrabaud
    Institut Cochin, Département Maladies Infectieuses Institut National de la Sante et de la Recherche Medicale U567, 27 rue du Faubourg Saint Jacques, Bâtiment G Roussy, 75014 Paris, France
    Cancer Res 67:1054-61. 2007
    ..Thus, RASSF1A and RASSF1C have opposite effects on beta-catenin degradation. Our results suggest that RASSF1C expression in the absence of RASSF1A could play a role in tumorigenesis...
  11. ncbi Docking of HIV-1 Vpr to the nuclear envelope is mediated by the interaction with the nucleoporin hCG1
    Erwann Le Rouzic
    Institut Cochin, Department of Infectious Diseases, CNRS UMR8104, INSERM U567, Universite Paris 5, Paris, France
    J Biol Chem 277:45091-8. 2002
    ..This association of Vpr with a component of the nuclear pore complex may contribute to the disruption of the nuclear envelope and to the nuclear import of the viral DNA...