Elisabeth Le Rumeur

Summary

Country: France

Publications

  1. doi request reprint Dystrophin: more than just the sum of its parts
    Elisabeth Le Rumeur
    Universite de Rennes 1, UMR CNRS 6026 Interactions Cellulaires et Moléculaires, Equipe RMN et Interactions lipides protéines, IFR 140, Faculte de Medecine, CS 34317, 35043 Rennes Cedex, France
    Biochim Biophys Acta 1804:1713-22. 2010
  2. ncbi request reprint Role of the mode of sensory stimulation in presurgical brain mapping in which functional magnetic resonance imaging is used
    E Le Rumeur
    Fédération d Imagerie Médicale, Centre Hospitalier Regional Pontchaillou, Rennes, France
    J Neurosurg 93:427-31. 2000
  3. ncbi request reprint Interaction of dystrophin rod domain with membrane phospholipids. Evidence of a close proximity between tryptophan residues and lipids
    Elisabeth Le Rumeur
    Laboratoire de Résonance Magnétique Nucléaire en Biologie et Médecine, Unité Propre de Recherche de l Enseignement Supérieur EA 2230, Faculte de Medecine, CS 34317, Rennes 35043 cedex, France
    J Biol Chem 278:5993-6001. 2003
  4. ncbi request reprint Binding of the dystrophin second repeat to membrane di-oleyl phospholipids is dependent upon lipid packing
    Elisabeth Le Rumeur
    UMR CNRS 6026 IFR 140, Equipe RMN Interactions lipides protéines, Faculte de Medecine, Universite de Rennes 1, CS 34317, 35043 Rennes Cedex, France
    Biochim Biophys Acta 1768:648-54. 2007
  5. pmc A Two-amino Acid Mutation Encountered in Duchenne Muscular Dystrophy Decreases Stability of the Rod Domain 23 (R23) Spectrin-like Repeat of Dystrophin
    Sébastien Legardinier
    UMR CNRS 6026 Interactions Cellulaires et Moléculaires, Equipe RMN et Interactions Lipides Protéines and UMR CNRS 6061 Génétique et Développement, Universite de Rennes 1, IFR 140, FacultédeMédecine, CS 34317, 35043 Rennes Cedex, France
    J Biol Chem 284:8822-32. 2009
  6. doi request reprint Mapping of the lipid-binding and stability properties of the central rod domain of human dystrophin
    Sébastien Legardinier
    Universite de Rennes 1, UMR CNRS 6026, Interactions Cellulaires et Moleculaires, IFR 140, Faculte de Medecine, CS 34317, 35043 Rennes Cedex, France
    J Mol Biol 389:546-58. 2009
  7. doi request reprint Sub-domains of the dystrophin rod domain display contrasting lipid-binding and stability properties
    Sébastien Legardinier
    Universite de Rennes 1, UMR CNRS 6026, Interactions Cellulaires et Moleculaires, Equipe, RMN et Interactions Lipides Protéines, IFR 140, Faculte de Medecine, CS 34317, 35043, Rennes Cedex, France
    Biochim Biophys Acta 1784:672-82. 2008
  8. ncbi request reprint NMR of molecules interacting with lipids in small unilamellar vesicles
    Gregory Da Costa
    RMN Interactions Lipides Protéines, UMR CNRS 6026, IFR 140, PRiSM, Universite de Rennes 1, 35043, Rennes Cedex, France
    Eur Biophys J 36:933-42. 2007
  9. doi request reprint Becker muscular dystrophy severity is linked to the structure of dystrophin
    Aurélie Nicolas
    Universite de Rennes 1, avenue du professeur Leon Bernard, 35043 Rennes, France, CNRS UMR 6290, Institut de Génétique et Développement de Rennes, 35043 Rennes, France
    Hum Mol Genet 24:1267-79. 2015
  10. doi request reprint Cholesterol favors the anchorage of human dystrophin repeats 16 to 21 in membrane at physiological surface pressure
    Sarah Ameziane-Le Hir
    Universite de Rennes 1, 35042 Rennes, France UMR CNRS 6251, Institut de Physique de Rennes, Campus Beaulieu, F 35042 Rennes, France UMR CNRS 6290, Equipe SIM, Campus Villejean, F 35043 Rennes, France Université Européenne de Bretagne, 5 Boulevard Laennec, F 35000 Rennes, France
    Biochim Biophys Acta 1838:1266-73. 2014

Collaborators

  • Olivier Delalande
  • Steve J Winder
  • Sylvie Tuffery-Giraud
  • Francois Gaboriau
  • Jean Francois Hubert
  • C Rondeau-Mouro
  • Jacques Gallay
  • Aurélie Nicolas
  • Sébastien Legardinier
  • Céline Raguénès-Nicol
  • Sarah Ameziane-Le Hir
  • Véronique Vié
  • Arnaud Bondon
  • Gregory Da Costa
  • Baptiste Legrand
  • Serge Hardy
  • Christophe Tascon
  • Chantal Rocher
  • France Leturcq
  • Rabah Ben Yaou
  • Emmanuel Giudice
  • Joe Sarkis
  • Clément de Guibert
  • Soizic Chevance
  • Nicolas Cluchague
  • Mireille Claustres
  • Angélique Chéron
  • Gilles Paboeuf
  • Anne Renault
  • Jamel Chelly
  • Céline Lucchetti-Miganeh
  • Jean Claude Kaplan
  • Frédérique Barloy-Hubler
  • Pierre Jannin
  • Catherine Allaire
  • Arnaud Biraben
  • Christian Barillot
  • Jean Christophe Ferre
  • Camille Maumet
  • Olivier Le Bihan
  • Liza Mouret
  • Celine Moreau
  • Yan Cherel
  • Geneviève Leray
  • Sandrine Pottier

Detail Information

Publications18

  1. doi request reprint Dystrophin: more than just the sum of its parts
    Elisabeth Le Rumeur
    Universite de Rennes 1, UMR CNRS 6026 Interactions Cellulaires et Moléculaires, Equipe RMN et Interactions lipides protéines, IFR 140, Faculte de Medecine, CS 34317, 35043 Rennes Cedex, France
    Biochim Biophys Acta 1804:1713-22. 2010
    ....
  2. ncbi request reprint Role of the mode of sensory stimulation in presurgical brain mapping in which functional magnetic resonance imaging is used
    E Le Rumeur
    Fédération d Imagerie Médicale, Centre Hospitalier Regional Pontchaillou, Rennes, France
    J Neurosurg 93:427-31. 2000
    ..The aim of this study was to evaluate different types of sensory stimulation used to distinguish between microvasculature and venous drainage on functional magnetic resonance (fMR) images with blood oxygen level-dependent (BOLD) contrast...
  3. ncbi request reprint Interaction of dystrophin rod domain with membrane phospholipids. Evidence of a close proximity between tryptophan residues and lipids
    Elisabeth Le Rumeur
    Laboratoire de Résonance Magnétique Nucléaire en Biologie et Médecine, Unité Propre de Recherche de l Enseignement Supérieur EA 2230, Faculte de Medecine, CS 34317, Rennes 35043 cedex, France
    J Biol Chem 278:5993-6001. 2003
    ..The use of membrane-bound quenchers allowed us to conclude that dystrophin rod domain lies along the membrane surface and may be involved in a structural array comprising membrane and cytoskeletal proteins as well as membrane lipids...
  4. ncbi request reprint Binding of the dystrophin second repeat to membrane di-oleyl phospholipids is dependent upon lipid packing
    Elisabeth Le Rumeur
    UMR CNRS 6026 IFR 140, Equipe RMN Interactions lipides protéines, Faculte de Medecine, Universite de Rennes 1, CS 34317, 35043 Rennes Cedex, France
    Biochim Biophys Acta 1768:648-54. 2007
    ..Taken together, these results show that the binding involves electrostatic forces in addition to hydrophobic ones...
  5. pmc A Two-amino Acid Mutation Encountered in Duchenne Muscular Dystrophy Decreases Stability of the Rod Domain 23 (R23) Spectrin-like Repeat of Dystrophin
    Sébastien Legardinier
    UMR CNRS 6026 Interactions Cellulaires et Moléculaires, Equipe RMN et Interactions Lipides Protéines and UMR CNRS 6061 Génétique et Développement, Universite de Rennes 1, IFR 140, FacultédeMédecine, CS 34317, 35043 Rennes Cedex, France
    J Biol Chem 284:8822-32. 2009
    ..Our results suggest that it may participate in mechanical weakening of dystrophin-deficient muscle...
  6. doi request reprint Mapping of the lipid-binding and stability properties of the central rod domain of human dystrophin
    Sébastien Legardinier
    Universite de Rennes 1, UMR CNRS 6026, Interactions Cellulaires et Moleculaires, IFR 140, Faculte de Medecine, CS 34317, 35043 Rennes Cedex, France
    J Mol Biol 389:546-58. 2009
    ..These lipid-binding domains should thus maintain a structural link between cytoskeletal actin and sarcolemma via the membrane phospholipids...
  7. doi request reprint Sub-domains of the dystrophin rod domain display contrasting lipid-binding and stability properties
    Sébastien Legardinier
    Universite de Rennes 1, UMR CNRS 6026, Interactions Cellulaires et Moleculaires, Equipe, RMN et Interactions Lipides Protéines, IFR 140, Faculte de Medecine, CS 34317, 35043, Rennes Cedex, France
    Biochim Biophys Acta 1784:672-82. 2008
    ....
  8. ncbi request reprint NMR of molecules interacting with lipids in small unilamellar vesicles
    Gregory Da Costa
    RMN Interactions Lipides Protéines, UMR CNRS 6026, IFR 140, PRiSM, Universite de Rennes 1, 35043, Rennes Cedex, France
    Eur Biophys J 36:933-42. 2007
    ..Special care is finally given to the influence of the kinetic of the interactions for the proton NMR of bound molecules in SUV, which can constitute a good model for the study of dynamical processes at the membrane surface...
  9. doi request reprint Becker muscular dystrophy severity is linked to the structure of dystrophin
    Aurélie Nicolas
    Universite de Rennes 1, avenue du professeur Leon Bernard, 35043 Rennes, France, CNRS UMR 6290, Institut de Génétique et Développement de Rennes, 35043 Rennes, France
    Hum Mol Genet 24:1267-79. 2015
    ..Disease progression in BMD patients appears to be dependent on the deletion itself and associated with a specific structure of dystrophin at the deletion site. ..
  10. doi request reprint Cholesterol favors the anchorage of human dystrophin repeats 16 to 21 in membrane at physiological surface pressure
    Sarah Ameziane-Le Hir
    Universite de Rennes 1, 35042 Rennes, France UMR CNRS 6251, Institut de Physique de Rennes, Campus Beaulieu, F 35042 Rennes, France UMR CNRS 6290, Equipe SIM, Campus Villejean, F 35043 Rennes, France Université Européenne de Bretagne, 5 Boulevard Laennec, F 35000 Rennes, France
    Biochim Biophys Acta 1838:1266-73. 2014
    ..These results suggest that the anchorage of dystrophin to the membrane in vivo may be stabilized by cholesterol-rich nano-domains in the inner leaflet of sarcolemma...
  11. doi request reprint Resisting sarcolemmal rupture: dystrophin repeats increase membrane-actin stiffness
    Joe Sarkis
    Universite Europeenne de Bretagne, Rennes, France
    FASEB J 27:359-67. 2013
    ..This mechanical link is likely to be a major contributing factor to the shock absorber function of dystrophin and muscle sarcolemmal integrity on mechanical stress...
  12. doi request reprint The spectrin family of proteins: a unique coiled-coil fold for various molecular surface properties
    Aurélie Nicolas
    Universite de Rennes 1, 35000 Rennes, France CNRS UMR6290, Institut de Génétique et Développement de Rennes, CS 34317, 35043 Rennes, France
    J Struct Biol 186:392-401. 2014
    ..The repeats within the family are far from identical, which is consistent with their multiple interactions with different cellular partners, including proteins and membrane lipids. ..
  13. pmc Assessment of the structural and functional impact of in-frame mutations of the DMD gene, using the tools included in the eDystrophin online database
    Aurélie Nicolas
    Universite de Rennes, Rennes, France
    Orphanet J Rare Dis 7:45. 2012
    ..In-frame DMD mutations are less frequent and result in a protein with partial wild-type dystrophin function. The aim of this study was to highlight structural and functional modifications of dystrophin caused by in-frame mutations...
  14. pmc Proton NMR detection of porphyrins and cytochrome C in small unilamellar vesicles: role of the dissociation kinetic constant
    Gregory Da Costa
    Resonance Magnetique Nucleaire Interactions Lipids Proteines, Centre National de la Recherche Scientifique, UMR 6026, Institut Federatif de Recherche 140, Universite de Rennes 1, Rennes, France
    Biophys J 90:L55-7. 2006
    ..Since several peptides and proteins are expected to be associated with lipids having relatively fast dynamics, this study addresses, as a first example, the interaction of cytochrome c...
  15. pmc Computational study of the human dystrophin repeats: interaction properties and molecular dynamics
    Baptiste Legrand
    Universite de Rennes 1, Rennes, France
    PLoS ONE 6:e23819. 2011
    ....
  16. ncbi request reprint beta-Dystroglycan can be revealed in microsomes from mdx mouse muscle by detergent treatment
    Nicolas Cluchague
    Faculte de Medecine, UMR CNRS 6026, CS 34317, 35043 Rennes Cedex France
    FEBS Lett 572:216-20. 2004
    ..This result shows that, in dystrophin-deficient muscles, beta-dystroglycan is indeed targeted to the plasma membrane but remains inaccessible to classical solubilizing treatments and to antibodies used for immunolocalization...
  17. doi request reprint A new twist to coiled coil
    Elisabeth Le Rumeur
    Universite Europeenne de Bretagne, 35000 Rennes, France
    FEBS Lett 586:2717-22. 2012
    ..In the case of dystrophin several of these functions overlap in the space of a few repeats...
  18. doi request reprint FMRI language mapping in children: a panel of language tasks using visual and auditory stimulation without reading or metalinguistic requirements
    Clément de Guibert
    INSERM, U746, Faculty of Medicine, CS 34317, F 35043 Rennes Cedex, France
    Neuroimage 51:897-909. 2010
    ..The use of several different tasks may improve the sensitivity and specificity of fMRI...