Research Topics
| D Le BihanSummaryCountry: France Publications
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Detail Information
Publications
Looking into the functional architecture of the brain with diffusion MRIDenis Le Bihan
Anatomical and Functional Neuroimaging Laboratory, , , and Federative Institute of Functional Neuroimaging (IFR 49, 4 Place du General Leclerc, 91401 Orsay, France
Nat Rev Neurosci 4:469-80. 2003- What to expect from MRI in the investigation of the central nervous system?D Le Bihan
Unité de neuro imagerie anatomique et fonctionnelle, Service Hospitalier Frederic Joliot, CEA, Orsay, France
C R Acad Sci III 323:341-50. 2000..Preliminary data suggest that diffusion MRI visualizes dynamic tissue changes associated with large neuronal activation and space orientation of large bundles of myelinated axons in the white matter... 
Direct and fast detection of neuronal activation in the human brain with diffusion MRIDenis Le Bihan
Human Brain Research Center, Kyoto University Graduate School of Medicine, Yoshida konoe cho, Sakyo ku, Kyoto 606 8501, Japan
Proc Natl Acad Sci U S A 103:8263-8. 2006..Although the exact mechanisms remain to clarify, access to such an early and direct physiological marker of cortical activation with MRI will provide opportunities for functional neuroimaging of the human brain...- Diffusion tensor imaging: concepts and applicationsD Le Bihan
Service Hospitalier Frederic Joliot, CEA, 91406 Orsay, France
J Magn Reson Imaging 13:534-46. 2001..The aim of this article is to review the concepts behind DTI and to present potential applications... - Fiber tracking in q-ball fields using regularized particle trajectoriesM Perrin
Service Hospitalier Frederic Joliot, CEA, 91401 Orsay, France
Inf Process Med Imaging 19:52-63. 2005..The method is validated using a phantom of bundle crossing made up of haemodialysis fibers. The method is also applied to the detection of the auditory tract in three human subjects... - MR diffusion-based inference of a fiber bundle model from a population of subjectsV El Kouby
Service Hospitalier Frederic Joliot, CEA, 91401 Orsay, France
Med Image Comput Comput Assist Interv 8:196-204. 2005..The second clustering matches these bundles across subjects in order to provide a list of candidates for the bundle model. The method is applied on a population of eleven subjects and leads to the inference of 17 such candidates... - Assessment of the early organization and maturation of infants' cerebral white matter fiber bundles: a feasibility study using quantitative diffusion tensor imaging and tractographyJ Dubois
CEA, Service Hospitalier Frederic Joliot, Orsay, F91401, France IFR49, Paris, France
Neuroimage 30:1121-32. 2006..The results are in good agreement with the known stages of white matter maturation and myelination, and the proposed approach might provide important insights on brain development... - A framework based on spin glass models for the inference of anatomical connectivity from diffusion-weighted MR data - a technical reviewJ F Mangin
Service Hospitalier Frederic Joliot, CEA, Orsay, France
NMR Biomed 15:481-92. 2002..Experimental results are presented for the simplest spin glass model made up of compass needles located in the center of each voxel of a tensor based acquisition... 
Structural asymmetries in the infant language and sensori-motor networksJ Dubois
CEA, UNAF, CEA DSV I2BM Service Hospitalier Frédéric Joliot, 91403 Orsay, France
Cereb Cortex 19:414-23. 2009..These results suggest that the early macroscopic geometry, microscopic organization, and maturation of these white matter bundles are related to the development of later functional lateralization...- Visual perception of motion and 3-D structure from motion: an fMRI studyA L Paradis
Service Hospitalier Frederic Joliot, CEA, Orsay and Laboratoire de Physiologie de la Perception et de l Action, CNRS College de France, Paris, France
Cereb Cortex 10:772-83. 2000..As this region is already known to be involved in the coding of static object shape, our results suggest that it might integrate various cues for the perception of 3-D shape... - Parallel-transmission-enabled magnetization-prepared rapid gradient-echo T1-weighted imaging of the human brain at 7 TM A Cloos
CEA, DSV, I2BM, Neurospin, LRMN, Gif sur Yvette, France
Neuroimage 62:2140-50. 2012..Overall, these findings indicate that the k(T)-point-based pTx solution is an excellent candidate for UHF 3D imaging, where patient safety is a major concern due to the increase of specific absorption rates... - Optimized diffusion gradient orientation schemes for corrupted clinical DTI data setsJ Dubois
Service Hospitalier Frederic Joliot, CEA, Orsay, France
MAGMA 19:134-43. 2006.... - Towards inference of human brain connectivity from MR diffusion tensor dataC Poupon
Service Hospitalier Frederic Joliot, CEA, 4 Place du General Leclerc, 91401 Cedex, Orsay, France
Med Image Anal 5:1-15. 2001..Finally, we propose a study of the tracking behavior according to the weight given to the regularization and some examples of the tracking results with in vivo human brain data... - Coordinate-based versus structural approaches to brain image analysisJ F Mangin
Service Hospitalier Frederic Joliot, CEA, Orsay, France
Artif Intell Med 30:177-97. 2004..Then, the matching of new individual data with a priori known structural models is described, using the recognition of the cortical sulci as a prototypical example... - Imaging unconscious semantic primingS Dehaene
INSERM U 334, Service Hospitalier Frederic Joliot, CEA DRM DSV, Orsay, France
Nature 395:597-600. 1998..A stream of perceptual, semantic and motor processes can therefore occur without awareness... - Brain tissue water comes in two pools: evidence from diffusion and R2' measurements with USPIOs in non human primatesD Le Bihan
Neurospin, I BM, CEA, Gif sur Yvette, France
Neuroimage 62:9-16. 2012..Those results have implications for human studies using BMS contrast agents, as well as BOLD and diffusion fMRI... - Reduced-distortion diffusion MRI of the craniovertebral junctionM Iima
Department of Diagnostic Imaging and Nuclear Medicine and Human Brain Research Center, Kyoto University Graduate School of Medicine, Kyoto, Japan
AJNR Am J Neuroradiol 33:1321-5. 2012..Our purpose was to evaluate the potential for diffusion MR imaging using RS-EPI compared with SS-EPI in the assessment of the CVJ... - Automatic fiber bundle segmentation in massive tractography datasets using a multi-subject bundle atlasP Guevara
I 2 BM, CEA, Gif sur Yvette, France
Neuroimage 61:1083-99. 2012..It was successfully used to segment the deep white matter bundles in a second database of 20 brains and most of the superficial white matter bundles in 10 subjects of the same database... - Transient decrease in water diffusion observed in human occipital cortex during visual stimulationA Darquie
Service Hospitalier Frederic Joliot, Commissariat a l Energie Atomique, 4 Place du General Leclerc, 91401 Orsay Cedex, France
Proc Natl Acad Sci U S A 98:9391-5. 2001..These preliminary results suggest a new approach to produce images of brain activation with MRI from signals directly associated with neuronal activation, and not through changes in local blood flow... - Letter binding and invariant recognition of masked words: behavioral and neuroimaging evidenceS Dehaene
Institut National de la Sante et de la Recherche Medicale, Unit 562, Service Hospitalier Frederic Joliot, Orsay, France
Psychol Sci 15:307-13. 2004..Our results indicate that an invariant binding of letters into words is achieved unconsciously through a series of increasingly invariant stages in the left occipito-temporal pathway... - Distortion correction and robust tensor estimation for MR diffusion imagingJ F Mangin
Service Hospitalier Frederic Joliot, CEA, 91401 Orsay, France
Med Image Anal 6:191-8. 2002..Several experiments prove that the whole procedure highly improves the quality of the final diffusion maps... - Water diffusion compartmentation and anisotropy at high b values in the human brainC A Clark
Department of Medical Research, Service Hospitalier Frederic Joliot, Orsay, France
Magn Reson Med 44:852-9. 2000.... - Anatomy of verbal memory: a functional MRI studyS Dupont
CEA SHFJ, place du General Leclerc, F 91406 Orsay, France
Surg Radiol Anat 24:57-63. 2002..In addition, the 24-h-delayed retrieval also activated a larger parietal region and the right hippocampus. These findings suggest that fMRI is a reliable method with which to perform anatomical studies... - Bilateral hemispheric alteration of memory processes in right medial temporal lobe epilepsyS Dupont
CEA, SHFJ, Orsay, France
J Neurol Neurosurg Psychiatry 73:478-85. 2002..Functional MRI (fMRI ) was used to investigate right medial temporal lobe epilepsy (RTLE) effects on verbal memory... - Distributed and overlapping cerebral representations of number, size, and luminance during comparative judgmentsPhilippe Pinel
INSERM Unit 562, Service Hospitalier Frederic Joliot, CEA DRM DSV, 4 Place du General Leclerc, 91401 Orsay Cedex, France
Neuron 41:983-93. 2004.... - Single-trial classification of parallel pre-attentive and serial attentive processes using functional magnetic resonance imagingManuela Piazza
Inserm U562 NeuroImagerie Cognitive, Service Hospitalier Frederic Joliot, CEA DRM DSV, 4 Place du General Leclerc, F 91401 Orsay Cedex, France
Proc Biol Sci 270:1237-45. 2003..Beyond the subitizing/counting debate, this approach may prove useful to probe the attentional demands of other cognitive tasks... - Condition-dependent functional connectivity: syntax networks in bilingualsSilke Dodel
Service Hospitalier Frederic Joliot, CEA, IFR49, 91401 Orsay, France
Philos Trans R Soc Lond B Biol Sci 360:921-35. 2005.... - Localization of human frontal eye fields: anatomical and functional findings of functional magnetic resonance imaging and intracerebral electrical stimulationE Lobel
, CEA, Orsay, France
J Neurosurg 95:804-15. 2001.... - Automatized clustering and functional geometry of human parietofrontal networks for language, space, and numberOlivier Simon
, CEA/DSV, Orsay, France
Neuroimage 23:1192-202. 2004..Anatomically, our results in humans are closely homologous to the known connectivity of parietal and frontal regions in the macaque monkey... - kT -points: short three-dimensional tailored RF pulses for flip-angle homogenization over an extended volumeM A Cloos
CEA, DSV, I2BM, Neurospin, LRMN, Gif sur Yvette, France
Magn Reson Med 67:72-80. 2012.... - Visualizing the neural bases of a disconnection syndrome with diffusion tensor imagingN Molko
INSERM, , Orsay Cedex, France
J Cogn Neurosci 14:629-36. 2002..The present approach, based on the "negative tracking" of degenerated bundles, provides new perspectives on the understanding of human brain connections and disconnections... - Slice acquisition order and blood oxygenation level dependent frequency content: an event-related functional magnetic resonance imaging studyA L Paradis
, CEA, , 91406, Orsay, France
MAGMA 13:91-100. 2001..Our study also shows that important physiological information is carried by high frequency components that should not be filtered out... - fMRI study of taste cortical areas in humansA Faurion
Neurobiologie Sensorielle, S H F J, C E A, Orsay, France
Ann N Y Acad Sci 855:535-45. 1998.... - Topographical layout of hand, eye, calculation, and language-related areas in the human parietal lobeOlivier Simon
, IFR 49, , CEA/DSV, Orsay, France
Neuron 33:475-87. 2002..These results suggest human homologs of the monkey areas AIP, MIP, V6A, and LIP and imply a large cortical expansion of the inferior parietal lobule correlated with the development of human language and calculation abilities... - Functional and structural alterations of the intraparietal sulcus in a developmental dyscalculia of genetic originNicolas Molko
INSERM U 562, Cognitive Neuroimaging, Service Hospitalier Frederic Joliot, CEA DSV, IFR 49 Orsay, France
Neuron 40:847-58. 2003..Thus, a genetic form of developmental dyscalculia can be related to both functional and structural anomalies of the right intraparietal sulcus, suggesting a crucial role of this region in the development of arithmetic abilities... - Microstructural correlates of infant functional development: example of the visual pathwaysJessica Dubois
Unité de Neuroimagerie Anatomique et Fonctionnelle, Commissariat à l Energie Atomique Saclay Division des Sciences du Vivant Institut d imagerie Biomédicale Service Hospitalier Frédéric Joliot, 91401 Orsay, France
J Neurosci 28:1943-8. 2008..Thus, in addition to microstructural information, DTI provides noninvasive exquisite information on the functional development of the brain in human infants... - Retinotopic organization of visual mental images as revealed by functional magnetic resonance imagingIsabelle Klein
Anatomical and Functional Neuroimaging Laboratory, SHFJ/DRM/DSV/CEA, 4, , 91401 Orsay, France
Brain Res Cogn Brain Res 22:26-31. 2004..These findings strongly support that visual imagery and perception share low-level anatomical substrate and functional processes. Binding of spatial features is suggested as one possible mechanism... - Asynchrony of the early maturation of white matter bundles in healthy infants: quantitative landmarks revealed noninvasively by diffusion tensor imagingJessica Dubois
UNAF, Service Hospitalier Frederic Joliot, CEA, Orsay, France
Hum Brain Mapp 29:14-27. 2008..Thus, this approach provides new quantitative landmarks for further noninvasive research on brain-behavior relationships during normal and abnormal development... - Water-diffusion slowdown in the human visual cortex on visual stimulation precedes vascular responsesSatoru Kohno
Human Brain Research Center, Kyoto University Graduate School of Medicine, Kyoto, Japan
J Cereb Blood Flow Metab 29:1197-207. 2009..These results suggest that the observed decrease in water diffusion reflects early events that precede the vascular responses, which could originate from changes in the extravascular tissue... - An intrinsic diffusion response function for analyzing diffusion functional MRI time seriesToshihiko Aso
Human Brain Research Center, Kyoto University Graduate School of Medicine, Kyoto, Japan
Neuroimage 47:1487-95. 2009..Some non-linearities in the responses were observed, mainly after the end of the stimulation... - Cerebral bases of subliminal and supraliminal priming during readingSid Kouider
Cognitive Neuroimaging Unit, INSERM U562, SHFJ, CEA DSV, Orsay, France
Cereb Cortex 17:2019-29. 2007..In the absence of attention, however, their access to a second stage of distributed parieto-frontal processing may remain blocked... - Artifacts and pitfalls in diffusion MRIDenis Le Bihan
Anatomical and Functional Neuroimaging Laboratory, Service Hospitalier Frederic Joliot, Commissariat a l Energie Atomique, Orsay, France
J Magn Reson Imaging 24:478-88. 2006..In this article we review those artifacts and pitfalls on a qualitative basis, and introduce possible strategies that have been developed to mitigate or overcome them... - A magnitude code common to numerosities and number symbols in human intraparietal cortexManuela Piazza
Institut National de la Sante et de la Recherche Medicale INSERM, Cognitive Neuroimaging Unit, Service Hospitalier Frederic Joliot, F 91401 Orsay, France
Neuron 53:293-305. 2007..They support the idea that symbols acquire meaning by linking neural populations coding symbol shapes to those holding nonsymbolic representations of quantities... - Dynamics of prefrontal and cingulate activity during a reward-based logical deduction taskClaire Landmann
INSERM 562, Cognitive Neuroimaging, Service Hospitalier Frederic Joliot, Commissariat à l Energie Atomique Département de Recherche Médicale Direction des Sciences du Vivant, Orsay Cedex, and Collège de France, Paris, France
Cereb Cortex 17:749-59. 2007..In summary, the dynamics of effortful mental deduction can be tracked with fMRI and relate to a distributed network engaging prefrontal cortex and its interconnected cortical and subcortical regions... - Motor execution and imagination networks in post-stroke dystoniaStephane Lehericy
Service Hospitalier Frederic Joliot, CEA, Orsay, France
Neuroreport 15:1887-90. 2004..Mental representation of movements with each hand resulted in overactivity in bilateral parietal, premotor and prefrontal areas. These results suggest that execution and mental representation of movement are altered in these patients... - Foot, hand, face and eye representation in the human striatumEmmanuel Gerardin
, Department of Medical Research, CEA, Orsay, France
Cereb Cortex 13:162-9. 2003..These data present evidence for a somatotopic organization of the human striatum which corresponds with the topography of corticostriatal projections described in the non-human primates... - Arteriovenous brain malformations: is functional MR imaging reliable for studying language reorganization in patients? Initial observationsStephane Lehericy
Department of Neuroradiology, Hopital de la Salpetriere, 47 Boulevard de l Hopital, 75013 Paris, France
Radiology 223:672-82. 2002.... - Tuning curves for approximate numerosity in the human intraparietal sulcusManuela Piazza
, CEA/DSV, 91401 Orsay Cedex, France
Neuron 44:547-55. 2004..Anatomically, the intraparietal site coding for number in humans is compatible with that observed in macaque monkeys. Our results therefore suggest an evolutionary basis for human elementary arithmetic... - The 'wet mind': water and functional neuroimagingDenis Le Bihan
Neurospin, Bâtiment 145, CEA Saclay, 91191 Gif sur Yvette, France
Phys Med Biol 52:R57-90. 2007..The biophysical mechanisms of brain activation are then reassessed to reveal their intimacy with the physical properties of water, which may come to be regarded as the 'molecule of the mind'... - Syntax production in bilingualsNarly Golestani
Institute of Cognitive Neuroscience, University College London, 17 Queen Square, London WC1N 3AR, UK
Neuropsychologia 44:1029-40. 2006.... - Distinct unimodal and multimodal regions for word processing in the left temporal cortexLaurent Cohen
Institut de Neurologie, Hopital de la Salpetriere, AP HP, Paris, France
Neuroimage 23:1256-70. 2004..Both areas might have been confounded in past work. Our results also suggest a possible homolog of the VWFA in the auditory stream, the auditory word form area, located in the left anterior superior temporal sulcus... - Foot, face and hand representation in the human supplementary motor areaHanna Chainay
Department of Neuroradiology, INSERM U610, , , 75651 Paris Cedex, France
Neuroreport 15:765-9. 2004..These results support the somatotopic organization of the human SMA and suggest that the paracentral sulcus represents a landmark for body representation... - From the diffusion coefficient to the diffusion tensorDenis Le Bihan
NMR Biomed 15:431-4. 2002..Over the last few years many articles have been published dealing with those matters. This special issue is thus timely to provide readers with the synthesis and the overall viewpoints from leading contributors to the field... - Distinct striatal regions support movement selection, preparation and executionEmmanuel Gerardin
Inserm U610 2Inserm U289, , Paris, France
Neuroreport 15:2327-31. 2004..These results suggest that these three aspects of movement are represented within distinct basal ganglia regions... - Longitudinal diffusion changes in cerebral hemispheres after MCA infarctsFrederique Buffon
Department of Neurology, CHU Lariboisière, Universite Paris VII, Paris, France
J Cereb Blood Flow Metab 25:641-50. 2005..These results suggest that micro- and macrostructural tissue modifications can be detected with diffusion tensor imaging in regions remote from the ischemic area in both hemispheres... - Subliminal convergence of Kanji and Kana words: further evidence for functional parcellation of the posterior temporal cortex in visual word perceptionKimihiro Nakamura
EHESS CNRS ENS, Paris, France
J Cogn Neurosci 17:954-68. 2005..These results thus allow us to separate script-specific and script-independent regions in the posterior temporal lobe, while demonstrating that both can be activated subliminally... - Fast reproducible identification and large-scale databasing of individual functional cognitive networksPhilippe Pinel
INSERM U562 IFR 49, Cognitive Neuroimaging Unit, Gif sur Yvette, France
BMC Neurosci 8:91. 2007..This protocol captures the cerebral bases of auditory and visual perception, motor actions, reading, language comprehension and mental calculation at an individual level... - The visual word form area: a prelexical representation of visual words in the fusiform gyrusStanislas Dehaene
, France
Neuroreport 13:321-5. 2002..We propose that the occasional activation of the fusiform gyrus when listening to spoken words is due to the topdown recruitment of visual orthographic or object representations... - Late plasticity for language in a child's non-dominant hemisphere: a pre- and post-surgery fMRI studyLucie Hertz-Pannier
Department of Medical Research, Service Hospitalier Frederic Joliot, CEA and Institut Federatif de Recherche 49, France
Brain 125:361-72. 2002..It also suggests a limit for removal of the dominant hemisphere beyond the age of 6 years, a classical limit for the critical period of language acquisition...