- Antiproliferative effects of nitrosulindac on human colon adenocarcinoma cell linesC Lavagna
Laboratoire de Gastroentérologie et de Nutrition, Faculte de Medecine, Universite de Nice Sophia Antipolis, 28, Avenue de Valombrose, 06107 Nice Cedex 2, France
Biochem Biophys Res Commun 284:808-16. 2001..Moreover, neither sulindac, nor nitrosulindac, were able to inhibit the NF-kappa B pathway. These data suggested that nitrosulindac could be a better solution compared to other NSAIDs in the treatment of colon cancer...
- Nitric oxide-releasing non steroidal anti-inflammatory drugs: a new generation of anti-tumoral moleculesChristian Lavagna
Laboratoire de Gatroentérologie et de Nutrition, Université de Nice Sophia Antipolis Faculté de Médecine 28, Ave de Valombrose 06107 Nice cedex 2, France
Curr Cancer Drug Targets 3:407-26. 2003..In this review, we sumarise the recent findings in the mechanisms and pathways involved in the antitumoral effects of both NSAIDs and NO-NSAIDs as well as the clinical trials performed with these compounds...