Stephane Laurent

Summary

Country: France

Publications

  1. ncbi request reprint Local pulse pressure is a major determinant of large artery remodelling
    S Laurent
    Department of Pharmacology and EMI INSERM 0107, Hopital Europeen Georges Pompidou, Paris, France
    Clin Exp Pharmacol Physiol 28:1011-4. 2001
  2. ncbi request reprint Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients
    S Laurent
    Department of Pharmacology and INSERM U 337, Broussais Hospital, Paris, France
    Hypertension 37:1236-41. 2001
  3. ncbi request reprint Evidence for benefits of perindopril in hypertension and its complications
    Stephane Laurent
    Department of Pharmacology and INSERM U652, Hopital Europeen Georges Pompidou, 20 rue Leblanc, 75015 Paris, France
    Am J Hypertens 18:155S-162S. 2005
  4. ncbi request reprint [Predictors of cardiovascular mortality and morbidity in hypertension]
    Stephane Laurent
    Service de Pharmacologie et INSERM EMI 0107, Hopital Europeen Georges Pompidou, Paris, France
    Curr Med Res Opin 21:S7-11. 2005
  5. ncbi request reprint Recent advances in arterial stiffness and wave reflection in human hypertension
    Stephane Laurent
    Department of Pharmacology and INSERM U652, Hopital Europeen Georges Pompidou, Assistance Publique Hopitaux de Paris, Universite Paris 5, 20, rue Leblanc, 75015 Paris, France
    Hypertension 49:1202-6. 2007
  6. ncbi request reprint Structural and genetic bases of arterial stiffness
    Stephane Laurent
    Department of Pharmacology and INSERM EMI 107, Hopital Europeen Georges Pompidou, Paris, France
    Hypertension 45:1050-5. 2005
  7. ncbi request reprint Pulse pressure reduction and cardiovascular protection
    Stephane Laurent
    Department of Pharmacology and INSERM U652, Hopital Europeen Georges Pompidou, Paris, France
    J Hypertens Suppl 24:S13-8. 2006
  8. ncbi request reprint Expert consensus document on arterial stiffness: methodological issues and clinical applications
    Stephane Laurent
    Department of Pharmacology and Hôpital Européen Georges Pompidou, Universite Paris Descartes, Faculte de Medecine, Assistance Publique Hopitaux de Paris, INSERM U652, 20 rue Leblanc, 75015 Paris, France
    Eur Heart J 27:2588-605. 2006
  9. ncbi request reprint Arterial stiffness and stroke in hypertension: therapeutic implications for stroke prevention
    Stephane Laurent
    Department of Pharmacology and INSERM EMI 107, Hopital Europeen Georges Pompidou, 20 rue Leblanc, Paris, 75015, France
    CNS Drugs 19:1-11. 2005
  10. ncbi request reprint Clinical applications of arterial stiffness: therapeutics and pharmacology
    Stephane Laurent
    Department of Pharmacology, Hĵpital Européen Georges Pompidou, Paris, France
    Am J Hypertens 15:453-8. 2002

Detail Information

Publications99

  1. ncbi request reprint Local pulse pressure is a major determinant of large artery remodelling
    S Laurent
    Department of Pharmacology and EMI INSERM 0107, Hopital Europeen Georges Pompidou, Paris, France
    Clin Exp Pharmacol Physiol 28:1011-4. 2001
    ..4. We suggest that the effects of pulse pressure on large artery remodelling may explain part of its predictive value on cardiovascular events...
  2. ncbi request reprint Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients
    S Laurent
    Department of Pharmacology and INSERM U 337, Broussais Hospital, Paris, France
    Hypertension 37:1236-41. 2001
    ..This study provides the first direct evidence that aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in patients with essential hypertension...
  3. ncbi request reprint Evidence for benefits of perindopril in hypertension and its complications
    Stephane Laurent
    Department of Pharmacology and INSERM U652, Hopital Europeen Georges Pompidou, 20 rue Leblanc, 75015 Paris, France
    Am J Hypertens 18:155S-162S. 2005
    ....
  4. ncbi request reprint [Predictors of cardiovascular mortality and morbidity in hypertension]
    Stephane Laurent
    Service de Pharmacologie et INSERM EMI 0107, Hopital Europeen Georges Pompidou, Paris, France
    Curr Med Res Opin 21:S7-11. 2005
    ....
  5. ncbi request reprint Recent advances in arterial stiffness and wave reflection in human hypertension
    Stephane Laurent
    Department of Pharmacology and INSERM U652, Hopital Europeen Georges Pompidou, Assistance Publique Hopitaux de Paris, Universite Paris 5, 20, rue Leblanc, 75015 Paris, France
    Hypertension 49:1202-6. 2007
  6. ncbi request reprint Structural and genetic bases of arterial stiffness
    Stephane Laurent
    Department of Pharmacology and INSERM EMI 107, Hopital Europeen Georges Pompidou, Paris, France
    Hypertension 45:1050-5. 2005
    ..These data provide strong evidence that arterial stiffness is affected by the amount and density of stiff wall material and the spatial organization of that material...
  7. ncbi request reprint Pulse pressure reduction and cardiovascular protection
    Stephane Laurent
    Department of Pharmacology and INSERM U652, Hopital Europeen Georges Pompidou, Paris, France
    J Hypertens Suppl 24:S13-8. 2006
    ....
  8. ncbi request reprint Expert consensus document on arterial stiffness: methodological issues and clinical applications
    Stephane Laurent
    Department of Pharmacology and Hôpital Européen Georges Pompidou, Universite Paris Descartes, Faculte de Medecine, Assistance Publique Hopitaux de Paris, INSERM U652, 20 rue Leblanc, 75015 Paris, France
    Eur Heart J 27:2588-605. 2006
    ....
  9. ncbi request reprint Arterial stiffness and stroke in hypertension: therapeutic implications for stroke prevention
    Stephane Laurent
    Department of Pharmacology and INSERM EMI 107, Hopital Europeen Georges Pompidou, 20 rue Leblanc, Paris, 75015, France
    CNS Drugs 19:1-11. 2005
    ....
  10. ncbi request reprint Clinical applications of arterial stiffness: therapeutics and pharmacology
    Stephane Laurent
    Department of Pharmacology, Hĵpital Européen Georges Pompidou, Paris, France
    Am J Hypertens 15:453-8. 2002
    ..Directions for future therapeutic trials are suggested...
  11. doi request reprint Aortic, carotid and femoral stiffness: how do they relate? Towards reference values
    Stephane Laurent
    Department of Pharmacology and Inserm U872, European Hospital Georges Pompidou, Paris, France
    J Hypertens 26:1305-6. 2008
  12. ncbi request reprint Arterial stiffness: a new surrogate end point for cardiovascular disease?
    Stephane Laurent
    Department of Pharmacology and INSERM U652, Georges Pompidou European Hospital, Paris France
    J Nephrol 20:S45-50. 2007
    ..This remains to be established in populations at low to medium CV risk Eth i.e., with hypertension, dyslipidemia, diabetes and moderate chronic kidney disease...
  13. ncbi request reprint Pathophysiology of hypertension in the elderly
    Stephane Laurent
    Department of Pharmacology, EMI U 0107 Inserm, Hopital Europeen Georges Pompidou, 20 rue Leblanc, 75015 Paris, France
    Am J Geriatr Cardiol 11:34-9. 2002
    ..In this elderly population, further research is needed concerning the pathophysiology, epidemiology, and pharmacology of hypertension...
  14. ncbi request reprint Aortic stiffness is an independent predictor of fatal stroke in essential hypertension
    Stephane Laurent
    Department of Pharmacology and INSERM EMI 0107, Hopital Europeen Georges Pompidou, Paris, France
    Stroke 34:1203-6. 2003
    ..The influence of arterial stiffness on the occurrence of stroke has never been demonstrated. Our aim was to establish the relationship between aortic stiffness and stroke death in hypertensive patients...
  15. ncbi request reprint Arterial stiffness in arterial hypertension
    Stephane Laurent
    Department of Pharmacology and INSERM U 652, Hopital Europeen Georges Pompidou, Paris, France
    Curr Hypertens Rep 8:179-80. 2006
  16. ncbi request reprint Evidence for carotid and radial artery wall subclinical lesions in renal fibromuscular dysplasia
    Pierre Boutouyrie
    Department of Pharmacology and INSERM EMI U 0107, Hopital Europeen Georges Pompidou, Paris, France
    J Hypertens 21:2287-95. 2003
    ....
  17. ncbi request reprint Brachial pressure-independent reduction in carotid stiffness after long-term angiotensin-converting enzyme inhibition in diabetic hypertensives
    Anne Isabelle Tropeano
    Department of Pharmacology and INSERM U 652, Georges Pompidou European Hospital, Paris, France
    Hypertension 48:80-6. 2006
    ..They also suggest that long-term administration of high doses (8 mg) of perindopril is required to improve carotid structure and function in hypertensive patients with type 2 diabetes...
  18. ncbi request reprint Aortic stiffness is an independent predictor of primary coronary events in hypertensive patients: a longitudinal study
    Pierre Boutouyrie
    Department of Pharmacology and INSERM EMI 0107, Hopital Europeen Georges Pompidou, Paris, France
    Hypertension 39:10-5. 2002
    ..This study provides the first direct evidence in a longitudinal study that aortic stiffness is an independent predictor of primary coronary events in patients with essential hypertension...
  19. ncbi request reprint Increased carotid wall stress in vascular Ehlers-Danlos syndrome
    Pierre Boutouyrie
    Department of Pharmacology and INSERM EMI 0107, Hopital Europeen Georges Pompidou, Paris, France
    Circulation 109:1530-5. 2004
    ..Affected patients are at risk for arterial dissection or rupture, the main cause of death. To understand the pathogenesis of the vascular lesions, we used a biomechanical approach and determined steady and pulsatile wall stress...
  20. ncbi request reprint Carotid and aortic stiffness: determinants of discrepancies
    Anna Paini
    Department of Pharmacology, Hopital Europeen Georges Pompidou, INSERM U652, Universite Paris Descartes, Faculte de Medecine, Paris, France
    Hypertension 47:371-6. 2006
    ..In these cases, the aorta stiffened more than the carotid artery with age and other cardiovascular risk factors...
  21. pmc Arterial remodeling associates with CKD progression
    Marie Briet
    Department of Pharmacology and Institut National de la Santé et de la Recherche Médicale U970 PARCC, Hopital Europeen Georges Pompidou, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, 20, rue Leblanc, 75015 Paris, France
    J Am Soc Nephrol 22:967-74. 2011
    ..In conclusion, maladaptive remodeling of the carotid artery and increased pulse pressure independently associate with faster decline of renal function and progression to ESRD...
  22. ncbi request reprint Lowering of brachial pulse pressure in 9379 hypertensives with type 2 diabetes and reduction of cardiovascular events
    Anne Isabelle Tropeano
    Department of Pharmacology and INSERM U652, Hopital Europeen Georges Pompidou, Universite Paris Descartes, Faculte de Medecine, Paris, France
    Blood Press 17:26-33. 2008
    ..During the 9 months follow-up, the physician in charge was asked to reinforce treatment in order to lower PP, using preferentially a fixed low-dose perindopril/indapamide combination...
  23. ncbi request reprint Endothelial function and chronic exposure to air pollution in normal male subjects
    Marie Briet
    Faculté de Médecine René Descartes, Universite Paris Descartes, INSERM, UMR872, Paris, France
    Hypertension 50:970-6. 2007
    ..Gaseous pollutants affect large artery endothelial function, whereas particulate matter exaggerates the dilatory response of small arteries to ischemia...
  24. ncbi request reprint Glucose level is a major determinant of carotid intima-media thickness in patients with hypertension and hyperglycemia
    Anne Isabelle Tropeano
    Department of Pharmacology and INSERM EMI 0107, Hopital Europeen Georges Pompidou, Paris, France
    J Hypertens 22:2153-60. 2004
    ..Carotid intima-media thickness (CIMT) is an independent predictor for cardiovascular events. High blood pressure is a major determinant of CIMT...
  25. doi request reprint Association of menopause and hormone replacement therapy with large artery remodeling
    Anne Gompel
    Universite Paris Descartes, Assistance Publique Hopitaux de Paris, Hotel Dieu, Paris, France
    Fertil Steril 96:1445-50. 2011
    ..To evaluate the remodeling of large arteries according to age at menopause, duration of menopause, and use of hormone therapy (HT)...
  26. doi request reprint Carotid plaque, arterial stiffness gradient, and remodeling in hypertension
    Hélène Beaussier
    Department of Pharmacology, Inserm U872, Hopital Europeen Georges Pompidou, Universite Paris Descartes, France
    Hypertension 52:729-36. 2008
    ..This may generate a high level of stress concentrations and fatigue, exposing the plaque to a greater risk of rupture...
  27. ncbi request reprint Influence of pravastatin on carotid artery structure and function in dyslipidemic HIV-infected patients receiving antiretroviral therapy
    Franck Boccara
    Department of Pharmacology, Universite Paris Descartes, Faculte de Medecine, INSERM 652, Hopital Europeen Georges Pompidou, Paris, France
    AIDS 20:2395-8. 2006
    ..Age and body mass index were independent determinants of IMT of the CCA. Mean arterial pressure, age, duration of HIV infection and protease inhibitor exposure determined aortic stiffness...
  28. ncbi request reprint Physiological genomics of human arteries: quantitative relationship between gene expression and arterial stiffness
    Séverine Durier
    Department of Pharmacology and INSERM EMI 107, Paris, France
    Circulation 108:1845-51. 2003
    ....
  29. doi request reprint Large artery stiffening and remodeling are independently associated with all-cause mortality and cardiovascular events in chronic kidney disease
    Alexandre Karras
    Departments of Nephrology, Hopital Europeen Georges Pompidou, Assistance Publique Hopitaux de Paris, Paris, France
    Hypertension 60:1451-7. 2012
    ..This study shows that increased aortic stiffness and carotid internal diameter are independent predictors of mortality in patients with stages 2 to 5 chronic kidney disease and that aortic stiffness improves the prediction of the risk...
  30. doi request reprint Carotid artery mechanical properties and stresses quantified using in vivo data from normotensive and hypertensive humans
    Ingrid Masson
    CNRS EAC 4396, Centre de Recherches Chirurgicales, Faculte de Medecine, Université Paris Est Créteil Val de Marne UPEC, 8 rue du General Sarrail, 94010 Creteil, France
    Biomech Model Mechanobiol 10:867-82. 2011
    ..These results are consistent with prior reports on effects of age and hypertension, but provide increased insight into evolving contributions of cell and matrix mechanics to arterial behavior in vivo...
  31. doi request reprint Long-term reduction in aortic stiffness: a 5.3-year follow-up in routine clinical practice
    Hafid Ait-Oufella
    Department of Pharmacology, European Hospital Georges Pompidou, France
    J Hypertens 28:2336-41. 2010
    ..Whether a direct blood pressure-independent reduction in aortic stiffness can occur after several years of antihypertensive treatment has never been unequivocally demonstrated...
  32. doi request reprint Importance of arterial stiffness as cardiovascular risk factor for future development of new type of drugs
    Pierre Boutouyrie
    Faculté de Médecine René Descartes, Universite Paris Descartes, INSERM UMRS872 Equipe 1, 15 rue de l Ecole de Medecine, Paris F 75006, France
    Fundam Clin Pharmacol 22:241-6. 2008
    ..In parallel to this demonstration, points to be improved are the homogenization and spreading of the technique of measurement, the establishment of a reference value database...
  33. ncbi request reprint Arterial stiffness and angiotensinogen gene in hypertensive patients and mutant mice
    Erwan Bozec
    Department of Pharmacology, Hôpital Européen Georges Pompidou and Institut National de la Santé et de la Recherche Médicale EMI 0107, Paris, France
    J Hypertens 22:1299-307. 2004
    ....
  34. ncbi request reprint Increased stiffness of the carotid wall material in patients with spontaneous cervical artery dissection
    David Calvet
    Department of Pharmacology and INSERM EMI 0107, Hopital Europeen Georges Pompidou, Paris, France
    Stroke 35:2078-82. 2004
    ..The study aim was to determine the elastic properties of a cervical artery, the common carotid artery, and a distal muscular artery, the radial artery in sCAD patients...
  35. ncbi request reprint Very-low-dose combination of perindopril and indapamide: efficacy on blood pressure and target-organ damage
    Stephane Laurent
    Service de Pharmacologie, INSERM EMI 107, Hopital Europeen Georges Pompidou, 20 rue Leblanc, 75015 Paris, France
    J Hypertens Suppl 21:S11-8. 2003
    ..To review the safety and efficacy of the very-low-dose combination of perindopril 2 mg and indapamide 0.625 mg (Per2/Ind0.625) in essential hypertension, in relation to blood pressure control and target-organ damage...
  36. doi request reprint Accelerated arterial stiffening and gene expression profile of the aorta in patients with coronary artery disease
    Celine Fassot
    Faculty of Medicine, University Paris Descartes, Department of Pharmacology, Georges Pompidou European Hospital, Paris, France
    J Hypertens 26:747-57. 2008
    ..Arterial stiffness increases further when CRF is associated with hypertension. We hypothesized that, in patients with mild CRF, aortic gene expression profile would include genes involved in arterial calcifications and enlargement...
  37. doi request reprint Age-independent association between arterial and bone remodeling in mild-to-moderate chronic kidney disease
    Marie Briet
    Universite Paris Descartes, INSERM, UMR872, Paris, France
    Nephrol Dial Transplant 25:191-7. 2010
    ..We made the hypothesis that bone disease could be associated with the carotid outward remodeling in parallel with the decline of renal function in this population...
  38. doi request reprint Amlodipine-valsartan combination decreases central systolic blood pressure more effectively than the amlodipine-atenolol combination: the EXPLOR study
    Pierre Boutouyrie
    Department of Pharmacology, INSERM U970, Hopital Europeen Georges Pompidou, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, Paris, France
    Hypertension 55:1314-22. 2010
    ..The amlodipine-valsartan combination decreased central (systolic and pulse) pressure and AIx more than the amlodipine-atenolol combination...
  39. ncbi request reprint Arterial stiffness and pulse pressure in CKD and ESRD
    Marie Briet
    Department of Pharmacology and INSERM Institut National de la Santéet de la Recherche Médicale U970 PARCC, Hopital Europeen Georges Pompidou, Paris, France
    Kidney Int 82:388-400. 2012
    ....
  40. doi request reprint Aortic stiffness is reduced beyond blood pressure lowering by short-term and long-term antihypertensive treatment: a meta-analysis of individual data in 294 patients
    Kim Thanh Ong
    Hopitaux de Paris, Hopital Europeen Georges Pompidou, France bINSERM U970, France
    J Hypertens 29:1034-42. 2011
    ..We aimed to determine whether the artery stiffness can be improved because of antihypertensive treatments independently of blood pressure lowering...
  41. doi request reprint Cardiovascular risk assessment through target organ damage: role of carotid to femoral pulse wave velocity
    Pierre Boutouyrie
    Universite Paris Descartes, Faculté de Médecine René Descartes, INSERM, UMR872, and Assistance Publique Hopitaux de Paris, Hopital Europeen Georges Pompidou, Department of Pharmacology, Paris, France
    Clin Exp Pharmacol Physiol 35:530-3. 2008
    ....
  42. doi request reprint Thromboangiitis obliterans and endothelial function
    Michel Azizi
    Universite Paris Descartes, Faculte de Medecine, Paris, France
    Eur J Clin Invest 40:518-26. 2010
    ..This study compares endothelial function and large artery stiffness between 10 TAO patients assessed during an exacerbation phase and 10 age- and sex-matched control subjects...
  43. ncbi request reprint Rationale, design and methods of the CASHMERE study
    Tabassome Simon
    Department of Pharmacology, Paris VI University, Saint Antoine University Hospital AP HP, Paris, France
    Fundam Clin Pharmacol 18:131-8. 2004
    ..The results are expected for 2007...
  44. ncbi request reprint Comparison of angiotensin II-induced blood pressure and structural changes in Fischer 344 and Wistar Kyoto rats
    Jocelyne Blanc
    Laboratory of Pharmacology, Institut National de la Sante et de la Recherche Medicale, INSERM E0107, Paris, France
    Clin Exp Pharmacol Physiol 31:466-73. 2004
    ..Angiotensin II increased BP in F344 rats, but did not exaggerate the increase in BP during the startle reaction...
  45. ncbi request reprint Angiotensinogen gene M235T polymorphism and reduction in wall thickness in response to antihypertensive treatment
    Erwan Bozec
    Department of Pharmacology, INSERM EMI 0107, Hopital Europeen Georges Pompidou, 20 rue Leblanc, 75015 Paris, France
    Clin Sci (Lond) 105:637-44. 2003
    ..In conclusion, these data suggest that the angiotensinogen TT genotype at position 235 is a genetic marker for early carotid atherosclerosis in a hypertensive population and its regression under antihypertensive treatment...
  46. doi request reprint Frequent and widespread vascular abnormalities in human signal transducer and activator of transcription 3 deficiency
    Marie Olivia Chandesris
    Hematology Department, Necker Children s Hospital, Assistance Publique Hopitaux de Paris, 149 rue de Sevres, Paris, France
    Circ Cardiovasc Genet 5:25-34. 2012
    ..Although vascular abnormalities have been reported in some patients, the prevalence, characteristics, and etiology of these features have yet to be described...
  47. pmc In utero exposure to maternal diabetes impairs vascular expression of prostacyclin receptor in rat offspring
    Jean Paul Duong Van Huyen
    NSERM U872, Centre de Recherche des Cordeliers, Universite s Pierre et Marie Curie et Paris Descartes, Paris, France
    Diabetes 59:2597-602. 2010
    ..To evaluate modifications of arterial structure, gene expression, and function in our model of rats exposed to maternal diabetes...
  48. pmc Characterization of arterial wall mechanical behavior and stresses from human clinical data
    Ingrid Masson
    CNRS UMR 7054, Faculte de Medecine, Universite Paris 12, 8 rue du General Sarrail, Creteil F 94010, France
    J Biomech 41:2618-27. 2008
    ..Hence, the proposed approach was able to identify complex geometric and material parameters directly from non-invasive in vivo human data...
  49. pmc Arterial and renal consequences of partial genetic deficiency in tissue kallikrein activity in humans
    Michel Azizi
    Centre d Investigations Cliniques 9201, Assistance Publique des Hôpitaux de Paris and INSERM, Universite Paris V, Paris, France
    J Clin Invest 115:780-7. 2005
    ....
  50. doi request reprint Differences in emotion processing in patients with essential and secondary hypertension
    Silla M Consoli
    Assistance Publique Hopitaux de Paris, Department of C L Psychiatry, European Georges Pompidou Hospital, Paris, France
    Am J Hypertens 23:515-21. 2010
    ..Alexithymia and related emotion-processing variables, however, have never been examined as a function of the type of hypertension, essential (EH) or secondary (SH)...
  51. doi request reprint Sequential nephron blockade versus sequential renin-angiotensin system blockade in resistant hypertension: a prospective, randomized, open blinded endpoint study
    Guillaume Bobrie
    Assistance Publique, Hopitaux de Paris, Hopital Europeen Georges Pompidou, Paris, France
    J Hypertens 30:1656-64. 2012
    ..To compare two drug regimens to treat resistant hypertension...
  52. ncbi request reprint Multiaxial mechanical characteristics of carotid plaque: analysis by multiarray echotracking system
    Anna Paini
    Department of Pharmacology, Universite Paris Descartes, Faculte de Medecine, INSERM U652, Hopital Europeen Georges Pompidou, Paris, France
    Stroke 38:117-23. 2007
    ..Carotid plaque rupture depends on the various types of mechanical stresses. Our objective was to determine the multiaxial mechanical characteristics of atherosclerotic plaque and adjacent segment of the common carotid artery...
  53. doi request reprint Effect of celiprolol on prevention of cardiovascular events in vascular Ehlers-Danlos syndrome: a prospective randomised, open, blinded-endpoints trial
    Kim Thanh Ong
    Assistance Publique, Hopitaux de Paris, Hopital Europeen Georges Pompidou, Paris, France
    Lancet 376:1476-84. 2010
    ..Our aim was to assess the ability of celiprolol, a β(1)-adrenoceptor antagonist with a β(2)-adrenoceptor agonist action, to prevent arterial dissections and ruptures in vascular Ehlers-Danlos syndrome...
  54. ncbi request reprint Arterial remodeling and stiffness in patients with pseudoxanthoma elasticum
    Dominique P Germain
    Service de Pharmacologie et INSERM EMI 0107, Hopital Europeen Georges Pompidou, Paris, France
    Arterioscler Thromb Vasc Biol 23:836-41. 2003
    ..The aim of the present study was to determine large artery phenotype in patients with pseudoxanthoma elasticum (PXE), a genetic disease characterized by proteoglycan accumulation and fragmented elastic fibers in connective tissues...
  55. doi request reprint Aortic stiffness as a tissue biomarker for predicting future cardiovascular events in asymptomatic hypertensive subjects
    Stephane Laurent
    Department of Pharmacology, European Georges Pompidou Hospital, Assistance Publique Hopitaux de Paris, INSERM U970 and University Paris Descartes, France
    Ann Med 44:S93-7. 2012
    ....
  56. doi request reprint Mechanical and structural characteristics of carotid plaques by combined analysis with echotracking system and MR imaging
    Hélène Beaussier
    Department of Pharmacology and INSERM U970, Hopital Europeen Georges Pompidou, Paris, France
    JACC Cardiovasc Imaging 4:468-77. 2011
    ..The purpose of this study was to correlate the arterial mechanics of carotid atherosclerotic plaques assessed from echotracking with their composition by high-resolution magnetic resonance imaging (HR-MRI)...
  57. doi request reprint Aortic stiffness measurement improves the prediction of asymptomatic coronary artery disease in stroke/transient ischemic attack patients
    David Calvet
    Paris Descartes University, Centre de Psychiatrie et Neurosciences INSERM UMR 894, Paris, France Department of Neurology, Centre Hospitalier Sainte Anne, Paris, France
    Int J Stroke 9:291-6. 2014
    ..Aortic stiffness is an independent predictor of coronary events...
  58. ncbi request reprint Day or night blood pressures to predict cardiovascular events?
    Stephane Laurent
    Department of Pharmacology and INSERM U652, Hopital Europeen Georges Pompidou, 75015 Paris, France
    Lancet 370:1192-3. 2007
  59. ncbi request reprint Alpha1-antitrypsin gene polymorphisms are not associated with renal arterial fibromuscular dysplasia
    Jérôme Perdu
    Assistance Publique Hopitaux de Paris, Hopital Europeen Georges Pompidou, Department of Medical Genetics, Paris, France
    J Hypertens 24:705-10. 2006
    ..Case reports have associated alpha1-antitrypsin deficiency and FMD. The aim of this study was to test the implication of the alpha1-antitrypsin (AAT) gene in a large cohort of patients with renal FMD...
  60. ncbi request reprint Antihypertensive effects of fasidotril, a dual inhibitor of neprilysin and angiotensin-converting enzyme, in rats and humans
    S Laurent
    Department of Pharmacology and INSERM U 337, Broussais Hospital, Paris, France
    Hypertension 35:1148-53. 2000
    ....
  61. ncbi request reprint Local pulse pressure and regression of arterial wall hypertrophy during long-term antihypertensive treatment
    P Boutouyrie
    Department of Pharmacology, INSERM U 337, Broussais Hospital, Paris, France
    Circulation 101:2601-6. 2000
    ....
  62. ncbi request reprint Clinical benefit of very-low-dose perindopril-indapamide combination in hypertension
    S Laurent
    Unite de Pharmacologie Clinique, Service de Pharmacologie, Hĵpital Européen Georges Pompidou, Paris, France
    J Hypertens Suppl 19:S9-14. 2001
    ..To review the efficacy and safety of the very-low-dose combination of 2 mg perindopril and 0.625 mg indapamide in essential hypertension...
  63. pmc Large-vessel correlates of cerebral small-vessel disease
    Marion Brisset
    INSERM U708, Neuroepidemiology, Paris, France
    Neurology 80:662-9. 2013
    ..Our aim was to investigate the relationship of carotid structure and function with MRI markers of cerebral ischemic small-vessel disease...
  64. doi request reprint New drugs, procedures, and devices for hypertension
    Stephane Laurent
    Department of Pharmacology, European Georges Pompidou Hospital, Assistance Publique Hopitaux de Paris, Paris, France
    Lancet 380:591-600. 2012
    ..The effectiveness and safety of new devices and procedures should be carefully assessed in patients with resistant hypertension, thus leading to a new era of outcome trials and evidence-based guidelines...
  65. doi request reprint Ultrastructural scoring of skin biopsies for diagnosis of vascular Ehlers-Danlos syndrome
    Kim Thanh Ong
    Assistance Publique Hopitaux de Paris, Hopital Europeen Georges Pompidou, INSERM U970, Universite Paris Descartes, Paris, France
    Virchows Arch 460:637-49. 2012
    ..Presence of two or more signs (either abnormal fibroblast, presence of lysosomes in the fibroblast or abnormal basal lamina) is very evocative of vEDS...
  66. ncbi request reprint [Drugs and arterial stiffness in hypertensive patients]
    Stephane Laurent
    INSERM EMI 0107, Hopital Europeen Georges Pompidou, Paris, France
    Drugs 63:1-8. 2003
    ..They should be performed in patients at high cardiovascular risk, on a large scale and a long-term basis, and include all-cause and cardiovascular mortality and cardiovascular morbidity'...
  67. pmc Influence of graded changes in vasomotor tone on the carotid arterial mechanics in live spontaneously hypertensive rats
    P Lacolley
    Department of Internal Medicine, Broussais Hospital, Paris, France
    Br J Pharmacol 115:1235-44. 1995
    ....
  68. doi request reprint Coronary artery disease. Are β-blockers truly helpful in patients with CAD?
    Nicolas Danchin
    Department of Cardiology, Hopital Europeen Georges Pompidou, 20 rue Leblanc, Paris, France
    Nat Rev Cardiol 10:11-2. 2013
    ..The role of β-blockers for secondary prevention in these patients should be reconsidered...
  69. doi request reprint Defining vascular aging and cardiovascular risk
    Stephane Laurent
    Department of Pharmacology, Hopital Europeen Georges Pompidou, INSERM U970, Universite Paris Descartes, Paris, France
    J Hypertens 30:S3-8. 2012
    ..These broadly include aortic and carotid stiffening; aortic and carotid lumen dilation; endothelial dysfunction (usually measured via brachial flow-mediated dilatation); and carotid intima-media thickness...
  70. ncbi request reprint Physicians' degree of motivation regarding their perception of hypertension, and blood pressure control
    Silla M Consoli
    Department of Medical Psychology and Consultation Liaison Psychiatry, Georges Pompidou European Hospital, Assistance Publique Hopitaux de Paris, Paris, France
    J Hypertens 28:1330-9. 2010
    ..Despite clear international guidelines, the achievement of blood pressure (BP) control is still disappointing...
  71. ncbi request reprint [Large artery and left ventricular remodelling in Fabry disease.]
    Pierre Boutouyrie
    Universite Paris Descartes, Faculte de Medecine, Département de Pharmacologie et Inserm U 652, Hopital Europeen Georges Pompidou, Assistance Publique Hopitaux de Paris, 20 rue Leblanc, 75015 Paris, France
    Med Sci (Paris) 21:30-2. 2005
    ..These results show that tissues of the cardiovascular system tend to be oversensitive to trophic signals in patients with Fabry disease. double dagger...
  72. ncbi request reprint Rilmenidine: a novel approach to first-line treatment of hypertension
    S Laurent
    Department of Internal Medicine, INSERM (U. 337, Broussais Hospital, Paris, France
    Am J Hypertens 5:99S-105S. 1992
    ..In contrast with clonidine, no sodium retention or weight gain were observed during chronic treatment with RIL.(ABSTRACT TRUNCATED AT 250 WORDS)..
  73. ncbi request reprint Fenestrations of the carotid internal elastic lamina and structural adaptation in stroke-prone spontaneously hypertensive rats
    S Boumaza
    , INSERM U337, Paris, France
    Hypertension 37:1101-7. 2001
    ..We suggest that these structural modifications of the vascular wall play a synergistic role in the mechanical adaptation to a high level of stress in SHRSP...
  74. ncbi request reprint [Central control of the baroreflex response to phenylephrine by dihydropyridines in the anesthetized rat]
    P Lacolley
    Laboratoire de pharmacologie et INSERM U 228, Paris, France
    Arch Mal Coeur Vaiss 81:119-23. 1988
    ..c.v.). BAY i.c.v. dit not change BRS in Wistar rats. These results indicate that DHP may centrally modulate BRS in SHR and suggest a central sympatho-excitatory effect for BAY mediated by an enhanced release of acetylcholine...
  75. ncbi request reprint Mechanical strength of the isolated carotid artery in SHR
    G Cohuet
    , Inserm EMI, U460, Paris, LMP, , France
    Hypertension 38:1167-71. 2001
    ..We have demonstrated that static elasticity of the arterial wall and mechanical strength are similar in carotid arteries from SHR and WKY...
  76. doi request reprint Reference intervals for common carotid intima-media thickness measured with echotracking: relation with risk factors
    Lian Engelen
    Department of Pharmacology and INSERM U970, Hopital Europeen Georges Pompidou, Paris, France
    Eur Heart J 34:2368-80. 2013
    ..We therefore aimed to establish reference intervals of CCIMT, obtained using the probably most accurate method at present (i.e. echotracking), to help interpretation of these measures...
  77. doi request reprint Arterial stiffness is increased in patients with inflammatory bowel disease
    Luca Zanoli
    Department of Internal Medicine, University of Catania, Catania, Italy
    J Hypertens 30:1775-81. 2012
    ..In these patients, the chronic low-grade inflammation may predispose to vascular remodelling and arterial stiffening. We aimed at studying arterial stiffness in IBD patients...
  78. doi request reprint Ambulatory arterial stiffness index does not accurately assess arterial stiffness
    Jan G Kips
    Heymans Institute of Pharmacology, Gent University, Gent, Belgium
    J Hypertens 30:574-80. 2012
    ..Using a previously validated one-dimensional computer model of the arterial circulation, the relative importance of the different determinants of the AASI was explored...
  79. doi request reprint Renal artery diameter, renal function and resistant hypertension in patients with low-to-moderate renal artery stenosis
    Luca Zanoli
    Department of Internal Medicine, University of Catania, Italy
    J Hypertens 30:600-7. 2012
    ..We aimed to identify the association of reference diameter and minimal luminal renal artery diameter with glomerular filtration rate (GFR) and resistant hypertension in a high cardiovascular risk population...
  80. ncbi request reprint Contrasting circadian rhythms of blood pressure among inbred rat strains: recognition of dipper and non-dipper patterns
    Alexandra Basset
    INSERM EMI 0107, Laboratoire de Biomécanique et Pharmacologie de la Paroi Artérielle, Paris, France
    J Hypertens 22:727-37. 2004
    ....
  81. ncbi request reprint Hemodynamic effects of the anti-hypertensive agent ketanserin in hypertension in man
    Y A Weiss
    Diagnosis Center, Broussais Hospital, Paris
    Acta Cardiol 42:329-37. 1987
    ....
  82. ncbi request reprint [Pulse pressure and echocardiographic parameters in essential arterial hypertension]
    B Pannier
    Centre de Diagnostic, , Paris, France
    Arch Mal Coeur Vaiss 81:33-7. 1988
    ..Conclusion: arterial hypertension is linked with left ventricular hypertrophy which is increased when pulsed pressure is enhanced. This fact could give evidence of importance of pulsatory work in cardiac consequence of hypertension...
  83. ncbi request reprint Central interactions between dihydropyridines and cholinergic systems in the control of blood pressure in rat
    A M Brisac
    Département de Pharmacologie et Unité INSERM 228, Faculté de Médecine Broussais Hôtel Dieu, Paris, France
    Brain Res 435:160-6. 1987
    ..The participation of central DHP sites in the cholinergic transmission in genetic hypertension is discussed...
  84. ncbi request reprint Distension capacity of the carotid artery and ambulatory blood pressure monitoring. Effects of age and hypertension
    R S Cunha
    Department of Internal Medicine, Broussais Hospital, Paris, France
    Am J Hypertens 8:343-52. 1995
    ..Thus, in addition to the level of blood pressure, carotid artery distension is specifically influenced by two factors independently implicated in the epidemiologic cardiovascular risk: pulse pressure and heart rate...
  85. ncbi request reprint Influence of diuretics on brachial artery diameter and distensibility in hypertensive patients
    S Laurent
    Department of Internal Medicine, Broussais Hospital, Paris, France
    Fundam Clin Pharmacol 4:685-93. 1990
    ..The study indicates that, in hypertensive patients of middle age, diuretics did not change brachial artery diameter and distensibility, whether the drug caused an increase or a decrease in plasma potassium levels...
  86. ncbi request reprint Noninvasive detection of an increased vascular mass in untreated hypertensive patients
    X Girerd
    Department of Internal Medicine, Broussais Hospital, Paris, France
    Am J Hypertens 7:1076-84. 1994
    ..Circumferential wall stress, calculated from diastolic internal diameter, wall thickness, and diastolic blood pressure, was not different in the three groups.(ABSTRACT TRUNCATED AT 250 WORDS)..
  87. ncbi request reprint Lack of association between renin-angiotensin system, gene polymorphisms, and wall thickness of the radial and carotid arteries
    X Girerd
    From the Department of Internal Medicine and INSERM U337, the Department of Pharmacology and INSERM U337 and the Laboratory of Molecular Biology, Broussais Hospital, Paris, France
    Hypertension 32:579-83. 1998
    ..These results suggest that these gene polymorphisms have an undetectable role in the geometry of the radial and carotid arteries compared with usual determinants such as blood pressure and age...
  88. ncbi request reprint Effects of acupuncture on radial artery hemodynamics: controlled trials in sensitized and naive subjects
    P Boutouyrie
    , , Paris, France
    Am J Physiol Heart Circ Physiol 280:H628-33. 2001
    ..Our results demonstrate that real acupuncture is associated with an objective vasodilatation of the radial artery in patients regularly exposed to acupuncture, but not in naive subjects...
  89. ncbi request reprint Inheritance of arterial lesions in renal fibromuscular dysplasia
    J Perdu
    AP HP, Department of Genetics, Hopital Europeen Georges Pompidou, Paris, France
    J Hum Hypertens 21:393-400. 2007
    ..The carotid score obtained by high-resolution echotracking may provide a non-invasive surrogate marker for renal FMD of potential value for use in linkage strategies on large pedigrees...
  90. ncbi request reprint Arterial stiffness and enlargement in mild-to-moderate chronic kidney disease
    M Briet
    Department of Physiology, Hopital Europeen Georges Pompidou, Assistance Publique Hopitaux de Paris, Paris, France
    Kidney Int 69:350-7. 2006
    ..Arterial enlargement and increased arterial stiffness occur in parallel with the decline in renal function in patients with mild-to-moderate CKD...
  91. ncbi request reprint [The best of hypertension in 2002]
    S Laurent
    Service de Pharmacologie et INSERM EMI 0107, Hopital Europeen Georges Pompidou, 20, rue Lablanc, 75015 Paris
    Arch Mal Coeur Vaiss 96:9-13. 2003
    ....
  92. ncbi request reprint The wall to lumen ratio of the radial artery in patients with Raynaud's phenomenon
    J J Mourad
    Department of Internal Medicine, Broussais Hospital, Paris, France
    J Vasc Res 34:298-305. 1997
    ..It is suggested that the geometrical and mechanical changes of this artery may favor the downstream occlusive phenomena observed in patients with PRP and SSc...
  93. ncbi request reprint Arterial remodelling in Fabry disease
    P Boutouyrie
    Department of Pharmacology, INSERM EMI 107, Hopital Europeen Georges Pompidou, Paris, France
    Acta Paediatr Suppl 91:62-6. 2002
    ..We therefore set out to compare parameters of arterial wall structure and function in a cohort of patients with Fabry disease and an age-matched control group...
  94. ncbi request reprint [Anomalies in the hemodynamic response to short lasting emotional stress in essential hypertensive subjects]
    S Laurent
    Centre de Diagnostic, , Paris, France
    Arch Mal Coeur Vaiss 82:1099-103. 1989
    ..The lack of change in D suggest an increase in vascular tone of large arteries likely contributing to the rise in pulse pressure during MA in both groups...
  95. ncbi request reprint Influence of tamoxifen on carotid intima-media thickness in postmenopausal women
    T Simon
    Department of Pharmacology, St Antoine University Hospital, Paris, France
    Circulation 106:2925-9. 2002
    ..The goal of this study was to determine the influence of tamoxifen on IMT-CCA in menopausal women...
  96. ncbi request reprint [Flow-dependent vasodilation of the brachial artery in the normotensive and essential hypertensive patient]
    P Brunel
    Centre de Diagnostic, , Paris, France
    Arch Mal Coeur Vaiss 81:71-4. 1988
    ..Increasing the duration of DO from 2 to 4 mn further enhanced the reactive blood flow velocity but did not change the magnitude of the reactive brachial artery vasodilation.(ABSTRACT TRUNCATED AT 250 WORDS)..
  97. ncbi request reprint [The best of 2001. Arterial hypertension]
    S Laurent
    Service de Pharmacologie, INSERM EMI 107, Hopital Europeen Georges Pompidou, 20, rue Leblanc, 75015 Paris
    Arch Mal Coeur Vaiss 95:9-12. 2002
    ....
  98. ncbi request reprint Renal and systemic hemodynamics in borderline hypertension
    G M London
    Diagnosis Center, Broussais Hospital, Paris, France
    Am J Hypertens 1:127S-130S. 1988
    ..No significant changes in glomerular filtration rate and renal filtration fraction were observed. The study clearly demonstrated that renal ischemia was absent in young patients with borderline hypertension...
  99. ncbi request reprint Simultaneous determination of the acid/base antihypertensive drugs celiprolol, bisoprolol and irbesartan in human plasma by liquid chromatography
    E Caudron
    Laboratoire de Pharmacologie, Hopital Europeen Georges Pompidou, 20 rue Leblanc, 75015 Paris, France
    J Chromatogr B Analyt Technol Biomed Life Sci 801:339-45. 2004
    ....