S Latour

Summary

Country: France

Publications

  1. pmc Regulation of natural cytotoxicity by the adaptor SAP and the Src-related kinase Fyn
    Coralie Bloch-Queyrat
    Laboratoire du Développement Normal et Pathologique du Système Immunitaire, Unité Institut National de la Santé et de la Recherche Medicale 429, Hopital Necker Enfants Malades, 75015 Paris, France
    J Exp Med 202:181-92. 2005
  2. pmc Defective NKT cell development in mice and humans lacking the adapter SAP, the X-linked lymphoproliferative syndrome gene product
    Benoit Pasquier
    Laboratoire du Développement Normal et Pathologique du Système Immunitaire, Unité INSERM 429
    J Exp Med 201:695-701. 2005
  3. ncbi request reprint Molecular and immunological basis of X-linked lymphoproliferative disease
    Sylvain Latour
    Unité INSERM U429, Hopital Necker Enfants Malades, Paris, France
    Immunol Rev 192:212-24. 2003
  4. ncbi request reprint The SAP family of adaptors in immune regulation
    Sylvain Latour
    Unité INSERM U429, Hopital Necker Enfants Malades, 149 rue de Sevres, 75015 Paris, France
    Semin Immunol 16:409-19. 2004
  5. ncbi request reprint Proximal protein tyrosine kinases in immunoreceptor signaling
    S Latour
    Laboratory of Molecular Oncology, IRCM, 110 Pine Avenue West, H2W 1R7, Montreal, Quebec, Canada
    Curr Opin Immunol 13:299-306. 2001
  6. ncbi request reprint Natural killer T cells and X-linked lymphoproliferative syndrome
    Sylvain Latour
    Inserm U768, Hopital Necker Enfants Malades, Paris, France
    Curr Opin Allergy Clin Immunol 7:510-4. 2007
  7. ncbi request reprint Regulation of SLAM-mediated signal transduction by SAP, the X-linked lymphoproliferative gene product
    S Latour
    Laboratory of Molecular Oncology, IRCM, 110 Pine Ave West, Montreal, Quebec, Canada H2W 1R7
    Nat Immunol 2:681-90. 2001
  8. ncbi request reprint Bidirectional negative regulation of human T and dendritic cells by CD47 and its cognate receptor signal-regulator protein-alpha: down-regulation of IL-12 responsiveness and inhibition of dendritic cell activation
    S Latour
    McGill Cancer Center, McGill University and Institut de Recherches Cliniques, Montreal, Quebec, Canada
    J Immunol 167:2547-54. 2001
  9. pmc Dok-3, a novel adapter molecule involved in the negative regulation of immunoreceptor signaling
    S Lemay
    McGill Cancer Centre, McGill University, Montreal, Quebec, Canada H3G 1Y6
    Mol Cell Biol 20:2743-54. 2000
  10. ncbi request reprint High expression of inhibitory receptor SHPS-1 and its association with protein-tyrosine phosphatase SHP-1 in macrophages
    A Veillette
    McGill Cancer Centre, McGill University, Montreal, Quebec, Canada H3G 1Y6
    J Biol Chem 273:22719-28. 1998

Collaborators

  • Andre Veillette
  • A Fischer
  • Frederic Rieux-Laucat
  • Luo Yin
  • C Picard
  • H Tanaka
  • J Zhang
  • J Yu
  • M Arock
  • G Delespesse
  • F P Lindberg
  • M Daeron
  • Jean Laurent Casanova
  • A R Gennery
  • Pamela L Schwartzberg
  • A Durandy
  • Elie Haddad
  • Riyan Chen
  • Stéphanie Rigaud
  • Marie Claude Fondaneche
  • Francis Relouzat
  • Francoise Le Deist
  • Benoit Pasquier
  • Coralie Bloch-Queyrat
  • Romain Roncagalli
  • Salima Hacein-Bey-Abina
  • Zhongjun Dong
  • Marjorie Côte
  • Anne Laure Rougemont
  • Genevieve De Saint Basile
  • Mario Ernesto Cruz-Munoz
  • Genevieve de Saint-Basile
  • Xiaochu Shi
  • Nathalie Lambert
  • Umaima Al-Alem
  • Ricardo Sorensen
  • Lily Leiva
  • Charles C Berry
  • Chantal Martinache
  • Marina Cavazzana-Calvo
  • Marianne Debre
  • Frederic D Bushman
  • S Lemay
  • Annick Lim
  • Bernd H Belohradsky
  • Julia Hauer
  • Gary P Wang
  • Stephane Blanche
  • Musa Al-Harbi
  • Nathalie Prince
  • Abdullah Alangari
  • Ulrich Blank
  • Mickaël M Ménager
  • Gehad El-Ghazali
  • Ming Chao Zhong
  • Catherine Schaffner
  • Astrid Cariou
  • Gael Menasche
  • Patrick Nitschke
  • D Davidson
  • Nizar Mahlaoui
  • Fahad Al-Manjomi
  • Agathe Burgess
  • Laura Rubbia-Brandt
  • Steven R Martin
  • M Y Cao
  • Jean Christophe Fournet
  • Marie Noel Primeau
  • Patrick Revy
  • Pauline Soulas
  • Lionel Galicier
  • Véronique Mateo
  • James E R Taylor
  • Nathalie Forey
  • Cuiling Li
  • Shaohua Zhang
  • Zhao Qi Wang
  • Sean V Tavtigian
  • Rusung Tan
  • Ala Aoukaty

Detail Information

Publications28

  1. pmc Regulation of natural cytotoxicity by the adaptor SAP and the Src-related kinase Fyn
    Coralie Bloch-Queyrat
    Laboratoire du Développement Normal et Pathologique du Système Immunitaire, Unité Institut National de la Santé et de la Recherche Medicale 429, Hopital Necker Enfants Malades, 75015 Paris, France
    J Exp Med 202:181-92. 2005
    ..They also could help to explain the high propensity of patients who have XLP disease to develop lymphoproliferative disorders...
  2. pmc Defective NKT cell development in mice and humans lacking the adapter SAP, the X-linked lymphoproliferative syndrome gene product
    Benoit Pasquier
    Laboratoire du Développement Normal et Pathologique du Système Immunitaire, Unité INSERM 429
    J Exp Med 201:695-701. 2005
    ..They also identify for the first time a defect in NKT cells associated with a human primary immunodeficiency, revealing a potential role of NKT cells in the immune response to EBV...
  3. ncbi request reprint Molecular and immunological basis of X-linked lymphoproliferative disease
    Sylvain Latour
    Unité INSERM U429, Hopital Necker Enfants Malades, Paris, France
    Immunol Rev 192:212-24. 2003
    ..Functional and genetic analyses suggest that the phenotype associated with XLP is caused in large part by defects in the functions of SLAM-related receptors due to SAP deficiency...
  4. ncbi request reprint The SAP family of adaptors in immune regulation
    Sylvain Latour
    Unité INSERM U429, Hopital Necker Enfants Malades, 149 rue de Sevres, 75015 Paris, France
    Semin Immunol 16:409-19. 2004
    ..Several lines of evidence indicate that defects in the activities of SLAM-related receptors caused by SAP deficiency account for the immune dysfunctions associated with XLP...
  5. ncbi request reprint Proximal protein tyrosine kinases in immunoreceptor signaling
    S Latour
    Laboratory of Molecular Oncology, IRCM, 110 Pine Avenue West, H2W 1R7, Montreal, Quebec, Canada
    Curr Opin Immunol 13:299-306. 2001
    ..And fifth, it was suggested that proximal kinases implicated in immunoreceptor-mediated signal transduction may be regulated by protein degradation via binding to c-Cbl, a ubiquitin ligase...
  6. ncbi request reprint Natural killer T cells and X-linked lymphoproliferative syndrome
    Sylvain Latour
    Inserm U768, Hopital Necker Enfants Malades, Paris, France
    Curr Opin Allergy Clin Immunol 7:510-4. 2007
    ..Here I will review this information and discuss the issues involved...
  7. ncbi request reprint Regulation of SLAM-mediated signal transduction by SAP, the X-linked lymphoproliferative gene product
    S Latour
    Laboratory of Molecular Oncology, IRCM, 110 Pine Ave West, Montreal, Quebec, Canada H2W 1R7
    Nat Immunol 2:681-90. 2001
    ..They also provide insights into the pathophysiology of a severe human lymphoproliferative disease...
  8. ncbi request reprint Bidirectional negative regulation of human T and dendritic cells by CD47 and its cognate receptor signal-regulator protein-alpha: down-regulation of IL-12 responsiveness and inhibition of dendritic cell activation
    S Latour
    McGill Cancer Center, McGill University and Institut de Recherches Cliniques, Montreal, Quebec, Canada
    J Immunol 167:2547-54. 2001
    ..Therefore, CD47 on T cells and its cognate receptor SIRP-alpha on DC define a novel regulatory pathway that may be involved in the maintenance of homeostasis by preventing the escalation of the inflammatory immune response...
  9. pmc Dok-3, a novel adapter molecule involved in the negative regulation of immunoreceptor signaling
    S Lemay
    McGill Cancer Centre, McGill University, Montreal, Quebec, Canada H3G 1Y6
    Mol Cell Biol 20:2743-54. 2000
    ....
  10. ncbi request reprint High expression of inhibitory receptor SHPS-1 and its association with protein-tyrosine phosphatase SHP-1 in macrophages
    A Veillette
    McGill Cancer Centre, McGill University, Montreal, Quebec, Canada H3G 1Y6
    J Biol Chem 273:22719-28. 1998
    ..Taken together, these findings indicate that SHPS-1 is likely to play a significant role in macrophages, at least partially as a consequence of its capacity to recruit SHP-1...
  11. pmc Clnk, a novel SLP-76-related adaptor molecule expressed in cytokine-stimulated hemopoietic cells
    M Y Cao
    McGill Cancer Centre, McGill University, Montreal, Quebec, Canada H3G 1Y6
    J Exp Med 190:1527-34. 1999
    ..Furthermore, they suggest that Clnk may be involved in a cross-talk mechanism between cytokine receptor and immunoreceptor signaling...
  12. pmc Molecular dissection of 2B4 signaling: implications for signal transduction by SLAM-related receptors
    Riyan Chen
    Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Quebec, Canada
    Mol Cell Biol 24:5144-56. 2004
    ....
  13. ncbi request reprint Interactions of CD45-associated protein with the antigen receptor signaling machinery in T-lymphocytes
    A Veillette
    McGill Cancer Centre, McGill University, Montreal, Quebec H3G 1Y6, Canada
    J Biol Chem 274:14392-9. 1999
    ..Moreover, they raise the possibility that one of the functions of CD45-AP is to recognize activated Lck molecules and bring them into the vicinity of CD45...
  14. pmc Association between SAP and FynT: Inducible SH3 domain-mediated interaction controlled by engagement of the SLAM receptor
    Riyan Chen
    Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montreal, Quebec, Canada
    Mol Cell Biol 26:5559-68. 2006
    ..Together, these data elucidate further the events initiating SLAM-SAP signaling in immune cells. Moreover, they identify a strictly inducible interaction mediated by an SH3 domain...
  15. ncbi request reprint The SLAM family of immune-cell receptors
    Andre Veillette
    Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montreal, Quebec, Canada
    Curr Opin Immunol 15:277-85. 2003
    ..The existence of the SLAM family broadens the spectrum of receptors known to be involved in immunomodulation...
  16. pmc Regulation of high-affinity IgE receptor-mediated mast cell activation by murine low-affinity IgG receptors
    M Daeron
    Laboratoire d Immunologie Cellulaire et Clinique, INSERM U255, Institut Curie, Paris, France
    J Clin Invest 95:577-85. 1995
    ..This regulation of Fc epsilon RI-mediated mast cell activation is of potential interest in mast cell physiology and in allergic pathology...
  17. doi request reprint Essential function for SAP family adaptors in the surveillance of hematopoietic cells by natural killer cells
    Zhongjun Dong
    Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montreal, Quebec, Canada
    Nat Immunol 10:973-80. 2009
    ..Hence, the SAP family is essential for the elimination of unwanted hematopoietic cells by NK cells...
  18. pmc A unique insert in the linker domain of Syk is necessary for its function in immunoreceptor signalling
    S Latour
    McGill Cancer Centre, McGill University, Montreal, Quebec, Canada H3G 1Y6
    EMBO J 17:2584-95. 1998
    ..Furthermore, they provided evidence that the linker region can regulate the ability of Syk to bind ITAMs, thus identifying a novel function for this domain...
  19. ncbi request reprint Negative regulation of natural killer cell function by EAT-2, a SAP-related adaptor
    Romain Roncagalli
    Clinical Research Institute of Montreal, Montreal, Quebec H2W 1R7, Canada
    Nat Immunol 6:1002-10. 2005
    ..These data identify a previously unknown mechanism of NK cell inhibition. Moreover, they indicate that EAT-2 and SAP have distinct and at times opposing functions in natural immunity...
  20. ncbi request reprint Consequence of the SLAM-SAP signaling pathway in innate-like and conventional lymphocytes
    Andre Veillette
    Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montreal, Quebec, Canada H2W 1R7
    Immunity 27:698-710. 2007
    ..The importance of the SLAM-SAP pathway in normal immunity is highlighted by the finding that SAP is mutated in humans suffering from the immunodeficiency X-linked lymphoproliferative disease...
  21. doi request reprint Chronic active gastritis in X-linked lymphoproliferative disease
    Anne Laure Rougemont
    Department of Pathology, CHU Sainte Justine, Universite de Montreal, Quebec, Canada
    Am J Surg Pathol 32:323-8. 2008
    ..No infectious cause was determined. We favor a dysimmune mechanism in the development of this chronic atrophic gastritis, presenting a striking similarity to the recently described atrophic autoimmune pangastritis...
  22. pmc Efficacy of gene therapy for X-linked severe combined immunodeficiency
    Salima Hacein-Bey-Abina
    Department of Biotherapy, Necker Enfants Malades Hospital, Paris, France
    N Engl J Med 363:355-64. 2010
    ..We reviewed long-term outcomes after gene therapy in nine patients with X-linked severe combined immunodeficiency (SCID-X1), which is characterized by the absence of the cytokine receptor common gamma chain...
  23. ncbi request reprint XIAP deficiency in humans causes an X-linked lymphoproliferative syndrome
    Stéphanie Rigaud
    Inserm 768, Laboratoire du Développement Normal et Pathologique du Système Immunitaire, Univ René Descartes, Paris, F 75015, France
    Nature 444:110-4. 2006
    ..Furthermore, by identifying an XLP immunodeficiency that is caused by mutations in XIAP, we show that XIAP is a potent regulator of lymphocyte homeostasis in vivo...
  24. ncbi request reprint Negative regulation of immunoreceptor signaling
    Andre Veillette
    Laboratory of Molecular Oncology, IRCM, 110 Pine Avenue West, Montreal, Quebec, Canada H2W 1R7
    Annu Rev Immunol 20:669-707. 2002
    ..Genetic evidence indicates that this inhibitory machinery is crucial for normal immune cell homeostasis...
  25. ncbi request reprint Binding of SAP SH2 domain to FynT SH3 domain reveals a novel mechanism of receptor signalling in immune regulation
    Sylvain Latour
    Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montreal, Quebec, H2W 1R7, Canada
    Nat Cell Biol 5:149-54. 2003
    ..These observations characterize a biologically important signalling mechanism in which an adaptor molecule composed only of an SH2 domain links a receptor devoid of intrinsic catalytic activity to the kinase required for its function...
  26. pmc Munc18-2 deficiency causes familial hemophagocytic lymphohistiocytosis type 5 and impairs cytotoxic granule exocytosis in patient NK cells
    Marjorie Côte
    Inserm U768, Hopital Necker Enfants Malades, Paris, France
    J Clin Invest 119:3765-73. 2009
    ..These data indicate that STXBP2 is required at a late step of the secretory pathway for the release of cytotoxic granules by binding syntaxin 11, another component of the intracellular membrane fusion machinery...
  27. ncbi request reprint Impaired Ig class switch in mice deficient for the X-linked lymphoproliferative disease gene Sap
    Umaima Al-Alem
    International Agency for Research on Cancer, Lyon, France
    Blood 106:2069-75. 2005
    ..While XLP is believed to cause defects in T, natural killer T (NKT), and natural killer (NK) cells, our results indicate that B cells are also affected...
  28. ncbi request reprint [An X-linked lymphoproliferative syndrome (XLP) caused by mutations in the inhibitor-of-apoptosis gene XIAP]
    Stéphanie Rigaud
    Med Sci (Paris) 23:235-7. 2007