- Spb1p-directed formation of Gm2922 in the ribosome catalytic center occurs at a late processing stageBruno Lapeyre
Centre de Recherche de Biochimie Macromoleculaire, 1919 Route de Mende, 34293 Montpellier, France
Mol Cell 16:663-9. 2004..Thus, eukaryotes have maintained a site-specific enzyme to catalyze the methylation of a nucleotide that plays a crucial role in ribosome biogenesis and translation...
- Trm11p and Trm112p are both required for the formation of 2-methylguanosine at position 10 in yeast tRNASuresh K Purushothaman
Centre de Recherche de Biochimie Macromoleculaire du CNRS, 34293 Montpellier, France
Mol Cell Biol 25:4359-70. 2005..In addition, TRM11 interacts genetically with TRM1, thus suggesting that the absence of m(2)G10 and m(2)(2)G26 affects tRNA metabolism or functioning...
- Trm7p catalyses the formation of two 2'-O-methylriboses in yeast tRNA anticodon loopLionel Pintard
Centre de Recherche de Biochimie Macromoleculaire du CNRS, 1919 Route de Mende, F 34293 Montpellier cedex 5, France
EMBO J 21:1811-20. 2002..We propose that each eukaryotic enzyme is located in a different cell compartment, in which it would methylate a different RNA that can adopt a very similar secondary structure...
- Trm112p is a 15-kDa zinc finger protein essential for the activity of two tRNA and one protein methyltransferases in yeastMarie Hélène Mazauric
Centre de Recherche de Biochimie Macromoleculaire, University of Montpellier 1 and 2, 34293 Montpellier, France
J Biol Chem 285:18505-15. 2010..Trm112p is associated with other partners involved in ribosome biogenesis and chromatin remodeling, suggesting that it has additional roles in the cell...
- MRM2 encodes a novel yeast mitochondrial 21S rRNA methyltransferaseLionel Pintard
Centre de Recherche de Biochimie Macromoleculaire, CNRS, Montpellier, France
EMBO J 21:1139-47. 2002..Our data suggest that this universally conserved modified nucleotide plays an important function in vivo, possibly by inducing conformational rearrangement of the peptidyl transferase centre...
- mRNA decay is rapidly induced after spore germination of Saccharomyces cerevisiaeMuriel Brengues
, 1919 Route de Mende, 34293 Montpellier Cedex 5, France
J Biol Chem 277:40505-12. 2002..We present evidence that there is ongoing transcription and translation in nongerminating yeast spores incubated in water at 30 degrees C, suggesting that these activities could play a role in spore long term survival...