Research Topics
| Bruno LapeyreSummaryCountry: France Publications
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Detail Information
Publications
Spb1p-directed formation of Gm2922 in the ribosome catalytic center occurs at a late processing stageBruno Lapeyre
Centre de Recherche de Biochimie Macromoleculaire, 1919 Route de Mende, 34293 Montpellier, France
Mol Cell 16:663-9. 2004..Thus, eukaryotes have maintained a site-specific enzyme to catalyze the methylation of a nucleotide that plays a crucial role in ribosome biogenesis and translation...
Trm11p and Trm112p are both required for the formation of 2-methylguanosine at position 10 in yeast tRNASuresh K Purushothaman
Centre de Recherche de Biochimie Macromoleculaire du CNRS, 34293 Montpellier, France
Mol Cell Biol 25:4359-70. 2005..In addition, TRM11 interacts genetically with TRM1, thus suggesting that the absence of m(2)G10 and m(2)(2)G26 affects tRNA metabolism or functioning...
Trm7p catalyses the formation of two 2'-O-methylriboses in yeast tRNA anticodon loopLionel Pintard
Centre de Recherche de Biochimie Macromoleculaire du CNRS, 1919 Route de Mende, F 34293 Montpellier cedex 5, France
EMBO J 21:1811-20. 2002..We propose that each eukaryotic enzyme is located in a different cell compartment, in which it would methylate a different RNA that can adopt a very similar secondary structure...
Trm112p is a 15-kDa zinc finger protein essential for the activity of two tRNA and one protein methyltransferases in yeastMarie Hélène Mazauric
Centre de Recherche de Biochimie Macromoleculaire, University of Montpellier 1 and 2, 34293 Montpellier, France
J Biol Chem 285:18505-15. 2010..Trm112p is associated with other partners involved in ribosome biogenesis and chromatin remodeling, suggesting that it has additional roles in the cell...
MRM2 encodes a novel yeast mitochondrial 21S rRNA methyltransferaseLionel Pintard
Centre de Recherche de Biochimie Macromoleculaire, CNRS, Montpellier, France
EMBO J 21:1139-47. 2002..Our data suggest that this universally conserved modified nucleotide plays an important function in vivo, possibly by inducing conformational rearrangement of the peptidyl transferase centre...
mRNA decay is rapidly induced after spore germination of Saccharomyces cerevisiaeMuriel Brengues
, 1919 Route de Mende, 34293 Montpellier Cedex 5, France
J Biol Chem 277:40505-12. 2002..We present evidence that there is ongoing transcription and translation in nongerminating yeast spores incubated in water at 30 degrees C, suggesting that these activities could play a role in spore long term survival...
