Maryse Lapeyre-Mestre

Summary

Country: France

Publications

  1. ncbi request reprint Drug interactions with cholinesterase inhibitors: an analysis of the French pharmacovigilance database and a comparison of two national drug formularies (Vidal, British National Formulary)
    Neda Tavassoli
    Clinical Pharmacology Department, Centre of Pharmacoepidemiology and Drug Information, Pharmacoepidemiology Unit, Faculty of Medicine, Paul Sabateir University, Toulouse, France
    Drug Saf 30:1063-71. 2007
  2. ncbi request reprint [Use of the capture-recapture method to assess the frequency of "serious" adverse drug reactions: experience of Toulouse University Hospital]
    Jean Louis Montastruc
    Laboratoire de Pharmacologie Medicale et Clinique, Unité de Pharmacoépidémiologie, EA 3696, Faculte de Medecine, Toulouse
    Bull Acad Natl Med 192:421-30; discussion 430-1. 2008
  3. ncbi request reprint Incidence and cost of adverse drug reactions in a French cancer institute
    M Lapeyre-Mestre
    Department of Clinical Pharmacology, Faculte de Medecine, Toulouse, France
    Eur J Clin Pharmacol 53:19-22. 1997
  4. ncbi request reprint Vinorelbine-related cardiac events: a meta-analysis of randomized clinical trials
    Maryse Lapeyre-Mestre
    Department of Clinical Pharmacology, centre Midi Pyrénées de pharmacovigilance, de Pharmacoépidémiologie, et d Information sur le Médicament, Faculty of Medicine, 37 Allees Jules Guesde, BP 7202, 31073 Toulouse Cedex, France
    Fundam Clin Pharmacol 18:97-105. 2004
  5. ncbi request reprint [Management of acute infantile diarrhoea: a study on community pharmacy counseling in the Midi-Pyrenees region]
    M Lapeyre-Mestre
    EA 3696, Unité de Pharmaco épidémiologie, Service de Pharmacologie Clinique, Faculte de Medecine, 37, allée Jules Guesde, BP 7202, 31073 Toulouse cedex 7, France
    Arch Pediatr 11:898-902. 2004
  6. ncbi request reprint Triptan use and risk of cardiovascular events: a nested-case-control study from the French health system database
    S Lugardon
    Unité de Pharmacoépidémiologie, EA 3696, Service de Pharmacologie Clinique, Faculte de Medecine, Universite Paul Sabatier, 37 Allees Jules Guesde, 31000, Toulouse, France
    Eur J Clin Pharmacol 63:801-7. 2007
  7. ncbi request reprint [Taking drugs in the working environment: a study in a sample of 2106 workers in the Toulouse metropolitan area]
    Maryse Lapeyre-Mestre
    Service de Pharmacologie Clinique, EA 3696, Unité de Pharmacoépidémiology, IFR 126, Faculte de Medecine, Toulouse, France
    Therapie 59:615-23. 2004
  8. ncbi request reprint Non-steroidal anti-inflammatory drug-related hepatic damage in France and Spain: analysis from national spontaneous reporting systems
    Maryse Lapeyre-Mestre
    Service de Pharmacologie Clinique, centre Midi Pyrénées de pharmacovigilance, de Pharmacoepidemiologie et d Informations sur le Medicament, EA3696, Universite Paul Sabatier, Toulouse, France
    Fundam Clin Pharmacol 20:391-5. 2006
  9. ncbi request reprint Opiate maintenance with buprenorphine in ambulatory care: a 24-week follow-up study of new users
    M Lapeyre-Mestre
    EA 3696, Unit of Pharmacoepidemiology, Department of Clinical Pharmacology, Centre d Evaluation et d Information sur la Pharmacodependance, 37 Allees Jules Guesde, 31073 Toulouse 7, France
    Drug Alcohol Depend 72:297-303. 2003
  10. doi request reprint Potentially inappropriate medication use among patients with Alzheimer disease in the REAL.FR cohort: be aware of atropinic and benzodiazepine drugs!
    Francois Montastruc
    Laboratoire de Pharmacologie Medicale et Clinique, Faculte de Medecine, Universite de Toulouse, 37 Allees Jules Guesde, 31000 Toulouse, France
    Eur J Clin Pharmacol 69:1589-97. 2013

Detail Information

Publications113 found, 100 shown here

  1. ncbi request reprint Drug interactions with cholinesterase inhibitors: an analysis of the French pharmacovigilance database and a comparison of two national drug formularies (Vidal, British National Formulary)
    Neda Tavassoli
    Clinical Pharmacology Department, Centre of Pharmacoepidemiology and Drug Information, Pharmacoepidemiology Unit, Faculty of Medicine, Paul Sabateir University, Toulouse, France
    Drug Saf 30:1063-71. 2007
    ..Cholinesterase inhibitors (ChEIs) could be involved in several drug-drug interactions (DDIs) because of their complex pharmacodynamic and/or pharmacokinetic properties...
  2. ncbi request reprint [Use of the capture-recapture method to assess the frequency of "serious" adverse drug reactions: experience of Toulouse University Hospital]
    Jean Louis Montastruc
    Laboratoire de Pharmacologie Medicale et Clinique, Unité de Pharmacoépidémiologie, EA 3696, Faculte de Medecine, Toulouse
    Bull Acad Natl Med 192:421-30; discussion 430-1. 2008
    ..9% of inpatients (95% CI 2.3, 3.5) during the first half of 2001. This study confirms the lack of exhaustiveness of ADR reporting, whatever the data source, and underlines the value of merging data from different databases...
  3. ncbi request reprint Incidence and cost of adverse drug reactions in a French cancer institute
    M Lapeyre-Mestre
    Department of Clinical Pharmacology, Faculte de Medecine, Toulouse, France
    Eur J Clin Pharmacol 53:19-22. 1997
    ..The incidence and the cost of adverse drug reactions (ADR) in patients treated by cancer chemotherapy were assessed using hospital database records from 1993 in a French regional cancer institute...
  4. ncbi request reprint Vinorelbine-related cardiac events: a meta-analysis of randomized clinical trials
    Maryse Lapeyre-Mestre
    Department of Clinical Pharmacology, centre Midi Pyrénées de pharmacovigilance, de Pharmacoépidémiologie, et d Information sur le Médicament, Faculty of Medicine, 37 Allees Jules Guesde, BP 7202, 31073 Toulouse Cedex, France
    Fundam Clin Pharmacol 18:97-105. 2004
    ..Vinorelbine-related cardiac events concern about 1% of treated patients in clinical trials. However, the risk associated with VNR seems to be similar to that of other chemotherapeutic agents in the same indications...
  5. ncbi request reprint [Management of acute infantile diarrhoea: a study on community pharmacy counseling in the Midi-Pyrenees region]
    M Lapeyre-Mestre
    EA 3696, Unité de Pharmaco épidémiologie, Service de Pharmacologie Clinique, Faculte de Medecine, 37, allée Jules Guesde, BP 7202, 31073 Toulouse cedex 7, France
    Arch Pediatr 11:898-902. 2004
    ..However, drugs available in children without prescription form are scarce, and most of the over-the-counter drugs have not been tested and approved in children...
  6. ncbi request reprint Triptan use and risk of cardiovascular events: a nested-case-control study from the French health system database
    S Lugardon
    Unité de Pharmacoépidémiologie, EA 3696, Service de Pharmacologie Clinique, Faculte de Medecine, Universite Paul Sabatier, 37 Allees Jules Guesde, 31000, Toulouse, France
    Eur J Clin Pharmacol 63:801-7. 2007
    ..The use of triptans (5-HT agonists) in the treatment of migraine is associated with a potential increasing risk of cardiovascular events and raises the question of the relationship between overuse and the occurrence of ischemic events...
  7. ncbi request reprint [Taking drugs in the working environment: a study in a sample of 2106 workers in the Toulouse metropolitan area]
    Maryse Lapeyre-Mestre
    Service de Pharmacologie Clinique, EA 3696, Unité de Pharmacoépidémiology, IFR 126, Faculte de Medecine, Toulouse, France
    Therapie 59:615-23. 2004
    ..The aim of this study was to investigate the frequency and characteristics of "supportive" drug use and addictive behaviour in the working environment...
  8. ncbi request reprint Non-steroidal anti-inflammatory drug-related hepatic damage in France and Spain: analysis from national spontaneous reporting systems
    Maryse Lapeyre-Mestre
    Service de Pharmacologie Clinique, centre Midi Pyrénées de pharmacovigilance, de Pharmacoepidemiologie et d Informations sur le Medicament, EA3696, Universite Paul Sabatier, Toulouse, France
    Fundam Clin Pharmacol 20:391-5. 2006
    ..These discrepancies could be explained in part not only by reporting rates, but also by difference in drug use patterns and/or by genetic or environmental factors...
  9. ncbi request reprint Opiate maintenance with buprenorphine in ambulatory care: a 24-week follow-up study of new users
    M Lapeyre-Mestre
    EA 3696, Unit of Pharmacoepidemiology, Department of Clinical Pharmacology, Centre d Evaluation et d Information sur la Pharmacodependance, 37 Allees Jules Guesde, 31073 Toulouse 7, France
    Drug Alcohol Depend 72:297-303. 2003
    ..The aim of this study was to assess the patterns of buprenorphine prescription use in ambulatory care and retention rate under treatment during a 24-week follow-up period...
  10. doi request reprint Potentially inappropriate medication use among patients with Alzheimer disease in the REAL.FR cohort: be aware of atropinic and benzodiazepine drugs!
    Francois Montastruc
    Laboratoire de Pharmacologie Medicale et Clinique, Faculte de Medecine, Universite de Toulouse, 37 Allees Jules Guesde, 31000 Toulouse, France
    Eur J Clin Pharmacol 69:1589-97. 2013
    ..The aim of our study was to assess the prevalence of PIM in community-dwelling patients diagnosed with mild-to-moderate AD and identify the clinical factors associated with PIM prescriptions...
  11. doi request reprint Prevalence and associations of the use of proton-pump inhibitors in nursing homes: a cross-sectional study
    Philipe de Souto Barreto
    Gérontopôle de Toulouse, Institut du vieillissement, Centre Hospitalo Universitaire de Toulouse CHU Toulouse, Toulouse, France
    J Am Med Dir Assoc 14:265-9. 2013
    ..Very scarce information is available about the use of proton-pump inhibitors (PPI) in nursing homes (NH). This study investigated the factors associated with PPI use among NH residents...
  12. doi request reprint The importance of drug-drug interactions as a cause of adverse drug reactions: a pharmacovigilance study of serotoninergic reuptake inhibitors in France
    Francois Montastruc
    Laboratoire de Pharmacologie Medicale et Clinique, UMR INSERM U1027, Equipe de Pharmacoépidémiologie, Faculte de Medecine, Universite de Toulouse, 37 Allees Jules Guesde, 31000 Toulouse, France
    Eur J Clin Pharmacol 68:767-75. 2012
    ..To quantify the importance of drug-drug interactions (DDIs) in the occurrence of adverse drug reactions (ADRs) reported with serotoninergic reuptake inhibitors in a pharmacovigilance database...
  13. doi request reprint Hospitalizations because of adverse drug reactions in elderly patients admitted through the emergency department: a prospective survey
    Pascale Olivier
    Unit of Pharmacoepidemiology, University of Toulouse, Toulouse, France
    Drugs Aging 26:475-82. 2009
    ..Thus, the aim of this prospective study was to assess the incidence of ADRs and associated factors leading to hospital admissions in the elderly population...
  14. ncbi request reprint Pharmacovigilance for evaluating adverse drug reactions: value, organization, and methods
    Jean Louis Montastruc
    Medical and Clinical Pharmacology Laboratory, Pharmacoepidemiology Unit, EA 3696, IFR INSERM 126, Paul Sabatier University, School of Medicine, Toulouse, France
    Joint Bone Spine 73:629-32. 2006
  15. ncbi request reprint [Drugs, Parkinson's disease and parkinsonian syndroms: recent advances in pharmacovigilance]
    Jean Louis Montastruc
    Laboratoire de Pharmacologie Medicale et Clinique, Unité de Pharmacoépidémiologie, UA 3696, IFR 126, Universite Paul Sabatier, Faculte de Medecine, Toulouse, France
    Therapie 61:29-38. 2006
    ..It is also an important mediator for pleasure, hedonic regulations and sexual behaviour. This review also underlines the major role of spontaneous reports to the pharmacovigilance systems to identify new adverse drug reactions...
  16. doi request reprint Effectiveness of drug tests in outpatients starting opioid substitution therapy
    Julie Dupouy
    Département universitaire de médecine générale, Universite de Toulouse, Faculte de Medecine, 133 route de Narbonne, 31063 Toulouse, France
    J Subst Abuse Treat 44:515-21. 2013
    ..55 (95% CI: 0.38-0.80). Use of a drug test in follow-up of opioid substitution treatment, although rarely prescribed, significantly improved treatment retention...
  17. doi request reprint Non-steroidal anti-inflammatory drugs (NSAIDs) and hypertension treatment intensification: a population-based cohort study
    Jean Pascal Fournier
    Laboratoire de Pharmacologie Medicale et Clinique, Faculte de Medecine, Universite Paul Sabatier, 37 Allees Jules Guesde, 31000, Toulouse, France
    Eur J Clin Pharmacol 68:1533-40. 2012
    ..We examined whether the introduction of NSAID into the treatment regimen would induce an intensification of hypertension treatment (defined as the introduction of a new antihypertensive drug)...
  18. ncbi request reprint Modifications of low-molecular weight heparin use in a French university hospital after implementation of new guidelines
    Sophie Leclerc-Foucras
    Department of Anesthesiology, Toulouse University Hospital, Toulouse, France
    Drug Saf 30:409-17. 2007
    ..This study assesses LMWH use before and after the implementation of these guidelines...
  19. doi request reprint Persistent use of analgesic medications in mild-to-moderate Alzheimer's disease
    Adeline Gallini
    INSERM, UMR1027, 31062, Toulouse, France
    Drugs Aging 30:439-45. 2013
    ..Previous studies have reported a lower use of analgesics in patients with Alzheimer's disease (AD) than in non-AD elderly. To date, no study has focused on persistent analgesic use in patients with mild-to-moderate AD...
  20. pmc Trends of reporting of 'serious'vs. 'non-serious' adverse drug reactions over time: a study in the French PharmacoVigilance Database
    Guillaume Moulis
    CHU Toulouse, Service de Pharmacologie Clinique, centre Midi Pyrénées de pharmacovigilance, de Pharmacoepidemiologie et d Informations sur le Medicament, Toulouse, F 31059, France
    Br J Clin Pharmacol 74:201-4. 2012
    ..Among them, 'seriousness' of the reaction is one of the most important. • However, evolution in the reporting of 'serious'vs.'non-serious' ADRs over time for the same drug remains unknown...
  21. doi request reprint Importance of cytochrome P450 (CYP450) in adverse drug reactions due to drug-drug interactions: a PharmacoVigilance study in France
    Anne Charlotte Danton
    Service de Pharmacologie Clinique, centre Midi Pyrénées de pharmacovigilance, de Pharmacoepidemiologie et d Informations sur le Medicament, Centre Hospitalier Universitaire de Toulouse, Toulouse, France
    Eur J Clin Pharmacol 69:885-8. 2013
    ..Our aim was to characterize Adverse Drug Reactions (ADRs) related to drug-drug interactions (DDIs) related to involvement of cytochrome P450 (CYP450) isoenzymes in a pharmacovigilance database...
  22. doi request reprint [Opiate substitution treatment's cycles in a five-year followed-up cohort in ambulatory practice]
    Julie Dupouy
    Département universitaire de médecine générale, Faculte de Medecine, Toulouse, France
    Therapie 68:155-61. 2013
    ..To describe opiate substitution treatment (OST) cycles in a five year followed-up cohort of patients initiating OST during 5 years in ambulatory practice...
  23. ncbi request reprint [Prescribing drugs by international non-proprietary name: the perception of health and non-health professionals]
    Julie Biga
    Service de Pharmacologie Clinique, centre Midi Pyrénées de pharmacovigilance, de Pharmacoépidémiologie et d Information sur le Médicament, Unité de Pharmacoépidémiologie, Faculte de Medecine, Toulouse, France
    Therapie 60:401-7. 2005
    ..The aim of this study was to evaluate the perceptions of health professionals and non-health professionals with regard to prescribing drugs by their international non-proprietary name (INN) in the Midi-Pyrénées area, France...
  24. doi request reprint Buprenorphine versus methadone in pregnant opioid-dependent women: a prospective multicenter study
    Isabelle Lacroix
    Centre Hospitalier Universitaire de Toulouse, Laboratoire de Pharmacologie Medicale et Clinique, Centre d Evaluation et d Information sur la Pharmacodépendance et d Addictovigilance, INSERM U1027, Universite de Toulouse, Toulouse, France
    Eur J Clin Pharmacol 67:1053-9. 2011
    ..Ninety pregnant women exposed to buprenorphine and 45 to metadone were selected for the study...
  25. doi request reprint [Prevalence of diabetes in france and drug use: study based on the French pharmacovigilance database]
    Stéphanie Berthet
    Unité de Pharmacoépidémiologie, EA 3696, Universite Paul Sabatier, Faculte de Medecine, Toulouse, France
    Therapie 62:483-8. 2007
    ..The aim of this study was to investigate the use of the French Pharmacovigilance Database to estimate characteristics of drug utilization in specific diseases...
  26. ncbi request reprint Gender differences in adverse drug reactions: analysis of spontaneous reports to a Regional Pharmacovigilance Centre in France
    Jean Louis Montastruc
    Service de Pharmacologie Clinique, Unité de Pharmacoépidémiologie, centre Midi Pyrénées de pharmacovigilance, de Pharmacoepidemiologie et d Informations sur le Medicament, Centre Hospitalier Universitaire, 31073 Toulouse, France
    Fundam Clin Pharmacol 16:343-6. 2002
    ..These results confirm that female gender is a risk factor for the development of ADRs...
  27. pmc Cancer risk of anti-TNF-α at recommended doses in adult rheumatoid arthritis: a meta-analysis with intention to treat and per protocol analyses
    Guillaume Moulis
    CHU Toulouse, Service de Medecine Interne, Toulouse, France
    PLoS ONE 7:e48991. 2012
    ..Furthermore, the relative interest of modified intention to treat or per protocol analyses to assess such sparse events remains unknown...
  28. ncbi request reprint Coxibs: evolution of prescription's behaviour in France
    Julie Biga
    Laboratoire de Pharmacologie Medicale et Clinique, Unité de Pharmaco épidémiologie, EA 3696, IFR 126, Universite Paul Sabatier, Faculté de Médecine de Toulouse, Toulouse, France
    Fundam Clin Pharmacol 21:317-25. 2007
    ....
  29. doi request reprint Prescribed drugs and violence: a case/noncase study in the French PharmacoVigilance Database
    Nadège Rouve
    Service de Pharmacologie Clinique, centre Midi Pyrénées de pharmacovigilance, de Pharmacoépidémiologie et d Information sur les Médicaments, Centre Hospitalier Universitaire de Toulouse, Toulouse, France
    Eur J Clin Pharmacol 67:1189-98. 2011
    ..Our aim was to identify prescribed drugs associated with violent behaviours using the French PharmacoVigilance Database (FPVD)...
  30. doi request reprint Anxious and depressive symptoms in Parkinson's disease: the French cross-sectionnal DoPaMiP study
    Laurence Negre-Pages
    Department of Clinical Pharmacology, University Hospital, Toulouse, France
    Mov Disord 25:157-66. 2010
    ..Both symptoms were commonly associated in the same PD patients, but were correlated with different clinical/therapeutic features, suggesting different underlying pathophysiological mechanisms...
  31. ncbi request reprint [Patterns of non steroidal anti-inflammatory drug use in ambulatory care]
    Stephanie Lugardon
    Service de Pharmacologie Clinique, Unité de Pharmacoépidémiologie, EA 3696, IFR 126, Faculte de Medecine, Toulouse, France
    Therapie 61:109-14. 2006
    ..This study confirms the wide use of NSAIDs and describes their target population. It underlines the interest of Health Insurance System Database for better knowledge of drug use in ambulatory care in France...
  32. ncbi request reprint [Which analgesic after dextropropoxyphene withdrawal? A survey in a sample of general practitioners in southwest of France]
    Serge Bismuth
    Département Universitaire de Médecine Générale de Midi Pyrénées, Universite de Toulouse, Toulouse, France
    Therapie 66:25-8. 2011
    ..7%) and tramadol alone or associated with paracetamol (74.6%) in chronic pain. Switching to other level 2 analgesic drugs after the withdrawal of dextropropoxyphene should be closely monitored because the safety profile of other drugs...
  33. ncbi request reprint [New methods for studying drug associated risk: experience of the Toulouse Regional Pharmacovigilance Center]
    Jean Louis Montastruc
    Laboratoire de Pharmacologie Medicale et Clinique, Unité de Pharmacoépidémiologie, EA 3696, IFR INSERM 126, Faculte de Medecine, 37 Allees Jules Guesde, BP 7202, 31073 Toulouse 7, France
    Bull Acad Natl Med 189:493-502; discussion 502-5. 2005
    ..Finally, ADR perception analysis is a useful method to evaluate the perceived social and medical importance of drug risks in different populations (public, pharmacists, general practitioners, medical specialists)...
  34. doi request reprint High maintenance dosage of clopidogrel is associated with a reduced risk of stent thrombosis in clopidogrel-resistant patients
    Neda Tavassoli
    Medical and Clinical Pharmacology Laboratory, Pharmacoepidemiology Unit, Faculty of Medicine, Toulouse University, Toulouse, France
    Am J Cardiovasc Drugs 10:29-35. 2010
    ..Some recent studies have suggested that a higher clopidogrel maintenance dosage could enhance ex vivo platelet inhibition and thereby overcome resistance to clopidogrel...
  35. doi request reprint Statins and erectile dysfunction: results of a case/non-case study using the French Pharmacovigilance System Database
    Catherine Do
    Universite de Toulouse, UPS, Unité de Pharmacoépidémiologie EA 3696, Toulouse, France
    Drug Saf 32:591-7. 2009
    ..The relationship between ED and exposure to statins has not clearly been established even though a number of significant case reports have associated ED with exposure to statins...
  36. pmc Using a capture-recapture method to assess the frequency of adverse drug reactions in a French university hospital
    Stephanie Lugardon
    Unit of Pharmacoepidemiology, EA 3696, IFR 126 Health and Society, University Paul Sabatier, Toulouse, France
    Br J Clin Pharmacol 62:225-31. 2006
    ....
  37. ncbi request reprint Follow-up of adverse drug reactions from peginterferon alfa-2b-ribavirin therapy
    Haleh Bagheri
    Service de Pharmacologie Clinique, centre Midi Pyrénées de pharmacovigilance, de Pharmacoepidemiologie et d Informations sur le Medicament, Faculte de Medecine, Hopitaux de Toulouse, Toulouse, France
    Pharmacotherapy 24:1546-53. 2004
    ..To investigate the adverse drug reactions (ADRs) from peginterferon alfa-2b plus ribavirin in patients infected with the hepatitis C virus (HCV)...
  38. doi request reprint Comparison of chronic analgesic drugs prevalence in Parkinson's disease, other chronic diseases and the general population
    Christine Brefel-Courbon
    Service de Pharmacologie Clinique, CHU Toulouse, France
    Pain 141:14-8. 2009
    ..PD patients were more exposed than the general population and diabetics to opiates, acetaminophen, and adjuvant analgesics chronic use...
  39. doi request reprint Adverse drug reactions to local anaesthetics: a review of the French pharmacovigilance database
    Regis Fuzier
    Laboratoire de Pharmacologie Medicale et Clinique, Unité de Pharmacoépidémiologie, EA 3696, Universite de Toulouse, Faculte de Medecine, and Service de Pharmacologie Clinique, Centre Hospitalier Universitaire de Toulouse, Toulouse, France
    Drug Saf 32:345-56. 2009
    ..The most common adverse drug reactions (ADRs) to LAs are neurological (seizures) and cardiac (conduction disorders, cardiac arrests). However, little is known about other adverse drug reactions (ADRs)...
  40. ncbi request reprint Influence of HCV or HBV coinfection on adverse drug reactions to antiretroviral drugs in HIV patients
    Emmanuelle Guitton
    Laboratoire de Pharamcologie Médicale et Clinique, Unité de Pharmacoépidémiologie EA3696, IFR 126, Faculte de Medecine, 37 Allees Jules Guesde, Toulouse Cedex 7, 31073, France
    Eur J Clin Pharmacol 62:243-9. 2006
    ....
  41. ncbi request reprint [Methods for the measurement of drug consumption: application to antibiotics]
    Agnes Sommet
    Unité de Pharmacoépidémiologie, EA 3696, Service de Pharmacologie Clinique, Universite Paul Sabatier, Toulouse, France
    Therapie 60:553-9. 2005
    ..The aim of this article is to present and compare the different methods used to study drug consumption...
  42. pmc Which adverse events are related to health care during hospitalization in elderly inpatients?
    Julie Dupouy
    CHU Toulouse, Service de Post Urgences Médicales Médecine Interne, Place du Docteur Baylac, 31079 Toulouse, Cedex 9, France
    Int J Med Sci 10:1224-30. 2013
    ..Adverse events result in longer hospital stays and increase costs and mortality. We aimed to assess incidence of adverse events occurring during hospitalization in a post-emergency unit and to describe their characteristics...
  43. ncbi request reprint Antipsychotic use and mortality risk in community-dwelling Alzheimer's disease patients: evidence for a role of dementia severity
    Virginie Gardette
    Universite de Toulouse III, France
    Curr Alzheimer Res 9:1106-16. 2012
    ..To date, antipsychotic risks outweigh their benefits in BPSD for which non-pharmacological approaches remain the first-line strategy and should be privileged...
  44. doi request reprint Drug-induced immune thrombocytopenia: a descriptive survey in the French PharmacoVigilance database
    Guillaume Moulis
    Department of Internal Medicine, Toulouse University Hospital, Toulouse, France
    Platelets 23:490-4. 2012
    ..Ezetimibe may induce chronic ITP. Drug-induced ITP is rarely severe. Finally, this study also shows that chronicity of ITP does not rule out the possibility of an iatrogenic cause...
  45. doi request reprint A comparative study of adverse drug reactions during two heat waves that occurred in France in 2003 and 2006
    Agnes Sommet
    Laboratoire de Pharmacologie Medicale et Clinique, Unité de Pharmacoépidémiologie, INSERM U1027, Universite de Toulouse, Faculte de Medecine, Toulouse, 31000, France
    Pharmacoepidemiol Drug Saf 21:285-8. 2012
    ..Thus, we wanted to describe the main characteristics of heat-related 'serious' ADRs occurred in patients older than 70 years during these two events in France (2003 and 2006)...
  46. doi request reprint Safety of amide local anesthetics: new trends
    Regis Fuzier
    University of Toulouse, Unit of Pharmacoepidemiology, EA3696, Clinical Pharmacology Department, CHU, 37 Allees Jules Guesde, Toulouse 31000, France
    Expert Opin Drug Saf 9:759-69. 2010
    ..Neurologic and cardiovascular events are the most frequent adverse reactions related to local anesthetics use. Recently, new trends have been developed on this topic...
  47. doi request reprint Evaluation of abuse and dependence on drugs used for self-medication: a pharmacoepidemiological pilot study based on community pharmacies in France
    Ludivine Orriols
    Unité de Pharmacoépidémiologie, EA 3696 Université de Toulouse, Toulouse, France
    Drug Saf 32:859-73. 2009
    ..Some of these drugs contain psychoactive substances with a potential for abuse and dependence. However, there is a lack of data concerning their problematic use in a wide population...
  48. pmc Reporting rate of adverse drug reactions to the French pharmacovigilance system with three step 2 analgesic drugs: dextropropoxyphene, tramadol and codeine (in combination with paracetamol)
    Neda Tavassoli
    Laboratoire de Pharmacologie Medicale et Clinique, Unité de Pharmacoépidémiologie, EA3696, Universite de Toulouse, Faculte de Medecine, 31000 Toulouse, France
    Br J Clin Pharmacol 68:422-6. 2009
    ..The aim was to compare the reporting rate of ADRs between tramadol/paracetamol (TRM+P), codeine/paracetamol (COD+P) and dextropropoxyphene/paracetamol (DXP+P)...
  49. ncbi request reprint Drug related falls: a study in the French Pharmacovigilance database
    Emmanuelle Souchet
    Service de Pharmacologie Clinique, Unité de Pharmacoépidémiologie, centre Midi Pyrénées de pharmacovigilance, de Pharmacoepidemiologie et d Informations sur le Medicament, Faculte de Medecine, Toulouse Cedex, France
    Pharmacoepidemiol Drug Saf 14:11-6. 2005
    ..To investigate the risk of falls associated with drugs among the French population using data reported to the French spontaneous reporting system and recorded in the French Pharmacovigilance database...
  50. ncbi request reprint Survey of forged prescriptions to investigate risk of psychoactive medications abuse in France: results of OSIAP survey
    Olivia Boeuf
    Unit of Pharmacoepidemiology, Service de Pharmacologie Clinique, Centre d Evaluation et d Information sur les Pharmacodépendances, University Paul Sabatier, Toulouse, France
    Drug Saf 30:265-76. 2007
    ..To describe patterns of drug diversion from 2001 to 2004 in France and to define different profiles of forged prescriptions...
  51. ncbi request reprint Drug-induced yawning: a review of the French pharmacovigilance database
    Agnes Sommet
    Laboratoire de Pharmacologie Medicale et Clinique, Unité de Pharmacoépidémiologie, EA 3696, IFR INSERM 126, Universite Paul Sabatier, Faculte de Medecine, Toulouse, France
    Drug Saf 30:327-31. 2007
    ..To review the reports with 'yawning' as an adverse drug reaction (ADR) reported into the French Pharmacovigilance Database...
  52. doi request reprint Predictive factors of discontinuation and switch of cholinesterase inhibitors in community-dwelling patients with Alzheimer's disease: a 2-year prospective, multicentre, cohort study
    Virginie Gardette
    Department of Epidemiology and Public Health, Toulouse University Hospital, Université de Toulouse UPS, INSERM U558, Gerontopole, Toulouse, France
    CNS Drugs 24:431-42. 2010
    ..There is a lack of data concerning the optimal drug treatment duration and the reasons for discontinuation, particularly outside the clinical trial setting...
  53. ncbi request reprint Utilisation and safety of low molecular weight heparins: prospective observational study in medical inpatients
    Philippe Cestac
    Department of Clinical Pharmacology, centre Midi Pyrénées de pharmacovigilance, de Pharmacoepidemiologie et d Informations sur le Medicament, Faculte de Medecine, Toulouse, France
    Drug Saf 26:197-207. 2003
    ....
  54. doi request reprint Adverse drug reactions to gabapentin and pregabalin: a review of the French pharmacovigilance database
    Regis Fuzier
    Pharmacoepidemiology Research Unit, INSERM 1027, University of Toulouse, and Department of Clinical Pharmacology, Toulouse University Hospital, Toulouse, France
    Drug Saf 36:55-62. 2013
    ..Gabapentin and pregabalin are widely used as antineuropathic pain drugs. Their use is also associated with the development of adverse drug reactions (ADRs), mainly neuropsychiatric...
  55. ncbi request reprint [Profile of psychoactive substances consumption in workplace]
    Olivia Bœuf-Cazou
    Universite de Toulouse, Toulouse, France
    Therapie 66:155-65. 2011
    ..The aim of this study was to identify profiles of psychoactive substances consumers among workers according to their professional characteristics...
  56. doi request reprint Exposure to inhibitors of the renin-angiotensin system is a major independent risk factor for acute renal failure induced by sucrose-containing intravenous immunoglobulins: a case-control study
    Guillaume Moulis
    U1027 INSERM Pharmacoepidemiology Unit, Department of Clinical Pharmacology Centre Régional Midi Pyrénées de PharmacoVigilance, de Pharmacoépidémiologie et d Informations sur les Médicaments, Toulouse University Hospital, University of Toulouse, Toulouse, France
    Pharmacoepidemiol Drug Saf 21:314-9. 2012
    ..This study was aimed at quantifying the risk of IVIg-RF associated with exposure to drugs that modify intrarenal hemodynamics...
  57. ncbi request reprint [Pharmacologic criteria for medical substitution in opiate dependence]
    Jean Louis Montastruc
    Service de Pharmacologie Clinique, Centre d Evaluation et d Informations sur la Pharmacodépendance CEIP, CHU de Toulouse, Toulouse, France
    Therapie 58:123-5. 2003
    ..These criteria were applied to methadone, buprenorphine and other drugs that were proposed in the treatment of opioid dependence (such as morphine or codeine)...
  58. doi request reprint Drug prescribing before and during pregnancy in south west France: a retrolective study
    Sophie Crespin
    Service de Pharmacologie Clinique, CHU de Toulouse, Centre Midi Pyrnes de Pharmacovigilance, de Pharmaco pidmiologie et dInformation sur le Mdicament, Unit de Pharmaco pidmiologie, INSERM U1027, Universit de Toulouse, France
    Drug Saf 34:595-604. 2011
    ..Nevertheless, it is often possible to replace a drug with another one that has been better evaluated...
  59. doi request reprint [Drugs and heat wave: SIRIUS, a multicentric case-control study in patients older than 65 years during 2007 summer in France]
    Agnes Sommet
    Laboratoire de Pharmacologie Medicale et Clinique, Unité de Pharmacoépidémiologie EA3696, Universite de Toulouse, Universite Paul Sabatier, Faculte de Medecine, Toulouse, France
    Therapie 64:295-301. 2009
    ..To evaluate in real conditions the role of drugs in heat-related adverse effects...
  60. pmc Cannabis-related hospitalizations: unexpected serious events identified through hospital databases
    Emilie Jouanjus
    Universite de Toulouse, UPS, Equipe de Pharmacoépidémiologie INSERM U 1027, Faculte de Medecine, 37 Allees Jules Guesde, F 31000 Toulouse, France
    Br J Clin Pharmacol 71:758-65. 2011
    ..However, the risk related to cannabis consumption is not well established. The present study aimed to assess cannabis-related adverse events leading to hospitalization, and to estimate the corresponding annual risk for consumers...
  61. ncbi request reprint Drug counselling in pregnancy: an opinion survey of French community pharmacists
    Christine Damase-Michel
    Department of Pharmacology, Research Unit of Pharmacoepidemiology, Faculte de Medecine, Toulouse, France
    Pharmacoepidemiol Drug Saf 13:711-5. 2004
    ..The aim of the present study was to determine whether community pharmacists recommend appropriate medications and give valid information to pregnant women...
  62. doi request reprint Indicators of benzodiazepine use in nursing home residents in France: a cross-sectional study
    Philipe de Souto Barreto
    Gérontopôle de Toulouse, Institut du vieillissement, Centre Hospitalo Universitaire de Toulouse CHU Toulouse, Toulouse, France
    J Am Med Dir Assoc 14:29-33. 2013
    ..Little information is available about associations between nursing home (NH) structural and organizational aspects and benzodiazepine prescriptions, particularly for long-acting drugs. This study addressed this knowledge gap...
  63. ncbi request reprint Doctor shopping reveals geographical variations in opioid abuse
    Sandra Nordmann
    Centre d Evaluation et d Information de la Pharmacodépendance Addictovigilance PACA Corse, Hopital Timone, Pharmacologie Clinique, Institut des Neurosciences de la Timone, Faculte de Medecine, Aix Marseille Université UMR 7289 CNRS, Marseille, France
    Pain Physician 16:89-100. 2013
    ..Prescription opioid abuse is not homogeneous due to varying patterns of use and different geographic preferences. Because doctor shopping is one of the main sources of diversion, it has previously been used to estimate drug abuse...
  64. pmc Drug safety of rosiglitazone and pioglitazone in France: a study using the French PharmacoVigilance database
    Stéphanie Berthet
    Unité INSERM 1027, Equipe de Pharmacoépidémiologie, Universite de Toulouse, Toulouse, France
    BMC Clin Pharmacol 11:5. 2011
    ..The aim of our study was to investigate the profile of adverse drug reactions (ADRs) related to TZDs and to investigate potential risk factors of these ADRs...
  65. doi request reprint On-site drugs of abuse urinary screening tests for the management of opiate-addicted patients: a survey among French general practitioners
    Julie Dupouy
    University of Toulouse, Department of Family Practice, Faculte de Medecine Rangueil, Toulouse, France
    Eur Addict Res 18:175-83. 2012
    ..Most of the GPs did not perform ODUTs because they were unaware of whether such tests were reliable or available. Many French GPs treating opiate-addicted patients regularly did not perform ODUTs and lacked knowledge of them...
  66. pmc Laboratory monitoring of patients treated with antihypertensive drugs and newly exposed to non steroidal anti-inflammatory drugs: a cohort study
    Jean Pascal Fournier
    Laboratoire de Pharmacologie Medicale et Clinique, Faculte de Medecine, Universite Paul Sabatier, Toulouse, France
    PLoS ONE 7:e34187. 2012
    ..Thus, monitoring of serum creatinine and potassium is recommended when a first dispensing of NSAID occur in patients treated with these drugs...
  67. doi request reprint Spinal anesthesia failure after local anesthetic injection into cerebrospinal fluid: a multicenter prospective analysis of its incidence and related risk factors in 1214 patients
    Regis Fuzier
    Unit of Pharmacoepidemiology, Clinical Pharmacology Department, University of Toulouse, Toulouse, France
    Reg Anesth Pain Med 36:322-6. 2011
    ..The aim of this prospective multicenter study was to assess the incidence of spinal anesthesia failure, excluding technical problems, and then to suggest independent factors leading to failure...
  68. doi request reprint Impact of long-term benzodiazepine use on cognitive functioning in young adults: the VISAT cohort
    Olivia Boeuf-Cazou
    U1027 INSERM Pharmacoepidemiology Unit, Faculty of Medicine, University of Toulouse, 37, allées Jules Guesde, 31000, Toulouse, France
    Eur J Clin Pharmacol 67:1045-52. 2011
    ..The aim of this study was to determine the impact of benzodiazepine use on cognitive functions in a young adult population...
  69. doi request reprint QT interval prolongation: prevalence, risk factors and pharmacovigilance data among methadone-treated patients in France
    Aurélie Perrin-Terrin
    Unité de Pharmacoépidémiologie EA3696, INSERM, U558, Faculte de Medecine Purpan, Universite de Toulouse, UPS, 37 Allées Jules Guesde F 31000 Toulouse, France
    Fundam Clin Pharmacol 25:503-10. 2011
    ..A cardiac evaluation, with at least a systematic ECG, could be useful during methadone treatment, particularly in case of recent modification of the regimen...
  70. doi request reprint [Buprenorphine for the treatment of opioid dependence: a study on generic substitution conducted in community pharmacies]
    Gaëlle Julians-Minou
    Unité de Pharmacoépidémiologie, EA 3696, Universite de Toulouse, Centre d Evaluation et d Information sur la Pharmacodépendance Addictovigilance, Service de Pharmacologie Clinique, Hopitaux de Toulouse, France
    Therapie 65:241-7. 2010
    ..To describe the evolution of buprenorphine prescription form characteristics before and after the application of a measure of the French Social Security system aimed to encourage the use of generic drugs...
  71. ncbi request reprint [Coxibs, which real therapeutic advance?: Recent pharmacoepidemiological data]
    Jean Louis Montastruc
    Service de Pharmacologie Clinique du Centre Hospitalier Universitaire de Toulouse, France
    Therapie 59:201-5. 2004
    ..Currently marketed coxibs do not appear to meet the previously defined criteria for therapeutic advance...
  72. ncbi request reprint [Pharmacoepidemiology in clinical practice]
    Jean Louis Montastruc
    Service de Pharmacologie Clinique, Faculté de médecine BP 7202, 31073 Toulouse
    Rev Prat 52:701-3. 2002
  73. doi request reprint Factors associated with psychoactive drug initiation in a sample of workers in France: results of the VISAT cohort study
    O Boeuf-Cazou
    Universite de Toulouse, UPS, Unité de Pharmacoépidémiologie EA3696, Faculte de Medecine Purpan, F 31000Toulouse, France
    Pharmacoepidemiol Drug Saf 19:296-305. 2010
    ..To identify which psychosocial factors at work are associated with the initiation of psychoactive drug use in a cohort of healthy French workers...
  74. pmc Detection and incidence of drug-induced liver injuries in hospital: a prospective analysis from laboratory signals
    H Bagheri
    Laboratoire de Pharmacologie Medicale et Clinique, centre Midi Pyrénées de pharmacovigilance, de Pharmacoepidemiologie et d Informations sur le Medicament, Centre Hospitalier Universitaire, Faculte de Medecine, Toulouse, France
    Br J Clin Pharmacol 50:479-84. 2000
    ..Our objectives were to assess the detection and incidence of drug-induced liver abnormalities in a university hospital inpatient population and to evaluate the underreporting rate of drug-induced liver injury...
  75. ncbi request reprint Fertility and outcomes of pregnancy after chemotherapy in a sample of childbearing aged women
    G Durrieu
    Service de Pharmacologie Clinique, centre Midi Pyrénées de pharmacovigilance, de Pharmacoépidémiologie et d Information sur le Médicament, Faculte de Medecine, 37, allées Jules Guesde, 31073 Toulouse Cx, France
    Fundam Clin Pharmacol 18:573-9. 2004
    ..A prospective and systemic survey would be the only means able to clarify the actual cancer therapy on reproductive outcome and to investigate the long-term effects in the progeny...
  76. ncbi request reprint Long-term mortality results of the randomized controlled study comparing bromocriptine to which levodopa was later added with levodopa alone in previously untreated patients with Parkinson's disease
    J L Montastruc
    Service de Pharmacologie Clinique, centre Midi Pyrénées de pharmacovigilance, de Pharmacoépidémiologie et d Informations sur le Médicament and Centre d Investigation Clinique, Faculté de Médecine and Hôpitaux de Toulouse, France
    Mov Disord 16:511-4. 2001
    ..71-1.95]), in group D (0.98 [0.42-1.93]), or in group B/D (1.53 [0.70-2.92]). In this population, we were unable to find any favourable effect of an early use of bromocriptine on mortality in PD in comparison with levodopa alone...
  77. doi request reprint Evolution of drug consumption in a sample of French workers since 1986: the 'Drugs and Work' study
    O Boeuf-Cazou
    Universite de Toulouse, UPS, Unité de Pharmacoépidémiologie EA3696, Faculte de Medecine Purpan, 37 Allees Jules Guesde, F 31000 Toulouse, France
    Pharmacoepidemiol Drug Saf 18:335-43. 2009
    ..The aim of this study was to describe the changing patterns of drug use in French workers since 1986 and to evaluate the impact of programs developed to reduce drug consumption...
  78. ncbi request reprint Perception of the risk of gastrointestinal adverse drug reactions with non-steroidal anti-inflammatory drugs (including coxibs): differences among general practitioners, gastroenterologists and rheumatologists
    J L Montastuc
    Service de Pharmacologie Clinique, Unité de Pharmacoépidémiologie, Faculte de Medecine, 37 Allees Jules Guesde, BP 7202, 31073 Toulouse cedex 7, France
    Eur J Clin Pharmacol 59:685-8. 2003
    ..To compare the perception of risk of gastrointestinal adverse drug reactions (ADRs) with non-steroidal anti-inflammatory drugs (NSAIDs) (including coxibs) in general practitioners, gastroenterologists and rheumatologists...
  79. ncbi request reprint Assessing the feasibility of using an adverse drug reaction preventability scale in clinical practice: a study in a French emergency department
    Pascale Olivier
    Department of Clinical Pharmacology, centre Midi Pyrénées de pharmacovigilance, Faculty of Medicine, Toulouse University Hospital, Toulouse, France
    Drug Saf 25:1035-44. 2002
    ..To assess the preventability of adverse drug reactions (ADRs) leading to hospital admissions and to investigate the feasibility of the use of a standardised preventability scale in clinical practice...
  80. doi request reprint Assessment of abuse potential of benzodiazepines from a prescription database using 'doctor shopping' as an indicator
    Vincent Pradel
    Centre d Evaluation et d Information sur la Pharmacodépendance CEIP PACA Corse, Centre Associé, Service de Pharmacologie Clinique, Marseille, France
    CNS Drugs 24:611-20. 2010
    ..Doctor shopping (the simultaneous use of several physicians by a patient) is one of the most important ways in which prescription drugs, in particular benzodiazepines, are diverted...
  81. doi request reprint Second meeting of the French CEIP (Centres d'Evaluation et d'Information sur la Pharmacodépendance). Part I: how to evaluate and prevent the abuse and dependence on hypnotic/anxiolytic drugs?
    Joëlle Micallef-Roll
    Centre d Evaluation et d Information sur la Pharmacodépendance CEIP Addictovigilance, PACA Corse, Centre Associé, Service de Pharmacologie Clinique, Marseille, France
    Therapie 64:355-64. 2009
    ..Despite this evidence, there is a scarcity of information on the factors associated with a such behaviour and its screening, assessment, diagnosis and treatment...
  82. ncbi request reprint Pharmacological and clinical evidences on the potential for abuse and dependence of propofol: a review of the literature
    Anne Roussin
    Service de Pharmacologie Clinique, Centre d Evaluation et d Information sur la Pharmacodépendance de Toulouse, EA 3696, Universite Paul Sabatier, Faculte de Medecine, 31000 Toulouse, France
    Fundam Clin Pharmacol 21:459-66. 2007
    ..The aim of this review was to provide an overview of molecular, animal and clinical pharmacological data of the literature evidencing the potential for abuse and dependence of propofol...
  83. doi request reprint Immediate- and delayed-type allergic reactions to amide local anesthetics: clinical features and skin testing
    Regis Fuzier
    Laboratoire de Pharmacologie Medicale et Clinique, Unité de Pharmacoépidémiologie EA3696, Faculte de Medecine, Universite de Toulouse, Universite Paul Sabatier, Toulouse, France
    Pharmacoepidemiol Drug Saf 18:595-601. 2009
    ..Among them, allergic reactions are considered rare. The aim of this study was to describe the main characteristics of ADRs induced by amide type local anesthetic drugs...
  84. doi request reprint Severe necrotizing soft-tissue infections and nonsteroidal anti-inflammatory drugs
    C Souyri
    Department of Clinical Pharmacology, Pharmacovigilance Regional Centre, Toulouse University Hospital, Toulouse, France
    Clin Exp Dermatol 33:249-55. 2008
    ..The use of nonsteroidal anti-inflammatory drugs (NSAIDs) has been implicated as a contributing factor, but their role remains debated...
  85. doi request reprint Was the thrombotic risk of rofecoxib predictable from the French Pharmacovigilance Database before 30 September 2004?
    A Sommet
    Laboratoire de Pharmacologie Medicale et Clinique, Unité de Pharmacoépidémiologie, EA 3696, Universite de Toulouse, Faculte de Medecine, 37 Allees Jules Guesde, Toulouse, France
    Eur J Clin Pharmacol 64:829-34. 2008
    ..The aim of this study was to investigate whether this kind of signal could have been seen using the French Pharmacovigilance Database before this date of rofecoxib withdrawal...
  86. ncbi request reprint Upper gastrointestinal adverse drug reactions and cyclo-oxygenase-2 inhibitors (celecoxib and rofecoxib): a case/non-case study from the French Pharmacovigilance Database
    S Lugardon
    Service de Pharmacologie Clinique, centre Midi Pyrénées de pharmacovigilance, de Pharmacoépidémiologie et d Information sur le Médicament, Unité de Pharmacoépidémiologie, EA 3696, IFR 126, Faculte de Medecine, Toulouse, France
    Eur J Clin Pharmacol 60:673-7. 2004
    ..To evaluate the gastrointestinal safety of cyclo-oxygenase-2 inhibitors under their real conditions of use. DESIGN. Case/non-case study...
  87. ncbi request reprint Risk of serious extrapyramidal symptoms in patients with Parkinson's disease receiving antidepressant drugs: a pharmacoepidemiologic study comparing serotonin reuptake inhibitors and other antidepressant drugs
    Mireille Gony
    Service de Pharmacologie Clinique, Unité de Pharmacoépidémilogie and Centre Midi Pyrénées de Pharmacovigilance, de Pharmacoépidémilogie et d Informations sur le Médicament du Centre Hospitalier Universitaire, Faculté de Médecine de Toulouse, France
    Clin Neuropharmacol 26:142-5. 2003
    ..This study failed to find any significant difference in the occurrence of serious EPS according to the different classes of antidepressant drugs in patients with PD treated with dopaminergic antiparkinsonian drugs...
  88. ncbi request reprint [Muscular pain and hypolipidaemic drugs: a cross-sectional study in cardiological outpatient practice]
    Julie Biga
    Service de Pharmacologie Clinique, centre Midi Pyrénées de pharmacovigilance, de Pharmacoépidémiologie et d Information sur le Médicament, Hopitaux de Toulouse, Toulouse, France
    Therapie 60:295-7. 2005
    ..The present study investigates the frequency of reports of muscular pain in cardiological outpatients...
  89. ncbi request reprint Increased exposure to statins in patients developing chronic muscle diseases: a 2-year retrospective study
    L Sailler
    Unit of Pharmacoepidemiology, EA 3696, Clinical Pharmacology Department, Paul Sabatier University, 37 Allées Jules Guesdes, 31000 Toulouse, France
    Ann Rheum Dis 67:614-9. 2008
    ..Case reports have suggested that lipid-lowering drugs (LLDs), especially statins, could induce or reveal chronic muscle diseases. We conducted a study to evaluate the association between chronic muscle diseases and prior exposure to LLDs...
  90. ncbi request reprint Buprenorphine in pregnant opioid-dependent women: first results of a prospective study
    I Lacroix
    Service de Pharmacologie Clinique, Centre Hospitalier Universitaire, Faculte de Medecine, Toulouse, France
    Addiction 99:209-14. 2004
    ..To report results on the prospective follow-up of 34 pregnant women exposed to buprenorphine maintenance for opiate dependence...
  91. ncbi request reprint Treatment of acute renal colic in a French emergency department: a comparison of simulated cases and real cases in acute pain assessment and management
    R Jean
    , , University Hospital, Faculty of Medicine, Toulouse, France
    Eur J Clin Pharmacol 57:685-9. 2001
    ..CONCLUSION: These results show a clear difference between intention to treat and real prescriptions for patients suffering from acute renal colic...
  92. ncbi request reprint [Follow-up of 'medications and pregnancy' at the Midi-Pyrenees Pharmacovigilance Center']
    T Lemoine
    , , Service de Pharmacologie Clinique, , , 31073 Toulouse, France
    Therapie 56:287-93. 2001
    ..Women included in the present survey were more often exposed to potentially harmful drugs than the general population. However, the rates of obstetric and/or neonatal complications appear similar to those reported in France as a whole...
  93. ncbi request reprint Blood concentrations of hydroxychloroquine and its desethyl derivative correlate negatively with the percentage of CD45RO+ cells among CD4+ lymphocytes in hydroxychloroquine-treated lupus patients
    Laurent Sailler
    Service de Pharmacologie Clinique, Unité de Pharmacoépidémiologie EA3696, INSERM IFR 126, Faculte de Medecine, Université Paul Sabatier 31000 Toulouse, France
    Ann N Y Acad Sci 1108:41-50. 2007
    ..Lupus patients had less CD3+CD4+CD45RO+ cells than controls (P = 0.03). In lupus patients, HCQ and DHCQ may alter the generation or the blood circulation of CD4+CD45RO+ lymphocytes in a concentration-dependent pattern...
  94. ncbi request reprint Heat-related morbidity in patients with orthostatic hypotension and primary autonomic failure
    Atul Pathak
    Laboratoire de Pharmacologie Medicale et Clinique, Faculte de Medecine, Toulouse, France
    Mov Disord 20:1213-9. 2005
    ..9%), midodrine (45.5%), or midodrine plus fludrocortisone (28.6%). This study shows that AF patients have a poor clinical outcome when exposed to high temperatures and that heat exposure is a risk factor for OH worsening...
  95. ncbi request reprint Neurotological complications after radiosurgery versus conservative management in acoustic neuromas: a systematic review-based study
    Young Je Shin
    Department of Otolaryngology, Purpan Hospital, Toulouse, France
    Acta Otolaryngol 123:59-64. 2003
    ..The aim of this study was to compare neurotological complications resulting from two treatment alternatives to microsurgery: radiosurgery and observation...
  96. ncbi request reprint Psychoactive drug consumption: performance-enhancing behaviour and pharmacodependence in workers
    T B Ngoundo-Mbongue
    Department of Clinical Pharmacology, Research Unit of Pharmacoepidemiology, EA 3696, Toulouse, France
    Pharmacoepidemiol Drug Saf 14:81-9. 2005
    ..The aim of this study was to investigate factors associated to psychoactive medication use and dependence in working environment during a 1-year period...
  97. ncbi request reprint [Assessment of drug-related risk using expected/observed methods (standardized rate method): definition and application to pharmacovigilance]
    M A Oscar
    Service de Pharmacologie Clinique, Centre Midi Pyrénées Pharmacovigilance, de Pharmacoépidémiologie et d Information sur le Médicament, Toulouse, France
    Therapie 57:402-6. 2002
    ..This method allows a quick and cheap risk assessment, although the quality of available data may limit validity of results. In this case, the hypothesis need to be examined by further ad-hoc clinical and pharmacoepidemiological studies...
  98. ncbi request reprint Adverse drug reactions in patients older than 70 years during the heat wave occurred in France in summer 2003: A study from the French PharmacoVigilance Database
    F Michenot
    Service de Pharmacologie Clinique, centre Midi Pyrénées de pharmacovigilance, de Pharmacoepidemiologie et d Informations sur le Medicament, Centre Hospitalier Universitaire de Toulouse, France
    Pharmacoepidemiol Drug Saf 15:735-40. 2006
    ....
  99. pmc Perception of the risk of adverse drug reactions: differences between health professionals and non health professionals
    V Bongard
    Laboratoire de Pharmacologie Medicale et Clinique, Unité de Pharmacoépidémiologie, Faculté de Médecine and Hôpitaux de Toulouse, France
    Br J Clin Pharmacol 54:433-6. 2002
    ..To investigate how risk of adverse drug reactions (ADRs) of several drug classes is perceived by health vs non health professionals...
  100. ncbi request reprint Detection and incidence of drug-induced agranulocytosis in hospital: a prospective analysis from laboratory signals
    N Tavassoli
    centre Midi Pyrénées de pharmacovigilance, de Pharmacoepidemiologie et d Informations sur le Medicament, Unité de Pharmacoépidémiologie EA 3696, Universite Paul Sabatier, Faculte de Medecine, Toulouse, France
    Eur J Clin Pharmacol 63:221-8. 2007
    ..Our objectives were to assess the detection and incidence of drug-induced agranulocytosis in two university hospitals using hematology laboratory data...
  101. ncbi request reprint [Inter-regional differences in dysthyroidism due to amiodarone: comparison of spontaneous notifications in Aquitaine, Midi-Pyrenees and Languedoc-Roussillon]
    H Bagheri
    Service de Pharmacologie Clinique, , , , , 31073 Toulouse, France
    Therapie 56:301-6. 2001
    ..1 months +/- 24.5) when compared with Aquitaine (28.7 +/- 28.1) or Languedoc-Roussillon (43.4 +/- 45). Our results show an interregional difference in the occurrence of hypo/hyperthyroidism due to amiodarone...